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MAPK15 — TLR4

Text-mined interactions from Literome

Jiang et al., J Biol Chem 2003 (MAP Kinase Signaling System) : However, we find that, in response to dsRNA, TLR3 can mediate the activation of both NFkappaB and mitogen activated protein ( MAP ) kinases in IL-1-unresponsive mutant cell lines, including IRAK-deficient I1A and I3A cells, which are defective in a component that is downstream of IL-1R but upstream of IRAK
Haralambieva et al., J Med Microbiol 2004 : Together the results indicate that C. pneumoniae triggers rapid TLR4 mediated p44/p42 MAPK activation in human fibroblasts and chemical enhancement of MAPK phosphorylation modulates in vitro infection at the molecular level
Lentschat et al., J Immunol 2005 : In addition to inhibition of TLR4 mediated MAPK phosphorylation in macrophages, mastoparan blunted IL-1R associated kinase-1 kinase activity induced by LPS, but not by TLR2 agonists, yet failed to affect phosphorylation of Akt by phosphoinositol-3-kinase induced by either TLR2- or TLR4 mediated signaling
Schnyder-Candrian et al., J Immunol 2005 (Leukocytosis...) : In conclusion, LPS provokes acute bronchoconstriction that is TNF dependent and p38 MAPK mediated, whereas the neutrophil recruitment is independent of TNF but depends on LPS/TLR4 induced signals mediated by p38 MAPK
Otterbein et al., Cell Mol Biol Incl Cyto Enzymol 2005 : Furthermore, inhibition of p38 MAPK attenuated CO/E. coli induced surface expression of TLR4 and abrogated the CO effects on E. coli phagocytosis
Chen et al., Cancer Res 2005 (Genetic Predisposition to Disease...) : The Toll-like receptor 4 (TLR4) presents the bacterial lipopolysaccharide (LPS), which interacts with ligand binding protein and CD14 ( LPS receptor ) and activates expression of inflammatory genes through nuclear factor-kappaB and mitogen activated protein kinase signaling
Salojin et al., J Immunol 2006 (Arthritis, Experimental...) : MKP-1-deficient macrophages also show enhanced constitutive and TLR induced activation of p38 MAPK
Didierlaurent et al., Mol Cell Biol 2006 : Activation of interleukin-1 (IL-1) receptor ( IL-1R ), Toll-like receptor 2 (TLR2), and TLR4 triggers NF-kappaB and mitogen activated protein kinase ( MAPK ) -dependent signaling, thereby initiating immune responses
Chi et al., Proc Natl Acad Sci U S A 2006 (Shock, Septic) : Thus, p38 MAPK plays a critical role in mediating IL-10 synthesis in TLR signaling
Yadav et al., Blood 2006 : We determined that mitogen activated protein kinase ( MAPK ) activation and tumor necrosis factor-alpha (TNF-alpha) production in macrophage infected with Mycobacterium avium or M smegmatis is dependent on myeloid differentiation factor 88 ( MyD88 ) and TLR2 but not TLR4 , MR, or CR3
Cuschieri et al., J Leukoc Biol 2006 : Although PKC activation by PMA had no effect on naïve cells, it did result in reversal in tolerance induced suppression of TLR4 and HSP70 lipid raft mobilization, MAPK activation , and TNF-alpha production
Pathak et al., J Immunol 2006 : HP0175 induced IL-6 gene expression was critically dependent on TLR4 dependent NF-kappaB and MAPK activation ... TLR4/PI3K dependent ERK1/2 and p38 MAPK signaling converged upon activation of mitogen- and stress activated protein kinase 1 ( MSK1 )
Moeinpour et al., Mol Immunol 2007 (Hemorrhage...) : Inflammatory mediators, Toll-like receptor ( TLR ) and myeloid differentiation adaptor protein ( MyD88 ) expression, and the activation of mitogen activated protein kinase ( MAPK ) were determined ... These findings suggest that 17beta-estradiol normalizes epidermal keratinocytes inflammatory responses following trauma-hemorrhage by preventing the upregulation of TLR4 mediated MAPK activation
Yanagawa et al., J Immunol 2007 : TLR4 mediated activation of p38 MAPK was markedly suppressed, whereas that of ERK1/2 was enhanced in the TLR4,2 primed DCs compared with naive DCs
Fang et al., Am J Physiol Lung Cell Mol Physiol 2007 (MAP Kinase Signaling System...) : Lipopolysaccharide (LPS) induces acute lung injury ( ALI ) via Toll-like receptor 4 (TLR4) mediated MAPK activation
Banerjee et al., Immunol Cell Biol 2007 : Toll-like receptor ( TLR ) signaling leads to the activation of mitogen activated protein kinase and nuclear factor-kappaB signaling pathways
Li et al., Acta Anaesthesiol Taiwan 2007 (Inflammation) : The p47phox- and Rac 1-dependent NADPH oxidase activation, ROS production, and MAPK signaling pathways play critical roles in endotoxin enhanced TLR4 expression and TLR4 mRNA stabilization in VSMCs
Robinson et al., Mol Cell Biol 2007 : Tumor progression locus 2 (TPL-2) kinase is essential for Toll-like receptor 4 activation of the mitogen activated protein kinase extracellular signal regulated kinase ( ERK ) and for upregulation of the inflammatory cytokine tumor necrosis factor (TNF) in lipopolysaccharide (LPS) stimulated macrophages
Zhou et al., World J Gastroenterol 2008 (Adenocarcinoma...) : Viable LBG or LBG- ( s ) pretreatment attenuated the expression of TLR4 , inhibited the phosphorylation of TAK1 and p38MAPK , prevented the activation of NF-kappaB, and consequently blocked IL-8 production
Park et al., J Immunol 2009 : Protein kinase D1 (PKD1) has been shown to be involved in certain MAPK activation and cytokine expression by several TLR ligands
Liu et al., Cell Physiol Biochem 2010 : More importantly, our data provide novel evidence that CRP exerts a proinflammatory action via TLR4 dependent signaling pathway ( AT(1)R-p38 MAPK-TLR4-PKCalpha ) in VSMCs
Michelsen et al., Atherosclerosis 2010 (Carotid Artery Diseases...) : Our main findings were : ( 1 ) serum YKL-40 levels were significantly elevated in patients with carotid atherosclerosis, with particularly high levels in those with symptomatic disease ; ( 2 ) patients with recent ischemic symptoms ( within 2 months ) had higher YKL-40 mRNA levels in carotid plaque than other patients ; ( 3 ) in vitro, the beta-adrenergic receptor agonist isoproterenol, toll-like receptor (TLR) 2 and TLR4 agonists, and in particular releasate from activated platelets significantly increased the expression of YKL-40 in THP-1 monocytes and ( 4 ) in vitro, YKL-40 increased matrix metalloproteinase-9 expression and activity in THP-1 monocytes, involving activation of p38 mitogen activated protein kinase
Liu et al., Brain Res 2010 (Bone Neoplasms...) : Tibia tumor induced cancer pain involves spinal p38 mitogen activated protein kinase activation via TLR4 dependent mechanisms ... These results demonstrate that TLR4 dependent phosphorylation of p38MAPK in spinal cord of rats might contribute to the development and maintenance of bone cancer pain, and p38MAPK and TLR4 would possibly be the potential targets for pain therapy
Doyle et al., FASEB J 2011 (Muscular Atrophy) : TLR4 mediated activation of p38 MAPK is necessary and sufficient for the up-regulation of atrogin1/MAFbx and autophagosomes, resulting in myotube atrophy
Dogan et al., Microbes Infect 2011 : Pneumolysin induced CXCL8 production by nasopharyngeal epithelial cells is dependent on calcium flux and MAPK activation via Toll-like receptor 4 ... Ply induces production of CXCL8 by nasopharyngeal cells using signalling mechanisms involving Ca ( 2+ ) mobilisation and activation of MAPK and NF-?B via TLR4
Gorina et al., Glia 2011 : Mitogen activated protein kinases ( MAPK ) were also involved in TLR4 signaling in a MyD88 independent fashion
Barona et al., J Pharm Pharmacol 2011 : Polymyxin ( TLR4 inhibitor ), SB203580 ( p38 MAPK inhibitor ), SP600125 ( JNK1/2 inhibitor ) and U0126 ( MEK1/2 inhibitor ) antagonized the effects of the LPS on ACh induced contractions in duodenal smooth muscle
Lee et al., Immune network 2011 : Here, we show that deoxypohophyllotoxin (DPT) induces maturation and activation of bone marrow derived DCs via Toll-like receptor (TLR) 4 activation of MAPK and NF-?B
Tsai et al., PloS one 2011 : These results strongly suggest that Der-p2 is capable of triggering B cell activation and MKP-1 activated p38/MAPK dephosphorylation regulated TLR4 induction, which subsequently enhances host immune, defense responses and development of effective allergic disease therapeutics in B cells
Yang et al., Infect Immun 2011 (Plague) : Analysis of this network showed that signaling pathways important for host immune responses were preferentially targeted by Y. pestis, including the pathways involved in focal adhesion, regulation of cytoskeleton, leukocyte transendoepithelial migration, and Toll-like receptor ( TLR ) and mitogen activated protein kinase ( MAPK ) signaling
Shimazu et al., Infect Immun 2012 : In addition, we demonstrated that L. jensenii TL2937 attenuated the expression of proinflammatory cytokines and chemokines caused by ETEC or LPS challenge by downregulating TLR4 dependent nuclear factor?B ( NF-?B ) and mitogen activated protein kinase ( MAPK ) activation
Song et al., Toxicol Pathol 2012 : The regulatory effect of complement on TLR signaling was mediated by the anaphylatoxins C5a and C3a through a receptor dependent mechanism and involved increased mitogen activated protein kinase and nuclear factor ?B activation
Avila et al., Innate Immun 2012 : Lyn kinase controls TLR4 dependent IKK and MAPK activation modulating the activity of TRAF-6/TAK-1 protein complex in mast cells
Zbinden-Foncea et al., Med Sci Sports Exerc 2012 (MAP Kinase Signaling System) : TLR2 and TLR4 activate p38 MAPK and JNK during endurance exercise in skeletal muscle
Yee et al., Eur J Immunol 2013 : ß2 integrins inhibit TLR responses by regulating NF-?B pathway and p38 MAPK activation
de Almeida et al., Infect Immun 2013 (Brucellosis...) : Furthermore, our findings demonstrated that the mitogen activated protein kinase ( MAPK ) signaling pathway is impaired in TLR2, TLR6 , and TLR2/6 knockout ( KO ) DCs when infected with B. abortus, which may account for the lower proinflammatory cytokine production observed in TLR6 KO mouse dendritic cells
Dimitrakopoulos et al., Microbes Infect 2013 : B. melitensis caused a delayed, TLR2 dependent MAPK activation
Yang et al., Lab Invest 2013 (Acute Lung Injury...) : Inhibition of TLR4 expression in the lung tissue by infection with pGCSIL-GFP-lentivirus expressing small hairpin RNAs targeting the TLR4 gene ( TLR4-shRNA lentivirus ) significantly attenuated ALI, lung inflammation, and activity of p38MAPK and AP-1 in the lung tissue
Zhong et al., Science signaling 2013 (MAP Kinase Signaling System...) : Deficiency in USP25 enhanced the extent of ubiquitination of TRAF3 and accelerated its degradation after TLR4 activation, which potentiated TLR4 induced activation of NF-?B ( nuclear factor ?B ) and MAPK ( mitogen activated protein kinase ) signaling, but inhibited activation of the transcription factor IRF3 ( interferon regulatory factor 3 )