Zhou et al., Mol Cell Neurosci 2004
:
The results showed that Tat expression resulted in a significant increase in glial fibrillary acidic protein (GFAP) expression, a cellular marker of astrocyte activation or astrocytosis
Zou et al., Glia 2010
(HIV Infections) :
Involvement of p300 in constitutive and HIV-1 Tat activated expression of glial fibrillary acidic protein in astrocytes ... We have shown that Tat activates GFAP expression in astrocytes [ Zhou et al., ( 2004 ) Mol Cell Neurosci 27 : 296-305 ] and that GFAP is an important regulator of Tat neurotoxicity [ Zou et al., ( 2007 ) Am J Pathol 171 : 1293-1935 ] ... However, the underlying mechanisms for Tat mediated GFAP up-regulation are not understood ... Using siRNA, we further showed that p300 regulated both constitutive and Tat mediated GFAP expression
Wayman et al., Neuroreport 2012
:
Optical density measurements showed a Tat induced increase in glial fibrillary acidic protein expression, indicating astrogliosis in the cortical regions