Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Pedraza-Sánchez et al., Clinical and vaccine immunology : CVI 2013 : LPS or LAM induced TNF-a production was 5 to 18 times higher in AB than in CB monocytes, whereas interleukin-1a (IL-1a) stimulated similar levels of TNF-a in both groups, suggesting that decreased responses to LPS or LAM in CB are unlikely to be due to differences in the MyD88 dependent signaling pathway
Neta et al., J Exp Med 1992 (Hypoglycemia...) : Thus, it is difficult to identify the cytokine primarily responsible for a particular biologic effect, since IL-1 and TNF stimulate one another, and both IL-1 and TNF stimulate IL-6
Kim et al., Phytother Res 2002 : We therefore examined whether IL-1 mediated inhibition of TNF-alpha secretion from primary astrocytes by Sesim-Tang ... Our results suggest that Sesim-Tang may inhibit TNF-alpha secretion by inhibiting IL-1 secretion and that Sesim-Tang has an antiinflammatory activity in the central nervous system
Shlopov et al., Arthritis Rheum 2000 (Osteoarthritis) : In response to TNFalpha stimulation, messenger RNA ( mRNA ) levels for the IL-1 receptor I (IL-1RI), IL-1RII , TNF receptor II (TNFR II), and IL-6 receptor as well as the level of proinflammatory cytokines, such as IL-1alpha, IL-1beta, lymphotoxin beta, TNFalpha, and IL-6, also increased
Nakae et al., Int Immunol 2003 (Dermatitis, Contact...) : IL-1 induced tumor necrosis factor-alpha elicits inflammatory cell infiltration in the skin by inducing IFN-gamma-inducible protein 10 in the elicitation phase of the contact hypersensitivity response ... On the other hand, TNF-alpha , induced by IL-1 , was necessary for the induction of local inflammation during the elicitation phase
Seatter et al., Shock 1995 : LPS1 significantly increased LPS2 triggered monocyte secretion of IL-1 , IL-6, and PGE2, but inhibited TNF release
Turner et al., Am J Physiol Heart Circ Physiol 2009 (MAP Kinase Signaling System...) : IL-1alpha ( 0.001-10 ng/ml, 0-6 h ) stimulated IL-1beta, TNF-alpha , and IL-6 mRNA expression with distinct temporal and concentration profiles, resulting in increased cytokine secretion
Hoffman , Lymphokine Res 1986 : We investigated the effect of tumor necrosis factor (TNF) on interleukin-1 (IL-1) production by mouse macrophages
Tufano et al., Eur Cytokine Netw 1991 : At concentration of 10 micrograms/ml ; PA induces roughly +180 % release of TNF with respect to controls, while release of IL-1 alpha is about 500 % control values, and is higher than those obtained when cells are treated with TA and MDP ; IL-6 release is higher than that stimulated by Con A, used as standard challenge
Bogdan et al., J Biol Chem 1992 : IL-10 not only suppressed TNF release to a 25-fold greater extent than TGF-beta, but also inhibited release of IL-1
Kim et al., Frontiers in bioscience (Landmark edition) 2009 (Myocardial Infarction) : TNF-alpha released from ischemic heart after acute MI increases the production of other cytokines such as interleukin-1 (IL-1) , interleukin-6 (IL-6) and adhesion molecules such as intercellular adhesion molecule-1 ( ICAM-1 )
Luber-Narod et al., J Immunol 1994 : We investigated whether IL-1 mediates the SP enhancement of TNF-alpha secretion
Rinehart et al., Exp Hematol 1997 : In contrast, IL-1 induced monocyte secretion of tumor necrosis factor (TNF) was inhibited by HCS
Mpiga et al., Scand J Immunol 2006 (Chlamydia Infections) : When infected HeLa cells were co-cultured with THP-1 cells, IL-6 and IL-8 secretion was sustained, IL-1beta expression followed a bell shaped curve and IL-10, IL-12p70 and TNF-alpha synthesis was down regulated
Li et al., Neuroscience 2009 (Disease Models, Animal...) : Interestingly, treatment with EP2 antagonist AH-6809 resulted in suppression of hypoxia induced EP2, IL-1beta and iNOS mRNA and protein expression, TNF-alpha protein expression and intracellular cAMP level in BV-2 cells
Jacobsen et al., J Immunol 1996 : The bidirectional effects of TNF-alpha on hematopoietic growth factor induced survival of hematopoietic progenitors were reflected in that TNF-alpha enhanced apoptosis of Lin- Sca-1+ cells when combined with SCF, whereas TNF-alpha synergistically suppressed apoptosis in response to IL-1alpha
Dunn et al., Glia 2002 (Brain Ischemia) : TaqMan real-time quantitative PCR analysis revealed that IL-1 stimulated gene expression of tumor necrosis factor-alpha (TNF) in striatal cultures
Lieb et al., J Neurochem 1996 (Astrocytoma) : For a better understanding of their pathogenic role, we analyzed signal transduction pathways mediating the interleukin (IL)-1 beta induced synthesis of IL-6 and tumor necrosis factor alpha (TNF alpha) in the human astrocytoma cell line U373 MG
Kim et al., Immunopharmacol Immunotoxicol 2000 : We therefore examined whether IL-1 mediated inhibition of TNF-alpha production from primary astrocytes by TO ... Our results suggest that TO may inhibit TNF-alpha production by inhibiting IL-1 production and that TO has an antiinflammatory activity in the central nervous system
Kasid et al., Cancer Res 1990 : Both TNF and LT mRNA were minimally induced by IL-1 alpha , IL-3, interferon ( IFN ) -alpha, or IFN-gamma
Yoshimatsu et al., Int J Mol Med 2001 (Osteoarthritis) : IL-1alpha induced the production of IL-6, GM-CSF and TNFalpha from immortalized chondrocytes
Takane et al., Biochem Biophys Res Commun 1993 : The supplementation of cycloheximide ( CHX ) together with IL-1 beta resulted in the superinduction of TNF-alpha mRNA, suggesting that de novo protein synthesis is not required in IL-1 induced TNF-alpha mRNA expression
Yao et al., J Biol Chem 2008 (Bone Resorption) : TNF induces IL-1 expression and activates c-Fos, a transcription factor required in OCPs for osteoclast formation
Kumagai et al., J Antibiot (Tokyo) 1995 : Cytogenin enhanced productions of IL-1 alpha by macrophages and IFN gamma and GM-CSF by spleen cells although it did not enhanced production of TNF alpha by macrophages and IL-6 by macrophages and spleen cells
Joyce et al., Eur J Immunol 1994 : Further, IL-1 alpha stimulated production of TNF-alpha was diminished by IL-10 and only a small proportion of this TNF-alpha was bioactive, consistent with increased production of inhibitory soluble TNF-R
Akaogi et al., Endocr Metab Immune Disord Drug Targets 2006 (Arthritis, Experimental...) : PGE2 is also produced in response to proinflammatory cytokines, which in turn negatively regulates both IL-17 and TNF-alpha expression and TNF/IL-1 induced activation of fibroblast-like synoviocytes through EP2/EP4 receptors, resulting in the modulation of proinflammatory cascades
Elias et al., Chest 1990 (Pneumonia...) : To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the effects of recombinant interleukin-1, tumor necrosis factor , and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production, interleukin-1-beta production, and interleukin-6 production
Cardona et al., J Biomed Mater Res 1992 : When LPS was present, however, monocytes associated with all of the materials released IL-1 ; and TNF release was greatly augmented
Yucel-Lindberg et al., J Periodontal Res 1995 : The results indicate that TNF alpha induces production of cell associated IL-1 in gingival fibroblasts, which can be upregulated by a PKC dependent pathway
Danis et al., Clin Exp Immunol 1995 : TNF-alpha also up-regulated production of IL-1 alpha , IL-1 beta, IL-1Ra and IL-6 by monocytes, but the variability in the results of cells cultured from the same individuals on different occasions was greater
Wagteveld et al., Leukemia 1992 (Leukemia, Myeloid, Acute) : IL-1 induced the endogenous secretion of GM-CSF, IL-6, and TNF in most cases ... In contrast, no secretion of growth factors was induced by IL-4, whereas in 2 cases IL-4 suppressed the IL-1 induced secretion of GM-CSF, TNF , and IL-6
Kawai et al., Clin Immunol 2013 (Granulomatous Disease, Chronic...) : Here, we show that thalidomide suppressed TNF-a induced NF-?B activation and ATP induced IL-1ß secretion, but did not interrupt the production of IL-1ß, IL-6, IL-8, and TNF-a in response to lipopolysaccharide in CGD monocytes
Bluthé et al., Psychoneuroendocrinology 1994 (Body Weight) : To test the possibility of central induction of IL-1 by TNF alpha , mice pretreated with IL-1 receptor antagonist ( IL-1ra, 1.8 micrograms/mouse, ICV ) were injected with 90 ng TNF alpha
Gorospe et al., J Biol Chem 1993 : These results indicate that the TNF mediated induction of IL-1 can be entirely accounted for by stabilization of this mRNA
Hori et al., Cancer Res 1989 (Neoplasms, Experimental) : The purpose of this study was to determine if recombinant murine interleukin 1 beta ( rMu-IL-1 beta ) alone or in combination with recombinant murine gamma-interferon ( rMu-IFN-gamma ) could activate murine macrophages to be tumoricidal against tumor necrosis factor (TNF)-insensitive target cells and to evaluate the possible role of interleukin 1 (IL-1) in murine macrophage activation by recombinant murine tumor necrosis factor ( rMu-TNF ) plus rMu-IFN-gamma ... There was no evidence, however, that the production of IL-1 was required for macrophage activation by rMu-TNF in combination with rMu-IFN-gamma
Arnush et al., J Immunol 1998 (Diabetes Mellitus, Type 1) : Resident macrophages appear to be the source of IL-1 , as a 7-day culture of rat islets at 24 degrees C ( conditions known to deplete islets of lymphoid cells ) prevents TNF + LPS induced iNOS expression, nitrite production, and the inhibitory effects on insulin secretion
Dube et al., Proc Natl Acad Sci U S A 2001 (Yersinia Infections) : Furthermore, a bacterial mutant that does not induce IL-1 alpha expression but induces normal levels of IL-1 beta, TNF-alpha , and IFN-gamma, causes greatly reduced intestinal inflammation and is attenuated by LD ( 50 ) analysis in the C57BL/6 mouse model
Lv et al., Braz J Med Biol Res 2012 : In the PS group, TNF-a increased at 1, 3, and 5 weeks and IL-1ß increased significantly after 1 and 3 weeks of stress, and then decreased to normal levels by 5 weeks
Arrighi et al., J Immunol 2001 (Dermatitis, Allergic Contact) : Likewise, SB203580 partially prevented the up-regulation of IL-1alpha, IL-1beta , IL-lRa, and TNF-alpha mRNA upon stimulation with LPS and TNF-alpha , as well as the release of bioactive TNF-alpha induced by LPS
Shieh et al., J Immunol 1994 : In vivo, TNF decreased the binding of TNF ( > 88 % ), G-CSF ( > 89 % ), and IL-1 ( > 73 % ) within 30 min, but increased IL-1 binding ( > 4.8-fold ) after 10 h
Kurt-Jones et al., J Immunol 1987 : Endothelial cell membrane IL-1 activity was induced within 24 hr of culture with TNF or lipopolysaccharide, and increased up to 72 hr of incubation
Speiser et al., Neoplasma 1993 (Breast Neoplasms...) : IL-1 alpha induced, TNF alpha mediated HLA class II ( DR ) antigen up-regulation in a human ductal breast carcinoma cell line ZR-75-1
Julen et al., Mol Immunol 1992 : Its in vivo effect on C3 secretion might be secondary to the TNF-alpha induced release of IL-1 and/or IL-6
Lee et al., J Biol Chem 1993 : Deletion analysis of the 5'-flanking region of the TSG6 DNA linked to the chloramphenicol acetyltransferase reporter gene revealed that a construct containing TSG6 DNA from positions -165 to +78 could be transcriptionally activated by interleukin(IL)-1 , and to a lesser extent by TNF , upon transfection into FS-4 fibroblasts
Turner et al., J Immunol 1989 : IL-1 alpha and IL-1 beta mRNA were induced with LPS or TNF ... If added simultaneously CHX blocked TNF induced IL-1 gene transcription, suggesting that TNF may induce factors required for IL-1 gene transcription
Bauer et al., J Cell Biochem 2007 (Carcinoma, Hepatocellular...) : In hepatocytes or human hepatoma cells TNFalpha is expressed at extremely low levels but TNFalpha biosynthesis can be induced by interleukin (IL)-1beta or 12-O-tetradecanoylphorbol-13-acetate ( TPA )
Ahn et al., J Neurotrauma 2004 (Brain Injuries) : IL-1alpha and IL-1beta mRNA expression increased significantly ( p < 0.05 vs. sham-injury ) after severe TBI and IL-6 and TNFa mRNA expression increased significant ( p < 0.05 vs. sham-injury ) after both moderate and severe TBI
Phillips et al., Clin Exp Immunol 1995 : Similarly, TGF-alpha, interferon-gamma (IFN-gamma), IL-6, and tumour necrosis factor-alpha (TNF-alpha) substantially increased HaCAT cell IL-1 alpha , but had no effect on the IL-1Ra, with a concomitant reduction in the icIL-1Ra : IL-1 alpha ratio
Makó et al., Cytometry A 2010 : Moreover, expression of E-selectin, IL-6, and IL-8 was induced most efficiently by IL-1ß , while LPS and TNF-a had less effect, whereas we did not find such a difference in ICAM-1 and MCP-1 expression
Arntzen et al., Acta Obstet Gynecol Scand 1997 : TNF activity was detected in samples from nine women, whereas IL-1 was not found in any sample
Werling et al., Vet Immunol Immunopathol 1995 (Enzootic Bovine Leukosis) : Despite their higher IL-1 beta concentration, supernatants from BLV positive cows stimulated proliferation of murine thymocytes in the MTT ( 3- ( 4,5-dimethylthiazol-2-yl ) -2,5-biphenyl tetrazolium bromide ) assay similar to supernatants from BLV negative cows, but showed about 30 % less IL-1 activity than supernatants from BLV negative cows on the IL-1 dependent cell line LBRM-33 1 A-5, and about five times more tumor necrosis factor (TNF) activity on the TNF-sensitive murine fibroblast cell line L-929
McClellan et al., Cytokine 2012 (Adenomatous Polyposis Coli...) : Gene expression ( mRNA ) of MCP-1, IL-1ß, IL-6 and TNF-a was increased in sections 2 and 3 starting at week 12 ( P < 0.05 ), with further increases in MCP-1, IL-1ß and IL-6 at 16 weeks ( P < 0.05 )
Kular et al., Journal of neuroinflammation 2012 (Disease Models, Animal...) : In vitro, results based on cultured DRG neurons showed that siRNA mediated inhibition of NOV enhanced IL-1ß- and TNF-a induced MMP-2, MMP-9 and CCL2 expression whereas NOV addition inhibited TNF-a induced MMP-9 expression through ß1 integrin engagement
Le et al., J Immunol 1987 : FS-4 cells did not secrete soluble IL 1 in response to TNF ... Dexamethasone suppressed the synthesis of TNF induced MA-IL 1 ... The ability of TNF to induce IL 1 synthesis in FS-4 fibroblasts at the transcriptional level was confirmed by S1 nuclease protection assay ... Induction with TNF resulted in the appearance of IL 1-alpha mRNA and a very significant increase in IL 1-beta mRNA, indicating that TNF induces the synthesis of both IL 1-alpha and IL 1-beta in FS-4 cells
Vézina Audette et al., Osteoarthritis Cartilage 2013 : LPS and IL-1ß significantly increased the expression of pro-inflammatory cytokines ( TNF-a , IL-8 and IL-6 ; and IL-1ß and IL-8 respectively )
Douvdevani et al., Kidney Int 1994 : We found that LPS, TNF alpha and IL-1 alpha alone, or in combination, caused an increase in IL-1 alpha and -beta mRNA levels
Castelli et al., Cancer Res 1994 (Melanoma) : In addition, IL-1 alpha and IL-6 were negatively regulated by soluble IL-6 and TNF-alpha
Lavnikova et al., J Cell Physiol 1996 (Cell Transformation, Neoplastic) : These data suggest a potential involvement of endogenous TNF-alpha in IL-1 induced cytostasis and nitric oxide production
Kang et al., Exp Dermatol 1996 : Differential regulation of IL-1 and IL-1 receptor antagonist in HaCaT keratinocytes by tumor necrosis factor-alpha and transforming growth factor-beta 1
Ntrivalas et al., Hum Immunol 2007 : When PBMC were cultured with a2NTD, there was a 2.5-fold increase in IL1A and IL1B gene expression and no induction of TNF gene expression
Lazenby et al., Cytokine 1992 : Characterization of the TNF-R by flow cytometric analysis revealed increased membrane expression of the 75 kDa, but not the 55 kDa, TNF binding protein as a result of IL-1 costimulation
Kimble et al., Endocrinology 1995 (Bone Resorption...) : To this aim, rats were ovariectomized and treated for 2 weeks with either IL-1 receptor antagonist (IL-1ra), an inhibitor of IL-1 , or TNF binding protein (TNFbp) , an inhibitor of TNF
Elias et al., Am J Respir Cell Mol Biol 1990 : Interleukin-1 and tumor necrosis factor synergistically stimulate lung fibroblast interleukin-1 alpha production ... Induction of fibroblast IL-1 alpha by IL-1 and/or TNF may be an important mechanism amplifying IL-1 mediated biologic events at sites of local inflammation
Liu et al., J Mol Neurosci 2011 : The PKA specific agonist N6-benzoyladenosine-3,5-cAMP ( 6-Bnz-cAMP ) not only inhibited the transcription and production of tumor necrosis factor-a (TNF-a) and interleukin-1ß (IL-1ß) but also enhanced the transcription and expression of IL-10, while the Epac selective analog 8- ( 4-chlorophenylthio ) -2-O-methyladenosine-3,5-cAMP ( 8-pCPT-2'-O-Me-cAMP ) merely repressed the TNF-a expression
Kim et al., Pharmacol Res 1999 : We therefore investigated whether IL-1 mediated inhibition of TNF-alpha secretion from astrocytes by RGAE ... These results suggest that RGAE may inhibits TNF-alpha secretion by inhibiting IL-1 secretion and that RGAE has an anti-inflammatory activity in the central nervous system curing some pathological disease states
Shibata et al., J Invest Dermatol 2010 (Psoriasis) : Furthermore, IL-27 alone greatly induced in vitro CXCL9, CXCL10, and CXCL11 production and tyrosine phosphorylation of signal transducer and activator of transcription 1 in normal human keratinocytes, while it suppressed the tumor necrosis factor-alpha induced production of IL-1alpha and CCL20
Kitamura et al., Cell Mol Life Sci 1998 : Central IL-1 differentially regulates peripheral IL-6 and TNF synthesis ... The results suggest that brain IL-1 induces peripheral production of IL-6, but not of TNF , through autonomic nervous system activation
Candela et al., J Exp Med 1991 : Sphingosine appeared to stimulate TNF alpha induced PGE2 production independent of TNF alpha mediated interleukin 1 (IL-1) production, because anti-IL-1 antibodies and IL-1 receptor antagonist protein (IRAP) did not inhibit TNF alpha induced PGE2 production or the stimulatory effect of sphingosine
Huether et al., Gene 1993 : Northern blot analysis reveals a single 1.7-kb mRNA species that is differentially regulated by lipopolysaccharide, phorbol myristate acetate, and tumor necrosis factor but is not regulated by human recombinant IL-1
van Hinsbergh et al., Blood 1988 : Therefore, it is unlikely that TNF acts through the induction of IL-1 secretion by endothelial cells
Bigoni et al., J Orthop Res 2013 (Knee Injuries...) : Interestingly, IL-1ra levels remained always significantly lower than normally reported levels, and TNF-a levels did not increase after trauma
Modéer et al., Cytokine 1993 : IL-1 alpha , IL-1 beta and TNF-alpha , but not EGF nor TGF-alpha, stimulated prostaglandin E2 ( PGE2 ) formation in the gingival fibroblasts
Cubitt et al., Invest Ophthalmol Vis Sci 1995 : These results demonstrate that both IL-1 alpha and TNF-alpha could induce keratocytes to produce nanogram levels of IL-6 but IL-1 alpha was a 30-fold more effective inducer
Dimri et al., Lymphokine Cytokine Res 1994 : Adherent human peripheral blood monocytes cultured for 2 weeks in the presence of GM-CSF or IL-3 were examined for viability and adherence, expression of membranal HLA-DR, CD-14, and IL-1 alpha , and LPS triggered TNF-alpha production
Kim et al., Phytother Res 2002 : We therefore examined whether IL-1 mediated inhibition of TNF-alpha secretion from primary astrocytes by SSGP ... Our results suggest that SSGP may inhibit TNF-alpha secretion by inhibiting IL-1 secretion and that SSGP has an antiinflammatory activity in the CNS
Delwel et al., Leukemia 1990 (Leukemia, Myeloid, Acute) : Hemopoietin-1 activity of interleukin-1 (IL-1) on acute myeloid leukemia colony forming cells ( AML-CFU ) in vitro : IL-1 induces production of tumor necrosis factor-alpha which synergizes with IL-3 or granulocyte-macrophage colony stimulating factor ... Thus, the effect of IL-1 on AML-CFU proliferation is not the result of direct activation of AML progenitors, but IL-1 stimulates the release of TNF-alpha by AML cells and endogenous TNF subsequently synergizes with IL-3 or GM-CSF
Gowen et al., Endocrinology 1990 : These results suggest that human osteoblasts, which have been shown previously to respond to TNF alpha, can synthesize and release TNF in response to IL1 and granulocyte-macrophage colony stimulating factor
Hawkins et al., Am J Vet Res 1995 (Horse Diseases...) : The induction of IL-1, IL-1 inhibitory activity IL-6, WBC, and total protein concentration responses are largely independent of TNF activity in synovial fluid of horses receiving endotoxin intra-articularly
Caldwell et al., Blood 1995 : Interleukin-1 alpha upregulates tumor necrosis factor receptors expressed by a human bone marrow stromal cell strain : implications for cytokine redundancy and synergy ... IL-1 alpha induction of TNF receptors reaches a peak after 6 hours and gradually returns to baseline level by 24 hours ... A kinetic study comparing IL-1/TNF synergistic induction of growth factor secretion with IL-1 alpha induction of TNF receptors shows that these events occur in parallel ... In contrast with the induction of TNF receptors by IL-1 alpha , treatment with TNF alpha has no effect on either the number of IL-1 receptors expressed by CDCL cells or IL-1 receptor ligand binding affinity
Burger et al., Gynecol Oncol 1994 (Ovarian Neoplasms) : TNF and IL-1 inhibitors originate from tumor cells and tumor associated macrophages and probably block TNF and IL-1 activity locally and regionally in ovarian carcinoma patients
Rannou et al., Joint Bone Spine 2006 (Arthritis, Rheumatoid) : Experimental data suggest that IL-1 may be involved chiefly in joint destruction and TNF in joint inflammation
Bondeson et al., Arthritis Res Ther 2006 (Inflammation...) : Another interesting observation was that in these osteoarthritis cultures of synovial cells, IL-1beta production was independent of TNF-alpha , in contrast to the situation in rheumatoid arthritis
Polzer et al., Ann Rheum Dis 2010 (Arthritis, Experimental...) : To determine whether TNF directly triggers bone loss or requires IL1 , human TNFalpha mice ( hTNFtg ) were crossed with mice lacking IL1alpha and IL1beta ( IL1 ( -/- ) hTNFtg )
Kumar et al., J Cell Physiol 2001 (Bone Resorption) : In addition, IL-1 and TNF also activated p38 MAPK in fetal rat long bones and p38 MAPK inhibitors inhibited IL-1- and TNF stimulated bone resorption in vitro in a dose dependent manner ( IC ( 50 ) s 0.3 -- 1 microM )
Hirata et al., Am J Respir Cell Mol Biol 1998 (Lung Neoplasms) : The TNF-alpha level in the supernatants significantly increased at 120 min after allergen stimulation, and the interleukin (IL)-1beta level increased in 4 of 15 samples
Brown et al., Journal of inflammation (London, England) 2008 : TNF release from LPS stimulated human peripheral blood mononuclear cells was inhibited with IC50s 16 +/- 6 nM and 14 +/- 8 nM, ( mean +/- S.D. ) for SB-203580 and VX-745 and IL-1 was inhibited with IC50s of 20 +/- 8 nM and 15 +/- 4 nM ( mean +/- S.D. ), respectively
Chustz et al., Am J Respir Cell Mol Biol 2011 (Inflammation) : Messenger ( m ) RNAs for IL-1F6 and IL-1F9, but not IL-1F5, IL-1F8 or IL-1F10, were significantly up-regulated by TNF , IL-1ß, IL-17 and the Toll-like receptor (TLR)3 ligand double stranded ( ds ) RNA
Moe et al., J Cell Mol Med 2011 (Ventricular Remodeling) : Nox2 and Nox4 siRNA were used to determine whether or not Nox2 and Nox4 mediated TNF-a induced ROS and upregulation of IL-1ß and IL-6 in adult human cardiomyocytes ... Nox2 and Nox4 siRNA significantly attenuated TNF-a induced ROS and upregulation of IL-1ß and IL-6 in cardiomyocytes
Chyczewska et al., Roczniki Akademii Medycznej w Białymstoku (1995) 1997 (Cachexia...) : IL-1 stimulates necrotizing activity of TNF-alpha and augments cachexia by anabolism of lipid induction
Kim et al., Immunopharmacol Immunotoxicol 2001 : We therefore examined whether IL-1 mediated inhibition of TNF-alpha secretion from primary astrocytes by Chilbokeum ... Our results suggest that Chilbokeum may inhibit TNF-alpha secretion by inhibiting IL-1 secretion and that Chilbokeum has an antiinflammatory activity in the central nervous system
Pober , Ciba Found Symp 1987 (Inflammation) : TNF and LT induce reciprocal tachyphylaxis for the reinduction of H4/18 binding but do not inhibit induction by IL-1 alpha and IL-1 beta ; similarly, IL-1 alpha and IL-1 beta induce reciprocal tachyphylaxis but do not inhibit TNF or LT
Yap et al., Biochim Biophys Acta 1991 : Tumor necrosis factor (TNF) inhibits interleukin (IL)-1 and/or IL-6 stimulated synthesis of C-reactive protein (CRP) and serum amyloid A (SAA) in primary cultures of human hepatocytes
Kim et al., Int J Immunopharmacol 1998 : We therefore investigated whether IL-1 mediated inhibition of TNF-alpha secretion from astrocytes by ACAE ... These results suggest that ACAE may inhibit TNF-alpha secretion by inhibiting IL-1 secretion and that ACAE has a antiinflammatory activity in the central nervous system
de Rochemonteix-Galve et al., Infect Immun 1991 : After a second inhalation exposure, cell associated and extracellular TNF-alpha activity could not be detected , whereas IL-1 activity was markedly enhanced
Jayaraman et al., J Immunol 2013 : IL-1ß directly augments TNF signaling in macrophages through the upregulation of TNF secretion and TNFR1 cell surface expression, and results in activation of caspase-3
Eigler et al., Biochem Biophys Res Commun 1993 : 3-Morpholino-sydnonimine ( SIN-1 ) enhanced IL-1 alpha induced TNF synthesis to a maximum of 272 % ( mean of n = 5 donors ), with 100 % set as TNF production by stimulation with IL-1 alpha alone
Wei et al., Biochem Biophys Res Commun 1990 : The experiments reported here demonstrate that in cultured human muscle cells, IL-1 induces ferritin H mRNA and protein as effectively as TNF ... TNF and IL-1 were additive in their effects on ferritin H expression, and IL-1 induction of ferritin H was not blocked by anti-TNF antibodies
Stashenko et al., J Periodontol 1991 (Alveolar Bone Loss...) : As determined by ELISA of tissue extracts, IL-1 beta and TNF alpha were detected in all diseased sites, whereas IL-1 alpha was present in 8/22 sites, IL-1 beta was present in highest concentration ( mean +/- SEM : 11,695 +/- 2,888 pg/ml ; 672 pM ), followed by TNF alpha ( 434 +/- 135 pg/ml ; 26 pM ), and IL-1 alpha ( 342 +/- 160 pg/ml ; 20 pM )
Tilg et al., Blood 1995 (Hepatitis C...) : In addition, IFN alpha suppressed significantly interleukin (IL)-1 alpha induced TNF alpha protein synthesis by human peripheral blood mononuclear cells
Buchan et al., Clin Exp Immunol 1988 (Arthritis, Rheumatoid) : TNF bioactivity was also detected which may be of importance as TNF induces the production of IL-1
Navarro et al., Pharmacol Biochem Behav 2013 (Pain) : The analgesic mechanisms of piracetam were related to inhibition of carrageenin- and TNF-a induced production of IL-1ß as well as prevention of carrageenin induced decrease of reduced glutathione, ferric reducing ability and free radical scavenging ability in the paw
Tomita et al., Gene Ther 2000 (Glomerulonephritis) : Therefore, we examined the effect of NFkappaB decoy ODN transfection on TNF-alpha induced endogenous interleukin (IL)-1alpha , IL-1beta, IL-6, ICAM-1 and VCAM-1 gene expression as assessed by RT-PCR and Northern blotting
Nagaki et al., Gastroenterol Jpn 1991 (Liver Diseases) : These results strongly suggest that IL-1 has a inhibitory effect on hepatocytes in terms of DNA synthesis and that TNF indirectly induces hepatocellular damage through the serine proteases which are possibly activated by the cytokine in vivo
Puren et al., J Clin Invest 1998 : IL-18 did not induce antiinflammatory cytokines, IL-1Ra , or IL-10, although IL-18 induction of TNFalpha was inhibited by IL-10
Chantry et al., Eur J Immunol 1989 (Cryoglobulinemia) : Tumor necrosis factor-alpha , which is a potent inducer of IL 1, also enhanced IL 1 production following stimulation with suboptimal doses of the immune complex
Van bezooijen et al., J Bone Miner Res 1999 (Bone Resorption) : In addition, IL-17 increased TNF-alpha induced IL-1alpha , IL-1beta, and IL-6 mRNA expression in fetal mouse metatarsals and IL-1alpha and IL-6 mRNA expression in MC3T3-E1 cells
Andersson et al., J Lab Clin Med 2002 : Thus captopril reduced TNF-alpha induced IL-1beta and IL-1betamRNA synthesis in monocytes, in vitro, probably through interference with NF-kappaB activation of the IL-1beta gene
Wuthrich et al., Kidney Int 1990 (Cell Transformation, Viral) : However, stimulation with IL-1 alpha or LPS induces TNF-alpha transcripts
Kaji et al., Int J Cancer 1995 (Carcinoma...) : IL-1 alpha production by PCI cells was up-regulated by TNF-alpha
Kakinuma et al., Obstet Gynecol 1997 (Obstetric Labor, Premature) : Interleukin-1 alpha induced trophoblastic apoptosis and increased the serum level of tumor necrosis factor-alpha
Bashir et al., Arch Dermatol Res 2009 : Moreover, we found that IL-1alpha , a cytokine also present in irradiated skin, substantially and synergistically enhances the induction of TNF-alpha by UVB, and the induction of TNF-alpha by this combination of UVB with IL-1alpha is mediated through increased TNF-alpha gene transcription
Delomenie et al., Exp Cell Res 1993 : Intracellular IL-1 alpha and IL-1 beta levels were markedly enhanced by IL-1 beta and TNF alpha
Wang et al., Shock 2004 (Inflammation...) : We conclude that p38 MAPK is involved in endotoxin induced myocardial contractile dysfunction and myocardial TNF-alpha production ; however, p38 MAPK 's involvement in IL-1 and IL-6 production may be indirectly mediated by TNF-alpha
Taylor , Arthritis Rheum 1994 (Arthritis, Rheumatoid) : IL-1 could cause increased TNF alpha binding and TNFR shedding in inflamed joints
Boehm et al., Exp Dermatol 1996 (Dermatitis, Toxicodendron...) : The data provide evidence for an in vivo role for epidermal IL-1 alpha , IL-1 beta and TNF-alpha transcription in the regulation of IL-1 beta and TNF-alpha polypeptide levels in the epidermis in response to this common contact allergen
Dinarello , Semin Oncol 1997 (Disease) : Interferon-alpha2b is a potent inhibitor in vitro of the induction of IL-1 and tumor necrosis factor by IL-1 and can induce high circulating levels of the anti-inflammatory soluble tumor necrosis factor receptor and IL-1 receptor antagonist in humans
Van Bladel et al., Cytokine 1991 (Carcinoma, Hepatocellular...) : IL-1 had no effect on TNF binding to HepG2
Seitz et al., Br J Rheumatol 1995 (Arthritis, Rheumatoid) : In addition, clinical improvement was associated with decreased synthesis of IL-1 beta, TNF-alpha and IL-8 induced by bacterial lipopolysaccharide, IL-1 alpha and IL-1 beta in PBMC in vitro
Tsay et al., Cytokine 2013 (Burns...) : Blocking TNF-a enhances Pseudomonas aeruginosa induced mortality in burn mice through induction of IL-1ß
De Bandt et al., Metabolism 1994 : These results indicate that ( 1 ) in the conditions of the study, IL-1 beta has no direct effect on hepatic amino acid exchanges and utilization ; ( 2 ) TNF alpha which exerted an inhibitory effect on these parameters, could be involved in the reduced amino acid exchanges during the end stage of sepsis ; ( 3 ) the TNF alpha induced increase in glucose uptake could be related to an inhibition of gluconeogenesis and/or to the activation of glucose utilization by Kupffer cells ; ( 4 ) IL-1 beta and TNF alpha both potentiate the action of glucagon on hepatic amino acid uptake and utilization ; and ( 5 ) complex interactions between Kupffer cells and hepatocytes on the one hand and between cytokines and hormones on the other hand could account for the differences in hepatic metabolism according to the stage of the response to injury
Kutsch et al., J Invest Dermatol 1993 : Tumor necrosis factor-alpha induces interleukin-1 alpha and interleukin-1 receptor antagonist production by cultured human keratinocytes ... Only TNF-alpha induced IL-1ra and IL-1 alpha production ... The IL-1 alpha and IL-1ra response to TNF-alpha stimulation showed a varied pattern among different keratinocyte strains over 72 h of culture on plain plastic
Bristulf et al., Neurosci Lett 1995 : Furthermore, IL-1 beta also induced increases in TNF alpha and c-fos mRNAs
Bartholdi et al., Eur J Neurosci 1997 (Listeriosis...) : While TNF alpha is expressed in a very narrow time window, IL-1 can be detected in a second phase in a subset of polymorphonuclear granulocytes which immigrate into the spinal cord around 6 h. Message for the chemokines MIP-1alpha and beta is expressed in a generalized way in the grey matter of the entire spinal cord around 24 h and gets again restricted to the cellular infiltrate at the lesion site at 4 days following injury
Chung et al., J Immunol 1990 : Astrocyte TNF-alpha production by IFN-gamma/LPS stimulation can be inhibited by the addition of anti-rat IFN-gamma antibody, whereas IFN-gamma/IL-1 induced TNF-alpha production is inhibited by antibody to either IFN-gamma or IL-1 beta
Malik et al., Br J Cancer 1992 (Cystadenocarcinoma...) : Analysis of peritoneal fluid and tumour xenografts showed that TNF induced murine IL-1 in the tumour bearing mice
Voronov et al., Proc Natl Acad Sci U S A 2003 (Adenocarcinoma...) : In addition to the in vivo findings, IL-1 contributed to the production of vascular endothelial cell growth factor and tumor necrosis factor in cocultures of peritoneal macrophages and tumor cells
Fujiwara et al., J Immunol 1992 : These findings suggest that autocrine/paracrine IL-1 is involved in the initial generation of LAK activity and, in particular, that TNF expression could be induced via an IL-1 autocrine pathway
Dekaris et al., J Immunol 1999 : These results suggest that the IL-1 induction of corneal LC migration is largely mediated by TNFR function, whereas TNF-alpha induction of LC migration is independent of IL-1RI activity
Endres et al., Immunology 1996 : Three weeks after ending aspirin medication, ex vivo IL-1 beta and TNF synthesis induced by exogenous IL-1 alpha was elevated threefold compared to the pre-aspirin value ( P = 0.01 and P = 0.005, respectively )
Klegeris et al., Neurobiol Aging 2005 (Neuroblastoma) : Such toxicity was induced by the following combinations : interferon-gamma (IFN-gamma) with tumor necrosis factor-alpha (TNF-alpha) ; IFN-gamma with interleukin (IL) 1alpha or IL-1beta in the presence of TNF-alpha ; and IL-6 with TNF-alpha
Otsu et al., Pharmacology 2011 : EM900 also suppressed IL-1ß induced IL-1ß and TNF-a expression in A549 cells
Corsini et al., Toxicol Appl Pharmacol 1996 (Dermatitis, Contact) : By reverse transcription-polymerase chain reaction we were able to show that the neutralizing antibody also partially prevented TBT induced in vivo IL-6 expression but no TBT induced TNF-alpha expression, suggesting a paracrine effect of IL-1alpha on IL-6 production but not TNF-alpha expression and indicating that other inflammatory mediators are involved
McGillicuddy et al., Diabetes 2011 (Inflammation...) : Coculture of WT, but not IL-1RI ( -/- ) macrophages, with 3T3L1 adipocytes enhanced IL-6 and TNF-a secretion, reduced adiponectin secretion, and impaired adipocyte insulin sensitivity
Katz et al., J Immunol 1989 : Because TNF induces membrane IL-1 in fibroblasts, it is possible to speculate that the effects of TNF on fibroblasts are due to induction of IL-1
Shingu et al., Life Sci 1991 : Recombinant human IL-1 beta and TNF-alpha stimulate production of IL-1 alpha and IL-1 beta by vascular smooth muscle cells and IL-1 alpha by vascular endothelial cells
Bry et al., Biochim Biophys Acta 1993 : TNF-alpha ( 50 ng/ml ) increased the number of IL-1 receptors to 2930 +/- 590
Ikejima et al., J Infect Dis 1990 : IL-1 alpha stimulated both IL-1 beta and TNF-alpha , but there was no correlation in the amount of TNF-alpha or IL-1 beta synthesized in the PBMC of 29 individuals ... Coincubation with interferon-gamma (IFN-gamma) did not change the amount of IL-1 induced TNF-alpha , whereas in the same culture IFN-gamma inhibited ( greater than 70 % ) ... These studies demonstrate that IL-1 induced TNF-alpha production in vivo and in vitro
Balato et al., Arch Dermatol Res 2013 (Inflammation...) : Vitamin D ( vitD ) and analogs have been shown to suppress TNF-a induced IL-1a in human keratinocytes (KCs)
Choi et al., Immunopharmacol Immunotoxicol 2002 : Therefore, we investigated whether IL-1 mediated inhibition of TNF-alpha secretion from astrocytes by YH-Tang ... These results suggest that YH-Tang may indirectly inhibit TNF-alpha secretion by inhibiting IL-1 secretion
Gessani et al., J Biol Regul Homeost Agents 1988 : Freshly harvested murine peritoneal macrophages and a line of transformed murine macrophages ( RAW ) were used in experiments designed to investigate the effect of different interferons ( IFN ) and interleukin-1 (IL-1) on tumor necrosis factor (TNF) receptors
Beissert et al., J Invest Dermatol 1998 (Hypersensitivity, Delayed...) : Previous experiments indicated that the suppressive effects of IL-1alpha on induction of immunity may be mediated by TNF alpha ... Therefore, the ability of IL-1alpha or IL-1beta to induce epidermal cell production of TNF alpha was assessed
McHugh et al., Proc Soc Exp Biol Med 2000 (Genetic Predisposition to Disease...) : These results indicate that TNF-alpha is important in controlling L. pneumophila replication, and IL-1 can regulate TNF-alpha levels, affecting susceptibility of macrophages to infection with an intracellular opportunistic pathogen like Legionella
Grabbe et al., J Invest Dermatol 1994 (Neoplasms, Experimental) : Thus, interleukin-1 alpha may be an important regulator of Langerhans cell antigen presenting function, having effects that are partially mediated via interleukin-1 alpha induced up-regulation of tumor necrosis factor-alpha secretion within the skin
Yao et al., Inflammation 2004 (Hepatitis) : Time course studies revealed an increased production of TNF-a preceding the IL-1 production, suggesting that increased TNF-alpha levels could be involved in the increased IL-1 production
Debs et al., J Immunol 1988 : We found that aerosolized murine rIFN-gamma or recombinant human TNF-alpha increased IL-1 production by both alveolar macrophages and blood monocytes for at least 5 days after administration
Kataranovski et al., Physiol Res 1999 (Acute-Phase Reaction...) : While serum IL-1 activity was elevated throughout the 3-day period of observation, the levels of serum TNF activity were enhanced after 12 h and on days 1 and 3 following scalding injury
Staugas et al., Infect Immun 1992 : Induction of tumor necrosis factor (TNF) and interleukin-1 (IL-1) by Pseudomonas aeruginosa and exotoxin A-induced suppression of lymphoproliferation and TNF, lymphotoxin, gamma interferon, and IL-1 production in human leukocytes
Rice et al., Shock 1994 (Inflammation) : CT-1501R also inhibited IL-1 alpha or IL-1 beta induction of either TNF-alpha or IL-1 beta and inhibited the synergistic effects of stimulation with both human IL-1 beta and murine TNF-alpha on release of human TNF-alpha
Hardyman et al., J Allergy Clin Immunol 2013 (Asthma) : TNF-a lowered transepithelial electrical resistance and increased fluorescent dextran permeability, caused loss of occludin and claudins from tight junctions with redistribution of p120 catenin and E-cadherin from adherens junctions, and also increased endogenous TNF-a, IL-6, IL-1ß , IL-8, thymic stromal lymphoprotein, and pro-matrix metalloprotease 9 release
Downs et al., Int J Immunopharmacol 1995 (Pulmonary Edema) : Associated with these improvements in organ dysfunction and survival was a modest decrease in LPS stimulated interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) secretion and a marked ( > 90 % ) inhibition of TNF secretion by MDL 101,002
Lee et al., Leuk Res 1993 : Purified T-cells did not produce significant levels of TNF-alpha , even in the presence of IL-1 and IL-6
Romas et al., Bone 2002 (Arthritis, Rheumatoid) : In addition, TNF-alpha induces IL-1 release by synovial fibroblasts and macrophages, and IL-1, together with RANKL, is a major survival and activation signal for nascent osteoclasts
Sato et al., FEBS Lett 1996 : By contrast, proMMP-3/prostromelysin 1 is up-regulated by TNFalpha or TPA in the presence of IL-1alpha , whose modulation is PKC dependent
Xu et al., J Immunol 2013 (Psoriasis) : Specific inhibition of miR-31 suppressed NF-?B-driven promoter luciferase activity and the basal and TNF-a induced production of IL-1ß , CXCL1/growth related oncogene-a, CXCL5/epithelial derived neutrophil activating peptide 78, and CXCL8/IL-8 in human primary keratinocytes
Demyanets et al., J Mol Cell Cardiol 2013 : Mitogen activated protein/extracellular signal regulated kinase inhibitor U0126 abrogated TNF-a- , IFN-?-, and IL-1ß induced and Janus activated kinase inhibitor I reduced IFN-? induced IL-33 production
Bertini et al., J Leukoc Biol 1989 : Pretreatment of mice with DEX protected against the depression of liver cytochrome P-450 by LPS or TNF but not by IL-1, suggesting that IL-1 directly depresses cytochrome P-450 and that DEX acts by inhibiting IL-1 synthesis in vivo induced by LPS or TNF
Maish et al., J Trauma 1999 : These results suggest that the inhibitory effects of TNF on cutaneous tissue repair are mediated in part by IL-1
Nita et al., Int J Biochem Cell Biol 2007 : In contrast, longer term incubation ( 18 h ) of monocytes with combined AAT/LPS results in a significant reduction in expression of both CD14 and TLR4, inhibition of LPS induced TNFalpha , IL-1 beta and IL-8 mRNA and protein expression
Nakamura et al., Immunity 2012 (Dermatitis...) : Unlike normal cells, MCs expressing mutant Nlrp3 produced IL-1ß in response to lipopolysaccharide or tumor necrosis factor-a (TNF-a)
Ribel-Madsen et al., Arthritis 2012 : TNF-a stimulation caused similar IL-1ß , IL-6, and IL-8 release in all groups
Hahn et al., J Clin Invest 1993 (Arthritis, Rheumatoid) : In particular, IL-1 beta and neopterin production were further enhanced by stimulation with either interferon-gamma (IFN-gamma) or TNF-alpha without a synergistic effect
Rodríguez-Berriguete et al., BMC cancer 2010 (Disease Progression...) : Inhibitions of IAPs, IL-1alpha and TNFalpha might be a possible target for PC treatment since IAPs are the proteins that inhibited apoptosis ( favour proliferation ) and IL-1alpha and TNFalpha would affect all the transduction pathway involucrate in the activation of transcription factors related to survival or proliferation ( NF-kB, Elk-1 or ATF-2 )
Tian et al., Rheumatol Int 2013 : Resveratrol inhibits TNF-a induced IL-1ß , MMP-3 production in human rheumatoid arthritis fibroblast-like synoviocytes via modulation of PI3kinase/Akt pathway ... The present study was designed to investigate the effects of resveratrol on TNF-a induced inflammatory cytokines production of IL-1ß and MMP3 in Rheumatoid arthritis ( RA ) Fibroblast-like synoviocytes ( FLS ) and further to explore the role of PI3K/Akt signaling pathway by which resveratrol modulates those cytokines production ... Activation of PI3K/Akt signaling pathway exists in TNF-a induced production of IL-1ß and MMP3 on RA FLS, which is hampered by PI3K inhibitor LY294002 ... Resveratrol attenuates TNF-a induced production of IL-1ß and MMP-3 via inhibition of PI3K-Akt signaling pathway in RA FLS, suggesting that resveratrol plays an anti-inflammatory role and might have beneficial effects in preventing and treating RA
Lyons et al., Infect Immun 2001 (Chronic Disease...) : This increased severity of disease was associated with reduced ocular IL-1alpha and increased tumor necrosis factor alpha mRNA production compared with WT mice
Werth et al., J Invest Dermatol 1999 : Ultraviolet B and interleukin-1 alpha synergistically increased tumor necrosis factor-alpha secretion by fibroblasts, a finding not seen with ultraviolet B alone nor with ultraviolet A or ultraviolet A1 combined with interleukin-1 alpha ... We conclude that interleukin-1 alpha in combination specifically with ultraviolet B induces fibroblasts to secrete tumor necrosis factor-alpha , and that this ultraviolet B-specific induction of tumor necrosis factor-alpha secretion is responsible for effects of ultraviolet B on the expression of matrix related genes in the skin
Shamji et al., Arthritis Rheum 2007 : IL-1Ra domain activity was evaluated by surface plasmon resonance, and in vitro antagonism of IL-1 mediated lymphocyte and thymocyte proliferation, as well as IL-1 induced tumor necrosis factor alpha (TNFalpha) expression and matrix metalloproteinase 3 (MMP-3) and ADAMTS-4 messenger RNA expression in human intervertebral disc fibrochondrocytes
Dett et al., J Immunol 1991 : Antibody neutralization studies indicated that IL-1 induces release of both TNF and LT ; however, IL-4 and IL-6 induce primarily LT release
Stich et al., Res Vet Sci 2011 : Lipopolysaccharide was a more potent inducer of IL-1ß and CXCL-8 than LTA or PG and LTA is a more potent inducer of CXCL-8 than PG. Based on these data, PAMPs from gram positive and negative bacteria induce TNF , IL-1ß and CXCL-8 production in feline whole blood
Barchowsky et al., Cytokine 2000 (MAP Kinase Signaling System) : Although both IL-1 and TNF activate NF-kappaB in these cells, only IL-1 induces collagenase-1 transcription
Li et al., J Oral Pathol Med 1996 (Mouth Diseases...) : TNF alpha stimulation increased IL-1 alpha production by both cell types and exhibited synergy with interferon gamma (IFN gamma), although the latter had no effect by itself
Wei et al., J Clin Invest 2005 (MAP Kinase Signaling System...) : Reflecting sequential signaling of the cytokines TNF and IL-1, TNF induces stromal cell expression of IL-1 and IL-1RI
Endo et al., Biochem Biophys Res Commun 1988 : Since, the effect of TNF was not inhibited by neutralization with antibody to IL-1 alpha and IL-1 beta, it seems that the mechanism is not mediated by endogenous IL-1 induced by TNF
Hawrylowicz et al., J Immunol 1989 : Although IL-4 or TNF did not induce significant B cell IL-1 expression, they both caused a modest, but reproducible enhancement when added in combination with IL-2
Kim et al., J Ethnopharmacol 1998 : We therefore also investigated whether IL-1 mediated inhibition of TNF-alpha secretion from primary astrocytes by PTAE ... These results suggest that PTAE may inhibit TNF-alpha secretion by inhibiting IL-1 secretion and that PTAE has an anti-inflammatory activity on the central nervous system curing some pathological disease states
Ikeda et al., Hepatology research : the official journal of the Japan Society of Hepatology 2008 : In cultured BEC, TNF-alpha, interleukin (IL)-1beta , IL-6, and interferon-gamma induced the expression of CDX2 mRNA, though only TNF-alpha additionally induced the expression of MUC2 mRNA
Jordan et al., Br J Pharmacol 1997 : In contrast approximately three fold more IL-8 was induced by IL-1alpha than by TNFalpha whereas significant RANTES production was induced only by TNFalpha
Kitazawa et al., J Clin Invest 1994 (Bone Resorption) : To investigate the contribution of IL-1, IL-6, and TNF to the increased osteoclastogenesis induced by estrogen deficiency, ovariectomized ( ovx ) mice were treated with either IL-1 receptor antagonist (IL-1ra), a competitive inhibitor of IL-1 , TNF binding protein (TNFbp), an inhibitor of TNF , or the anti-IL-6 antibody ( Ab ) 20F3 for the first 2 wk after surgery
Aiura et al., Infect Immun 1993 (Bacteremia...) : In vitro, IL-1ra inhibited S. epidermidis induced TNF from mononuclear cells by 31 % +/- 11 %, from spleen cells by 17 % +/- 4 % ( P < 0.05 ), and from whole blood by 42 % +/- 17 %
Huang et al., Head Neck 2010 (Carcinoma...) : LMP1 mediated IL-1alpha and IL-1beta production could be enhanced by tumor necrosis factor alpha (TNF-alpha) , determined by enzyme linked immunosorbent assay ( ELISA )
Zamir et al., Surg Gynecol Obstet 1993 : The present results suggest that TNF and IL-1 may regulate amino acid transport in skeletal muscle and that the effect of TNF , but not that of IL-1, is at least partly mediated by glucocorticoids
Venkataraman , Cryobiology 1997 : In vitro irradiation had an inconsistent effect on TNF-alpha production by the fresh PBMCs. Taken together, these results suggest that the endogenously hypersecreted TNF-alpha is indirectly responsible for the previously reported elevated IL-1- , IL-6-, and IL-10 secreting capabilities of frozen PBMCs
Locksley et al., J Immunol 1987 : Recombinant TNF-alpha caused IL-1 release by 4 hr with maximal levels of 17 U/ml by 24 hr ; half-maximal stimulation occurred at approximately 80 pM
Nagakawa et al., Immunopharmacol Immunotoxicol 1991 (Drug-Induced Liver Injury) : These results suggest that TNF plays a major role in the pathogenesis of galactosamine/LPS hepatitis in mice and that IL-1 alpha acts synergistically with TNF in this hepatitis model
Tsuji et al., Am J Pathol 1995 (Granuloma...) : Thus, interleukin-1 alpha and inducible nitric oxide synthase were induced mostly in the cells accumulated around the beads and also in some bronchiolar epithelial cells during the early phase ( 1 to 3 days ), whereas tumor necrosis factor-alpha was induced in the cells around the beads at the later resolution phase ( 3 to 7 days )
Arnush et al., J Clin Invest 1998 : Reverse transcriptase polymerase chain reaction was used to confirm that TNF + LPS + IFN-gamma stimulates the expression of both IL-1alpha and IL-1beta in human islets
Chida et al., Biochem Biophys Res Commun 2007 (Fever) : Peripheral TNFalpha, but not peripheral IL-1 , requires endogenous IL-1 or TNFalpha induction in the brain for the febrile response
Fang et al., Zhen Ci Yan Jiu 2007 (Inflammation) : Compared with control group, PGE2, IL-1beta and TNF-alpha contents in the toe tissue of model group increased significantly ; while in comparison with model group, PGE2 and IL-1beta levels in EA-post-treatment group, IL-1beta level in IND group decreased significantly ( P < 0.05 ), and TNF-alpha level in IND group increased significantly. No significant differences were found between model group and Rofecoxib and EA-pre-treatment groups in most time-courses of the hind-paw-volume, between model and IND, Rofecoxib and EA-pre-treatment groups in PGE2, between model and EA-pre-treatment groups in IL-1beta, and between model and Rofecoxib, EA-pre-treatment and EA-post-treatment groups in TNF-alpha contents ( P > 0.05 ) ... Compared with model group, IL-1beta mRNA expression of the local inflammatory tissues in IND and EA-post-treatment groups was down-regulated, and TNF-alpha mRNA expression in Rofecoxib and two EA groups down-regulated slightly
Fischer et al., J Immunol 1990 : Independent regulation of IFN-gamma and tumor necrosis factor by IL-1 in human T helper cells
Phipps et al., Eur J Immunol 1990 : Although constitutive production was low, tumor necrosis factor -alpha (TNF-alpha) stimulated 5-20-fold increases in IL 1 production in Thy-1- fibroblasts
Baroni et al., Arch Dermatol Res 2001 : Moreover, we demonstrated that M. furfur modulates proinflammatory and immunomodulatory cytokine synthesis by downregulating IL-1alpha and by inhibiting IL-6 and TNF-alpha and by upregulating IL-10 and TGF-beta1
Clarke et al., Mol Cell Proteomics 2013 (MAP Kinase Signaling System) : Mixed-effects modeling analysis of our data was vital for ascertaining that IL-1a and TGF-a treatment increased the activities of more pathways than IL-6 and TNF-a and that TGF-a and TNF-a increased p38 MAPK and c-Jun N-terminal kinase (JNK) phospho-protein levels in a synergistic manner
Hurme et al., Immunol Lett 1989 : IL-1 was also without effect, but TNF increased the proportion of HLA-DR+ cells in both CB and adult peripheral blood ( PBL ) -derived T lymphoblasts
Adams et al., J Clin Microbiol 1990 (Toxemia) : TNF-alpha cytotoxic activity is probably not due to the presence of interleukin-1 (IL-1) , alpha interferon, or gamma interferon in the sera since recombinant human IL-1, natural bovine IL-1, and recombinant bovine alpha and gamma interferons had no direct cytotoxic effects on WEHI-164 cells
Alsalameh et al., Z Rheumatol 1991 (Arthritis, Rheumatoid) : It will focus on interleukin-1 (IL-1) , IL-1 inhibitors, Tumor-Necrosis-Factor-alpha (TNF-alpha), TNF inhibitors , Interleukin-6 (IL-6), colony stimulating factors (CSF's), Interferon-gamma (IFN-gamma), growth factors, eicosanoids and prostaglandins, all of which are important in the effector phase of tissue destruction
Jobin et al., J Immunol 1998 : Induction of inducible nitric-oxide synthase (iNOS), IL-1beta , and IL-8 genes by IL-1beta, TNF-alpha , or PMA was blocked in Ad5 IkappaB infected cells but not in Ad5 LacZ controls as assayed by RT-PCR and ELISA
Ranta et al., Crit Care Med 1999 : IFN-gamma, IL-1beta , or LPS alone did not induce TNF-alpha production, whereas IFN-gamma and IL-1beta in combination were able to induce TNF-alpha production to some extent, and the production could be further increased with LPS
Brennan et al., Lancet 1989 (Arthritis, Rheumatoid...) : In rheumatoid arthritis, TNF alpha may be the main inducer of IL-1 , and anti-TNF alpha agents may be useful in treatment
Itoh et al., Biol Pharm Bull 2007 (Arthritis, Rheumatoid) : We found that a potent androgen, 5alpha-dihydrotestosterone ( DHT ) inhibits IL-1alpha mRNA expression induced by TNFalpha and the DHT effect was inhibited by an androgen receptor antagonist, hydroxyflutamide ( OHF ) ... These results suggest that DHT inhibits the TNFalpha induced IL-1alpha mRNA expression by inhibiting NF-kappaB activation, and contributes to the gender differences of the disease
Rinehart et al., Blood 1994 : CA also decreased IL-1 induced increase in plasma tumor necrosis factor levels at the time point examined
Hoffman , Vox Sang 1991 (Blood Group Incompatibility...) : Exposure to human RBC sensitized with antibodies to D or Fya antigens induced the rapid secretion of TNF , but not IL-1
Chan , Biochem Pharmacol 1995 : The pleiotropic cytokine tumor necrosis factor-alpha (TNF) induces the production of interleukin-1 beta (IL-1) , and, together, they play significant roles in many acute and chronic inflammatory diseases
Fischer et al., J Immunol 1991 : CD3-4-8-IL-2R+ thymocytes only produced small amounts of IL-2 when activated with calcium ionophore + PMA + IL-1, whereas CD3-4-8-IL-2R- thymocytes did not require IL-1 to produce IL-2, IFN-gamma, and TNF-alpha
Zhou et al., Malaria journal 2012 (Malaria, Falciparum) : Unopsonized IE induced secretion of IL-6 ( median= 622 pg/ml [ IQR=1,250-240 ], n=9 ) but no IL-1ß or TNF , whereas PPS opsonized IE induced secretion of IL-1ß ( 18.6 pg/mL [ 34.2-14.4 ] ) and TNF ( 113 pg/ml [ 421-17.0 ] ) and increased IL-6 secretion ( 2,195 pg/ml [ 4,658-1,095 ] )
Buonaguro et al., J Virol 1992 (Inflammation) : As TNF can increase the production of IL-1 and IL-6 and these inflammatory cytokines all enhance HIV-1 gene expression and affect the immune, vascular, and central nervous systems, the activation of TNF by Tat may be part of a complex pathway in which HIV-1 uses viral products and host factors to increase its own expression and infectivity and to induce disease
Amos et al., Rheumatology (Oxford) 2006 (Osteoarthritis) : The spontaneous production of macrophage produced pro-inflammatory cytokines varied : TNFalpha was modestly inhibited by IkappaBalpha overexpression, but interleukin (IL)-1 was unaffected
Gutteberg et al., APMIS 1990 : Using an in vitro model, we report the early effect of Escherichia coli ( E. coli ), Streptococcus agalactiea ( group B streptococci, GBS ) and recombinant tumor necrosis factor alpha (TNF) on the release of lactoferrin (LF) and the generation of interleukin-1 (IL-1) due to E. coli, using heparinized whole blood from healthy full-term newborns
Danis et al., Clin Exp Immunol 1990 : IL-1 production in response to LPS could be augmented by crude lymphokine, IFN-gamma, or tumour necrosis factor (TNF) alpha ... TNF-alpha preferentially augmented the production of cell associated IL-1 in LPS stimulated cultures ... TNF-alpha induced a significant amount of IL-1 ( mainly cell associated ) directly but could also induce IL-1 secretion when combined with IL-2 or IFN-gamma, or when in the presence of serum
Winzen et al., J Immunol 1993 : In cells of the fibroblastoid line SV-80, rapid down-modulation of TNF binding in response to TNF itself, or to IL-1 , was followed by a gradual recovery of binding, which occurred even in the continuous presence of the cytokines
Marquette et al., Int J Radiat Biol 2003 (Encephalitis) : Six hours after irradiation, IL-1beta levels had increased in the hypothalamus, thalamus and hippocampus, and TNFalpha and IL-6 levels had increased significantly in the hypothalamus
Arias-Diaz et al., Shock 2000 : SP-A inhibited the lipopolysaccharide (LPS) induced TNFalpha response of both interstitial and alveolar human Mphi, as well as the IL-1 response in iMphi
Goldring , Rheumatology (Oxford) 2003 (Arthritis, Rheumatoid...) : TNFalpha stimulates differentiation of osteoclast progenitors into mature osteoclasts and IL-1 acts directly on osteoclasts to increase the bone resorbing capacity of these cells
Melendez et al., J Biol Chem 1996 (Fibrosarcoma) : The induction of IL-1alpha by TNF can also be decreased by growth in 3 % oxygen as compared to growth in 21 % O2 ; in addition, growth in low oxygen lowers the basal level of IL-1alpha protein ... These findings indicate that both Mn-SOD and O2 may regulate the levels of a cellular oxidant involved in both basal and TNF induced IL-1alpha expression, presumably superoxide
Arinaga et al., Int J Immunopharmacol 1994 (Digestive System Neoplasms) : However, the ability of monocytes in PBM to produce TNF-alpha was significantly enhanced 5 days after the drug administration, although IL-1-alpha and IL-1-beta production was not augmented
Villacres et al., J Infect Dis 2012 (HIV Infections...) : Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß) , interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 12 (IL-12), and tumor necrosis factor a (TNF-a) responses to Toll-like receptor (TLR) 3 and TLR4 stimulation
Danis et al., Clin Exp Immunol 1991 : Effects of granulocyte-macrophage colony stimulating factor ( GM-CSF ), IL-2, interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and IL-6 on the production of immunoreactive IL-1 and TNF-alpha by human monocytes ... The effects of GM-CSF, IL-2, IFN-gamma, TNF-alpha and IL-6 on the production of IL-1 ( both secreted and cell associated ) and TNF-alpha by peripheral blood monocytes were studied ... GM-CSF, IL-2 and TNF-alpha directly induced the production of cell associated IL-1 but little or no IL-1 or TNF-alpha secretion
Grimble et al., Z Ernahrungswiss 1998 (Arthritis, Rheumatoid...) : We have found that the total C18 : 2 and 20 : 4 diacyl species of phosphatidylethanolamine in peritoneal macrophages relates in a positive curvilinear fashion with dietary linoleic acid intake ; that TNF induced IL1 and IL6 production relate in a positive curvilinear fashion to linoleic acid intake ; that leukotriene B4 production relates positively with dietary linoleic acid intake over a range of moderate intakes and is suppressed at high intakes, while PGE2 production is enhanced
Pereira et al., Kidney Int 1994 (Kidney Failure, Chronic) : The IL-1 receptor antagonist (IL-1Ra) binds to IL-1 receptors and blocks the activity of IL-1 , and a soluble form of the p55 TNF receptor ( TNFsRp55 ) binds and neutralizes TNF
Imaizumi et al., Arterioscler Thromb Vasc Biol 2000 : IL-1alpha induced expression and secretion of TNF-alpha protein, but LPS did not induce production of TNF-alpha protein
Fischer et al., Eur J Immunol 1997 (Toxoplasmosis, Animal) : The IL-6 response of parasitized astroglia was up-regulated by external tumor necrosis factor (TNF)-alpha and transforming growth factor (TGF)-beta 1, with only TNF-alpha enhancing simultaneous release of IL-1
Huang et al., Changgeng yi xue za zhi / Changgeng ji nian yi yuan = Chang Gung medical journal / Chang Gung Memorial Hospital 1999 : The spontaneous or IFN-gamma +TNF-alpha +IL-1 beta induced IL-8 release was significantly augmented after the addition of neutrophils
Call et al., Gen Comp Endocrinol 2000 : The release of IL-6 and TNF from the ZG, ZF, ZR, and medulla was increased by PDB, IL-1alpha , IL-1beta, and LPS
Barsness et al., Pediatr Surg Int 2004 (Respiratory Distress Syndrome, Adult) : In conclusion, IL-1beta induced IL-6 and TNFalpha production were greater in pediatric than adult PMs
Skelly et al., PloS one 2013 : Systemic IL-1ß could not induce significant blood TNF-a , but induced CNS TNF-a mRNA, while systemic TNF-a could induce IL-1ß in blood and brain
Faber et al., Nutrition & diabetes 2012 : Gene expression analyses showed that TNF-a and IL-1ß stimulate the adipocyte expression of TNF-a , IL-1ß and IL-6
Brunius et al., Life Sci 1993 : IL-1 alpha , IL-1 beta and TNF alpha , dose-dependently, stimulated PGE2 formation in gingival fibroblasts
Hültner et al., J Immunol 2000 : Here we report that in primary mouse bone marrow derived mast cells activated by ionomycin or IgE/Ag, the proinflammatory mediator IL-1 ( alpha or beta ) up-regulated production of IL-3, IL-5, IL-6, and IL-9 as well as TNF , i.e., cytokines implicated in many inflammatory processes including those associated with allergies and helminthic infections
Zwiech et al., Pol Arch Med Wewn 2005 (Glomerulonephritis, IGA) : Interleukin-1 receptor antagonist ( IL-1ra ) and tumor necrosis factor soluble receptors ( sTNFR ) type I and II reducing the activity of IL-1 and TNFalpha may inhibit inflammatory reactions
Ho et al., Biochem Pharmacol 2005 : Furthermore, we showed that t-RA could reduce IL-1 induced TNF-alpha production in chondrocytes
Ghosh et al., Glia 2012 (Central Nervous System Diseases...) : Accompanying TNF-a induced cyclic AMP reductions, but not IL-1ß , was increased cyclic AMP-PDE activity
Wesselius et al., J Lab Clin Med 1995 (Pulmonary Edema) : TNF activity in BAL fluid was markedly increased by LPS, TNF, and IL-1 + TNF, with a smaller increase induced by IL-1
Vogels et al., Infect Immun 1994 (Gram-Negative Bacterial Infections...) : Since IL-1 induces production of tumor necrosis factor alpha (TNF-alpha) , granulocyte-macrophage colony stimulating factor ( GM-CSF ), platelet activating factor (PAF), and arachidonic acid metabolites, we investigated the potential role of these substances in IL-1 induced protection
Kaushansky et al., J Immunol 1988 : Tumor necrosis factor-alpha and tumor necrosis factor-beta ( lymphotoxin ) stimulate the production of granulocyte-macrophage colony stimulating factor, macrophage colony stimulating factor, and IL-1 in vivo ... Using Northern blot analysis to detect tissue levels of hematopoietic growth factor-specific transcripts, and specific biologic and immunologic assays to detect the presence of colony stimulating factors in the serum, we have found that TNF-alpha and TNF-beta induce the transcription and production of granulocyte-macrophage-CSF, macrophage-CSF, and IL-1
Santos et al., Shock 1999 (Bacteremia) : Plasma LTB, and TNF were reduced by IL-1 blockade, compared with septic controls ... TNF release is stimulated in the presence of unopposed IL-1 and may be synergistic with it in the adverse hemodynamic effects of endogenous IL-1
Jevnikar et al., Kidney Int 1991 : We report that transformed TEC express low levels of TNF alpha in response to LPS or IL-1 alpha as a secreted product and as a cytotoxic membrane associated molecule displayed on the cell surface
Kim et al., J Ethnopharmacol 1999 : We therefore examined whether IL-1 mediated inhibition of TNF-alpha production from primary astrocytes by CmT. Treatment of CmT ( 1 and 10 microg/ml ) to astrocytes stimulated with both LPS and SP decreased IL-1 production significantly
Muthusamy et al., Oxidative medicine and cellular longevity 2011 (Inflammation...) : Effect of novel marine nutraceuticals on IL-1a mediated TNF-a release from UVB irradiated human melanocyte derived cells
Judd et al., Am J Physiol 1995 : ZG cells released IL-6 and TNF , and this release was stimulated by lipopolysaccharide, interleukin-1 alpha , interleukin-1 beta, a protein kinase C activator, and a calcium ionophore without affecting intracellular adenosine 3 ', 5'-cyclic monophosphate ( cAMP ) content
Niedbala et al., Biomed Biochim Acta 1991 : Therefore, it is unlikely that TNF acts through the induction of IL-1 secretion
Bahl et al., Agents Actions 1994 : Human recombinant tumour necrosis factor-alpha (TNF-alpha) and the calcium ionophores A23187 and ionomycin induced a concentration dependent increase of cell associated IL-1 but failed to cause release of IL-1 at concentrations producing maximal stimulation of cell associated IL-1
Abe et al., Nihon Rinsho Meneki Gakkai Kaishi 2013 : We also found that high-dose IgG specifically and completely inhibited accelerated expression of KD-related cytokines such as G-CSF, IL-6 and IL-1ß by HCAEC in response to TNF-a
van der Meer et al., J Endocrinol Invest 1996 : This study provides no arguments for the involvement of endogenous IL-1 in TNF alpha- or IL-6 induced activation of the HPA axis
Fioravanzo et al., Curr Alzheimer Res 2010 (Alzheimer Disease...) : Moreover RHAs secrete IL-1ß and, only after the Aß1-42 treatment, TNF-a promotes RCEC release of IL-1ß , IL-6 and TNF-a ... The removal of IL-1ß , TNF-a and/or VEGF, a strong angiogenic inducer highly over expressed in AD brains, by means of specific antibody coated beads in RHA media affects RCEC release of IL-1ß, IL-6 and TNF-a
Lange et al., Skin Pharmacol Appl Skin Physiol 2000 (Dermatitis) : Inflammation was induced by TNFalpha , resulting in an increased interleukin 1alpha (Il-1alpha) synthesis
Hua et al., J Neuroimmunol 2002 : Treatment with SB203580, a specific inhibitor of p38 mitogen activated protein kinases ( MAPK ), potently inhibited IL-1 mediated induction of iNOS and TNFalpha in cultures of human fetal astrocytes
Wankowicz et al., J Leukoc Biol 1988 (Inflammation) : In comparison, TNF alpha even at 100,000 U, induced only mild PMNL accumulations, although IL-1 alpha and TNF alpha were similarly active in inducing PMNL adherence to human umbilical vein endothelium
Chuluyan et al., Life Sci 1998 (Neuroblastoma) : VCAM-1 expression on SK-N-SH was induced by IL-1alpha and TNF alpha and IFN gamma synergized with TNF alpha in this respect on both NB cell lines
Yao et al., World J Gastroenterol 2004 (Hepatitis) : Time course studies revealed an increased production of TNF-alpha preceding the IL-1 production, suggesting that increased TNF-alpha levels could be involved in the increase of IL-1 production
Phillips et al., Thromb Res 1996 (Carcinoma, Hepatocellular...) : TNF-alpha suppresses IL-1 alpha and IL-6 upregulation of C4b binding protein in HepG-2 hepatoma cells
Sass et al., Inflamm Res 2002 (Drug-Induced Liver Injury) : TNF-pretreatment did not affect TNFR-1 expression in the liver and resulted in time dependent up-regulation of iNOS, IL-1beta and HO-1
Johnson et al., Exp Hematol 1991 : These results demonstrate that IL-1 alpha induced suppression of CFU-E is mediated through induction of TNF-alpha, IL-1 alpha stimulation of CFU-M was independent of TNF-alpha , and the in vivo hematopoietic effects of these cytokines do not strictly require intact T- and NK-cell function for activity
Laird et al., Hum Reprod 1996 : Interleukin 1 (IL-1) ( 1.4-140 pmol/l ) caused a dose dependent increase in TNF-alpha production by cells prepared from both proliferative and secretory endometrium
Kelley et al., Invest Ophthalmol Vis Sci 2007 : TNF-alpha significantly increased IL-1 RI levels
Hedrich et al., Rheumatol Int 2012 (Cryopyrin-Associated Periodic Syndromes) : In response to mild hypothermia, an enhanced IL-1ß expression by patient monocytes resulted in increased IL-6 and TNF-a secretion, as compared to control cells
Granowitz et al., J Immunol 1993 : This suppression was not specific for endotoxin ; IL-1 beta induced IL-1 alpha and TNF-alpha were reduced by 84 % ( p = 0.01 ) and 68 % ( p < 0.001 ), respectively
Turner et al., Cardiovasc Res 2007 (Coronary Disease) : Mechanism of TNFalpha induced IL-1alpha , IL-1beta and IL-6 expression in human cardiac fibroblasts : effects of statins and thiazolidinediones ... TNFalpha ( 0.1-10 ng/ml ) stimulated IL-6, IL-1alpha and IL-1beta mRNA expression in cardiac fibroblasts in a concentration dependent manner ... In contrast, TNFalpha induced IL-1alpha expression required both TNFRI and TNFRII subtypes and p38 MAPK and PI3K/Akt pathways, but was negatively regulated by the NF-kappaB pathway ... Neither statins ( simvastatin, fluvastatin ) nor TZDs ( ciglitazone, rosiglitazone, troglitazone ) had inhibitory effects on TNFalpha induced IL-6 secretion or IL-1alpha/beta mRNA expression ; indeed, cytokine expression was increased in response to TZDs ... Our data provide important insights into the regulation of pro-inflammatory cytokine expression in human cardiac fibroblasts and suggest that the myocardial anti-inflammatory effects of statins and TZDs are not due to inhibition of TNFalpha induced IL-1 or IL-6 expression by cardiac fibroblasts
Woolley et al., Immunology 1995 (Inflammation) : Immunocytochemistry of frozen sections from sponges showed that E-selectin expression was up-regulated markedly by TNF-alpha and PHA at 5 hr, only moderately by IL-1 alpha at 5 hr, and not at all by PMA at 5 hr
Hase et al., Proc Natl Acad Sci U S A 2006 : In parallel studies, we find that TSH directly inhibits TNFalpha production, reduces the number of TNFalpha producing osteoclast precursors, and attenuates the induction of TNFalpha expression by IL-1 , TNFalpha, and receptor activator of NF-kappaB ligand
Maeda et al., Cancer Immunol Immunother 1993 : To determine whether TNF played a role in the stimulation of IL-1 production by L-MTP-PE, normal human monocytes were incubated with L-MTP-PE or medium in the presence or absence of anti-TNF or anti IL-1 alpha plus anti IL-1 beta ... These data indicate that the up-regulation of IL-1 seen in monocytes following L-MTP-PE exposure may be due in part to the production of TNF
Koenders et al., Am J Pathol 2005 (Arthritis, Experimental...) : Interestingly, blocking IL-17 suppressed synovial expression of both IL-1beta and tumor necrosis factor-alpha, whereas blocking IL-1 did not affect tumor necrosis factor-alpha levels
Tabibzadeh et al., J Clin Endocrinol Metab 1994 : Expression of E-selectin on endothelial cells was induced only by IL-1 alpha , not by IFN gamma or TNF alpha
Erger et al., Int Arch Allergy Immunol 1998 : Although IL-1 did not support GM-CSF induced eosinophil transendothelial migration, IL-1 and TNF-alpha induced equivalent expression of ICAM-1 on HUVEC
Hsu et al., J Biol Chem 2001 (MAP Kinase Signaling System) : In brief, in murine macrophages J774A.1, OxLDL and fucoidan up-regulate TNF production ; additionally, fucoidan but not OxLDL induces IL-1 secretion, prointerleukin 1 ( proIL-1, precursor of IL-1 ) protein, and proIL-1 message
Tappia et al., Mol Cell Biochem 1996 : The relationship between altered membrane composition, eicosanoids and TNF induced IL1 and IL6 production in macrophages of rats fed fats of different unsaturated fatty acid composition
Passeri et al., Bone Miner 1994 : These findings suggest that TNF, but not IL-1 , is produced by murine bone cells and that endogenous TNF induces the IL-6 production, osteoclast formation, and bone resorption exhibited by these cultures under basal conditions
Filonzi et al., Atherosclerosis 1993 : Interleukin-1 (IL-1) and, to a lesser extent, tumor necrosis factor alpha (TNF alpha) stimulated GM-CSF formation within 3 h ; mRNA levels also increased particularly in the presence of the protein synthesis inhibitor, cycloheximide
Churchill et al., Brain Res 2006 : Relative to saline administration, IL1beta increased IL1beta, TNFalpha and IL6 mRNAs in the nucleus tractus solitarius (NTS), hypothalamus, hippocampus and somatosensory cortex ( SSctx ), but did not induce any changes in IL10 ... In the amygdala, IL1beta enhanced IL6 mRNA and TNFalpha increased IL1beta mRNAs ... In the insular cortex, IL1beta enhanced IL6 mRNA and TNFalpha increased IL1beta mRNA
Nakajima et al., J Immunol 2010 (Dermatitis, Contact...) : Furthermore, we showed that IL-1 directly enhanced TNF and chemokine expression in keratinocytes
Rickard et al., Osteoporos Int 1992 : The results showed that 17 beta-oestradiol ( 10 ( -10 ) and 10 ( -8 ) M ) inhibited IL-1 stimulated TNF release in a dose dependent manner in 7 out of 9 patients
Maret et al., Cytokine 2004 : We compared the production of IL-1alpha, IL-1beta , and of IL-1Ra isoforms by cultured human dermal ( HDF ) and synovial fibroblasts ( HSF ) in response to IL-1alpha, TNF-alpha , or direct T cell membrane contact
Wu et al., Gynecol Oncol 1994 (Ovarian Neoplasms) : Recombinant interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) can induce endogenous TNF-alpha mRNA expression and stimulate proliferation of epithelial ovarian cancer cells ... Antisense transfected cells showed a 4.5- to 26-fold reduction in IL-1 induced TNF-alpha secretion
Millward-Sadler et al., Arthritis Res Ther 2009 (Intervertebral Disc Degeneration) : Quantitative real-time polymerase chain reaction was used to assess the effect of TNF-alpha or IL-beta stimulation on the expression of matrix metalloproteinase (MMP)-3, -9 and -13, TNF-alpha, TNF receptor 1 (TNF-R1), TNF receptor 2 (TNF-R2), IL-1alpha , IL-1beta, IL-1 receptor 1 (IL-1R1) and IL-1 receptor antagonist (IL-1Ra)
Holtmann et al., J Immunol 1987 : IL-1 and PMA together had an additive effect on TNF binding
Hölscher et al., Infect Immun 1998 (Chagas Disease...) : Despite this defect, both mutant mouse strains had a rather normal proinflammatory cytokine response ( interleukin-12 [IL-12 ], IFN-gamma, IL-6 ), with the exception of an impaired tumor necrosis factor alpha and IL-1alpha response in IFN-gammaR ( -/- ) mice, demonstrating that only the latter two cytokines are dependent on IFN-gamma activation
Gutteberg et al., APMIS 1991 (Sepsis) : Using a whole blood in vitro model, we have investigated the effect of Escherichia coli ( E. coli ), Streptococcus agalactiae ( group B streptococci, GBS ) and tumor necrosis factor alpha (TNF) on the generation of lactoferrin (LF), interleukin-1 beta (IL-1) and tissue thromboplastin (TPL) in healthy newborns at term and their mothers ... E. coli, GBS and TNF had no significant effect on the production of IL-1
Pelloux et al., Parasitol Res 1996 (Astrocytoma) : TNF-alpha induced a significant decrease in the total number of tachyzoites, whereas IL-1-alpha surprisingly induced an increase in the number of tachyzoites
Knöfler et al., FEBS Lett 1997 (Choriocarcinoma...) : We show for the first time that interleukin-1 (IL-1) , a regulator of trophoblast development, induces TNF-alpha expression in proliferating cytotrophoblastic cells and purified term trophoblasts ... Besides demonstration of this novel mechanism of IL-1 stimulated TNF-alpha expression, our data indicate an important role of IL-1 in TNF-alpha production of cytotrophoblastic cells