Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Sullivan et al., J Cell Mol Med 2009 : TNF-alpha induced increased levels of c-Jun and C-Fos in the nucleus accompanied by phosphorylation of c-Jun ... Together, these results suggest that TNF-alpha induces expression and DNA binding of AP-1 resulting in increased transcription of the TGF-beta(1) gene
Bryce et al., Int Immunol 2006 (Hypersensitivity...) : We have previously reported that tumor necrosis factor receptor associated factor 1 ( TRAF1 ), an intracellular protein, which binds to a range of molecules, including tumor necrosis factor (TNF) receptor family members, regulates TNF induced NF-kappaB and AP-1 signaling as well as TCR triggered proliferative responses in T cells
Srivastava et al., J Biol Chem 2007 : Furthermore, overexpression of a dominant negative mutant of TAK1 blocked the TNF-alpha induced expression of MMP-9 and activation of NF-kappaB and AP-1
Ait-Ali et al., Mol Endocrinol 2004 : In addition, TNF-alpha increased the binding activity of activator protein-1 (AP-1) and stimulated transcription of a reporter gene containing AP-1-responsive elements in chromaffin cells
Rahman et al., J Biol Chem 1999 : Gel shift and supershift analysis showed that TNF-alpha increased AP-1 DNA binding which was predominantly formed by dimers of c-Jun
Yin et al., Biomed Pharmacother 2009 (Breast Neoplasms) : Using luciferase reporter assays, we demonstrated that TNF-alpha significantly increased activator protein-1 (AP-1) transcriptional activity in the MCF7 cells
Rahman , Biochem Pharmacol 2000 (Lung Diseases) : The promoter regions of the human gamma-GCS subunits contain AP-1 , NF-kappa B, and antioxidant response elements and are regulated by oxidants, growth factors, inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) , and anti-inflammatory agent ( dexamethasone ) in lung cells ... TNF-alpha also induces the activation of NF-kappa B and AP-1 and the subsequent increase in gamma-GCS heavy subunit transcription in these cells
Chen et al., Shock 2006 (Burns...) : Thermal injury also induces TNF-alpha dependent delay apoptosis and TNF-alpha independent AP-1 activation of neutrophil at 3 h after thermal injury
Zhao et al., Mol Endocrinol 1996 : These results suggest that TNF alpha , probably acting through ceramide formation, stimulates the binding of both c-fos and c-jun to the AP-1 element upstream of exon 1.4
Faggioli et al., Biochim Biophys Acta 2004 : In combination with p65 and/or C/EBPdelta, TAM-67 also synergistically activated the IL-6 promoter, while it inhibited TNF-alpha induced AP-1 activity directing an AP-1-responsive reporter plasmid
Manna et al., J Immunol 2000 : Leflunomide also inhibited TNF induced activation of AP-1 and the c-Jun N-terminal protein kinase activation
Yao et al., J Biol Chem 2008 (Bone Resorption) : TNF induces IL-1 expression and activates c-Fos , a transcription factor required in OCPs for osteoclast formation ... TNF could induce c-Fos expression in OCPs at sites of inflammation in bone to promote this autocrine mechanism and thus amplify bone loss
O'Hara et al., Cytokine 2009 : Silencing of Ref-1 in AGS cells inhibited basal and TNF-alpha induced AP-1 and NF-kappaB DNA binding activity, but not their nuclear accumulation
Mukhopadhyay et al., Toxicol Lett 2008 (MAP Kinase Signaling System) : TNF-alpha induces activating protein 1 (AP-1) activation via phosphorylation of mitogen activated protein kinases ( MAPKs )
Chen et al., J Pharmacol Exp Ther 2004 : PD98059 abolished TNF-alpha activated p42/44 MAPK phosphorylation and c-Fos up-regulation, whereas SP600125 inhibited TNF-alpha activated JNK and c-Jun phosphorylation ... Finally, the pretreatment of VSMCs with PTX or cilostamide, but not denbufylline, reduced TNF-alpha induced CCL2/MCP-1 production, which was preceded by attenuation of p65/NF-kappaB nuclear translocation, p42/44 MAPK, and JNK-c-Jun phosphorylation, and c-Fos up-regulation
Lee et al., Life Sci 2006 : Emodin was determined to inhibit TNF alpha induced activation of AP-1 promoter, an important nuclear transcription factor in MMP-1 expression
Lagoumintzis et al., Infect Immun 2003 : Activation of NF-kappa B and AP-1 by P. aeruginosa GLP may be involved not only in TNF-alpha induction but also in many of the inflammatory responses triggered in the course of infection with P. aeruginosa
Liu et al., J Neurosci 2000 : However, pretreatment with oATP downregulated activation of NF-kappaB and AP-1 by IL-1beta or TNFalpha
Yamauchi et al., Fertil Steril 2004 (Endometriosis) : Electrophoretic mobility shift assay revealed that U0126 attenuated activator protein-1 (AP-1) activation induced by TNF-alpha
Kähäri et al., J Biol Chem 1992 : These observations suggest that the inhibitory effects of TNF-alpha on elastin gene expression involve the transcription factor AP-1
Yasumoto et al., J Biol Chem 1992 (Stomach Neoplasms) : Moreover, gel retardation analyses revealed that TNF alpha and IFN gamma synergistically induced the binding of NF-kB like as well as AP-1 like proteins bound to these sites
Gertzberg et al., Am J Respir Cell Mol Biol 2000 : We tested the hypothesis that protein kinase ( PK ) G activation in response to nitric oxide ( ( * ) NO ) mediates tumor necrosis factor (TNF)-alpha induced activation of the transcription factor activating protein-1 (AP-1) in pulmonary microvessel endothelial monolayers ( PEM ) ... TNF treatment ( 1,000 U/ml ) for 4 h induced a significant increase in DNA binding of AP-1
Park et al., Nephrol Dial Transplant 2004 : We investigated the role of NF-kappa B and AP-1 in tumour necrosis factor alpha (TNF-alpha) induced monocyte chemoattractant protein 1 ( MCP-1 ) production in cultured human glomerular endothelial cells ( HGEC ) ... ( i ) TNF-alpha increased NF-kappa B and AP-1 binding activity
Seppänen et al., Oncol Res 1998 (Adenocarcinoma...) : In the present study, we have investigated the effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ), transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Kim et al., Vascul Pharmacol 2012 (Atherosclerosis...) : Furthermore, sulforaphane inhibited NK-?B and AP-1 activation induced by TNF-a
Graham et al., J Biol Chem 2006 : Analysis of differentiating epithelia showed that only well differentiated enterocytes activated the 4-kb long MLCK promoter in response to TNF, and consensus promoter reporters demonstrated that TNF induced NFkappaB activation decreased during differentiation while TNF induced AP-1 activation increased
Klampfer et al., Mol Cell Biol 1994 : Consistent with this possibility, IL-1 and TNF-alpha markedly increase the binding of Fos and Jun to the AP-1 site, and NF-IL6 activates the native TSG-6 promoter
Park et al., Int J Mol Med 2011 : GM3 synthase gene expression markedly suppressed the TNF-a stimulated transcriptional activity of activator protein-1 (AP-1) and nuclear factor-?B ( NF-?B ), which are the controlling factors of MMP-9 expression
Lengyel et al., Biochim Biophys Acta 1995 : Stimulation of urokinase expression by TNF-alpha requires the activation of binding sites for the AP-1 and PEA3 transcription factors
Masamune et al., J Cell Biochem 2006 : Curcumin inhibited interleukin-1beta- and TNF-alpha induced activation of activator protein-1 (AP-1) and mitogen activated protein ( MAP ) kinases ( ERK, c-Jun N-terminal kinase (JNK), and p38 MAP kinase ), but not of nuclear factor-kappaB (NF-kappaB)
Manna et al., Cancer Res 2000 : Oleandrin also blocked AP-1 activation induced by TNF and other agents and inhibited the TNF induced activation of c-Jun NH2-terminal kinase
Feng et al., Infect Immun 1999 : The high-level expression of TNF-alpha persisted over 2 h. Dexamethasone blocked the activation of both NF-kappaB and AP-1 and suppressed the production of TNF-alpha in TEP macrophages stimulated by M. penetrans lipid extract of PK-digested LAMPs
Adcock et al., Life Sci 1994 : The interaction of the transcription factors, activator protein 1 (AP-1) and nuclear factor kappa from B cells ( NF kappa B ) with DNA and glucocorticoid receptors was analysed by gel mobility shift assays following stimulation by tumour necrosis factor alpha (TNF alpha) and a phorbol ester ( PMA ) that activates protein kinase C. PMA and TNF alpha both caused significant ( 180-340 % ) increases in AP-1 and NF kappa B DNA binding which peaked at 15 minutes and decreased to a constant elevated level at between 1-3 hrs and was sustained for 24hrs
Hirota et al., Biochem Biophys Res Commun 2000 : We demonstrated here that intracellular localization of these redox molecules differ from each other and that the redox molecules differentially regulate NF-kappaB, AP-1 , and CREB activation induced by TNFalpha , PMA, and forskolin and by expression of signaling intermediate kinases, NIK, MEKK, and PKA in HEK293 cells
Yang et al., Biochem J 2005 : TNFalpha induces NF-kappaB ( nuclear factor kappaB ) and AP-1 ( activator protein 1 ) nuclear binding activities
Li et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2003 : To study the effect of nuclear transcription factor AP-1 on tumor necrosis factor alpha (TNF-alpha) or minimal modified low density lipoprotein ( mmLDL ) -induced expression of plasminogen activator inhibitor-1 ( PAI-1 ) in human vascular endothelial cells
Afonso et al., Free Radic Biol Med 2006 : In agreement with these findings, EMSA shows a TNF-alpha induced increase in AP-1 and a decrease in Sp1 DNA binding
Nakamura et al., J Am Soc Nephrol 2001 : The increase in TNF-alpha was attenuated by both a p42/p44 inhibitor, PD098059 ( 10 ( -6 ) M ), and a p38 inhibitor, SB203580 ( 10 ( -6 ) M ), and AP-1 binding activity was inhibited by PD098059
Shrivastava et al., Antioxid Redox Signal 1999 : In contrast, none of the radical quenchers had any significant effect on TNF induced AP-1 activation ... In this report, we investigated the effect of various superoxide radical quenchers -- pyrrolidine dithiocarbamate ( PDTC ), N-acetyl-L-cysteine (NAC), and glutathione ( GSH ) -- an hydroxyl radical quencher ( mannitol ), and lipid peroxide quenchers -- butylated hydroxytoluene ( BHT ) and butylated hydroxyanisole ( BHA ) -- on TNF induced activation of nuclear transcription factors-kappa B ( NF-kappa B ) and activator protein-1 (AP-1) , c-jun amino-terminal kinase ( JNK ), and apoptosis in human monocytic U937 cells ... Overall, these results suggest that hydroxyl radicals mediate TNF induced apoptosis but not activation of NF-kappa B, AP-1 , and JNK ; superoxide radicals mediate NF-kappa B and JNK activation but potentiate apoptosis ; and lipid peroxides are required for all the signals induced by TNF
Manna et al., J Immunol 2000 : Vesnarinone also blocked NF-kappa B activation induced by several other inflammatory agents, inhibited the TNF induced activation of transcription factor AP-1 , and suppressed the TNF induced activation of c-Jun N-terminal kinase and mitogen activated protein kinase kinase
Tsou et al., J Cell Biochem 2012 (Osteoarthritis) : TNF-a mediated AP-1-luciferase activity and c-Jun binding to the AP-1 element were inhibited by TNFR1 Ab, thioredoxin, SP600125, and SB203580
Abe et al., Am J Respir Cell Mol Biol 2000 : In accord with promoter analyses, an electrophoretic mobility shift assay showed that CAM repressed AP-1 binding in TNF-alpha treated BET-1A cells ; however, TNF-alpha induced both AP-1 and NF-kappaB binding activities in BET-1A cells
Yuksel et al., J Pharmacol Exp Ther 2003 : These observations strongly suggest that gabexate mesilate inhibited LPS induced TNF-alpha production in human monocytes by inhibiting activation of both NF-kappaB and AP-1
González et al., J Cell Biol 2000 : Our results show that glucocorticoids antagonize the TNF-alpha induced activation of AP-1 by causing the accumulation of inactive JNK without affecting its subcellular distribution
Li et al., Inhal Toxicol 2009 : Exposure to cigarette smoke upregulates AP-1 activity and induces TNF-alpha overexpression in mouse lungs
Jana et al., Free Radic Biol Med 2005 : All three cytokines alone induced the activation of AP-1 while IL-1beta and TNF-alpha but not IFN-gamma induced the activation of NF-kappaB
Arancibia et al., J Cell Mol Med 2011 : Cells expressing a PI3K mutant ( p85-dominant negative, DN ; p85 d478-511 ) and exposed to Pam ( 3 ) -Cys-Ser-Lys ( 4 ) in the presence or absence of dexamethasone, showed enhanced tumour necrosis factor ( TNF ) a expression while AP-1 and NF-?B transcriptional activity were repressed
Wang et al., Int Immunopharmacol 2009 (Disease Models, Animal...) : 3 h after resuscitation, pulmonary capillary leakage and wet/dry weight ratio, levels of tumor necrosis factor (TNF)-alpha , interleukin (IL)-6, malondialdehyde ( MDA ), oxidized and reduced glutathione ( GSH and GSSG ), myeloperoxidase (MPO) activity, nuclear factor (NF)-kappaB, activator protein (AP)-1 activation , and lung microscopic and ultrastructural histological changes were measured
Ortiz et al., Am J Physiol Lung Cell Mol Physiol 2002 (Body Weight...) : Enalapril protects mice from pulmonary hypertension by inhibiting TNF mediated activation of NF-kappaB and AP-1
Gauss et al., J Leukoc Biol 2005 : As p67phox can be up-regulated by tumor necrosis factor alpha (TNF-alpha) , which activates AP-1 , we hypothesized that TNF-alpha might regulate NCF2transcription via AP-1
Manna et al., Oncogene 1999 : gamma-GCS also abolished the activation of AP-1 induced by TNF and inhibited TNF induced activation of JNK and mitogen activated protein kinase kinase
Nakao et al., Biochem Biophys Res Commun 2007 : Endogenous TNFalpha in pOCs induced c-Fos and NFATc1
Takada et al., J Biol Chem 2004 : PTD-p65-P1 had no effect on TNF induced AP-1 activation
Marks et al., Am J Physiol 1996 : We found that epidermal growth factor (EGF) and tumor necrosis factor-alpha (TNF-alpha) transiently stimulate an increase in Fos protein that precedes stimulation of the gastrin promoter
Li et al., Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2008 : To study the role of activator protein-1 (AP-1) in the up-regulation expression of tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta1 ( TGF-beta(1) ) in silica stimulated macrophage cells ( RAW264.7 )
Manna et al., J Immunol 1998 : TNF induced activation of another nuclear transcription factor, AP-1 , was suppressed by IL-13 ... Thus, overall, these results demonstrate that IL-13 is a potent inhibitor of TNF mediated activation of NF-kappa B, AP-1 , and apoptosis, which may contribute to its previously described immunosuppressive and anti-inflammatory effects
Shyu et al., J Biomed Sci 2009 : The gel shift and promoter activity assay showed that TNF-alpha increased AP-1 binding activity and resistin promoter activity, while SP600125 and atorvastatin inhibited the AP-1 binding activity and resistin promoter activity induced by TNF-alpha
Manna et al., J Biol Chem 2000 : AP-1 activation induced by TNF and ceramide was also suppressed by hCG
Manna et al., J Biol Chem 2000 : Protein tyrosine kinase p56lck is required for ceramide induced but not tumor necrosis factor induced activation of NF-kappa B, AP-1 , JNK, and apoptosis ... p56 ( lck ) was also found to be required for ceramide induced but not TNF induced AP-1 activation
Skayian et al., Life Sci 2006 : It was concluded that TNF-alpha activates NF-kappaB and AP-1 and induces PGE ( 2 ) release which alters dose-dependently the activity of the pump by activating different EP receptors with different affinities for PGE ( 2 )
Shau et al., Biochem Biophys Res Commun 1998 : Tumor necrosis factor-alpha (TNF) activates the expression of activator protein-1 (AP-1) responsive genes ... We show here that over-expression of TxP-1 blocks TNF induced AP-1 activation in endothelial ECV304 cells, which was demonstrated by three independent experimental protocols : electromobility shift assay with AP-1 oligonucleotide probe ; reporter gene expression with AP-1 binding site, and interleukin-8 production, which is dependent on AP-1
Tsou et al., Toxicol Appl Pharmacol 2007 : We also demonstrated that intracellular glutathione does not modulate the activation of MAPKs and/or their downstream AP-1 induced by lower TNF-alpha ... Although AP-1 activation by the lower TNF-alpha was not detected in our systems, we could not rule out the possible involvement of transiently activated MAPKs/AP-1 in the regulation of TNF-alpha induced adhesion molecule expression
Asano et al., J Pharm Pharmacol 2006 : Addition of meloxicam into synovial fibroblast cultures inhibited dose-dependently mRNA expression for MMPs and TIMPs, which were increased by TNF-alpha stimulation, through the suppression of NF-kappaB and AP-1 activation
Lakshminarayanan et al., J Biol Chem 1998 : H2O2 and tumor necrosis factor-alpha induce differential binding of the redox-responsive transcription factors AP-1 and NF-kappaB to the interleukin-8 promoter in endothelial and epithelial cells ... H2O2 activated AP-1 but not NF-kappaB in A549, whereas TNFalpha activated AP-1 as well as NF-kappaB ... In HMEC-1, TNFalpha activated NF-kappaB but not AP-1 , while H2O2 did not activate either transcription factor ... Supershift analysis revealed H2O2 as well as TNFalpha induced AP-1 complexes containing c-Fos and JunD
Yarosh et al., Photodermatol Photoimmunol Photomed 2000 : Induction of membrane bound TNFalpha was also found in c-fos gene knockout mice deficient in the AP-1 transcription factor, suggesting that, although AP-1 containing c-fos signaling is required for some UV responses, AP-1 containing c-fos is not required for this TNFalpha activation
Ventura et al., Mol Cell Biol 2003 (MAP Kinase Signaling System) : c-Jun NH ( 2 ) -terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor ... We show that JNK is required for the normal regulation of AP-1 by TNF
Lendemans et al., J Endotoxin Res 2006 : In contrast, the broad-spectrum tyrosine kinase inhibitor genistein and the MEK-1 inhibitor ( PD98059 ) abrogated GM-CSF priming of TNF-alpha release and activation of both NF-kappaB and AP-1
Rao et al., J Biol Chem 2004 (Breast Neoplasms...) : hCG treatment prevented the tumor necrosis factor dependent NF-kappaB and AP-1 activation, which paralleled a decrease in the phosphorylation and degradation of IkappaBalpha
Shun et al., Ann Otol Rhinol Laryngol 2005 (Nasal Polyps) : A transient elevation of c-Fos and c-Jun messenger RNAs was induced by TNF-alpha , whereas COX-2 inhibitors NS-398 and meloxicam abolished the up-regulation of c-Fos ... The electrophoretic mobility shift assay revealed that TNF-alpha triggered AP-1 and DNA binding and again, NS-398 and meloxicam inhibited this reaction via reducing c-Fos synthesis
Herbein et al., Curr HIV Res 2008 : Since tumor necrosis factor alpha (TNFalpha) activates NF-kappaB and AP-1 , we investigated the role of exogenous Nef protein in TNFalpha stimulated U937 cells and primary macrophages ... We observed that exogenous Nef and TNFalpha synergistically activate NF-kappaB and AP-1 in U937 cells and primary macrophages resulting in enhanced stimulation of the HIV-1 long terminal repeat ( LTR ), and subsequently in enhanced viral replication in both chronically infected promonocytic U1 cells and acutely HIV-1 infected primary macrophages
Rahman et al., Mol Cell Biochem 2002 (Inflammation) : Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells : potential mechanism in gene transcription in lung inflammation ... H2O2, and TNF-a , and TSA all increased NF-kappaB and AP-1 DNA binding to their consensus sites assessed by the electrophoretic mobility shift assay
Yoshizumi et al., Exp Cell Res 2004 : Finally, TNF-alpha induced activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) activation and resultant intracellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) expressions were inhibited by ebselen
Seppänen et al., Eur J Endocrinol 2000 (Cystadenocarcinoma...) : The binding activity of AP-1 was found to be stimulated by the growth inhibitory cytokines, TGF-beta1 and TNF-alpha, and the binding of NF-kappaB was stimulated by TNF-alpha
Koo et al., Cell Biol Int 2013 : TNF-a increased DNA binding activity of AP-1 and NF-?B, whereas both AP-1 and NF-?B decoy oligodeoxynucleotides downregulated TNF-a induced MCP-1 mRNA expression ... MPA and Syk inhibitor attenuated TNF-a induced DNA binding activity of NF-?B and AP-1
Cho et al., Int Immunopharmacol 2004 : In view of the potential role of AP-1 in the induction of TNF-alpha , we next examined the inhibitory effects of arctigenin on the expression of TNF-alpha
Fichorova et al., Antimicrob Agents Chemother 2005 (Vaginitis) : Within 6 h of exposure, TNF-alpha and N-9 triggered NF-kappaB and AP-1/cFos activation and upregulated interleukins and an array of chemokines by vaginal and polarized cervical epithelial cells
Lee et al., Biochem Biophys Res Commun 2005 (Fibrosarcoma) : We also found that SM-7368 strongly inhibits TNF-alpha induced NF-kappaB activity but not AP-1 activity
Wang et al., Surgery 1998 (Carcinoma, Hepatocellular) : TNF-alpha increased c-jun and junD mRNA and c-Jun and JunD protein levels, as well as AP-1 binding activity
Wang et al., J Med Invest 2010 (MAP Kinase Signaling System...) : Strategies that neutralize TNF-alpha as well as inhibitors of MAPK-NF-kappa B- and/or AP-1 dependent pathways may be useful for suppressing the MMP-9 effect and thus preventing multiple organ failure in severe influenza
Andoh et al., Clin Exp Immunol 1999 : The EMSAs indicated that sodium butyrate suppressed TNF-alpha induced nuclear factor (NF)-kappaB- and activation protein (AP)-1-DNA binding activity, but enhanced TNF-alpha induced activation of CCAAT/enhancer binding protein ( C/EBP)beta (NF-IL-6 ) -DNA binding activity
Biswas et al., Antioxid Redox Signal 2005 : Curcumin inhibited both H2O2- and TNF-alpha mediated activation of NF-kappaB and AP-1 , and IL-8 release
Asschert et al., Int J Cancer 1999 (Ovarian Neoplasms) : TNF-alpha stimulation enhanced AP-1 and induced NF-KB but no NF-IL6 DNA binding in these cells
Takada et al., Mol Pharmacol 2008 (Neoplasms) : TNF is a potent inducer of activator protein-1 (AP-1) , and flavopiridol abrogated this activation in a dose- and time dependent manner ... Flavopiridol also inhibited the TNF induced induction of intercellular adhesion molecule-1, c-Myc, and c-Fos , all known to mediate tumorigenesis
Reiterer et al., J Nutr 2004 (Inflammation) : However, if zinc was added back, all PPAR agonists significantly downregulated the TNF-alpha mediated induction of inflammatory transcription factors NF-kappaB and AP-1 and significantly reduced the expression of their target genes, VCAM-1 and IL-6
Bischof , Early pregnancy (Online) 2001 : Among these we identified two oncogene products ( Jun and Fos ) which were activated by TNF or phorbol esters and which promoted the synthesis of MMP-9
Yang et al., Biochem Pharmacol 2013 : Finally, we showed that, in H9c2 cells, TNF-a stimulated AP-1 promoter activity, c-Jun mRNA expression, and c-Jun phosphorylation were attenuated by PP1, AG1478, AG1296, LY294002, SB202190, SP600125, or U0126
Flora et al., Neuromolecular Med 2002 (Inflammation) : Methamphetamine induced TNF-alpha gene expression and activation of AP-1 in discrete regions of mouse brain : potential role of reactive oxygen intermediates and lipid peroxidation
Chainy et al., Oncogene 2000 : Besides NF-kappaB, anethole also suppressed TNF induced activation of the transcription factor AP-1 , c-jun N-terminal kinase and MAPK-kinase
Lee et al., Oncol Rep 2008 (MAP Kinase Signaling System...) : The transactivation of TNF-alpha stimulated NF-kappaB, AP-1 and Sp-1 were inhibited by U0126 and SB203580 treatment
Bianchi et al., Neurobiol Aging 2010 (Encephalitis...) : We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via RAGE dependent activation of JNK ; ( 2 ) S100B upregulates IL-1beta and TNF-alpha expression in microglia via RAGE engagement ; and ( 3 ) S100B/RAGE induced upregulation of COX-2, IL-1beta and TNF-alpha expression requires the concurrent activation of NF-kappaB and AP-1
Chiu et al., Chin J Physiol 2002 : Moreover, in ECs either presheared or remained in a static condition prior to stimulation by TNF-alpha while under shear flow, the ability of TNF-alpha to induce AP-1-DNA binding activity in the nucleus was reduced
Yamashita et al., J Biol Chem 2007 : We report that RANKL and TNF can induce osteoclast formation directly from NF-kappaB p50/p52 double knockout ( dKO ) osteoclast precursors when either c-Fos or NFATc1 is expressed
Moon et al., J Cell Physiol 2004 : Furthermore, the transactivation of TNF-alpha stimulated NF-kappaB and AP-1 was inhibited by U0126 treatment ... Overexpression of RasN17 also abolished the TNF-alpha stimulated NF-kappaB and AP-1 activity
Jude et al., Am J Physiol Lung Cell Mol Physiol 2012 (Asthma...) : In human ASM ( HASM ) cells, TNF-a induces CD38 expression through activation of MAPKs, NF-?B, and AP-1 , and its expression is differentially elevated in cells from asthmatic patients compared with cells from nonasthmatic subjects
Yang et al., J Biol Chem 2003 (Carcinoma, Hepatocellular) : Tumor necrosis factor alpha (TNFalpha) , which activates both NF-kappa B and AP-1 , increased MAT2A expression in a dose- and time dependent manner, binding of both NF-kappa B and AP-1 to the MAT2A promoter and MAT2A promoter activity, with the latter effect blocked by site directed mutagenesis of the NF-kappa B and AP-1 binding sites
Sandur et al., Free Radic Biol Med 2007 : The suppression of TNF induced AP-1 activation by curcumin was also reversed by glutathione
Borgmann et al., Endothelium : journal of endothelial cell research 2002 : Alteration of cytokine release was accompanied by reduced basal and TNF-alpha stimulated nuclear factor-kappa B (NF-kappa B) and activator protein-1 (AP-1) activity
Yamada et al., J Urol 2005 (Urinary Bladder Neoplasms) : TNF-alpha also activated NF-kappaB, AP-1 and ERK1/2
Arnott et al., Oncogene 2004 (Skin Neoplasms) : Keratinocyte derived TNF-alpha acts as an endogenous tumour promoter and can also regulate AP-1 activity in mouse epidermis
Takeshita et al., J Oral Sci 2002 : The present study suggests a regulatory interference by 1alpha25 ( OH ) 2D3 for RA inhibition of TNF-alpha induced AP-1 activity in osteoblasts
Yogesha et al., J Immunol 2009 (Arthritis, Experimental...) : We found that IL-3 prevented TNF-alpha induced c-fos nuclear translocation and AP-1 DNA binding activity
Yang et al., Atherosclerosis 2010 : In cultured human aortic endothelial cells, TNF-alpha increased ET-1 through AP-1 and NF-kappaB, whereas MPA attenuated it by reducing both AP-1 and NF-kappaB DNA binding activities ... N-acetylcysteine, SP600125 ( JNK inhibitor ) and SB203580 ( p38 MAPK inhibitor ) attenuated TNF-alpha induced DNA binding activities of both AP-1 and NF-kappaB
Manna et al., J Immunol 2000 : p56lck was also found to be required for HIV-tat induced but not TNF induced AP-1 activation
Seidel et al., Schweiz Med Wochenschr 2010 : PDGF-BB and TNF-a activated AP-1 , which was also inhibited by DMF
Wang et al., Cytokine 2009 (Acute Lung Injury) : ZD 7155 also reduced the mRNA expression of TNF-alpha and IL-1 beta, inhibited the activation of NF-kappaB and AP-1 , and improved lung histopathology
Manna et al., Oncogene 2000 (Lung Neoplasms) : The increase in TNF receptors sensitized H596 cells to TNF induced activation of NF-kappaB, AP-1 and apoptosis ... A549 cells, however, were completely resistant to TNF induced activation of NF-kappaB, AP-1 and apoptosis
Das et al., Mol Cell Biochem 1995 (Adenocarcinoma...) : Likewise, some of the thiol modifying compounds inhibited AP-1 activation by TNF alpha or IL-1, whereas others did not
Vallejo et al., J Immunol 2000 (MAP Kinase Signaling System) : These results indicate that both NF-kappaB and AP-1 ( via p38 MAPK ) are involved in the regulation of TNF-alpha production in GBS stimulated neonatal monocytes
Mukhopadhyay et al., Oncogene 2001 (Prostatic Neoplasms) : TNF induced NF-kappaB activation but not AP-1 activation in LNCaP cells
Emch et al., Am J Physiol Regul Integr Comp Physiol 2001 : TNF-alpha induced c-Fos generation in the nucleus of the solitary tract is blocked by NBQX and MK-801
Kanda et al., Am J Physiol Cell Physiol 2007 : Histamine alone enhanced transcriptional activities of NF-kappaB and activator protein-1 (AP-1) and potentiated TNF-alpha induced NF-kappaB and AP-1 activities or IFN-gamma induced NF-kappaB and STAT1 activities ... Histamine induced c-Fos mRNA expression alone or together with TNF-alpha , whereas it did not further increase c-Jun mRNA levels enhanced by TNF-alpha ... These results suggest that histamine stimulates H1 receptor and potentiates TNF-alpha- or IFN-gamma induced hBD-2 production dependent on NF-kappaB, AP-1 , or STAT1 in human keratinocytes
Wang et al., Inflammation 2009 (Inflammation...) : Three hour after resuscitation, bacterial translocation ( BT ), intestinal permeability, ileal levels of tumor necrosis factor (TNF)-alpha , interleukin (IL)-6, malondialdehyde ( MDA ), oxidized and reduced glutathione ( GSH and GSSG ), myeloperoxidase (MPO) activity, nuclear factor (NF)-kappaB, activator protein (AP)-1 activation , and ileal microscopic and ultrastructural histological changes were measured
Brach et al., Leukemia 1993 (Leukemia, Myeloid, Acute) : The mitogenic response of AML blasts to tumor necrosis factor-alpha requires functional c-jun/AP-1
Brechter et al., Bone 2008 : EMSA showed that IL-1beta and TNF-alpha activated NF-kappaB and AP-1 in MG-63 cells
Tran-Thi et al., Hepatology 1995 : The results indicate a direct participation of NF-kappa B in the regulation of TNF-alpha synthesis and a differential effect of LPS on NF-kappa B and AP-1 , respectively
Kim et al., Molecules (Basel, Switzerland) 2008 (Breast Neoplasms) : Therefore, we further examined the effects of BBR on TNF-alpha induced AP-1 DNA binding activity which is a downstream target of ERK and p38 ... Our data showed that TNF-alpha induced AP-1 DNA binding activity was inhibited by BBR
Yuksel et al., Thromb Haemost 2002 (MAP Kinase Signaling System...) : These observations strongly suggest that APC inhibited LPS induced TNF-alpha production by inhibiting the activation of both NF-kappa B and AP-1 and that the inhibitory activity of APC might depend on its serine protease activity
Takeshita et al., J Oral Sci 2005 (Second Messenger Systems) : We previously demonstrated that tumor necrosis factor (TNF)-alpha stimulated the production of activation protein (AP)-1 , a transcriptional factor, in mouse osteoblastic MC3T3-E1 cells ... The present study thus suggests that SPP acts as a signal molecule in ceramide dependent signal transduction in TNF-alpha induced AP-1 in osteoblastic MC3T3-E1 cells
Siebert et al., Arthritis Rheum 2005 : TNFalpha induced activation of NF-kappaB and AP-1 was decreased in the primary dermal fibroblasts with the C43S TNFRSF1A mutation
Nishida et al., Am J Physiol Gastrointest Liver Physiol 2008 : Furthermore, LY294002 suppressed both IL-1beta- and TNF-alpha induced NF-kappaB activation and IL-1beta-, TNF-alpha-, and IFN-gamma induced activated protein-1 (AP-1) activation
Nijboer et al., Stroke 2009 (Cerebral Infarction...) : When NF-kappaB was inhibited after neonatal cerebral HI, JNK/AP-1 activity was increased and required for increased TNF-alpha expression
Kawauchi et al., Biol Pharm Bull 2007 : cPrG.HCl potently suppressed AP-1 activity induced by tumor necrosis factor (TNF) alpha and phorbol myristate acetate ( PMA )
Granet et al., Cytokine 2004 : IL-1 and TNF-alpha induced egr-1 and all AP-1 member expression, except fosB and junD
Hattori et al., Am J Physiol 1993 (Acute-Phase Reaction...) : In addition, IL-6, tumor necrosis factor-alpha , and IL-1 beta, cytokine regulators of the acute phase response, stimulated expression of an AP-1 responsive reporter gene introduced by DNA mediated transfection into adult rat hepatocytes in primary culture
Seppänen et al., Acta Obstet Gynecol Scand 2008 (Carcinoma, Endometrioid...) : We were able to show that IFN-gamma, TGF-beta(1) and TNF-alpha all increased the binding activity of transcription factor AP-1 ( AP-1 )
Manna et al., Biochem Pharmacol 1999 : Beta-lapachone also abolished TNF induced activation of AP-1 , c-Jun N-terminal kinase, and mitogen activated protein kinase kinase ( MAPKK or MEK )
Soto et al., Oncogene 1999 (Neoplasm Invasiveness) : Conversion of HPV 18 positive non-tumorigenic HeLa-fibroblast hybrids to invasive growth involves loss of TNF-alpha mediated repression of viral transcription and modification of the AP-1 transcription complex
Chen et al., Kidney Int 2003 : In contrast, curcumin, an activating protein (AP)-1 inhibitor, attenuated TNF-alpha stimulated phospho-c-Jun levels and fractalkine expression without discernible effects on TNF-alpha induced degradation of I-kappaBalpha or NF-kappaB nuclear translocation ... The present data indicate that TNF-alpha activation of PKCzeta/iota, p42/44 MAPK, c-Jun/AP-1 , and p65/NF-kappaB are involved in TNF-alpha stimulated MC fractalkine expression, with the soluble fractalkine mediating in part the TNF-alpha induced monocyte transmigration in vitro
Okajima , Curr Vasc Pharmacol 2004 (Hypotension...) : APC inhibits ET-induced TNF-alpha production in vitro in human monocytes by inhibiting activation of NFkappaB and AP-1 by inhibiting degradation of IkappaB and mitogen activated protein kinase pathways, respectively
Higuchi et al., Antioxid Redox Signal 2002 (Leukemia, Myeloid, Acute) : Additionally, tumor necrosis factor (TNF) induced activation of NF-kappaB and AP-1 observed in ML-1a was greatly reduced in clone 19
Lee et al., Br J Pharmacol 2003 : The effects of sauchinone on the inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase 2 (COX-2) gene expression and on the activation of transcription factors, nuclear factor-kappaB (NF-kappaB), CCAAT/enhancer binding protein (C/EBP), activator protein-1 (AP-1) and cAMP-response element binding protein ( CREB ) were determined in Raw264.7 cells as part of the studies on its anti-inflammatory effects