Gene interactions and pathways from curated databases and text-mining

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MAPK3 — TH

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Gelain et al., J Neurochem 2007 (Calcium Signaling) : The retinol induced rise in intracellular calcium then led to a second slower mechanism ; this involved an increase in reactive oxygen species, activation of extracellular signal regulated kinase 1/2 and serine31 phosphorylation and the maintenance of tyrosine hydroxylase activation for up to 2 h
Knowles et al., J Neuroendocrinol 2011 : Thus, ERK1/2 mediated serine 31 phosphorylation of tyrosine hydroxylase appears necessary but not sufficient for nicotinic activation of catecholamine synthesis in cervine chromaffin cells
Sutherland et al., Eur J Biochem 1993 : Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen activated protein ( MAP ) kinase and MAP-kinase activated kinases 1 and 2