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IRF1 — TLR4

Text-mined interactions from Literome

Nhu et al., J Endotoxin Res 2006 : Transcriptional regulation of lipopolysaccharide (LPS) induced Toll-like receptor ( TLR ) expression in murine macrophages : role of interferon regulatory factors 1 (IRF-1) and 2 ( IRF-2 ) ... Given that IRF-1 and IRF-2 counter-regulate the transcriptional activity of many genes, we hypothesized that IRF-1 and IRF-2 might also regulate TLR gene expression following LPS stimulation of murine macrophages
Abe et al., Arterioscler Thromb Vasc Biol 2008 (Inflammation...) : Statins inhibited TLR4 mediated activation of interferon ( IFN ) regulatory factor ( IRF)3 by either lipopolysaccharide (LPS) or palmitic acid, resulting in suppression of IFN-beta expression, but not that of NF-kappaB or JNK
Hickey et al., J Leukoc Biol 2008 : Adenylate cycalse toxin of Bordetella pertussis inhibits TLR induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells
Atzei et al., J Biol Chem 2010 : We now describe the first functional characterization of the human ortholog of Cactin ( hCactin ) and show that it acts as a negative regulator of TLRs. Overexpression of hCactin suppresses TLR induced activation of NF-?B and interferon-regulatory factor transcription factors and induction of TLR-responsive genes, whereas knockdown of endogenous hCactin augments TLR induction of these responses
Dhupar et al., Shock 2011 (Reperfusion Injury) : Together, these findings suggest that I/R induced release of acetylated HMGB1 is a process that is dependent on TLR4 mediated upregulation of IRF-1