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MAPK1 — TGFB2

Text-mined interactions from Literome

Han et al., J Biol Chem 2000 : TGF-beta1/TGF-beta2 increased phosphorylation of both mitogen activated protein ( MAP ) kinase and PPAR-gamma, whereas MAP kinase inhibitors reversed suppression of CD36 and inhibited PPAR-gamma phosphorylation induced by TGF-beta1/TGF-beta2
Johansson et al., J Cell Sci 2000 (Carcinoma, Squamous Cell) : In addition, transforming growth factor- ( beta ) ( TGF- ( beta ) activated p38 MAPK in both cell lines, and ERK2 in A-5 cells
Westermarck et al., Mol Cell Biol 2001 (MAP Kinase Signaling System) : In contrast, activation of stress activated c-Jun N-terminal kinase and p38 pathways by expression of constitutively active mutants of Rac, transforming growth factor beta activated kinase 1 ( TAK1 ), MAPK kinase 3 ( MKK3 ) , or MKK6 or by treatment with arsenite or anisomycin did not alone markedly enhance MMP-1 promoter activity
Bhowmick et al., J Biol Chem 2001 : Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity
Sato et al., J Invest Dermatol 2002 (Scleroderma, Systemic) : Role of p38 MAPK in transforming growth factor beta stimulation of collagen production by scleroderma and healthy dermal fibroblasts ... In conclusion, this study demonstrates a costimulatory role for p38 MAPK in transforming growth factor beta induction of the collagen type I gene
Kimoto et al., Invest Ophthalmol Vis Sci 2004 (MAP Kinase Signaling System) : TGF-beta 2 activates p38 MAPK and p38 MAPK plays a role in relaying the TGF-beta 2 signal to type I collagen production in the retinal pigment epithelium
Suzuki et al., Clin Exp Nephrol 2004 : Role of mitogen activated protein kinase in the regulation of transforming growth factor-beta induced fibronectin accumulation in cultured renal interstitial fibroblasts
Jamora et al., PLoS Biol 2005 (MAP Kinase Signaling System) : We found that transforming growth factor beta2 signaling is necessary to transiently induce the transcription factor Snail and activate the Ras-mitogen activated protein kinase ( MAPK ) pathway in the bud
Roux et al., J Biol Chem 2005 (Edema) : The inhibitory effect of IL-1beta on alpha ENaC expression was mediated by the activation of p38 MAPK in both rat and human ATII cells and was independent of the activation of alpha v beta6 integrin and transforming growth factor-beta
Leung et al., Nephrol Dial Transplant 2005 : The GDP induced VEGF and transforming growth factor ( TGF ) -beta synthesis in HPMC was partially reduced by either the p42/p44 MAPK inhibitor ( PD98059 ) or the PKC inhibitor ( staurosporine )
Saika et al., Lab Invest 2005 (Disease Models, Animal...) : Exogenous TGF-beta2 activates p38MAPK in ARPE-19 cells
Opperman et al., Dev Dyn 2006 : In summary, Tgf-beta2 stimulated Erk1/2 phosphorylation and induced Egf and Erk1/2 expression, associated with suture closure after 72 hr. Blocking Erk1/2 activity with PD inhibited these effects but increased Smad2/3 expression
Gaide Chevronnay et al., Endocrinology 2008 : In presence of ovarian steroids, MAPK inhibitors ( p38 and ERK pathways ) stimulated TGF-beta3 but inhibited TGF-beta2 expression ... The opposite regulation of TGF-beta2 and -beta3 by cAMP and MAPK could account for their distinct expression in vivo
Cheng et al., Molecular vision 2008 (Fibrosis) : TGFbeta2 induced sequential phosphorylation of Smad2 and Smad3 and p38 MAPK ... TGZ inhibited TGFbeta2 induced early Smad2 and Smad3 and late Smad3 phosphorylation but had no influence on TGFbeta2 induced p38 MAPK activation ... On the other hand, TGZ does not alter the levels of TGFbeta2 induced p38 MAPK phosphorylation, the effect of TGZ is unlikely to be mediated by p38 MAPK signaling
Pattabiraman et al., Am J Physiol Cell Physiol 2010 (Mechanotransduction, Cellular) : RhoAV14, lysophosphatidic acid, and TGF-beta(2) stimulated significant increases in Erk1/2 phosphorylation, paralleled by profound increases in fibronectin, serum response factor (SRF), and alpha-SMA expression
Krug et al., Hypertension 2010 : MR blockade and extracellular signal regulated kinase 1/2 mitogen activated protein kinase inhibition prevent age associated increases of transforming growth factor-beta , intercellular adhesion molecule 1, and procollagen 1
Leenders et al., J Biol Chem 2010 (Hypertrophy, Left Ventricular) : We show that transforming growth factor-beta mediated activation of p38 MAPK is necessary and sufficient to decrease KLF15 expression