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NFKB1 — TIRAP

Text-mined interactions from Literome

Bannerman et al., Biochem Biophys Res Commun 2002 : TIRAP mediates endotoxin induced NF-kappaB activation and apoptosis in endothelial cells ... Using a TIRAP dominant negative construct, we have identified a role for TIRAP in mediating LPS induced NF-kappaB activation and apoptosis in human endothelial cells
Andreakos et al., Blood 2004 : We found that MyD88 and Mal/TIRAP are essential for LPS induced I kappa B alpha phosphorylation, NF-kappa B activation, and interleukin 6 (IL-6) or IL-8 production in fibroblasts and endothelial cells in a pathway that also requires IKK2 ... In contrast, in macrophages neither MyD88, Mal/TIRAP , nor I kappa B kinase 2 (IKK2) are required for NF-kappa B activation or tumor necrosis factor alpha (TNF alpha), IL-6, or IL-8 production, although Mal/TIRAP is still involved in the production of interferon beta (IFN beta)
Sacre et al., J Endotoxin Res 2004 : In cell lines and murine models, parts of the signaling pathways involved have been elucidated with MyD88, Mal/TIRAP and IKK2 playing an important role in the induction of NF-kappaB ... We show that in primary human macrophages MyD88, Mal/TIRAP and IKK2 independent alternative pathways activate NF-kappaB and induce the expression of inflammatory cytokines, whereas in non-myeloid synovial fibroblasts MyD88 and/or Mal/TIRAP are essential adaptors for LPS signaling
Li et al., J Mol Med (Berl) 2005 : LPS induced, TLR4 mediated signaling employs multiple TIR-domain containing adaptors, MyD88/TIRAP to mediate NFkappaB activation, TRIF/TRAM for IRF3 activation
Qiu et al., Dev Comp Immunol 2008 : The over-expression of chicken MyD88-2 significantly induced the activation of NF-kappaB in vitro, suggesting that chicken MyD88-2 plays an important role in the innate immune responses of chicken
Radhakrishnan et al., J Biol Chem 2009 : We found that TcpB could efficiently block TIRAP induced NF-kappaB activation
Verstak et al., J Biol Chem 2009 (Bacterial Infections...) : MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4 mediated NF-kappaB proinflammatory responses
Liu et al., J Immunol 2010 : Overexpression of zebrafish Tirap in HEK293T cells did not activate NF-kappaB and IFN-beta, but slightly activated NF-kappaB in carp leukocyte cells