Gene interactions and pathways from curated databases and text-mining

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AKT1 — TBC1D4

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Kramer et al., Diabetes 2006 : While Akt and AMPK alpha2 activities are essential for AS160 phosphorylation by insulin and AICAR, respectively, neither kinase is indispensable for the entire effects of contraction on AS160 phosphorylation
Ramm et al., J Biol Chem 2006 : 14-3-3 proteins interact with AS160 in an insulin- and Akt dependent manner via an Akt phosphorylation site, Thr-642
Funai et al., Diabetes 2009 : To evaluate the roles of AMPK and Akt on insulin- or contraction stimulated PAS-AS160 , PAS-TBC1D1, and glucose transport, rat epitrochlearis was incubated with and without compound C ( inhibitor of AMPK ) or Wortmannin ( inhibitor of phosphatidylinositol [ PI] 3-kinase, which is upstream of Akt ) before and during insulin stimulation or contraction ... These data suggest that 1 ) insulin stimulates glucose transport and phosphorylation of AS160 and TBC1D1 in a PI 3-kinase/Akt dependent manner, 2 ) contraction stimulates PAS-AS160 ( but not PAS-TBC1D1 or glucose transport ) in a PI 3-kinase/Akt dependent manner, and 3 ) contraction stimulates PAS-TBC1D1 and glucose transport ( but not PAS-AS160 ) in an AMPK dependent manner