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RELA — TCF4

Text-mined interactions from Literome

Webster et al., Mol Cell Biol 1999 : Here we show that both p53 and NF-kappaB inhibit each other 's ability to stimulate gene expression and that this process is controlled by the relative levels of each transcription factor
Nonaka et al., J Neurotrauma 1999 (Brain Injuries) : Activation of transcription factor , nuclear factor kappa B (NF-kappaB) , has been shown to play a key role in inflammatory response, neuronal survival and signaling
Aggarwal et al., Biochem Pharmacol 2000 : The nuclear factor (NF)-kappa B and the genes regulated by this transcription factor have been shown to play a critical role in induction of resistance to killer agents
Caamaño et al., J Immunol 2000 (Chronic Disease...) : Together, these results suggest a role for NF-kappaB ( 2 ) in the regulation of lymphocyte apoptosis and a unique role for this transcription factor in maintenance of T cell responses required for long-term resistance to T. gondii
Abu-Amer et al., J Clin Invest 2001 : To address this issue, this study examined whether IL-4 induced STAT6 transcription factor blocks NF-kappaB transactivation
Whan Han et al., Br J Pharmacol 2001 : Ergolide inhibited nuclear factor-kappaB (NF-kappaB) activation, a transcription factor necessary for iNOS and COX-2 expression in response to LPS/IFN-gamma
Traincard et al., J Cell Sci 2001 : Addition and correction : the NF-kappa B-like DNA binding activity observed in Dictyostelium nuclear extracts is due to the GBF transcription factor
Mansky et al., J Biol Chem 2002 (MAP Kinase Signaling System) : Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling
Hoshino et al., J Exp Med 2002 (HIV Infections...) : This is associated with loss of an inhibitory CCAAT enhancer binding protein beta ( C/EBPbeta ) transcription factor and activation of nuclear factor (NF)-kappaB
Kokura et al., Free Radic Biol Med 2002 (Ischemia...) : In particular, oxidant induced activation of the multisubunit nuclear transcription factor , NFkappaB , has been implicated in the transcriptional upregulation of inflammatory genes like endothelial cell adhesion glycoproteins
Jeong et al., Cytokine 2002 : Expression of TNF-alpha and IL-6 was regulated by a transcription factor , nuclear factor (NF)-kappaB
Nakata et al., Kekkaku 2002 (HIV Infections...) : Reduction of expression of an inhibitory C/EBP beta transcription factor and activation of NF-kappa B are observed at the site of inflammation
Kelly et al., J Biol Chem 2003 : The data also indicate that activation of the transcription factor , nuclear factor kappa B (NF kappa B) , may play a role, since the inhibitory effect of LPS and IL-1 beta on LTP was attenuated by the NF kappa B inhibitor, SN50 ; consistently, LPS and IL-1 beta led to activation of NF kappa B in entorhinal cortex
Oya et al., Carcinogenesis 2003 (Carcinoma, Renal Cell...) : The serum CRP elevation correlated with the increased NF-kappa B activation , and therefore NF-kappa B may be a causative transcription factor of inflammatory paraneoplastic syndrome
Casal et al., Neurosci Res 2004 (Translocation, Genetic) : Abeta 25/35 alone did not induce NF-kappaB activation, but Abeta 25/35 plus IFN-gamma induced the activation of the transcription factor in the mixed and pure microglial cultures, although not in pure astroglia
Spiecker et al., Arch Biochem Biophys 2005 (Inflammation) : CYP2J2 possesses vascular protective effects, which include but are not limited to, protection against ischemia-reperfusion injury, suppression of reactive oxygen species following hypoxia-reoxygenation, inhibition of the pro-inflammatory transcription factor , nuclear factor-kappaB (NF-kappaB) , attenuation of vascular smooth muscle migration, and enhancement of a fibrinolytic pathway
Andela et al., J Clin Pathol 2005 (Bone Neoplasms...) : Dominant negative inhibition of nuclear factor kappa B (NF kappa B) signalling activity in a human osteosarcoma cell line ( Saos2 ) results in malignant reversion and the induction of the osteoblast differentiating transcription factor , Runx2/Cbfa1
Fiebeler et al., Heart Fail Rev 2005 (Cardiovascular Diseases) : This production contributes to nuclear factor kappaB (NF-kappaB) activation and the genes regulated by this transcription factor
Min et al., J Immunol 2005 : RT-PCR analysis and promoter assays revealed that expression of these cell adhesion molecules was transcriptionally regulated mainly by activation of the inflammatory transcription factor , NF-kappaB
Hsiung et al., J Neurochem 2005 : Stimulation of 5-HT 1A receptor also resulted in activation of NF-kappaB through a decrease in inhibitor of nuclear transcription factor-kappaB
Franchi et al., Nat Immunol 2006 (Salmonella Infections) : Here we demonstrate that salmonella strains either lacking flagellin or expressing mutant flagellin were deficient in activation of caspase-1 and in interleukin 1beta secretion, although transcription factor NF-kappaB dependent production of interleukin 6 or the chemokine MCP-1 was unimpaired
Nangle et al., Urology 2006 (Diabetes Mellitus, Experimental) : Oxidative or glyco-oxidative stress induced activation of the transcription factor , nuclear factor (NF)-kappaB , is associated with the neurovascular complications of diabetes mellitus
Erkel et al., Int Immunopharmacol 2007 (Autoimmune Diseases...) : Panepoxydone strongly inhibited hTNF-alpha, IL-8 and NF-kappaB promoter activity in LPS/TPA stimulated MonoMac6 cells with IC ( 50 ) values of 0.5-1 microg/ml by blocking the phosphorylation of IkappaB and subsequent binding of the activated NF-kappaB transcription factor to the DNA
Saito et al., Cancer Cell 2007 (Lymphoma, B-Cell...) : Activation of the CD40 receptor leads to NF-kappaB mediated induction of the IRF4 transcription factor , which, in turn, represses BCL6 expression by binding to its promoter region
Hyun Hwa Cho et al., Biochim Biophys Acta 2008 : Downregulation of lzts2 increased the proliferation of hASCs and hBMSC, and blocked the NF-kappaB inhibitor induced inhibitory effect on their proliferation and Tcf promoter activation
Sumi et al., Yakugaku Zasshi 2007 : Although IKKbeta activates transcription factor NF-kappaB and PTP1B negatively regulates the receptor-protein tyrosine kinase, such as epidermal growth factor receptor (EGFR) in cells, covalent modification of these proteins caused by 1,2-NQ results in inhibition of NF-kappaB activity and transactivation of EGFR
Gangoiti et al., Cell Signal 2008 : C1P stimulated the activity of NF-kappaB , and inhibitors of this transcription factor completely blocked macrophage proliferation
Fantini et al., Curr Drug Targets 2008 (Cell Transformation, Neoplastic...) : Moreover, the activation of the nuclear factor kappa B (NF kappa B) , a transcription factor activated by several cytokines released during inflammation and responsible for many of their proinflammatory effects, have been shown to promote the growth of the colon tumors in experimental models
Prasad et al., Journal of inflammation (London, England) 2008 : TNFalpha is one of the major proinflammatory cytokines that causes endothelial dysfunction by various mechanisms including activation of transcription factor NF-kappaB , a key transcription factor that regulates expression of CAMs
Slevogt et al., Nat Immunol 2008 : Here we demonstrate that the interaction of CEACAM1 with ubiquitous surface protein A1 expressed on M. catarrhalis or with opacity associated proteins on N. meningitidis resulted in reduced Toll-like receptor 2-initiated transcription factor NF-kappaB dependent inflammatory responses of primary pulmonary epithelial cells
Schütze et al., Results Probl Cell Differ 2009 (MAP Kinase Signaling System) : The death receptors tumor necrosis factor-receptor 1 ( TNF-R1 ) and CD95 ( Fas, APO-1 ) are known not only to signal for cell death via apoptosis but are also capable of inducing antiapoptotic signals via transcription factor NF-kappaB induction or activation of the proliferative mitogen activated protein kinase ( MAPK ) /ERK ( extracellular signal regulated kinase ) protein kinase cascades, resulting in cell protection and tissue regeneration
Sabolek et al., Stem Cells 2009 (MAP Kinase Signaling System) : Surprisingly, IL-1beta did not activate the NF-kappaB pathway or the transcription factor activating protein 1 (AP-1), but inhibition of nuclear translocation of NF-kappaB by SN50 facilitated IL-1beta induced Nurr1 expression and dopaminergic differentiation of mdNPCs
Ali et al., Int J Biochem Cell Biol 2010 : IL-1 induced NF-kappaB DNA binding and activation by this transcription factor and this was attenuated by curcumin and apigenin ... Taken together, these results suggest a potentially crucial role for NF-kappaB in the IL-1 induced expression of C/EBPdelta, and thereby downstream APP genes regulated by this transcription factor
Iliopoulos et al., Cell 2009 (Inflammation) : IL6 mediated activation of the STAT3 transcription factor is necessary for transformation, and IL6 activates NF-kappaB , thereby completing a positive feedback loop
Ohdaira et al., Comput Biol Chem 2009 (Lung Neoplasms) : Using a luciferase reporter assay, we also showed that hsa-miR-601 specifically repressed nuclear factor-kappaB (NF-kappaB) transcription factor dependent reporter expression, a key component of the immune-oncogenesis pathway
Kim et al., Age (Dordrecht, Netherlands) 2010 : It is also known that AGE enhance the generation of RS and that the binding of AGE to a specific AGE receptor ( RAGE ) induces the activation of the redox-sensitive, pro-inflammatory transcription factor , nuclear factor-kappa B (NF-kB)
Hwang et al., Cancer Biochem Biophys 1995 : The intranuclear transcription factor complexes contained two NF-kappa B heterodimers, p50/RelA and p50/c-rel. Taxol induced nuclear translocation of NF-kappa B was inhibited by pyrrolidine dithiocarbamate, an antioxidant, but not by cycloheximide, a protein synthesis inhibitor
Kalvakolanu et al., Proc Natl Acad Sci U S A 1993 (Teratoma) : We have recently shown that the adenovirus E1A gene products block interferon-alpha induced signal transduction and transcription factor NF-kappa B-mediated gene induction
Gasparro et al., Photochem Photobiol 1996 : In cellular studies with UV or photoactivatable agents, the activation of NF-kappa B , probably the most widely studied transcription factor , occurs after its release from an inhibiting factor, I kappa B
Lindholm et al., J Virol 1996 : Human T-cell lymphotropic virus type 1 Tax1 induces the activation and nuclear localization of the cellular transcription factor , NF-kappa B
Curtiss et al., Mol Cell Biol 1996 : This strongly suggests that activation of NF-kappaB is insufficient to activate transcription via the CD28RE-AP-1 element of the IL-2 promoter and that a different transcription factor , upregulated via the activation domain of the HTLV-1 Tax protein, may be involved
Singh et al., J Immunol 1996 (Leukemia, Myelomonocytic, Acute) : Viral replication, immune regulation, and induction of various inflammatory and growth-regulatory genes require activation of a nuclear transcription factor ( NF)-kappa B
Behl et al., J Neural Transm Suppl 1997 (Alzheimer Disease) : In addition, A beta induces NF-kB activity, a transcription factor thought to be regulated by oxidative stress
Faux et al., Environ Health Perspect 1997 : This would suggest that lipoxygenase metabolites of arachidonic acid, produced following lipid peroxidation, are involved in the cellular signalling events to NF-kappa B transcription factor induction by asbestos
Lentsch et al., J Immunol 1999 (Acute Disease...) : In the presence of anti-IL-13, activation of the transcription factor , NF-kappaB , was significantly increased in lung
Jaeschke et al., Hepatology 1999 (Endotoxemia...) : However, there was no significant difference in other critical parameters, e.g., activation of the transcription factor , nuclear factor-kappaB (NF-kappaB) , and soluble intercellular adhesion molecule-1 ( sICAM-1 ), parenchymal cell apoptosis, and neutrophil sequestration in the liver