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IL8 — TLR1

Text-mined interactions from Literome

Dziarski et al., J Endotoxin Res 2000 : Therefore, TLR2 is a functional receptor for both Gram positive and Gram negative bacteria and it induces activation of IL-8
Köllisch et al., Immunology 2005 : The TLR ligands peptidoglycan, Pam3Cys and flagellin which bind to TLR2, TLR1/TLR2 heterodimer, and TLR5, respectively, also induced IL-8 secretion, whereas no IL-8 was induced by LPS, R-848, loxoribine and cytosine guanine dinucleotide containing oligodeoxynucleotide
Raffatellu et al., Infect Immun 2005 : Collectively, these data suggest that the scarcity of neutrophils in intestinal infiltrates of typhoid fever patients is due to a capsule mediated reduction of TLR dependent IL-8 production in the intestinal mucosa
Kramer et al., J Leukoc Biol 2006 (Crohn Disease) : Moreover, they lack MDP induced enhancement of TLR mediated tumor necrosis factor alpha, interleukin (IL)-12 , and IL-10 production, which is observed in control DC with intact NOD2
Mueller et al., J Immunol 2006 : TLR4/MD-2 mediated LPS uptake and TLR ligand induced I-kappaBalpha phosphorylation and IL-8 secretion were significantly diminished in Th2 cytokine primed IECs
Cho et al., Immunol Lett 2007 (Arthritis, Rheumatoid) : Thus, TLR-2 activation in RA FLS by microbial constituents could be involved in the induction of VEGF and IL-8 and thereby promote inflammation either directly or via angiogenesis
Uehara et al., Mol Immunol 2007 : Anti-RP3 Abs markedly promoted the release of IL-8 induced by chemically synthesized TLR and NOD ligands mimicking bacterial components : TLR2-agonistic lipopeptide ( FSL-1 ), TLR3-agonistic poly I:C, TLR4-agonistic lipid A ( LA-15-PP ), TLR7/8-agonistic single stranded RNA ( ssPolyU ), TLR9-agonistic bacterial CpG DNA, NOD1-agonistic FK156/565 and NOD2-agonistic muramyldipeptide ( MDP ) in THP-1 cells and human peripheral blood mononuclear cells, although sole incubation with anti-PR3 Abs induced only a low level of IL-8
Kanczkowski et al., Horm Metab Res 2007 (Adrenal Cortex Neoplasms) : The aim of this study was to clarify the role of different TLR ligands in IL8 production in NCI-H295R cells
Koff et al., Am J Physiol Lung Cell Mol Physiol 2008 : We conclude that multiple TLR ligands induce airway epithelial cell production of IL-8 and VEGF via a Duox1 -- > ROS -- > TACE -- > TGF-alpha -- > EGFR phosphorylation pathway
Buchholz et al., Infect Immun 2008 (Inflammation) : IL-8 induced at 30 h postinfection by C. trachomatis was dependent on NOD1 signaling through RIP2 ; however, the IL-8 response was independent of MyD88 dependent TLR signaling
Wang et al., Blood 2008 : We and others have reported that Toll-like receptor ( TLR ) proteins are present on human neutrophils and that granulocyte-macrophage colony stimulating factor ( GM-CSF ) treatment enhances IL-8 ( CXCL8 ) secretion in response to stimulation with TLR ligands
Perez et al., Am J Physiol Lung Cell Mol Physiol 2008 (Cystic Fibrosis...) : In vitro, PPARgamma agonists reduced IL-8 and MMP-9 release from airway epithelial cells in response to PAO1 or TNFalpha/IL-1beta stimulation
Berndt et al., Equine Vet J 2009 (Airway Obstruction...) : In human airway epithelium, TLR2 activation leads to interleukin (IL)-8 production
Lee et al., J Parasitol 2010 : We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and MUC expression is regulated by interferon (IFN)-gamma, interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Im et al., Mol Immunol 2009 : Collectively, these results suggest that flagellin induced IL-8 expression requires formation of lipid rafts, intracellular TLR activation, and subsequent activation of PKC and MAP kinases leading to the activation of the transcription factors NF-kappaB and NF-IL6 in human alveolar type II epithelial cells
Suzuki et al., J Dent Res 2009 (Gingival Overgrowth) : In human gingival fibroblasts, cyclosporin alone did not induce evident inflammatory responses, but augmented the expression of CD54 and the production of interleukin (IL)-6 and IL-8 induced by TLR ligands, whereas phenytoin attenuated those responses
Manuse et al., Virology 2010 : Unexpectedly, TLR3 activation in infected cells led to enhanced IL-8 secretion, which correlated with increased RIG-I expression
Khan et al., J Immunol 2010 : Conversely, stable overexpression of Sigirr diminished NF-kappaB mediated IL-8 responses to TLR ligands
Han et al., Vet Microbiol 2010 : Involvement of TLR21 in baculovirus induced interleukin-12 gene expression in avian macrophage-like cell line HD11
Piconi et al., AIDS 2010 (HIV Infections) : Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V, activation of caspases 8 and 9, Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed
Chung et al., J Infect Dis 2010 (Hepatitis C, Chronic) : Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of interleukin 17 by naive CD4 ( + ) T cells in the presence of TLR ligands
Li et al., Int J Mol Med 2011 : In addition, Atg7 gene expression silencingled to down-regulation of TLR mediated IL-8 expression in IECs, which indicates a potential role of autophagy in generating innate-immune responses
Thornton et al., Neonatology 2012 : Toll-like receptor 1/2 stimulation induces elevated interleukin-8 secretion in polymorphonuclear leukocytes isolated from preterm and term newborn infants
Hanamsagar et al., Trends Immunol 2012 : TLR signaling triggers the transcriptional activation of pro-interleukin-1ß ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome
Li et al., eLife 2012 : A sequence containing 13 nucleotides near the active site of 23S rRNA ribozyme, which catalyzes peptide bond synthesis, was both necessary and sufficient to trigger TLR13 dependent interleukin-1ß production
Koblansky et al., Immunity 2013 (Genetic Predisposition to Disease...) : Toll-like receptor 11 ( TLR11 ) recognizes T. gondii profilin ( TgPRF ) and is required for interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice
Schamber-Reis et al., J Biol Chem 2013 (Disease Resistance...) : Altogether, our results indicate the redundant and essential role of nucleic acid sensing TLR3, TLR7 and TLR9 in inducing interleukin 12, development of a T1 response, and resistance to L. major infection in resistant C57BL/6 mice
Wu et al., PloS one 2013 : We showed that the hADSCs expressed Toll-like Receptors (TLR) 1 , TLR2, TLR3, TLR4, and TLR6 and that lipopolysaccharide (LPS) significantly induced the production of pro-inflammatory cytokines ( Cyclooxygenase-2 (Cox-2), Interleukin-1ß (IL-1ß), Interleukin-6 (IL-6), and Interleukin-8 (IL-8) )
Pugazhendhi et al., Int J Tuberc Lung Dis 2013 (Colonic Diseases...) : The mRNA expression of interleukin-8 (IL-8) , induced protein-10, tumour necrosis factor-alpha, IL-23 p19 and IL-12 p40, and Toll-like receptors (TLR) 1 and 2 in the ulcerated mucosa was increased in both intestinal TB and Crohn 's disease