Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Tanihara et al., Biochem Biophys Res Commun 1992 : However, PCR by using cDNA prepared from interleukin-1 beta (IL-1 beta) stimulated RPE cells revealed expression of the gene, suggesting in vivo production of TNF-alpha from RPE cells in response to IL-1 beta
Fernandez et al., J Leukoc Biol 1996 : Thus, GM-CSF increases IL-1 beta message accumulation in PMN at both the transcriptional and post-transcriptional levels by mechanisms that are different from TNF induction of IL-1 beta gene expression
Turner et al., Placenta 2002 : The inhibitors SB203580, PD98059, SN50, cycloheximide and D-ribofuranosylbenzimidazole each reduced the basal and TNFalpha stimulated secretion of IL-1beta and also reduced IL-6 secretion with the exception of SN50
Vecchiarelli et al., Infect Immun 1995 : The secretory response of these cytokines follows different pathways of macrophage activation ; in fact, complete inhibition of TNF-alpha does not affect IL-1 beta production and vice versa
Mølvig et al., Scand J Immunol 1990 (Diabetes Mellitus, Type 1) : We report that IL-1 beta and TNF-alpha responses of Mo from TNF-beta 10.5 kb homozygous healthy individuals were significantly higher than for TNF-beta 5.5/10.5 kb heterozygotes ... IL-1 beta and TNF-alpha responses of Mo from males ( 18-35 years ) with newly diagnosed ( n = 10 ) and long standing IDDM ( n = 10 ) and from age- and HLA-DR matched healthy males ( n = 10 ) were studied
Qin et al., Glia 2007 (Disease Models, Animal...) : Systemic TNFalpha and LPS administration activated microglia and increased expression of brain pro-inflammatory factors ( i.e., TNFalpha, MCP-1, IL-1beta , and NF-kappaB p65 ) in wild-type mice, but not in TNF R1/R2 ( -/- ) mice
Someya et al., Immunopharmacol Immunotoxicol 1996 (Endotoxemia...) : Meanwhile, DY-9973 did not inhibit IL-1 beta induced TNF-alpha production in U937 cells ... TNF-alpha production induced by LPS or IL-1 beta was similarly inhibited by treatment with herbimycin, a tyrosine kinase inhibitor
Jones et al., J Leukoc Biol 2001 (MAP Kinase Signaling System) : Unexpectedly, these TLR agonists induced tumor necrosis factor alpha secretion, whereas only LPS was capable of inducing interleukin-1beta and nitric oxide secretion
Lin et al., Mol Cell Endocrinol 1994 : IL-1beta alone in concentrations of 0.1, 1 and 10 ng/ml inhibited testosterone formation by 45 %, 62 % and 91 %, respectively, in the presence of TNF-alpha ( 10 ng/ml ), IL-1beta in a concentration as low as 0.1 ng/ml completely blocked hCG induced testosterone formation
Zhang et al., Am J Respir Cell Mol Biol 2007 (Asthma...) : Remicade, an anti-TNF-alpha antibody, markedly suppressed IL-1beta induced up-regulation of bradykinin B ( 1 ) and B ( 2 ) receptors, suggesting that TNF-alpha was involved in the up-regulation, which is further supported by the fact that IL-1beta enhanced TNF-alpha mRNA expression in the tracheae
Meusch et al., Arthritis Rheum 2009 (Arthritis, Rheumatoid) : Instead, transmembrane TNF reverse signaling inhibited the constitutive NF-kappaB activation in RA monocytes, suppressed IL-1beta secretion, and normalized spontaneous in vitro apoptosis
Mpiga et al., Scand J Immunol 2006 (Chlamydia Infections) : When infected HeLa cells were co-cultured with THP-1 cells, IL-6 and IL-8 secretion was sustained, IL-1beta expression followed a bell shaped curve and IL-10, IL-12p70 and TNF-alpha synthesis was down regulated
Li et al., Neuroscience 2009 (Disease Models, Animal...) : Interestingly, treatment with EP2 antagonist AH-6809 resulted in suppression of hypoxia induced EP2, IL-1beta and iNOS mRNA and protein expression, TNF-alpha protein expression and intracellular cAMP level in BV-2 cells
Weeks et al., DNA Cell Biol 1997 : This increase in CDS activity also leads to increased secretion of tumor necrosis factor-alpha and interleukin-6 from endothelial ECV304 cells upon stimulation with interleukin-1beta , suggesting that CDS overexpression may amplify cellular signaling responses from cytokines
Granowitz et al., J Immunol 1993 : This suppression was not specific for endotoxin ; IL-1 beta induced IL-1 alpha and TNF-alpha were reduced by 84 % ( p = 0.01 ) and 68 % ( p < 0.001 ), respectively
Kjellerup et al., Exp Dermatol 2008 (MAP Kinase Signaling System) : Furthermore, we show that the Mnk inhibitor CGP57380 is capable of inhibiting the phosphorylation of eIF4E in keratinocytes, and that the abolishment of eIF4E phosphorylation dramatically decreases the anisomycin induced protein release of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), IL-1beta and IL-6 as well as the IL-1beta induced protein release of TNF-alpha
Wetzler et al., Cancer Res 1990 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : However, granulocyte colony stimulating factor expression could be induced by recombinant human IL-1 beta ; while IL-6 could be induced by both IL-1 beta and tumor necrosis factor-alpha
Han et al., J Agric Food Chem 2007 : Compounds 1 and 2 inhibited tumor necrosis factor (TNF)-alpha induced up-regulation of vascular cell adhesion molecule-1 ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ), which also prevented adhesion of monocytes to HUVECs, and slightly suppressed the mRNA expression of the inflammation associated gene interleukin-1beta (IL-1beta)
Gustavsson et al., Retina 2008 (Diabetes Mellitus, Experimental...) : Ischemia induced increased expressions of TNF-alpha ( P < or= 0.012 ), IL-1beta ( P < or= 0.017 ), ICAM-1 ( P < or= 0.025 ), and IL-6 ( P = 0.012 ), and diabetes induced increased expression of caspase-1 ( P < or= 0.046 ), VCAM-1 ( P < or= 0.027 ), ICAM-1 ( P < or= 0.016 ), IL-1beta ( P = 0.016 ), and IL-6 ( P = 0.041 )
Beissert et al., J Invest Dermatol 1998 (Hypersensitivity, Delayed...) : Therefore, the ability of IL-1alpha or IL-1beta to induce epidermal cell production of TNF alpha was assessed
Tanida et al., Cytokine 2009 (Arthritis, Rheumatoid) : IL-1beta vigorously induced the production of CCL20 from FLSs of human RA and the production of CCL20 induced by TNF-alpha was partially attributed to a trace amount of IL-1beta induced by TNF-alpha
Panopoulos et al., J Biol Chem 2005 (Inflammation) : Iron mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha induced but not interleukin-1beta induced IkappaB kinase complex/nuclear factor-kappaB activation
Elias et al., Chest 1990 (Pneumonia...) : To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the effects of recombinant interleukin-1, tumor necrosis factor , and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production, interleukin-1-beta production, and interleukin-6 production
Turtinen et al., Microb Pathog 1989 : In both CMV infected and uninfected cultures, significant amounts of IL-1 beta protein were not detected until 24 h post induction, while maximum amounts of TNF were detected in culture supernatants by 3 h post induction, suggesting that TNF may play a role in IL-1 beta induction
Seitz et al., Br J Rheumatol 1995 (Arthritis, Rheumatoid) : In addition, clinical improvement was associated with decreased synthesis of IL-1 beta, TNF-alpha and IL-8 induced by bacterial lipopolysaccharide, IL-1 alpha and IL-1 beta in PBMC in vitro
Bianchi et al., Neurobiol Aging 2010 (Encephalitis...) : We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via RAGE dependent activation of JNK ; ( 2 ) S100B upregulates IL-1beta and TNF-alpha expression in microglia via RAGE engagement ; and ( 3 ) S100B/RAGE induced upregulation of COX-2, IL-1beta and TNF-alpha expression requires the concurrent activation of NF-kappaB and AP-1
Danis et al., Clin Exp Immunol 1995 : TNF-alpha also up-regulated production of IL-1 alpha, IL-1 beta , IL-1Ra and IL-6 by monocytes, but the variability in the results of cells cultured from the same individuals on different occasions was greater
Huang et al., Head Neck 2010 (Carcinoma...) : LMP1 mediated IL-1alpha and IL-1beta production could be enhanced by tumor necrosis factor alpha (TNF-alpha) , determined by enzyme linked immunosorbent assay ( ELISA )
Peltier et al., Am J Reprod Immunol 2008 (Premature Birth) : P4 enhanced the production of IL-1beta and IL-8, but inhibited TNF-alpha production by monocytes stimulated with either organism
Le et al., J Immunol 1987 : Induction with TNF resulted in the appearance of IL 1-alpha mRNA and a very significant increase in IL 1-beta mRNA, indicating that TNF induces the synthesis of both IL 1-alpha and IL 1-beta in FS-4 cells
Rambukkana et al., Lab Invest 1996 : After 24 hours, contact allergens not only increased the expression of IL-1 beta but also induced the expression of IL-1 alpha, TNF-alpha , GM-CSF, and IL-6 proteins mainly by suprabasal keratinocytes
Matsukawa et al., Lab Invest 1997 (Arthritis, Experimental...) : Maximum levels of TNF alpha and IL-8 were detected at 2 hours after LPS-injection, whereas IL-1 beta and IL-1 receptor antagonist (IL-1Ra) were detected at 6 and 9 hours, respectively ... These results provide new evidence that IL-8 as well as TNF alpha are the most proximal cytokines and induce subsequent production of IL-1 beta and IL-1Ra
Antras-Ferry et al., FEBS Lett 1997 : TNF-alpha rapidly induced Mn-SOD gene expression while IL-1beta was a strong but slow inducer of this gene
Arima et al., Am J Respir Cell Mol Biol 1999 (Asthma...) : BEAS-2B constitutively expressed IL-16 messenger RNA ( mRNA ) and protein ; IL-16 expression was significantly upregulated in a concentration dependent manner within 24 h by stimulation with histamine, IL-1beta , or tumor necrosis factor (TNF)-alpha whereas interferon-gamma did not significantly increase IL-16
Arrighi et al., J Immunol 2001 (Dermatitis, Allergic Contact) : Likewise, SB203580 partially prevented the up-regulation of IL-1alpha, IL-1beta , IL-lRa, and TNF-alpha mRNA upon stimulation with LPS and TNF-alpha , as well as the release of bioactive TNF-alpha induced by LPS
Judd et al., Am J Physiol 1995 : ZG cells released IL-6 and TNF , and this release was stimulated by lipopolysaccharide, interleukin-1 alpha, interleukin-1 beta , a protein kinase C activator, and a calcium ionophore without affecting intracellular adenosine 3 ', 5'-cyclic monophosphate ( cAMP ) content
Baur et al., J Endocrinol 2000 : In reaggregate cultures of rat anterior pituitaries IL-1 beta stimulated D1 and D2 dose-dependently and D2 activity was increased by TNF alpha
Ortiz-Arduan et al., Am J Physiol 1996 (Endotoxemia) : Lipopolysaccharides (LPS), interleukin-1 beta , interferon-gamma (IFN-gamma), and TNF-alpha increase the levels of Fas mRNA in cultured mesangial and tubular cells
Enríquez-de-Salamanca et al., Cytokine 2008 (Conjunctivitis, Allergic...) : After 48 h, TNF-alpha also induced a significant increase in IL-1beta , IL-3, and IP-10 secretion
Kato et al., Glycoconj J 2010 : Engagement of SIGNR1 on PEMs with an anti-SIGNR1-specific rat IgM antibody, ERTR9, induced production of IL-12 and tumor necrosis factor (TNF)-alpha from PEMs, while secretion of IL-6 and IL-1beta was not detected with the same treatment
Zhang et al., J Clin Endocrinol Metab 2001 : Dexamethasone inhibits tumor necrosis factor-alpha induced apoptosis and interleukin-1 beta release in human subcutaneous adipocytes and preadipocytes ... TNF alpha increased the messenger ribonucleic acid levels of ICE, TNF alpha, IL-1 beta , bcl-2, and NF kappa B in preadipocytes and adipocytes ( P < 0.01 ) ... Dex inhibited TNFalpha induced messenger ribonucleic acid expression of ICE, TNF alpha, and IL-1 beta ( P < 0.01 ), but not that of bcl-2 and NF kappa B ... TNF alpha stimulated IL-1 beta release from preadipocytes and adipocytes up to 20-fold, but the effect was abrogated by Dex ... In obesity, glucocorticoids may reduce TNF alpha actions in adipose tissue by inhibiting TNF alpha induced apoptosis, IL-1 beta release, and TNF alpha expression
Bauer et al., J Cell Biochem 2007 (Carcinoma, Hepatocellular...) : In hepatocytes or human hepatoma cells TNFalpha is expressed at extremely low levels but TNFalpha biosynthesis can be induced by interleukin (IL)-1beta or 12-O-tetradecanoylphorbol-13-acetate ( TPA ) ... Here, we show that IL-1beta and TPA stimulated TNFalpha gene transcription in hepatoma cells mediated by a composite TPA-responsive element/cAMP response element ... Both IL-1beta and TPA triggered phosphorylation and activation of the basic region leucine zipper transcription factors c-Jun and ATF2 and expression of dominant negative mutants of c-Jun and ATF2 reduced TNFalpha promoter activity and secretion of TNFalpha
Ahn et al., J Neurotrauma 2004 (Brain Injuries) : IL-1alpha and IL-1beta mRNA expression increased significantly ( p < 0.05 vs. sham-injury ) after severe TBI and IL-6 and TNFa mRNA expression increased significant ( p < 0.05 vs. sham-injury ) after both moderate and severe TBI
Moodie et al., FASEB J 2004 : However, H2O2, tumor necrosis factor-alpha (TNF-alpha), and IL-1beta significantly increased NF-kappaB activation and expression of IL-8 compared with control cells
Hou et al., Wei Sheng Yan Jiu 2012 : To investigate the effects of citreoviridin (CIT) on the expression of MCP-1, IL-1beta , IL-6 and IL-8 induced by TNF-alpha in human umbilical vein endothelial cells ( HUVECs )
Grooteman et al., ASAIO J 1995 : Interleukin 1 beta and interleukin 6 could not be detected at all, whereas tumor necrosis factor alpha levels were marginally elevated before and after HD with both membranes
Ferlito et al., J Leukoc Biol 2001 (Leukemia, Monocytic, Acute...) : However, neither TNF-alpha nor IL-1beta induced IRAK degradation or stimulated TNF-alpha or TxB2 production in naive cells
Obara et al., Arterioscler Thromb Vasc Biol 2000 (Arteriosclerosis) : In cells overexpressing IkappaBDeltaN, TNF-alpha dramatically induced apoptosis, whereas IL-1beta had no effect
Long et al., Am J Physiol 1990 (Fever) : These data support the hypotheses that IL-1 beta is responsible for a significant part of LPS fever and that TNF acts as an endogenous antipyretic to limit the magnitude of LPS fever in the rat
Shimada et al., J Immunol 2002 : Furthermore, IL-17, IL-1beta, and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs, and specific MAPK inhibitors ( SB203580, PD98059, and U0216 ) significantly reduced IL-17-, IL-1beta- , or TNF-alpha induced IL-6 secretion, indicating the role of MAPKs in the induction of IL-6
Jones et al., Osteoarthritis Cartilage 2009 (Osteoarthritis, Knee) : Over-expression of miR-9, miR-98 or miR-146 in isolated human chondrocytes reduced interleukin-1 beta (IL-1 beta) induced TNF-alpha production ... Functional analysis of miR-9, miR-98 and miR-146 in primary chondrocytes suggests a role in mediating the IL-1 beta induced production of TNF-alpha
Suzuki et al., Am J Pathol 1989 : IL-1, tumor necrosis factor (TNF) , and LPS not only enhanced the accumulation of c-sis mRNA, but also induced IL-1 beta gene expression
Pedersen et al., Scand J Immunol 2005 (Breast Neoplasms) : The lymph node homing chemokine receptor CCR-7 expression was induced by TNF-alpha + IL-1beta + IL-6 + prostaglandin E2 but was not induced by Poly I:C + TNF-alpha
Ruan et al., Curr Alzheimer Res 2009 (Alzheimer Disease...) : Expression of TNF-alpha was detected at 8 months of age, while IL-1 beta , IL-6 and MCP-1 at 10 months
Baudouin-Legros et al., Am J Physiol Cell Physiol 2005 : TNF-alpha decreases CFTR mRNA in human colon cell lines ( HT-29 ), but not in pulmonary cell lines ( Calu-3 ), and IL-1beta increases it only in Calu-3 cells
Pampfer et al., Cytokine 1999 (Hyperglycemia) : Interleukin 1beta mediates the effect of high D-glucose on the secretion of TNF-alpha by mouse uterine epithelial cells
Aida et al., Life Sci 2006 (Inflammation) : In the present study, we examined the effect of IL-1beta on the expression of IL-1beta, IL-6, IL-8, IL-11, tumor necrosis factor-alpha (TNF-alpha), and their receptors in human chondrocytes ... The expression of IL-1beta, IL-8, and TNF-alpha markedly increased in the presence of IL-1beta after day 14 of culture
Wang et al., Acta Pharmacol Sin 2005 (Hepatitis, Animal) : Furthermore, MT-Se significantly lowered an increase in TNF-alpha and IL-1beta levels in the liver and inhibited the production of TNF- alpha and IL-1beta by peritoneal macrophages
Kim et al., Neurosci Lett 2002 (Alzheimer Disease...) : The production of TNF-alpha and IL-6 was induced by IL-1beta and Abeta [ 25-35 ] and synergistically amplified by the co-stimulation of IL-1beta and Abeta [ 25-35 ]
Ntrivalas et al., Hum Immunol 2007 : When PBMC were cultured with a2NTD, there was a 2.5-fold increase in IL1A and IL1B gene expression and no induction of TNF gene expression
van der Velden et al., Cytokine 1998 (Second Messenger Systems) : IL-1 beta , and to a lesser extent, TNF-alpha and IL-4 increased NEP activity and expression, whereas IFN-gamma decreased NEP
Aman et al., Blood 1994 : Production of granulocyte-macrophage colony stimulating factor ( GM-CSF ), granulocyte-CSF (G-CSF), and interleukin-1 beta (IL-1 beta) in stromal cell layers was induced by incubation with IL-1 alpha, tumor necrosis factor (TNF) , or lipopolysaccharide (LPS)
Pober , Ciba Found Symp 1987 (Inflammation) : TNF and LT induce reciprocal tachyphylaxis for the reinduction of H4/18 binding but do not inhibit induction by IL-1 alpha and IL-1 beta ; similarly, IL-1 alpha and IL-1 beta induce reciprocal tachyphylaxis but do not inhibit TNF or LT
Choi et al., Food Chem Toxicol 2010 (Sarcoma) : This study was conducted to evaluate the efficacy of luteolin in regulating interleukin-1beta (IL-1beta) induced production of MMPs ( MMP-1 and -3 ) and cytokines ( tumor necrosis factor (TNF)-alpha and IL-6 ) in human synovial cell line, SW982
Ou-Yang et al., Yao Xue Xue Bao 2005 (Granuloma...) : Furthermore, ginkgolide B at concentrations of 1 x 10 ( -5 ) to 1 x 10 ( -7 ) mol x L ( -1 ) was shown to significantly inhibit TNF-alpha mRNA expression of U937 cells ; and at concentrations of 1 x 10 ( -5 ) and 1 x 10 ( -6 ) mol x L ( -1 ) could inhibit IL-1beta mRNA expression ... Ginkgolide B was shown to significantly inhibit angiogenesis of the murine chronic granulomatous air pouch model, reduce the IL-1beta and TNF-alpha levels in mice serums, and significantly inhibit IL-1beta and TNF-alpha mRNA expression and protein secretion in supernatants of U937 cell culture
Xu et al., Rheumatology (Oxford) 2007 (Arthritis, Rheumatoid) : The production of IL-1beta , IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate ( PDTC ), a chemical inhibitor of NF-kappaB ... TNF-alpha induced production of IL-1beta , IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha
Catanzaro et al., J Biol Regul Homeost Agents 2012 : In the present study, we examined the effect of a marine bioactive compound containing high-purity caviar derived DNA, collagen elastin and protein extracts from sturgeon ( LD-1227, Caviarlieri, Laboratoires Dom, Switzerland ) on IL-1beta induced activation and production of TNFalpha and MMP-13 in human osteo-arthritis ( OA ) chondrocytes and intracellular signaling factors ... LD-1227 significantly decreased IL-1beta stimulated gene expression and production of TNFalpha , MMP-1, MMP-13 and Col10A1 in human chondrocytes
Hamilton et al., J Leukoc Biol 1993 : There was a significant increase of IL-1 beta mRNA levels ( unstimulated cells ) on days 1 and 7, but TNF-alpha mRNA levels increased significantly on day 1 only
Manni et al., Rheumatol Int 1998 (Arthritis, Experimental) : Out data showed that IL-1 beta, but not TNF-alpha , induces an increase in NGF levels, while concomitant injection of both cytokines enhances the effect of IL-1 beta on NGF presence
Yin et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007 : The combination of TBP and TRBP was able to obviously inhibit both respiratory burst of monocytes induced by TNF-alpha and IFN-gamma and transcription level of IL-1beta and IL-8 mRNA induced by TNF-alpha
Powell et al., J Am Soc Nephrol 1991 (Fever...) : We conclude that : ( 1 ) plasma IL-1 beta and TNF-alpha are not chronically elevated in chronic renal failure, continuous ambulatory peritoneal dialysis, or HD patients ; ( 2 ) HD with new Cuprophan or cellulose triacetate membranes and high concentrations of dialysate endotoxin and bacteria does not cause elevation of circulating IL-1 beta or TNF-alpha ; and ( 3 ) pyrogenic reactions might be mediated by TNF-alpha
Marucha et al., J Immunol 1990 (Inflammation) : In the present study, we demonstrate that human peripheral blood PMN produce IL-1 beta in response to IL-1 alpha, IL-1 beta, and TNF-alpha
Downs et al., Int J Immunopharmacol 1995 (Pulmonary Edema) : Associated with these improvements in organ dysfunction and survival was a modest decrease in LPS stimulated interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) secretion and a marked ( > 90 % ) inhibition of TNF secretion by MDL 101,002
De Bandt et al., Metabolism 1994 : These results indicate that ( 1 ) in the conditions of the study, IL-1 beta has no direct effect on hepatic amino acid exchanges and utilization ; ( 2 ) TNF alpha which exerted an inhibitory effect on these parameters, could be involved in the reduced amino acid exchanges during the end stage of sepsis ; ( 3 ) the TNF alpha induced increase in glucose uptake could be related to an inhibition of gluconeogenesis and/or to the activation of glucose utilization by Kupffer cells ; ( 4 ) IL-1 beta and TNF alpha both potentiate the action of glucagon on hepatic amino acid uptake and utilization ; and ( 5 ) complex interactions between Kupffer cells and hepatocytes on the one hand and between cytokines and hormones on the other hand could account for the differences in hepatic metabolism according to the stage of the response to injury
Fan et al., Zhonghua Gan Zang Bing Za Zhi 2003 (Disease Models, Animal...) : The levels of endotoxin in aorta blood of NASH rats increased significantly at the 24th week ( 0.23 EU/L 0.06 EU/L vs 0.15 EU/L 0.03 EU/L, t > 2.179, p < 0.05 ) while the expression of CD(14) increased from the 4th week, and the Kupffer cells expressing lysozyme were activated, then kept increasing activation through the study. In NASH rats, the levels of serum TNF-a increased from the 8th week ( 26.39 pg/ml 24.21 pg/ml vs 9.82 pg/ml 9.29 pg/ml, t > 2.145, p < 0.05 ) and serum IL-1beta increased from the 16th week ( 23.76 pg/ml 21.81 pg/ml vs 6.25 pg/ml 2.98 pg/ml, t > 2.145, p < 0.05 )
Saperstein et al., Mediators Inflamm 2009 (Acute Disease...) : We determined the role of interleukin-1beta (IL-1beta) signaling on tumor necrosis factor alpha induced ( TNF-alpha ) lung neutrophil influx as well as neutrophil chemoattractant macrophage inflammatory protein ( MIP-2 ) and KC and soluble TNF-alpha receptor (TNFR) levels utilizing wildtype ( WT ), TNF receptor double knockout ( TNFR1/TNFR2 KO ), and IL-1beta KO mice after oropharyngeal instillation with TNF-alpha
Honorati et al., Osteoarthritis Cartilage 2002 (Osteoarthritis) : IL-17 and TNF-alpha stimulated IL-1beta release in few subjects
Guillén et al., Rheumatology (Oxford) 2008 (Osteoarthritis) : In addition, CORM-2 inhibited IL-1beta induced TNF-alpha but enhanced IL-1Ra production
Smith et al., Cancer Res 1990 : The induction of TNF and interleukin 1 beta (IL-1 beta) mRNA by exogenous TNF or IL-1 beta , as determined by Northern blot analysis, is time dependent in normal human monocytes isolated by countercurrent elutriation
Floege et al., Kidney Int 1990 : Stimulation with interleukin-1 beta (IL-1 beta) or tumor necrosis factor alpha (TNF alpha) induced up to 18-fold ( IL-1 beta ) or up to fourfold ( TNF alpha ) increases of prostanoid release
Pei et al., Osteoarthritis Cartilage 2006 (Chondrosarcoma) : IL-1beta and TNFalpha strongly induced the expression of MMP-1 and -13 in SW1353 cells and HACs, whereas only TNFalpha was found to induce the expression of these two MMPs in JJ012 cells
Zarantonelli et al., Infect Immun 2006 (Meningococcal Infections...) : Although tumor necrosis factor alpha production was reduced in mice infected with the mutant of devoid LOS, both LOS mutants induced production of other proinflammatory cytokines, such as interleukin-1beta (IL-1beta) , IL-6, and the murine IL-8 homolog KC. Together, these results suggest that meningococcal LOS plays a role during the early infectious and invasive process, and they further confirm that other, nonlipopolysaccharide components of Neisseria meningitidis may significantly contribute to the inflammatory reaction of the host
Chantry et al., J Immunol 1989 : TGF-beta inhibited in a dose dependent manner the induction of IL-1 beta by LPS or TNF but not by PHA and PMA
Bondeson et al., Arthritis Res Ther 2006 (Inflammation...) : Another interesting observation was that in these osteoarthritis cultures of synovial cells, IL-1beta production was independent of TNF-alpha , in contrast to the situation in rheumatoid arthritis
Cowland et al., J Immunol 2003 : IL-1beta induces a > 10-fold up-regulation of NGAL expression in the type II pneumocyte derived cell line A549 cells, whereas TNF-alpha , IL-6, and LPS had no effect
Seitz et al., J Clin Immunol 2003 (MAP Kinase Signaling System) : These data demonstrate that CQ inhibits IL-1 beta release from monocytes by interfering with pretranscriptional signaling and TNF-alpha release by posttranslational events whereas GST downregulates IL-1 beta secretion by interfering with posttranslational IL-1 beta processing
Deschner et al., J Biomech 2007 (Inflammation) : Application of CTS for only 1 or 2h during a 24h incubation with IL-1beta was sufficient to inhibit IL-1beta induced upregulation of TNF-alpha , TNFR2, and iNOS
Takayama et al., J Invest Dermatol 1999 : Both GM-CSF and TNF-alpha induced the migration of human Langerhans cells in vitro, whereas IL-1beta , IL-2, IL-10, IL-12, and IFN-gamma had no effect on Langerhans cell migration
Chowers et al., Gastroenterology 2001 (Enteritis) : Spontaneous and tumor necrosis factor (TNF)-alpha stimulated interleukin (IL)-8 and IL-1 beta secretion and mRNA expression were assessed in HT-29 and Caco-2 intestinal epithelial cell lines in the presence of a panel of heparin and heparan sulfate disaccharides
Mendoza et al., Hepatology 2001 (Liver Neoplasms...) : HSE cells treated with B16M-CM released interleukin (IL)-18 via tumor necrosis factor-alpha (TNF-alpha) dependent IL-1beta in vitro ... Thus, liver infiltrating B16M cells activated their adhesion to HSE through a sequential process involving TNF-alpha dependent IL-1beta , which induced IL-18 to up-regulate VCAM-1 via H ( 2 ) O ( 2 )
Yucel-Lindberg et al., J Periodontal Res 1995 : Addition of BK, in the presence of TNF alpha , for 1 h and 6 h, respectively, synergistically enhanced the TNF alpha induced IL-1 beta production, whereas BK alone did not induce IL-1 production
Rao et al., Mol Cell Biol 2005 (Inflammation) : Overexpression of IRAK1c suppressed NF-kappaB activation and blocked IL-1beta induced IL-6 as well as lipopolysaccharide- and CpG induced tumor necrosis factor alpha production in multiple cellular systems
Song et al., Int Immunopharmacol 2002 : Murine peritoneal macrophages ( PM ) on in vitro treatment with ginsan isolated from Panax ginseng induced mRNA of cytokines such as tumor necrosis factor (TNF)-alpha, interleukin-1 (IL-1)beta, interleukin-6 (IL-6) and interleukin-12 (IL-12) ; TNF-alpha mRNA induction was maximum within 3 h, IL-6 mRNA was gradually induced up to 24 h, and IL-1beta and IL-12 mRNA were highly induced at 24 h. IL-1beta and IL-6 protein levels also increased within 24 h in a dose dependent manner and reached a maximum with 100 microg/ml ginsan
Lisby et al., Exp Dermatol 2002 : The signalling mechanisms involved in both IL-1beta- and TNF-alpha mediated regulation of TNF-alpha are critically dependent upon protein kinase C ( PKC ), as demonstrated by blocking studies using protein kinase inhibitors
Slack et al., Blood 1990 (Cell Transformation, Viral) : Nuclear run-on analyses showed that IL-1 alpha transcriptionally activated the genes for IL-6, GM-CSF, and IL-1 beta, while TNF alpha transcriptionally induced expression of IL-6 and IL-1 beta
Reuss-Borst et al., Br J Haematol 1993 (Myelodysplastic Syndromes...) : During the acute phase of the disease with high remittent fever, painful skin lesions and maximal leucocytosis IL-6 and G-CSF serum levels were extremely high, while TNF-alpha was only slightly elevated and gamma-interferon and IL1-beta were not increased
Onai et al., Cardiovasc Res 2004 (Myocardial Reperfusion Injury) : TNF-alpha induced production of interleukin-1beta and monocyte chemoattractant protein-1 from cultured cardiomyocytes was reduced significantly by IMD-0354
Fernandes et al., Br J Pharmacol 2005 (Edema) : TNF-alpha was necessary for the local PAF induced IL-1beta production
Lu et al., Journal of neuroinflammation 2010 (Inflammation) : Resveratrol inhibited LPS induced expression and release of TNF-alpha , IL-6, MCP-1, and iNOS/NO in both cell types with more potency in microglia, and inhibited LPS induced expression of IL-1beta in microglia but not astrocytes
Manthey et al., Infect Immun 1993 : Herein, we examined the ability of these structures to regulate murine macrophage tumor necrosis factor (TNF) secretion and LPS-inducible gene expression ( tumor necrosis factor alpha [TNF-alpha ], interleukin-1 beta [IL-1 beta ], IP-10, type 2 TNF receptor [TNFR-2 ], D3, and D8 genes )
Tomita et al., Gene Ther 2000 (Glomerulonephritis) : Therefore, we examined the effect of NFkappaB decoy ODN transfection on TNF-alpha induced endogenous interleukin (IL)-1alpha, IL-1beta , IL-6, ICAM-1 and VCAM-1 gene expression as assessed by RT-PCR and Northern blotting
Fan et al., Immunology 2007 : LPS induced production of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), IL-10 and interferon-gamma-inducible protein-10 (IP-10); SA induced TNF-alpha , and IL-1beta production ; and GBS induced TNF-alpha, IL-6, IL-1beta , macrophage inflammatory protein-1alpha ( MIP-1alpha ) and keratinocyte chemoattract ( KC ) production were all decreased ( P < 0.05 ) in Galpha ( i2 ) ( -/- ) or Galpha ( i1/3 ) ( -/- ) mice compared with WT mice
Han et al., J Gerontol A Biol Sci Med Sci 2000 (Orthomyxoviridae Infections...) : Pulmonary interleukin (IL)-6, IL-1beta , and tumor necrosis factor (TNF)-alpha levels increased significantly postinfection
Bethea et al., J Neuroimmunol 1992 (Astrocytoma) : Interleukin-1 beta induction of tumor necrosis factor-alpha gene expression in human astroglioma cells ... In this study, we examined the effect of human recombinant interleukin-1 beta (IL-1 beta) on the expression of TNF-alpha by CH235-MG human malignant glioma cells ... Nuclear run-off analysis demonstrates that IL-1 beta causes transcriptional activation of the TNF-alpha gene, and CHX enhances IL-1 beta induced TNF-alpha transcription ... These results indicate that IL-1 beta , a cytokine present in the central nervous system during some pathological disease states, is a potent inducer of TNF-alpha in human malignant glioma cells
Andersson et al., J Lab Clin Med 2002 : Captopril impaired production of tumor necrosis factor-alpha induced interleukin-1beta in human monocytes is associated with altered intracellular distribution of nuclear factor-kappaB ... Thus captopril reduced TNF-alpha induced IL-1beta and IL-1betamRNA synthesis in monocytes, in vitro, probably through interference with NF-kappaB activation of the IL-1beta gene
Jiang et al., Chin Med Sci J 1997 (Shock, Hemorrhagic) : The results were : 1. expression of TNF alpha, IL-1 beta, IL-6 mRNA in vital organs successively increased after hemorrhagic shock and resuscitation, and TNF alpha expression was the first to appear followed by IL-1 beta
Marucha et al., J Immunol 1991 : We have previously demonstrated that Il-1 and TNF could rapidly, but transiently, induce gene expression of Il-1 beta in human polymorphonuclear leukocytes ( PMN ) at both the protein and mRNA level ... Using nuclear run-on transcription analysis, we found that within 1 h Il-1, TNF , and TNF plus Il-1 induced the transcription of the Il-1 beta gene by 33-, 61-, and 99-fold, respectively ... This abrogation of Il-1 beta mRNA accumulation was not caused by inhibition of induction of Il-1 beta transcription because TNF induction of transcription of Il-1 beta was not affected by simultaneous treatment with cycloheximide ... Thus, we report that Il-1 and TNF regulate IL-1 beta gene expression via both transcriptional and post-transcriptional mechanisms in vitro
Meda et al., Cell Immunol 1994 : Unlike IL-8, the LPS stimulated production of TNF and IL-1 beta, as well as the TNF stimulated production of IL-1 beta , was markedly enhanced by IFN-gamma over the entire incubation period ( up to 18 hr )
Delomenie et al., Exp Cell Res 1993 : Intracellular IL-1 alpha and IL-1 beta levels were markedly enhanced by IL-1 beta and TNF alpha
Walters et al., J Leukoc Biol 1995 : TNF primes polymorphonuclear leukocytes ( PMNs ) for enhanced oxidative and secretory activity and directly induces adhesion and IL-1 beta expression
Knöfler et al., FEBS Lett 1997 (Choriocarcinoma...) : However, treatment with cycloheximide did not prevent IL-1beta stimulated release of TNF-alpha , indicating that the cytokine can regulate TNF-alpha secretion at a posttranslational level, independently of TNF-alpha mRNA induction
Serlin et al., J Cell Biochem 2006 : Our results demonstrate a potent and dramatic increase in osteopontin expression induced by interleukin-1beta (IL-1beta) , whereas tumor necrosis factor-alpha , transforming growth factor-beta, and angiotensin II had minimal effect
Souza et al., J Endocrinol 2008 : Caspase-3 activity was increased by IL-1beta and the pro-inflammatory cytokine combination, and to a lesser extent by TNFalpha
Snegovskikh et al., Reprod Sci 2009 (Chorioamnionitis...) : This effect appears to be mediated at the level of gene transcription because stimulation with IL-1 beta ( but not TNF-alpha ) increased expression of VEGF mRNA as measured by real-time quantitative reverse transcriptase-polymerase chain reaction ( RT-qPCR ) ; a similar increase was seen in neuropilin-1/-2 ( but not Flt1 and KDR2 ) mRNA
Ikeda et al., Hepatology research : the official journal of the Japan Society of Hepatology 2008 : In cultured BEC, TNF-alpha, interleukin (IL)-1beta , IL-6, and interferon-gamma induced the expression of CDX2 mRNA, though only TNF-alpha additionally induced the expression of MUC2 mRNA
Wördemann et al., J Interferon Cytokine Res 1998 (Carcinoma, Hepatocellular...) : We studied effects of diverse drugs on the formation of immunoreactive TNF-alpha in the human hepatoma cell lines HepG2 and Hep3B, in which TNF-alpha production was induced by treatment ( 3 h incubation periods ) with interleukin-1beta ( IL-1beta, 300 pg/ml ) or phorbol myristate acetate ( PMA, 100 nmol/l ) ... Pentoxifylline ( 1 mg/ml ) did not influence PMA induced TNF-alpha production, but it augmented IL-1beta induced TNF-alpha production
Mustafa et al., Eur J Oral Sci 1998 : When gingival fibroblasts were treated simultaneously with triclosan ( 0.25, 0.5 microg/ml ) and TNFalpha ( 10 ng/ml ), the stimulatory effect of TNFalpha on IL-1beta production was reduced by the agent
Kim et al., Phytomedicine 2008 (Arthritis, Experimental) : As compared with rats treated with saline, BVA i.p. injected at doses of more than 20 microl/100g mouse once a day for 14 days inhibited the ability of inguinal lymph node cells to produce T cell cytokines interleukin-1beta , -2, -6, tumor necrosis factor-alpha and interferon-gamma when the cells were obtained from rats 24 days after immunization and cultured in vitro with CII
Jensen et al., J Endocrinol 2005 : Gel retardation experiments showed that hGH affects neither IFN-gamma+TNF-alpha induced STAT1 DNA binding nor IL-1beta and IFN-gamma+TNF-alpha induced NFkappaB DNA binding
Hakonarson et al., Am J Respir Cell Mol Biol 2001 (Asthma) : These pro-asthmatic- like changes in ASM responsiveness were associated with IL-1beta/ TNF-alpha induced mRNA expression of a host of proinflammatory genes that regulate transcription, cytokines and chemokines, cellular adhesion molecules, and various signal transduction molecules that regulate ASM responsiveness
Bristulf et al., Neurosci Lett 1995 : Furthermore, IL-1 beta also induced increases in TNF alpha and c-fos mRNAs
Konturek et al., Dig Dis Sci 2008 (Adenocarcinoma...) : Ghrelin caused a decrease in TNFalpha induced COX-2 and IL-1beta expression in OE-19 cells
Klegeris et al., Neurobiol Aging 2005 (Neuroblastoma) : Such toxicity was induced by the following combinations : interferon-gamma (IFN-gamma) with tumor necrosis factor-alpha (TNF-alpha) ; IFN-gamma with interleukin (IL) 1alpha or IL-1beta in the presence of TNF-alpha ; and IL-6 with TNF-alpha
Cumberbatch et al., Clin Exp Immunol 2003 : IL-1beta induced Langerhans ' cell migration and TNF-alpha production in human skin : regulation by lactoferrin
Majewska et al., Med Sci Monit 2012 (Uremia) : IL-1beta markedly diminished and TNF-alpha significantly increased cC concentration in culture supernatants
Schroeder et al., Hepatology 1998 : Parallel experiments examining IL-1beta mediated endogenous hepatocyte IL-1beta and TNF-alpha synthesis indicated no role for these cytokines in the induction of iNOS expression by IL-1beta
Qiu et al., Zhongguo Yao Li Xue Bao 1999 : SMT inhibited LPS induced nitric oxide release and increased IL-1 beta and IL-6 secretions in AM, but the TNF alpha levels remained unchanged
Shingu et al., Life Sci 1991 : Recombinant human IL-1 beta and TNF-alpha stimulate production of IL-1 alpha and IL-1 beta by vascular smooth muscle cells and IL-1 alpha by vascular endothelial cells
Brown et al., Biochem Biophys Res Commun 2007 (MAP Kinase Signaling System) : Tumor necrosis factor-alpha (TNFalpha) augmented IL-1beta stimulated release of MMP-9, but not MMP-2 or -3
Li et al., Hum Mol Genet 2004 (Crohn Disease) : In wild-type healthy control, CD and ulcerative colitis individuals, low-dose MDP and TNFalpha alone results in only modest IL-1beta protein induction
Al-Harthi et al., J Infect Dis 1997 : The in vitro efficacy of protease inhibitor to block tumor necrosis factor (TNF)-alpha , interleukin (IL)-6, IL-1alpha, and IL-1beta induction of HIV-1 was investigated
Blond et al., Brain Res 2002 (Encephalitis) : We found that IL-1beta induces de novo synthesis of additional IL-1beta but not TNFalpha , as determined by RT-PCR and ELISA, and TNFalpha does not induce either itself or IL-1beta
Cho et al., Int J Mol Med 2007 : However, it was unknown whether curcumin, showing inhibitory effects on NF-kappaB and MAPKs, attenuates the expression of TNF-alpha induced IL-1beta , IL-6, IL-8, and TNF-alpha as well as cyclin E expression in HaCaT cells ... We found that curcumin inhibited the expression of TNF-alpha induced IL-1beta , IL-6, and TNF-alpha, but not IL-8, in TNF-alpha treated HaCaT cells as well as the TNF-alpha induced cyclin E expression
Niemann-Jönsson et al., Arterioscler Thromb Vasc Biol 2001 : We report here that SMCs isolated from the neointima of injured rat aortas are characterized by increased expression of TNF-alpha in response to interleukin-1beta and gamma-interferon compared with medial SMCs. Basal and serum stimulated DNA synthesis was higher in intimal than in medial SMCs
Vasilescu et al., Eur Surg Res 1996 : Our results indicate that the leukocyte derived production of IL-6 and IL-1 beta in whole blood is stimulated directly by endotoxin and is not mediated by TNF alpha
Taneike et al., FEBS Lett 2002 (Hemolysis) : Here we demonstrated that E. coli carrying the cloned enterohemolysin operon ( hlyC, A, B, D genes ) from an STEC human strain induced the production of interleukin-1beta (IL-1beta) through its mRNA expression but not tumor necrosis factor-alpha from human monocytes
Sun et al., World J Gastroenterol 2006 : VacA alone induced expression of TNF-alpha , IL-8 and IL-1beta, while NaCl alone induced expression of TNF-alpha and IL-1beta
Watanabe et al., J Med Virol 2010 (Respiratory Syncytial Virus Infections) : On day 1 after infection, the secretion of both TNF-alpha and IL-6 decreased significantly in the bronchoalveolar lavage fluid prepared from RSV infected offspring exposed to DBDE perinatally, but IL-1beta increased
Cumberbatch et al., Arch Dermatol Res 1998 : The hypothesis is that IL-1beta induces the production by keratinocytes of tumour necrosis factor alpha (TNF-alpha) which acts in a paracrine fashion on LC to provide one signal for migration
Han et al., Int Immunopharmacol 2007 (Dermatitis, Irritant) : Moreover, TNF-alpha induced expression of cytokines, such as TNF-alpha and IL-1beta , and a chemokine, IL-8, were suppressed by silymarin treatment in human keratinocyte cell line, HaCaT
Ritchie et al., Cytokine 1997 : LPS- and IL-1 beta stimulated adrenal TNF release was inhibited by adenosine
Cho et al., Arthritis Rheum 2002 (Arthritis, Rheumatoid) : In a semiquantitative PCR, CSA increased IL-10 mRNA expression but strongly suppressed IL-1beta induced IL-15 and TNFalpha mRNA expression, indicating that the production of these cytokines by CSA was regulated at the transcriptional level
Gayle et al., Brain Res Bull 1998 (Brain Neoplasms...) : The data show that ( 1 ) IL-1beta induced a significant upregulation of TNF-alpha mRNA ; ( 2 ) the effect of IL-1beta on TNF-alpha mRNA expression was completely blocked by the concomitant application of IL-1Ra, which suggests specificity of IL-1beta action through the IL-1 signaling receptor ; ( 3 ) no detectable modulation of TNF-alpha mRNA expression was observed with the individual applications of TNF-alpha, IL-6, or IFN-alpha; (4) the concomitant treatments of TNF-alpha + IL-1beta or TNF-alpha + IL-1beta + IL-6 strongly upregulated TNF-alpha mRNA expression, whereas the concomitant application of TNF-alpha + IL-6 or IL-1beta + IL-6 induced a moderate increase ; and ( 5 ) IFN-alpha significantly attenuated induction of TNF-alpha mRNA by TNF-alpha + IL-1beta + IL-6
Taranta et al., Bone 2002 : Furthermore, both compounds were able to inhibit tumor necrosis factor (TNF)-alpha induced IL-1beta , but not IL-6, increase
Manni et al., Clin Exp Rheumatol 2003 (Inflammation...) : NGF down-regulates IL-1 beta induced TNF-alpha and iNOS production by OA synovial fibroblasts
Lin et al., Crit Care Med 2003 (Hyperoxia) : Endogenous nitric oxide may be an important endogenous inhibitor of hyperoxia + tumor necrosis factor-alpha induced leukocyte recruitment and subsequently tumor necrosis factor-alpha, interleukin-1 beta , and GRO/CINC-1 release
Boehm et al., Exp Dermatol 1996 (Dermatitis, Toxicodendron...) : The data provide evidence for an in vivo role for epidermal IL-1 alpha, IL-1 beta and TNF-alpha transcription in the regulation of IL-1 beta and TNF-alpha polypeptide levels in the epidermis in response to this common contact allergen
Kumamaru et al., Journal of neuroinflammation 2012 : Furthermore, we observed rapid tumor necrosis factor-a and IL-1b gene induction in conventional primary astrocyte cultures after IL-6 stimulation, which was due to the activation of the Janus kinase/signal transducer and activator of the transcription pathway in contaminating microglia
Bai et al., J Immunol 2010 (Tuberculosis) : Inhibition of endogenous IL-32 production in THP-1 cells that express one of three distinct shRNA-IL-32 constructs significantly decreased M. tuberculosis induction of TNF-alpha by approximately 60 %, IL-1beta by 30-60 %, and IL-8 by 40-50 % and concomitantly increased the number of cell associated M. tuberculosis bacteria compared with THP-1 cells stably expressing a scrambled shRNA
Rice et al., Shock 1994 (Inflammation) : CT-1501R also inhibited IL-1 alpha or IL-1 beta induction of either TNF-alpha or IL-1 beta and inhibited the synergistic effects of stimulation with both human IL-1 beta and murine TNF-alpha on release of human TNF-alpha
Hausman et al., Am J Obstet Gynecol 2003 : Uterine and cervical interleukin-1beta and interleukin-6 were decreased, and uterine tumor necrosis factor-alpha increased in celecoxib-B
Yang et al., J Cereb Blood Flow Metab 1999 (Arterial Occlusive Diseases...) : To investigate the role of IL- 1beta in regulation of tumor necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule-1 ( ICAM-1 ) during focal cerebral ischemia, the authors studied mutant mice deficient in the IL-1 converting enzyme (ICE) gene ( ICE knockout [ KO ] mice )
Van der Poll et al., Am J Physiol 1997 : To determine the effect of epinephrine on IL-1 beta production, the following experiments were performed : 1 ) blood obtained from subjects at 4-21 h after the start of a continuous infusion of epinephrine ( 30 ) produced less IL-1 beta after ex vivo stimulation with lipopolysaccharide (LPS), compared with blood drawn from subjects infused with saline ; 2 ) in whole blood in vitro, epinephrine caused a dose dependent decrease in LPS induced IL-1 beta production, which was likely mediated via adrenergic receptors ; and 3 ) inhibition of TNF and enhancement of IL-10 both contributed to epinephrine induced inhibition of IL-1 beta production
Pouliot et al., J Periodontal Res 1999 (Periodontal Diseases) : At nanomolar levels, the LXA4 and ATL analog 15 R/S-methyl-LXA4 each blocked TNF alpha stimulated IL-1 beta release by isolated human PMN in vitro ... The TNF alpha induced IL-1 beta gene expression was also regulated by 15 R/S-methyl-LXA4
Lindström et al., Eur J Pharmacol 2001 : Isolated rat stomach ECL cells generate prostaglandin E ( 2 ) in response to interleukin-1 beta , tumor necrosis factor-alpha and bradykinin
Yamaoka et al., Scand J Gastroenterol 1995 (Gastritis...) : Although IL-1 beta and IFN-gamma mRNA were detected in most specimens, IL-2, IL-3, IL-4, IL-5, IL-9, TNF-alpha , and IFN-beta mRNA were not detected at all
Cunningham et al., Neuropathol Appl Neurobiol 2002 (Prion Diseases) : The aim of this study was to determine whether, in the absence of IL-1beta and IL-6, tumour necrosis factor (TNF)-alpha may play an equivalent pro-inflammatory role, or if an anti-inflammatory cytokine profile dominates
Tummala et al., J Mol Cell Cardiol 2000 : DPI also inhibited TNF and LPS induced VCAM-1 and ICAM-1 cell surface expression and TNF- alpha, LPS, or IL-1 beta induced VCAM-1 and ICAM-1 mRNA accumulation
Xing et al., Neuropathology 2009 (AIDS Dementia Complex...) : IL-1beta was detected in the frontal white matter of all 11 cases where microglial nodules were observed to varying degrees, whereas TNF-alpha was detected in seven cases
Denizot et al., Cytokine 2000 : Addition of IL-4, but not IL-10 or TGF-beta, reduces the TNF-alpha induced cell associated IL-1beta ... In conclusion the pro-inflammatory molecule TNF-alpha stimulates bone marrow stromal cell associated IL-1beta levels while the anti-inflammatory cytokine IL-4 reduces the TNF-alpha induced effect
Gould et al., Kidney Int 2002 : BMP-7 represses the basal and TNF-alpha stimulated expression of the pro-inflammatory cytokines IL-6 and IL-1beta , the chemokines MCP-1 and IL-8, and the vasoconstrictor ET-2 in PTEC
Yang et al., Eur Respir J 2004 (Asthma) : In order to better understand the control of IL-1beta activity in the airway mucosa, the role ( s ) of tumour necrosis factor (TNF)-alpha , cyclic adenosine monophosphate ( cAMP ) and cyclic guanosine monophosphate ( cGMP ) in the release of IL-1beta and its inhibitors by cultured HAECs were examined ... cAMP increased constitutive and TNF-alpha stimulated IL-1beta release but reduced that of sIL-1RII
Gossye et al., Arthritis Rheum 2009 (Arthritis, Rheumatoid) : Quantitative polymerase chain reaction was performed to detect the tumor necrosis factor alpha (TNFalpha) induced cytokine gene expression of interleukin-1beta (IL-1beta) and to investigate the effects of DEX and CpdA in RA fibroblast-like synoviocytes ( FLS ) transfected with small interfering RNA ( siRNA ) against GR ( siGR ) compared with nontransfected cells
Arnush et al., J Clin Invest 1998 : Reverse transcriptase polymerase chain reaction was used to confirm that TNF + LPS + IFN-gamma stimulates the expression of both IL-1alpha and IL-1beta in human islets
Fang et al., Zhen Ci Yan Jiu 2007 (Inflammation) : Compared with model group, IL-1beta mRNA expression of the local inflammatory tissues in IND and EA-post-treatment groups was down-regulated, and TNF-alpha mRNA expression in Rofecoxib and two EA groups down-regulated slightly ... Compared with control group, PGE2, IL-1beta and TNF-alpha contents in the toe tissue of model group increased significantly ; while in comparison with model group, PGE2 and IL-1beta levels in EA-post-treatment group, IL-1beta level in IND group decreased significantly ( P < 0.05 ), and TNF-alpha level in IND group increased significantly. No significant differences were found between model group and Rofecoxib and EA-pre-treatment groups in most time-courses of the hind-paw-volume, between model and IND, Rofecoxib and EA-pre-treatment groups in PGE2, between model and EA-pre-treatment groups in IL-1beta, and between model and Rofecoxib, EA-pre-treatment and EA-post-treatment groups in TNF-alpha contents ( P > 0.05 )
Arinaga et al., Int J Immunopharmacol 1994 (Digestive System Neoplasms) : However, the ability of monocytes in PBM to produce TNF-alpha was significantly enhanced 5 days after the drug administration, although IL-1-alpha and IL-1-beta production was not augmented
Wei et al., Biochimie 2006 : Promutoxin is also able to stimulate the release of IL-12, TNFalpha, IL-6 and IL-1beta from human monocytes, and induce IL-2, TNFalpha and IL-6 release from T cells, indicating that this snake venom group IIA PLA(2) is actively involved in the inflammatory process in man caused by snake venom poisoning
Xu et al., Arthritis Rheum 2006 (Arthritis, Rheumatoid) : SMV prevented the increase in NF-kappaB activation and rise in IL-1beta and IL-6 levels induced by TNFalpha , whereas mevalonate and geranylgeranyl pyrophosphate reversed the inhibitory effects of SMV on activation of NF-kappaB and RhoA
Herbert et al., Eur J Pharmacol 1995 (Hyperemia) : Tumor necrosis factor-alpha prevents interleukin-1 beta from augmenting capsaicin induced vasodilatation in the rat skin
Vuolteenaho et al., Osteoarthritis Cartilage 2002 (Osteoarthritis, Knee) : TNFalpha-antagonists infliximab and etanercept inhibited TNFalpha induced NO production in a dose dependent manner but they had no effect on IL-1beta- , IL-17- and LPS stimulated NO synthesis
Song et al., Mol Immunol 2009 (Inflammation) : Ablation of IRAK-4 expression in human umbilical vein endothelial cells ( HUVEC ) with siRNA suppressed IL-1beta induced IL-6 and IL-8 production whereas IRAK-1 siRNA suppressed TNFalpha induced but not IL-1beta induced cytokine production
Shinozawa et al., Nihon rinsho. Japanese journal of clinical medicine 2004 (Disseminated Intravascular Coagulation...) : TNF augments inflammation, TNF and IFN-gamma induce coagulation, and IL-1beta induces coagulation and fibrinolysis
Jobin et al., J Immunol 1998 : Induction of inducible nitric-oxide synthase (iNOS), IL-1beta , and IL-8 genes by IL-1beta, TNF-alpha , or PMA was blocked in Ad5 IkappaB infected cells but not in Ad5 LacZ controls as assayed by RT-PCR and ELISA
Ranta et al., Crit Care Med 1999 : Unstimulated HUVECs did not produce detectable amounts of TNF-alpha, but IFN-gamma, IL-1beta , and LPS when added together induced TNF-alpha production of HUVECs in a time dependent manner ... IFN-gamma, IL-1beta , or LPS alone did not induce TNF-alpha production, whereas IFN-gamma and IL-1beta in combination were able to induce TNF-alpha production to some extent, and the production could be further increased with LPS
Matsui et al., J Ethnopharmacol 2009 : Aqueous extract of Vitex trifolia leaves showed significant dose- and time dependent inhibitory activity on interleukin (IL)-1 beta , IL-6 and iNOS mRNA synthesis, but slight effect on tumor necrosis factor (TNF)-alpha , all of which are involved in the inflammatory response
Wong et al., Immunol Cell Biol 1996 : While beta-casein had no significant effects on IFN gamma production by ovine blood lymphocytes, and TNF alpha production and MCH Class II antigen expression by ovine bronchoalveolar macrophages, it enhanced IL-1 beta production by the macrophages, beta-casein also had no influence on bovine NK cell activity against a virally infected cell line
Ryang et al., Parasitol Res 2007 (Echinostomiasis) : The IL-1beta expressions were inhibited by ketotifen in the two strains, but TNF-alpha expression was inhibited in the C3H/HeN mice after ketotifen treatment
Agarwal et al., J Periodontal Res 1995 : IL-1 beta activation of GF cells showed that IL-1 beta non only induces the expression of IL-6, IL-8 and TNF-alpha , but also acts in an autocrine manner of GF cells and induces IL-1 beta expression ... Pretreatment of GF cells with IL-1 beta resulted in the enhanced synthesis of TNF-alpha in response to additional IL-1 beta
Määttä et al., Toxicology 2006 : All the tested hardwood and softwood dusts induced TNF-alpha expression and inhibited IL-1beta expression
Klatt et al., Biomed Pharmacother 2006 (Osteoarthritis) : TAK1 downregulation reduces IL-1beta induced expression of MMP13, MMP1 and TNF-alpha
Hirata et al., Am J Respir Cell Mol Biol 1998 (Lung Neoplasms) : The TNF-alpha level in the supernatants significantly increased at 120 min after allergen stimulation, and the interleukin (IL)-1beta level increased in 4 of 15 samples
Huber et al., Mol Hum Reprod 2007 (Endometriosis) : Accordingly, hCG-A diminished IL-1beta induced TNF-alpha transcript levels and protein release measured by quantitative real-time PCR and enzyme linked immunosorbent assay ... The hormone also attenuated TNF-alpha dependent mRNA expression of IL-1beta
Van bezooijen et al., J Bone Miner Res 1999 (Bone Resorption) : In addition, IL-17 increased TNF-alpha induced IL-1alpha, IL-1beta , and IL-6 mRNA expression in fetal mouse metatarsals and IL-1alpha and IL-6 mRNA expression in MC3T3-E1 cells
Havard et al., Virology 2002 : We evaluated the constitutive and IL-1beta induced expression of GM-CSF and TNF-alpha and the expression/activity of NF-kappaB in HPV+ and HPV- cell lines
Brooks et al., Clin Exp Immunol 1996 (Arteritis...) : They have been shown previously to produce the cytokine IL-1 beta in response to stimulation with TNF
Song et al., Am J Physiol Lung Cell Mol Physiol 2000 : However, the LPS effects on TNF-alpha and IL-8 are inhibited by < 20 % and the effect on IL-1beta by < 50 %. Third, at Survanta levels of 1 mg/ml, SP-A induced responses are reduced by > 90 %, and although the inhibitory effects on LPS action increase, they still do not reach those seen with SP-A
Kawasaki et al., J Neurosci 2008 (Hyperalgesia...) : Consistently, TNFalpha and IL-1beta enhanced AMPA- or NMDA induced currents, and IL-1beta and IL-6 suppressed GABA- and glycine induced currents
Arnush et al., J Immunol 1998 (Diabetes Mellitus, Type 1) : IL-1beta appears to mediate the inhibitory actions of TNF + LPS on beta cell function as TNF + LPS induced expression of IL-1beta is fourfold higher than IL-1alpha, and Ab neutralization of IL-1beta prevents TNF + LPS induced nitrite production by rat islets
Ando et al., BMC physiology 2007 : Time and dose dependent expression of MAdCAM-1 in response to TNF-alpha , IL-1 beta and IFN-gamma was studied by immunoblotting
Totlandsdal et al., Toxicological sciences : an official journal of the Society of Toxicology 2008 : In lung cell cultures both particle types induced release of IL-6 and IL-1beta , whereas TNF-alpha was only detected upon exposure to St Louis particles
Marquette et al., Int J Radiat Biol 2003 (Encephalitis) : Six hours after irradiation, IL-1beta levels had increased in the hypothalamus, thalamus and hippocampus, and TNFalpha and IL-6 levels had increased significantly in the hypothalamus
Ho et al., Shock 2009 (Acute Disease...) : Intravenous LPS ( 10-50 mg/kg ) dose-dependently increased plasma endotoxin and reactive oxygen species in the blood, bile, and liver and increased plasma alanine aminotransferase and aspartate aminotransferase levels as well as TNF-alpha , monocyte chemoattractant protein 1, tissue inhibitor of metalloproteinase 1, IL-1beta , and IL-6 levels in the rats
Plata-Salamán et al., Am J Physiol 1998 (Fever...) : The results show that 1 ) both IL-1beta and IL-6 induce fevers in obese and lean rats ; 2 ) IL-1beta induces a significantly higher fever response in obese rats than it does in lean rats ; 3 ) IL-6 induces a significantly higher fever response in lean rats than it does in obese rats ; 4 ) IL-2 induces a moderate fever response in lean but not obese rats ; 5 ) TNF-alpha induces a similar fever response in obese and lean rats ; and 6 ) the fevers induced by each effective cytokine have different time courses
Liu et al., Proc Natl Acad Sci U S A 2009 : Neither JNK1 activation by IL-1beta or UV nor TNF-alpha induced activation of p38, ERK, or IkappaB kinase complex is affected by the loss of Miz1
Hall et al., J Biol Chem 2007 (Arthritis, Rheumatoid...) : These inhibitors selectively target Tpl2 in these cells, and they block LPS- and IL-1beta induced TNFalpha production in both primary human monocytes and human blood
Isumi et al., FEBS Lett 1999 : Adrenomedullin suppresses interleukin-1beta induced tumor necrosis factor-alpha production in Swiss 3T3 cells ... We demonstrated that adrenomedullin (AM) inhibited interleukin-1beta induced tumor necrosis factor-alpha (TNF-alpha) secretion and gene transcription in Swiss 3T3 fibroblasts maximally to 23 % and 18 % of control, while the other peptides elevating intracellular cAMP levels elicited much weaker effects
Wassen et al., Endocrinology 1996 : We conclude that 1 ) IL-1 beta decreases TSH release by a direct action on the pituitary ; 2 ) this effect is not due to elevated thyroid hormone uptake or increase T3 nuclear occupancy ; 3 ) IL-1 beta does not affect TRH induced TSH release or the release of other anterior pituitary hormones ; and 4 ) TNF alpha affects basal and TRH induced TSH release in the same way as IL-1 beta
Chung et al., J Immunol 1990 : IFN-gamma and IL-1 beta alone do not induce TNF-alpha production, however, the combined treatment of IFN-gamma and IL-1 beta results in a striking synergistic effect on astrocyte TNF-alpha production
Morello et al., J Immunol 2006 : IL-1beta and TNF-alpha rapidly activated p50 and p65, but not C-Rel, RelB, or p52, and both IL-1beta- and TNF-alpha stimulated A2AR expression was inhibited by the IkappaB kinase 2 inhibitor AS602868 in a concentration dependent manner
Zhang et al., J Leukoc Biol 2005 : In the present study, incubation of AM with unopsonized Pneumocystis organisms was not associated with release of interleukin (IL)-1beta , IL-6, or tumor necrosis factor (TNF)-alpha ( important cytokines in the host response to Pneumocystis ) and did not induce IL-1beta, IL-6, or TNF-alpha mRNA transcripts
Koyama et al., Am J Physiol 1998 : IL-1beta stimulated the release of G-CSF in a dose dependent fashion, but the time dependent profile of G-CSF showed that the concentration of G-CSF declined after 48 h. Tumor necrosis factor (TNF)-alpha , Escherichia coli lipopolysaccharide (LPS), and bradykinin ( BK ) stimulated A549 cells to release NCA that was inhibited by anti-G-CSF antibody
Chen et al., Neurosurgery 1993 (Brain Neoplasms...) : Furthermore, in U-87 cells, TNF-alpha enhanced both ICAM-1 and interleukin-1 beta (IL-1 beta) expression, and decreased immunoreactivity for transforming growth factor-beta ( TGF-beta ) protein
Pivirotto et al., Mol Cell Endocrinol 1995 : Tumor necrosis factor-alpha (TNF) dependent increase IL-1 beta mRNA levels were additive to the effects of the steroids ... Testosterone and TNF increased IL-1 beta protein release ( P < 0.05 ) while 17 beta-estradiol had little effect on release
Liu et al., J Neurosci 2000 : Pretreatment of astrocytes with P2 receptor antagonists, including suramin and periodate oxidized ATP ( oATP ), resulted in a significant downregulation of IL-1beta stimulated expression of nitric oxide, tumor necrosis factor ( TNFalpha ), and IL-6 at both the protein and mRNA levels, without affecting cell viability
Hörnquist et al., J Immunol 1997 (Colitis, Ulcerative) : Thus, IFN-gamma and IL-1beta levels were increased 13-fold and 30-fold, respectively, with more modest increases in IL-6 levels ( 5-fold ) and TNF levels ( 2-fold )
Call et al., Gen Comp Endocrinol 2000 : The release of IL-6 and TNF from the ZG, ZF, ZR, and medulla was increased by PDB, IL-1alpha, IL-1beta , and LPS
Simbirtsev et al., Eur Cytokine Netw 1992 : Recombinant IL-1 beta induced a very low level of TNF alpha production in PMA treated cells ... Similarly recombinant TNF alpha alone induced IL-1 beta synthesis only in a few U-937 cells
Kuwano et al., Free Radic Biol Med 2008 : Interleukin-1beta , flagellin, interferon-gamma, and tumor necrosis factor alpha (TNF-alpha) similarly induced Nox1 in a colon cancer cell line ( T84 ), whereas only TNF-alpha fully induced NOXO1 and upregulated superoxide producing activity by ninefold
Molnar-Kimber et al., Agents Actions 1993 : Zaprinast stimulated IL-1 beta and to a lesser extent TNF alpha production
Yang et al., Shock 2002 (Endotoxemia...) : Globin specifically inhibited LPS activity in the standard Limulus assay but did not inhibit interleukin-1beta mediated TNF synthesis ... Iron supplementation of macrophage cultures significantly increased interleukin-1beta induced TNF release
Swangchan-Uthai et al., Biol Reprod 2012 (Cattle Diseases...) : A 48 h, LPS time course study showed that TNF increased first at 1 h, followed by peak expression of IL1B at 6 h, and those of S100A8, S100A12, and LAP at 12 h
Oner et al., J Clin Endocrinol Metab 2008 (Chorioamnionitis...) : Compared with basal outputs by DCs incubated with E2, TNF-alpha enhanced MMP-1 and MMP-3 secretion by 14 +/- 3- and 9 +/- 2-fold, respectively, and IL-1beta increased MMP-1 and MMP-3 secretion by 13 +/- 3- and 19 +/- 2-fold, respectively ( P < 0.05 )
Ebisawa et al., J Immunol 1992 : IL-1 beta and TNF-alpha treatment of HuVEC ( 4 h, 5 ng/ml ) induced significant transendothelial migration of eosinophils ( a 4.1 +/- 0.4-fold ( IL-1 beta ) and 2.0 +/- 0.9-fold ( TNF-alpha ) increase from the spontaneous value of 3.2 +/- 0.3 % )
Gitter et al., Immunology 1989 : Further examination of IL-1 beta- and TNF alpha induced PGE2 secretion revealed IL-1 beta to be a more potent stimulator ; however, this observation may be due, in part, to differences in the kinetics of induction
Paulose et al., Microb Pathog 1998 : Supernatant from TPV infected cells significantly decreased the TNF-alpha but not IL-1 beta induced expression of these molecules
Chung et al., J Immunol 1992 (Second Messenger Systems) : Primary rat astrocytes express TNF-alpha protein in response to various stimuli including a combined treatment with IFN-gamma and LPS, or IFN-gamma and IL-1 beta ... This study was undertaken to further elucidate the mechanisms underlying TNF-alpha gene expression in the astrocyte, and to determine the intracellular signaling pathways involved in IFN-gamma/LPS and/or IFN-gamma/IL-1 beta induction of the TNF-alpha gene ... Two protein kinase C ( PKC ) inhibitors, H7 and staurosporine, abrogate IFN-gamma/LPS- and IFN-gamma/IL-1 beta induced TNF-alpha expression in a dose dependent manner
Barsness et al., Pediatr Surg Int 2004 (Respiratory Distress Syndrome, Adult) : There was no IL-10 production in IL-1beta stimulated adult PMs. IL-1beta induced TNF production was greater in children compared with adults ( 2152+/-166 vs. 592+/-188, P < 0.05 ) ... In conclusion, IL-1beta induced IL-6 and TNFalpha production were greater in pediatric than adult PMs
Fujiwara et al., Lab Invest 2002 (Arthritis, Experimental) : GROalpha does not seem to initiate TNFalpha , IL-1beta, and IL-8 in an early phase, but induces IL-1beta and IL-8 in a late phase
Demetri et al., Blood 1989 (Mesothelioma) : Interleukin-1 beta (IL-1 beta) transcripts were induced by EGF, TNF , or LPS and were inhibited by hydrocortisone ( HC )
Cardell et al., Pulm Pharmacol Ther 2008 : The present study was designed to evaluate the effects of IL-1beta on the expression of its corresponding receptor IL-1 RI, as well as on the closely related TNFalpha receptors TNF RI and TNF RII in airways using a mouse organ culture assay and intranasal inoculation model
Hahn et al., J Clin Invest 1993 (Arthritis, Rheumatoid) : In particular, IL-1 beta and neopterin production were further enhanced by stimulation with either interferon-gamma (IFN-gamma) or TNF-alpha without a synergistic effect
Wu et al., Kidney Int 2005 : In the present studies, we examine whether LXA ( 4 ) have inhibitory effects on tumor necrosis factor-alpha (TNF-alpha) induced productions of IL-1beta and IL-6 and proliferation of glomerular mesangial cells of rat, and explore the molecular mechanisms of signal pathway of LXA ( 4 ) ... LXA ( 4 ) also antagonized TNF-alpha stimulated IL-1beta and IL-6 synthesis, and these antagonisms were related to SHP-2 and NF-kappaB pathway dependent signal transduction
Soboslay et al., Clin Exp Immunol 1992 (Dermatitis...) : Peripheral blood mononuclear cells ( PBMC ) from untreated patients produced IL-1 beta, tumour necrosis factor-alpha (TNF-alpha) and IL-6 in response to mitogenic stimulation with phytohaemagglutinin ( PHA ), only low levels of IL-1 beta , IL-2 and TNF-alpha in response to OvAg, but higher amounts of IL-4 and interferon-gamma (IFN-gamma) in response to OvAg than control individuals
Burger et al., J Immunol 2004 : The production of TNF and IL-1beta was induced by membranes of stimulated T cells in the three types of target cells, whereas CD40LT induced TNF production in IFN-gamma-macrophages only
Brunius et al., Eur J Oral Sci 1996 (Gingival Hyperplasia) : TNF alpha , in contrast to PHT, dose-dependently stimulated the production of cell associated IL-1 beta ... The stimulatory effect of TNF alpha on IL-1 beta production was accompanied by enhanced PGE2 formation ... When PHT and TNF alpha were added simultaneously, the drug potentiated the stimulatory effect of TNF alpha on both IL-1 beta production and PGE2 formation ... The production of IL-1 beta induced by TNF alpha and the combination of TNF alpha and PHT was further enhanced in the presence of the prostaglandin endoperoxide ( PGH ) synthase inhibitors, indomethacin and flurbiprofen ... The PHT mediated enhancement of TNF alpha induced IL-1 beta production and PGE2 formation in gingival fibroblasts may be an important link in the pathogenesis of gingival overgrowth induced by PHT
Nishida et al., Am J Physiol Gastrointest Liver Physiol 2008 : Furthermore, LY294002 suppressed both IL-1beta- and TNF-alpha induced NF-kappaB activation and IL-1beta- , TNF-alpha-, and IFN-gamma induced activated protein-1 (AP-1) activation
Millward-Sadler et al., Arthritis Res Ther 2009 (Intervertebral Disc Degeneration) : Quantitative real-time polymerase chain reaction was used to assess the effect of TNF-alpha or IL-beta stimulation on the expression of matrix metalloproteinase (MMP)-3, -9 and -13, TNF-alpha, TNF receptor 1 (TNF-R1), TNF receptor 2 (TNF-R2), IL-1alpha, IL-1beta , IL-1 receptor 1 (IL-1R1) and IL-1 receptor antagonist (IL-1Ra)
Huang et al., Zhen Ci Yan Jiu 2007 (Disease Models, Animal...) : No IL-1beta and TNF-alpha were detected in the synovia in control group, while in the other 3 groups, synovia IL-1beta and TNF-alpha levels increased significantly
Sopasakis et al., Int J Obes Relat Metab Disord 2005 : TNFalpha increased the mRNA levels of TNFalpha itself as well as IL-6, IL-8, IL-1beta and PAI-1, but not leptin
Duan et al., Clin Cancer Res 2004 (Glioma) : However, in the resistant cells, the production of IL-1beta and IL-6 were specifically impaired in response to TNF-alpha
Yike et al., Mycopathologia 2002 (Apnea...) : Proinflammatory mediator IL-1beta increased more than 6-fold and TNF-alpha 30-fold ( p = 0.001 )
Matsukawa et al., Lab Invest 1998 (Arthritis) : These results provide evidence that IL-8 and TNFalpha were responsible for the production of IL-1beta and IL-1Ra, and that IL-1beta was responsible for the second phase of IL-1beta and IL-8 production
Lieb et al., J Neurochem 1996 (Astrocytoma) : For a better understanding of their pathogenic role, we analyzed signal transduction pathways mediating the interleukin (IL)-1 beta induced synthesis of IL-6 and tumor necrosis factor alpha (TNF alpha) in the human astrocytoma cell line U373 MG ... Whereas activation of protein kinase A was able to induce expression of the IL-6 gene, it did not induce TNF alpha gene expression and was not involved in IL-1 beta induced IL-6 and TNF alpha gene expression
Sass et al., Inflamm Res 2002 (Drug-Induced Liver Injury) : TNF-pretreatment did not affect TNFR-1 expression in the liver and resulted in time dependent up-regulation of iNOS, IL-1beta and HO-1 ... IL-1beta , iNOS and HO-1 neither mediated TNF-tolerance nor TNF cytotoxicity
Yavuzyilmaz et al., Aust Dent J 1995 (Gingival Hemorrhage...) : While IL-1 beta was detected in all of the GCF samples studied, TNF-alpha could only be detected in about half the samples
Sethu et al., J Immunol 2008 (Calcium Signaling...) : Furthermore, use of antisense oligonucleotides to reduce expression of PLD1 or PLD2 demonstrated that PLD1 is required for TNF-alpha induced production of several important cytokines, such as IL-1beta , IL-5, IL-6, and IL-13, in human monocytes
Mauviel et al., J Cell Biochem 1991 : Induction of interleukin-1 beta production in human dermal fibroblasts by interleukin-1 alpha and tumor necrosis factor-alpha
Turner et al., Cardiovasc Res 2007 (Coronary Disease) : Mechanism of TNFalpha induced IL-1alpha, IL-1beta and IL-6 expression in human cardiac fibroblasts : effects of statins and thiazolidinediones ... TNFalpha ( 0.1-10 ng/ml ) stimulated IL-6, IL-1alpha and IL-1beta mRNA expression in cardiac fibroblasts in a concentration dependent manner ... Pharmacological inhibitors and receptor neutralizing antibodies established that both TNFalpha induced IL-6 and IL-1beta expression was mediated via the TNFRI receptor and p38 mitogen activated protein kinase ( MAPK ), phosphoinositide 3-kinase (PI3K)/Akt and nuclear factor (NF)-kappaB pathways
Panja et al., Clin Exp Immunol 1995 : LPS, IFN-gamma or TNF-alpha had no effect on spontaneous IL-6 production, and neither resulted in the secretion of IL-1 beta or TNF-alpha
Elias et al., Proc Natl Acad Sci U S A 1989 : In addition, simultaneous stimulation with recombinant IL-1 ( alpha or beta ) and recombinant TNF resulted in a synergistic increase in IL-1 beta mRNA levels
Nita et al., Int J Biochem Cell Biol 2007 : In contrast, longer term incubation ( 18 h ) of monocytes with combined AAT/LPS results in a significant reduction in expression of both CD14 and TLR4, inhibition of LPS induced TNFalpha , IL-1 beta and IL-8 mRNA and protein expression
Zaga et al., Biol Reprod 2004 (Streptococcal Infections) : The TNFalpha was secreted by amnion and choriodecidua in the presence of LPS or GBS, and stimulation with GBS induced a greater synthesis of IL-1beta than did stimulation with LPS
Lang et al., Clin Nutr 2004 : The spontaneous and TNF-alpha stimulated secretion of IL-1beta , IL-8, IP-10 and MIG from HT-29 and Caco-2 cells was tested with, or without pretreatment with allicin
Rosengren et al., J Allergy Clin Immunol 2007 (Autoimmune Diseases...) : FCAS monocytes respond to mild hypothermia with IL-1beta release, which in turn induces autocrine transcription and secretion of IL-6 and TNF-alpha as well as stimulation of further IL-1beta production
Kwak et al., Infect Immun 2000 (Streptococcal Infections) : In contrast to the response to LPS, where TNF-alpha , IL-1beta, IL-6, and IL-8 appear almost simultaneously, the human monocyte response to GBS results in the production of TNF-alpha but delayed appearance of IL-1beta , IL-6, and IL-8
Zhang et al., J Am Dent Assoc 2003 (Chronic Disease...) : The results showed that lipopolysaccharide and tumor necrosis factor alpha, or TNF-alpha , induced COX-2 in macrophages, while IL-1beta and TNF-alpha induced COX-2 in oral epithelial cells
Damås et al., Basic Res Cardiol 2001 : ( ii ) In contrast, TNFalpha had no effect on IL-10 and only a modest effect on IL-1beta and IL-6 levels in these cells
Ledesma et al., Cytokine 2004 : Interleukin-1 beta (IL-1beta) induces tumor necrosis factor alpha (TNF-alpha) expression on mouse myeloid multipotent cell line 32D cl3 and inhibits their proliferation
Churchill et al., Brain Res 2006 : Relative to saline administration, IL1beta increased IL1beta, TNFalpha and IL6 mRNAs in the nucleus tractus solitarius (NTS), hypothalamus, hippocampus and somatosensory cortex ( SSctx ), but did not induce any changes in IL10 ... TNFalpha also increased TNFalpha and IL1beta mRNAs in the hypothalamus, hippocampus and SSctx. TNFalpha increased TNFalpha, IL1beta and IL10 mRNAs in the NTS, but did not induce any changes in IL-6 mRNA ... In the amygdala, IL1beta enhanced IL6 mRNA and TNFalpha increased IL1beta mRNAs ... In the insular cortex, IL1beta enhanced IL6 mRNA and TNFalpha increased IL1beta mRNA
Huang et al., Changgeng yi xue za zhi / Changgeng ji nian yi yuan = Chang Gung medical journal / Chang Gung Memorial Hospital 1999 : The spontaneous or IFN-gamma +TNF-alpha +IL-1 beta induced IL-8 release was significantly augmented after the addition of neutrophils
Maret et al., Cytokine 2004 : We compared the production of IL-1alpha, IL-1beta , and of IL-1Ra isoforms by cultured human dermal ( HDF ) and synovial fibroblasts ( HSF ) in response to IL-1alpha, TNF-alpha , or direct T cell membrane contact
Hirji et al., Int Arch Allergy Immunol 1999 : In addition, Ro 31-8220 ( a PKC inhibitor ) inhibited OX8 induced iNOS upregulation, NO and IL-1beta production, but did not inhibit TNF-alpha production
Hashizume et al., Rheumatology (Oxford) 2008 (Arthritis, Rheumatoid) : On the other hand, TNF-alpha and IL-17 did not induce RANKL expression, although TNF-alpha, IL-17 or IL-1beta stimulated cell growth and IL-6 production
Hadjiminas et al., Surgery 1994 (Bacteremia...) : Enhanced survival from cecal ligation and puncture with pentoxifylline is associated with altered neutrophil trafficking and reduced interleukin-1 beta expression but not inhibition of tumor necrosis factor synthesis
Griesinger et al., J Soc Gynecol Investig 2001 (Bacterial Infections...) : The pathogenic microorganisms induced a dose- and time dependent release of IL-1beta , IL-6, IL-8, and IL-10, whereas TNF-alpha secretion was not elevated
Patten et al., Naunyn Schmiedebergs Arch Pharmacol 2003 : Interleukin-1beta mediates endotoxin- and tumor necrosis factor alpha induced RGS16 protein expression in cultured cardiac myocytes
Yang et al., Vet Immunol Immunopathol 2007 : Human TNF-alpha induced the expression of IP-10 mRNA in porcine endothelial cells, while both human IFN-gamma and human IL-1beta failed
Didier et al., J Neurochem 2003 : Concomitantly, TNF-alpha induced IL-1beta mRNA expression by astrocytes in co-culture and this effect was partially prevented by ET-1 antibody neutralization
Compton et al., J Immunol 1998 : Reverse-transcription PCR analysis indicated up-regulation of mRNA for IL-8 as well as for IL-1 beta in response to tryptase or TNF-alpha
Prgomet et al., J Vet Med A Physiol Pathol Clin Med 2005 (Mastitis, Bovine) : Cytokine [tumour necrosis factor alpha (TNFalpha) , IL-1beta , IL-6 ] mRNA expression responses and transcriptional activity of CD14 and lactoferrin (LF) were quantified via a one-step real-time RT-PCR
Katz et al., Arthritis Rheum 2001 (Inflammation) : IL-17 ( 10 ng/ml ) stimulated the expression of IL-6 mRNA by 1.3-fold, while TNFalpha ( 1 ng/ml ) increased it by 3.7-fold, and IL-1beta ( 0.1 ng/ml ) increased it by > 30-fold
Contrino et al., Pediatr Res 1993 : In our present studies, we found that tumor necrosis factor-alpha and lipopolysaccharide could induce IL-1-beta expression in both neonatal and adult PMN and that neonatal PMN produced significantly more IL-1-beta when compared with adult PMN