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TLR5 — TNF

Text-mined interactions from Literome

Means et al., J Immunol 2001 (Tuberculosis) : Together, these data suggest that Mtb induced TNF-alpha production is largely dependent on TLR signaling
Takami et al., J Immunol 2002 : Moreover, various TLR ligands ( e.g., peptidoglycan, poly ( I:C ) dsRNA, LPS, and CpG motif of unmethylated DNA, which act as ligands for TLR2, 3, 4, and 9, respectively ) induced NF-kappa B activation and up-regulated TNF-alpha production in osteoclast precursor cells
Lucas et al., J Immunol 2003 : TLR ligands induced early and sustained secretion of TNF-alpha , macrophage-inflammatory protein (MIP) 1alpha and MIP-2 with later secretion of IL-10, IL-12, and TGF-beta1 ; apoptotic cells alone stimulated late TGF-beta1 secretion only
Goral et al., J Immunol 2005 (Inflammation) : Furthermore, different TLR ligands stimulated IL-6 and TNF-alpha production via signaling pathways, which showed unique characteristics
Levy et al., J Endotoxin Res 2005 : Differences between newborns and adults with respect to TLR induced TNF-alpha release extend to a range of TLR agonists, including bacterial lipopeptides, and are due to differences in soluble factors present in blood plasma ... Soluble factors in neonatal blood plasma suppress TLR induced TNF-alpha release from monocytes and efforts to identify and characterize these inhibitors are on-going
Suliman et al., FASEB J 2005 : In wild-type ( Wt ) mice injected with heat inactivated E. coli, hepatic TLR4 and TLR2 proteins were up-regulated with TLR dependent increases in transcript levels for tumor necrosis factor ( TNF-alpha ), interleukin 6, nitric oxide synthase-II ( iNOS ), and NADPH oxidase 2 (Nox2)
Flandin et al., Eur J Immunol 2006 (Inflammation...) : Silencing of TLR3, TLR2, IRAK-1 and myeloid differentiation factor 88 ( MyD88 ) expression by RNA interference revealed that both TLR are involved in the secretion of NO and TNF-alpha induced by L. donovani promastigotes
Deering et al., Clinical and vaccine immunology : CVI 2006 : Although a number of variables influence TLR ligand induced TNF responses, this assay can be optimized for potential clinical use to screen patients with primary immunodeficiencies affecting TLR function
Szczepański et al., Eur Arch Otorhinolaryngol 2006 (Cholesteatoma, Middle Ear...) : TLR-ligand binding results in cell signal transduction and subsequent production of various proinflammatory cytokines such as IL-1 and TNF-alpha
Hu et al., Immunity 2006 (Arthritis...) : We report that IFN-gamma augments induction of TNFalpha by TLR ligands, immune complexes, and zymosan by suppressing IL-10 production and thereby interrupting Stat3 mediated feedback inhibition
Levy et al., J Immunol 2006 : The adenosine system selectively inhibits TLR mediated TNF-alpha production in the human newborn ... Selective inhibition of neonatal TNF-alpha production is due to the distinct neonatal adenosine system, including relatively high adenosine concentrations in neonatal blood plasma and heightened sensitivity of neonatal mononuclear cells to adenosine A3 receptor mediated accumulation of cAMP, a second messenger that inhibits TLR mediated TNF-alpha synthesis but preserves IL-6 production
Ji et al., Zhong Xi Yi Jie He Xue Bao 2006 : QGHXR can protect liver cells by down regulating the expressions of CD14, TLR(4) and NF-kappaB and inhibiting TNF-alpha expression
Mohri et al., J Trauma 2006 (Systemic Inflammatory Response Syndrome) : Expression of HO-1, TLR2 , and TLR4 in monocytes was significantly enhanced in patients with severe SIRS compared with that in healthy volunteers, whereas intracellular TNF-alpha expression with peptidoglycan was significantly decreased ( p < 0.05 ) in patients compared with that in healthy volunteers
Kim et al., Immunol Lett 2007 (Arthritis, Rheumatoid...) : TLR stimulation of RA-FLS also induced the production of IL-1beta and TNF-alpha to a lesser extent ; however, it had no effect on IL-17 production
Shu et al., Clin Exp Immunol 2007 : natural killer ( NK ) 1.1 ( - ) CD11c ( + ) liver DC subsets ( conventional DCs, T cell receptor ( TcR ) beta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( - ) and plasmacytoid DCs, TcRbeta ( - ) NK1.1 ( - ) CD11c ( + ) B220 ( + ) ) efficiently endocytose dextran and produce significant levels of tumour necrosis factor (TNF)-alpha , interleukin (IL)-6 and IL-12 p40 in response to Toll-like receptor ( TLR ) ligands, with responses higher than splenic DCs
Koval'chuk et al., Zh Mikrobiol Epidemiol Immunobiol 2007 (Common Variable Immunodeficiency) : Spontaneous production of TNF-alpha by PBMC in patients with CVID was increased and accompanied by decrease in TNF-alpha production stimulated by each analyzed ligands except CpG. Observed changes in TLR dependent TNF-alpha production can play important role in pathogenesis of CVID
Sá-Nunes et al., J Immunol 2007 : Saliva at remarkably diluted concentrations ( < 1/2000 ) promotes a dose dependent inhibition of IL-12 and TNF-alpha production induced by all TLR ligands used
Ferwerda et al., J Leukoc Biol 2007 (Crohn Disease) : TLR induced TNF-alpha , IL-1beta, and IL-10 production is mediated through MyD88, whereas Toll-IL-1R domain containing adaptor inducing IFN-beta ( TRIF ) promoted the release of IL-1beta
Hawn et al., J Immunol 2007 (Inflammation...) : In addition, WT, but not Tlr5 ( -/- ), AMs produced TNF-alpha after stimulation with Lp. Live LpFlaA- did not induce TNF-alpha secretion in AM
Koval'chuk et al., Bull Exp Biol Med 2007 (Common Variable Immunodeficiency) : Reduced stimulated production of TNF-alpha in response to stimulation with TLR4 and TLR5 ligands in vitro was detected in patients with common variable immunodeficiency
Taneichi et al., Clin Immunol 2008 (Agammaglobulinemia...) : Stimulation with TLR2, TLR4 and TLR7/8 ligands, as well as TLR3 ligand, resulted in significantly lower production of TNF-alpha , but neither IL-6 nor IL-12p70, by DCs from XLA patients in comparison to normal controls
Prescott et al., J Allergy Clin Immunol 2008 (Hypersensitivity...) : Maternal allergy ( n = 59 ) was associated with significantly higher neonatal IL-12 and IFN-gamma responses to TLR2, TLR3, and TLR4 activation, whereas TNF-alpha and IL-6 responses to TLR2, TLR4, and TLR5 activation were significantly higher in newborns who subsequently had allergic disease ( n = 32 )
Behrens et al., J Immunol 2008 : A number of recent studies show that activation of CR3 on dendritic cells (DCs) suppresses TLR induced TNF-alpha and IL-12 production and inhibits effective Ag presentation ... TLR induced TNF-alpha and IL-12 production by bone marrow derived DCs occurs heterogeneously, with apoptotic cells inhibiting only certain populations depending on the TLR agonist
Croker et al., Proc Natl Acad Sci U S A 2008 (Autoimmune Diseases...) : TLR induced TNF and IL-1 production are normal in macrophages derived from spin mice
Wu et al., Hepatology 2009 : TLR stimulated expression of proinflammatory cytokines [ tumor necrosis factor alpha (TNF-alpha) , interleukin-6 (IL-6) ], and activation of IRF-3 was suppressed after up-regulation of HBV replication in HBV-Met cells
Huang et al., Infect Immun 2009 : These two beta-glucans failed to stimulate TNF-alpha in Dectin-1 ( beta-glucan receptor ) knockout BMDCs. Costimulation of wild-type BMDCs with beta-glucans and specific Toll-like receptor ( TLR ) ligands resulted in greatly enhanced TNF-alpha production but decreased IL-12p70 production compared with TLR agonists alone
Matsushita et al., Nature 2009 (Anemia...) : Macrophages from Zc3h12a ( -/- ) mice showed highly increased production of interleukin (IL)-6 and IL-12p40 ( also known as IL12b ), but not TNF , in response to TLR ligands
Jung et al., Immunol Lett 2009 (Arthritis, Experimental...) : Stimulation of TLR2, TLR4 , and TLR6 by their specific ligands increased the production of TNF-alpha in FLS from IL-1Ra-deficient mice ... These data show that TLR2, TLR4 , and TLR6 ligation synergistically stimulates the production of TNF-alpha and IL-1beta in IL-1Ra-deficient mice and suggest that TLRs contribute to the perpetuation of spontaneous arthritis in this animal model
Covacu et al., J Immunol 2009 : TLR activation induces TNF-alpha production from adult neural stem/progenitor cells
Cho et al., PloS one 2009 (Inflammation) : Utilizing this cell line, we screened a completely random lentiviral short hairpin RNA ( shRNA ) library for sequences that inhibited TLR mediated TNF-alpha production
West et al., Infect Immun 2009 (Burkholderia Infections...) : In macrophages, TLR4 and the adaptor molecule MyD88, but not TLR2 or TLR5, are required for tumor necrosis factor alpha production induced by B. thailandensis
Frazier et al., J Immunol 2009 (Escherichia coli Infections...) : MAPKs are crucial for TNF-alpha and IL-6 production by innate immune cells in response to TLR ligands
van Hoffen et al., Int Arch Allergy Immunol 2010 : Apically added LGG, TLR2 and NOD2 ligands, but not Bb, enhanced IFN-gamma, IL-12 and/or TNF-alpha secretion
Stamm et al., FEMS Immunol Med Microbiol 2010 (Vibrio Infections) : Results obtained using V. vulnificus type strain ATCC 27562 showed that ( 1 ) TLR4 signaling is myeloid differentiation factor 88 dependent and plays a key role in TNFalpha production by mouse blood and splenocytes stimulated ex vivo with inactivated V. vulnificus cells, ( 2 ) TLR4 signaling is deleterious in a mouse model of V. vulnificus infection, ( 3 ) signaling by TLR ( s ), exclusive of TLR4, is needed to eradicate infection, and ( 4 ) the TLR mediated TNFalpha response plays a critical role in determining the outcome of infection
Fang et al., FEMS Immunol Med Microbiol 2010 (West Nile Fever) : Viral antigens were detected in WNV infected gammadelta T cells.WNV infection or toll-like receptor ( TLR ) agonist treatment of gammadelta T cells induced the production of IFN-gamma, tumor necrosis factor-alpha and IL-6, which are known to promote DC maturation
Chávez-Sánchez et al., Hum Immunol 2010 : Our results suggest that mmLDL activates CD14, TLR4 , and TLR2, inducing the production of TNF-alpha and increasing the expression of TLR2 and TLR4
Mureith et al., AIDS 2010 (Disease Progression...) : Responses by THP-1 cells to TLR stimulation were quantified using Quanti-Blue colometric assay, and TLR induced tumor necrosis factor-alpha production of primary monocytes was quantified by intracellular cytokine staining using flow cytometry
Minematsu et al., Cell Signal 2011 : Treatment with VIVIT resulted in nuclear export of NFATc3/c4 and inhibited TLR activated TNF expression, suggesting that nuclear residence of NFATc is required for TLR related innate immune response
Das et al., Immunol Cell Biol 2012 (Leishmaniasis, Visceral) : In this report, we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages, leading to incapability for the production of inflammatory cytokines like tumor necrosis factor (TNF)-a and interleukin (IL)-1ß in response to TLR stimulation
Farrar et al., FASEB J 2012 (Disease Models, Animal...) : Activation of TLR leads to activation of NF-?B and release of proinflammatory cytokines, such as IL-6 and TNF-a
Kim et al., J Nutr Biochem 2012 (Myocardial Infarction...) : In CMs, TLR2 and monocyte chemoattractant protein (MCP)-1 mRNAs were increased by TNF-a , PGN or H/R, whereas they were blunted by curcumin
Panda et al., J Reprod Immunol 2012 (Pre-Eclampsia) : The expression of TLR induced production of TNF-a , IFN-a, IL-6, and IL-12 were measured by multicolor flow cytometry
Chamberlain et al., J Immunol 2012 (Arthritis, Rheumatoid...) : In conclusion, we document the potential role of TLR5 ligation in modulating transcription of TNF-a from RA synovial fluid and the strong correlation of TLR5 and TNF-a with each other and with disease activity score in RA monocytes
Movita et al., J Leukoc Biol 2012 : Interestingly, despite expression of TLR mRNA on Kupffer cells, ligation of TLR4, TLR7/8 , and TLR9 resulted in a weak induction of IL-10, low or undetectable levels of IL-12p40 and TNF , and up-regulation of CD40 on the surface
Hilda et al., FEMS Immunol Med Microbiol 2012 : Increased expression of CD32, CD64, TLR4 , and CXCR3 ; increased TNF-a secretion ; and downregulation of early apoptosis were observed in H37Rv infected neutrophils
Kim et al., Microb Pathog 2013 : In addition, TLR4 was required for the optimal production of IL-6, TNF-a , and IL-12 in BMDCs in response to A. baumannii
Deng et al., Immunol Cell Biol 2013 : Further, we demonstrated that TLR induced tumor necrosis factor-a and interferon-ß contributed to the differential phagocytosis of apoptotic neutrophils and bacteria by macrophages
Karrich et al., Blood 2013 : Although IL-21 did not affect TLR induced type I IFNs, IL-6, and TNF-a nor expression of major-histocompatibility-complex class II or costimulatory molecules, IL-21 markedly increased expression of the serine protease granzyme B (GrB)
Ferrante et al., Inflammation 2013 : Adenosine signaling suppresses the TLR dependent expression of TNF-a , IL-12, IFN-?, and several other inflammatory cytokines by macrophages and induces the expression of vascular endothelial growth factor ( VEGF ) and IL-10
Liu et al., J Neurosci 2013 : In cultured neurons, TLR7 activation induced IL-6 and TNF-a expression through Myd88
Römmler et al., J Immunol 2013 : Whereas TLR9 induced TNF-a secretion of bone marrow derived macrophages and conventional dendritic cells was equally inhibited by INH-ODN 2088 and G-modified INH-ODNs such as INH-ODN 24888, TLR7 induced TNF-a release and TLR7- and TLR9 induced IL-12p40 release were significantly more impaired by G-modified INH-ODNs