Gene interactions and pathways from curated databases and text-mining

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HES5 — TNF

Text-mined interactions from Literome

Lv et al., Anesth Analg 2006 (Endotoxemia) : HES significantly reduced the increased intestinal levels of tumor necrosis factor-alpha , IL-6, cytokine induced neutrophil chemoattractant-1, and the mRNAs in the endotoxemic rats
Lv et al., J Int Med Res 2005 (Endotoxemia...) : HES significantly reduced the LPS induced increase in intestinal levels of TNF-alpha , IL-1beta, IL-6, IL-8 and their corresponding mRNAs
Kawaguchi et al., Biol Pharm Bull 2004 (Salmonella Infections, Animal...) : In addition, HES markedly suppressed plasma levels of TNF-alpha and high mobility group box chromosomal protein 1 ( HMGB-1 ), decreased the number of apoptotic cells in livers and normalized the activated states of blood coagulation factors such as prothrombin time and platelet numbers caused by infection
Wang et al., Int Immunopharmacol 2009 (Disease Models, Animal...) : In addition, both HES and BL could attenuate the increase in TNF-alpha , IL-6, MPO levels and NF-kappaB activation
Sun et al., Chin Med J (Engl) 2011 (Reperfusion Injury) : HES130/0.4 lessened the release of TNF-a and IL-1ß consistent with the reduction of MPO activity, and HES 130/0.4 inhibited the activity of NF-?B in H-I/R group
Feng et al., Int Immunopharmacol 2010 (Disease Models, Animal...) : Meanwhile, HES could significantly reduce TNF-alpha , IL-6, and ICAM-1 mRNA, inhibit NF-kappaB activation, and down-regulate TLR2 and TLR4 expression in the brain
Lv et al., Acta Anaesthesiol Scand 2005 : HES significantly reduced the increased hepatic levels of TNF-alpha , IL-1beta, IL-6, IL-8 and the mRNAs in the endotoxemic rats
Schick et al., BMC gastroenterology 2012 (Blood Coagulation Disorders...) : HES improved liver microcirculation, cardiac index and DO2-I, but significantly increased IL-1ß, IL-6 and TNF-a levels and resulted in a mortality rate of 33 %