Gene interactions and pathways from curated databases and text-mining

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IL6 — TNF

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: IL6 → TNF (increases) Yoshida et al., Am J Physiol 1999*
    Evidence: TNF-a was dose dependently capable of inducing IL-6 release from NHBE and HS-24 cells (Fig. 5, A and C).
  • OpenBEL Selventa BEL large corpus: IL6 → TNF (increases) Newton et al., J Pharmacol Exp Ther 2007*
    Evidence: Similar levels of RANTES and MCP-1 release were induced by IL-1 and TNF treatments. However, the induction of IL-6, IL-8, and GMCSF by TNF was 50 to 80% lower than for IL-1, whereas TNF-induced GRO was some 35- to 40-fold lower than that for IL-1. In all instances, preincubation with PS-1145 or ML120B resulted in a significant attenuation of cytokine release (Fig. 6).
  • OpenBEL Selventa BEL large corpus: IL6 → TNF (increases) Newton et al., J Pharmacol Exp Ther 2007*
    Evidence: Thus, IL-6 release was substantially increased by both IL-1 and to a lesser extent by TNF. In each case, prior infection with the null adenovirus showed no significant effect, whereas dominant IBN reduced IL-6 release to near-background levels. Likewise, the dominant-negative IKK2 adenovirus prevented IL-6 release
  • OpenBEL Selventa BEL large corpus: IL6 → TNF (increases)
    Evidence: from full text - TNF-alpha exerts its pro-inflammatory effects through increased production of IL-1beta and IL-6, expression of adhesion molecules, proliferation of fibroblasts and procoagulant factors, as well as initiation of cytotoxic, apoptotic, acute-phase responses, and inhibition of apoptosis [8,9].
  • OpenBEL Selventa BEL large corpus: IL6 → TNF (increases) Yoshida et al., Am J Physiol 1999*
    Evidence: TNF-a significantly increased the production of IL-6 in WI-38-40 cells. However, DMSO was not able to inhibit the TNF-a-induced IL-6 enhancement in both protein and mRNA levels (Fig. 7). These results suggest that ROIs may not be involved in the production of IL-6 in human lung fibroblasts
  • OpenBEL Selventa BEL large corpus: IL6 → TNF (increases) Asselin et al., Cancer Res 2001*
    Evidence: The sentence (Jubilant) TNF-alpha induced IL-6 production was significantly decreased by infection with AxCAdnSTAT3 (adenovirus carrying dnSTAT3). is translated to Activation of IL6 (Homo sapiens) Protein by STAT3 (Homo sapiens) Protein The following edits have been made already none Links Doc Sourcerer for 11748261 IL6 (Homo sapiens) Protein STAT3 (Homo sapiens) Protein

Text-mined interactions from Literome

Mueller et al., Biochem Biophys Res Commun 2010 (Colonic Neoplasms...) : TNF-alpha similarly induces IL-6 and MCP-1 in fibroblasts from colorectal liver metastases and normal liver fibroblasts
Tokuda et al., Prostaglandins Leukot Essent Fatty Acids 2002 : It has recently been reported that tumor necrosis factor-alpha induced IL-6 synthesis is amplified by IL-17 in these cells
Vandevoorde et al., Biochem Biophys Res Commun 1991 (Fibrosarcoma...) : Tumor necrosis factor induced interleukin-6 expression and cytotoxicity follow a common signal transduction pathway in L929 cells ... Under conditions where TNF mediated cytotoxicity was either increased or decreased, depending on addition of activators or inhibitors, we found that the TNF induced IL6 gene expression was likewise enhanced or repressed
Spinas et al., J Infect Dis 1991 : The rise in TNF-alpha was followed by a rise in plasma IL-6 ( 27 +/- 12.8 ng/ml ), peaking 30-90 min thereafter
Goodman , Proc Soc Exp Biol Med 1994 : Both IL-1 and TNF can induce the synthesis of IL-6 by a variety of cells
Kim et al., Frontiers in bioscience (Landmark edition) 2009 (Myocardial Infarction) : TNF-alpha released from ischemic heart after acute MI increases the production of other cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6) and adhesion molecules such as intercellular adhesion molecule-1 ( ICAM-1 )
Soares et al., J Immunol 1998 : The vasoactive peptide maxadilan from sand fly saliva inhibits TNF-alpha and induces IL-6 by mouse macrophages through interaction with the pituitary adenylate cyclase activating polypeptide ( PACAP ) receptor
Aloisi et al., J Immunol 1992 : Production of hemolymphopoietic cytokines ( IL-6 , IL-8, colony stimulating factors ) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha
Dukic-Stefanovic et al., J Neurochem 2003 : NO and TNF-alpha , but not IL-6 production appear to be regulated independently, since NOS inhibitors did not decrease TNF-alpha secretion and a neutralizing TNF-alpha antibody did not reduce NO production, while employment of NOS inhibitors reduced significantly the secretion of IL-6
Yamane et al., Biochem Biophys Res Commun 2000 : Using neutrophils from EP2- and EP4-deficient mice in combination with EP2- and EP4-selective agonists, it was found that the augmentation of IL-6 was mediated mainly by the EP2 receptor and the suppression of TNF-alpha by the EP4 receptor and partially by the EP2 receptor
Fulton et al., J Infect Dis 1998 : Regulation of interleukin-12 by interleukin-10, transforming growth factor-beta, tumor necrosis factor-alpha , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra
Tokuda et al., J Cell Biochem 2004 : Interleukin (IL)-17 enhances tumor necrosis factor-alpha stimulated IL-6 synthesis via p38 mitogen activated protein kinase in osteoblasts ... It has been reported that IL-17 enhances TNF-alpha stimulated IL-6 synthesis in osteoblast-like MC3T3-E1 cells ... We previously showed that sphingosine 1-phosphate ( S1-P ) mediates TNF-alpha stimulated IL-6 synthesis in these cells ... SB203580 and PD169316, specific inhibitors of p38 MAP kinase, significantly reduced the enhancement by IL-17 of TNF-alpha stimulated IL-6 synthesis ... SB203580 and PD169316 inhibited the amplification by anisomycin of the TNF-alpha induced IL-6 synthesis ... Taken together, our results strongly suggest that IL-17 enhances TNF-alpha stimulated IL-6 synthesis via p38 MAP kinase activation in osteoblasts
Wetzler et al., Cancer Res 1990 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : However, granulocyte colony stimulating factor expression could be induced by recombinant human IL-1 beta ; while IL-6 could be induced by both IL-1 beta and tumor necrosis factor-alpha
Gustavsson et al., Retina 2008 (Diabetes Mellitus, Experimental...) : Ischemia induced increased expressions of TNF-alpha ( P < or= 0.012 ), IL-1beta ( P < or= 0.017 ), ICAM-1 ( P < or= 0.025 ), and IL-6 ( P = 0.012 ), and diabetes induced increased expression of caspase-1 ( P < or= 0.046 ), VCAM-1 ( P < or= 0.027 ), ICAM-1 ( P < or= 0.016 ), IL-1beta ( P = 0.016 ), and IL-6 ( P = 0.041 )
Evans et al., J Leukoc Biol 1992 (Rhabdomyosarcoma) : Tumor cell IL-6 gene expression is regulated by IL-1 alpha/beta and TNF alpha : proposed feedback mechanisms induced by the interaction of tumor cells and macrophages
Hideshima et al., Semin Oncol 2001 (Multiple Myeloma...) : Tumor necrosis factor-alpha (TNF-alpha) , which is produced by some MM cells, induces only low-level MM proliferation and MAPK activation in MM cells, but markedly upregulates IL-6 secretion from BMSCs and upregulates expression of adhesion molecules ( VLA-4 and LFA-1 ) on MM cells and their receptors ( VCAM-1 and ICAM-1 ) on BMSCs, with resultant increased binding of MM cells to BMSCs. Inhibition of TNF-alpha induced NF-kappaB activation with PS-341 inhibits both the upregulation of these molecules on MM cells and BMSCs and the resultant increased adhesion
Baykal et al., Clin Rheumatol 2003 (Familial Mediterranean Fever) : In FMF patients IL-6 , TNF-alpha , sIL-2r, ESR, CRP and fibrinogen levels increased with the acute-phase reaction, especially in the attack period
Lozanski et al., J Rheumatol 1992 (Lymphoma, Large B-Cell, Diffuse) : In contrast, flurbiprofen completely abolished IL-6 production by both cell lines and substantially inhibited IL-1 beta and TNF alpha production
Bachwich et al., Biochem Biophys Res Commun 1986 : Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages ... We have investigated the effect of tumor necrosis factor on the release of interleukin-1 and PGE2 from murine resident peritoneal macrophages ... Tumor necrosis factor causes an increase in the production of interleukin-1 and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M
Pituch-Noworolska et al., Haematologia (Budap) 1998 (Leukemia-Lymphoma, Adult T-Cell...) : The synthesis of IL-6 was significantly enhanced by TNF-alpha in BMMC and ALL-T while the presence of TNF-alpha had no effect on IL-6 synthesis in the culture of cALL leukemic cells
Holden et al., Br J Pharmacol 2007 : Similarly, H ( 3 ) and H ( 4 ) receptor agonists did not affect TNFalpha induced NF-kappaB dependent transcription, or IL-6 and IL-8 release at concentrations below 10 microM
Boelen et al., J Endocrinol 1997 (Euthyroid Sick Syndromes) : The LPS induced release of cytokines was affected by previous immunoneutralization as compared with control experiments with normal immunoglobulin ( IgG ) : anti-IL-1R did not affect serum TNF alpha but decreased serum IL-6, anti-TNF alpha decreased serum TNF alpha but not IL-6, anti-IL-6 did not affect serum TNF alpha but hugely increased IL-6 and anti-IFN gamma decreased both serum TNF alpha and IL-6
Carow et al., PLoS Pathog 2013 : Instead, SOCS3 expression in infected macrophages and DCs prevented the IL-6 mediated inhibition of TNF and IL-12 secretion and contributed to a timely CD4+ cell dependent IFN-? expression in vivo
Nash et al., Mol Cell Endocrinol 1992 : TNF alpha also induced secreted IL-6 to levels above that spontaneously secreted at all time points from 5 h to 48 h. Levels of common glycoprotein alpha-subunit and follicle stimulating hormone-beta ( FSH beta ) subunit mRNA were unaffected by TNF alpha ... We conclude that TNF alpha can regulate both GH and IL-6 synthesis in dispersed ovine pituitary cells
Kamitani et al., J Immunol 2011 : Using small interfering RNA mediated KAP1 knockdown, we found that endogenous KAP1 negatively regulated TNF-a induced IL-6 production in HeLa cells
Ammit et al., Am J Respir Cell Mol Biol 2000 : Tumor necrosis factor-alpha induced secretion of RANTES and interleukin-6 from human airway smooth-muscle cells ... Pretreatment of HASM with prostaglandin ( PG ) E ( 2 ), forskolin, or dibutyryl cAMP inhibited TNF-alpha induced RANTES secretion but increased TNF-alpha induced IL-6 secretion ... Reverse transcriptase/polymerase chain reaction and ribonuclease protection assays suggested that these opposite effects of increased [ cAMP ] ( i ) on TNF-alpha- induced IL-6 and RANTES secretion may occur at the transcriptional level ... Together, our data suggest that TNF-alpha induced IL-6 and RANTES secretion may be associated with NF-kappaB activation, and that inhibition of TNF-alpha stimulated RANTES secretion and augmentation of IL-6 secretion by increased [ cAMP ] ( i ) in HASM cells occurs via an NF-kappaB independent mechanism
De Bosscher et al., Proc Natl Acad Sci U S A 2005 (Inflammation) : We demonstrate that CpdA exerts an antiinflammatory potential by down modulating TNF induced proinflammatory gene expression, such as IL-6 and E-selectin, but, interestingly, does not at all enhance glucocorticoid response element-driven genes or induce GR binding to glucocorticoid response element dependent genes in vivo
Bouchelouche et al., Urology 2006 : TNF-alpha and IL-1beta ( 0.01 to 100 ng/mL ) induced secretion of IL-8, IL-6 , and RANTES in a dose and time dependent manner
Julen et al., Mol Immunol 1992 : Its in vivo effect on C3 secretion might be secondary to the TNF-alpha induced release of IL-1 and/or IL-6
Fan et al., Respir Res 2009 : For both NCI-H292 and NHBE cells, low arginine concentrations enhanced basal epithelial IL-6 and IL-8 production and synergized with TNF-alpha induced IL-6 and IL-8 production
Vanden Berghe et al., Biochem Pharmacol 2000 : Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6 ... NF-kappa B is the exclusive transcription factor for induction of the IL-6 gene in response to TNF and functions as the final trigger to activate a multiprotein complex, a so-called ` enhanceosome ', at the level of the IL-6 promoter ... However, activation of NF-kappa B alone is not sufficient for IL-6 gene induction in response to TNF , as inhibition of the coactivated extracellular signal regulated kinase and p38 MAPK pathways blocks TNF mediated gene expression
Schopka et al., J Biomed Mater Res B Appl Biomater 2009 : Analyzing functional properties of cells directly adhered to biomaterial revealed nonproliferative cells, which were capable of inflammatory stimulation in terms of TNF induced increase in interleukin-6 secretion and adhesion of inflammatory cells
Russell , Crit Care Med 2003 (Genetic Predisposition to Disease...) : Tumor necrosis factor-alpha , interleukin-1, and interleukin-6 increase tissue factor and inhibit fibrinolysis, thereby activating the extrinsic pathway
Blanque et al., Drugs Exp Clin Res 1997 : In human osteoblastic cells ( SaOS2 ) both basal and TNF alpha stimulated IL6 production were inhibited in a concentration related manner by SK & F 86002 but not by indomethacin
Mahieu et al., Blood 1994 : Some of them displayed a marked reduction of tumor necrosis factor (TNF) induced IL-6 production
Wang et al., Inflamm Res 2011 : Tumor necrosis factor-a induces expression and release of interleukin-6 by human urothelial cells ... We examined the effects of tumor necrosis factor-a (TNF-a) on expression and release of interleukin-6 (IL-6) by human urothelial cells ( HUCs ) and investigated whether the effects of TNF-a are mediated by mitogen activated protein kinase ( MAPK ) pathways ... The effects of selective blockers of MAPK pathways on TNF-a induced IL-6 expression and release were determined ... TNF-a increased IL-6 mRNA expression and stimulated release of IL-6 in a concentration- and time dependent manner ... TNF-a induced phosphorylation of ERK1/2 and JNK, and TNF-a induced IL-6 expression and release were inhibited by selective ERK1/2 and JNK blockers ... Also, the ERK1/2 and JNK pathways are involved in TNF-a induced expression and release of IL-6 in HUCs and may represent therapeutic targets in inflammatory urinary tract diseases
Ward et al., J Surg Res 2011 (Tissue Adhesions) : Enzyme linked immunoassay ( ELISA ) was used to evaluate interleukin-6 (IL-6) expression in response to IL-1ß and tumor necrosis factor-a (TNF-a) stimulation in vitro to validate MK2 kinase inhibition
Castelli et al., Cancer Res 1994 (Melanoma) : In addition, IL-1 alpha and IL-6 were negatively regulated by soluble IL-6 and TNF-alpha
Stachon et al., Prostate 2001 (Prostatic Hyperplasia) : The IL-6 secretion of HPEC was stimulated by VEGF and TNF-alpha , but not by ATP and bradykinin
Hess et al., J Immunol 1995 : A striking similarity to the requirements for TNF induced IL-6 production, which is mediated by the p55TNF receptor in SV80 cells, was observed
Zhang et al., Proc Natl Acad Sci U S A 1988 : TNF , IL-1, and forskolin all stimulated interleukin 6 (IL-6) mRNA levels in FS-4 cells ... In addition, our data on IL-6 induction by TNF and IL-1 suggest that other, yet unidentified, signal transduction mechanisms contribute to TNF and IL-1 actions on gene expression in human fibroblasts
Kelchtermans et al., Arthritis Res Ther 2009 (Arthritis, Experimental) : IL-17 and TNF-alpha synergistically induced granulocyte chemotactic protein-2 ( GCP-2 ), IL-6 and receptor activator of NFkappaB ligand ( RANKL ) in MEF
Benigni et al., J Immunol 1996 : Finally, we investigated the role of p55 and p75 in IL-6 induction by TNF in a murine brain endothelioma ... These data indicate that p55 plays a major role in TNF activation of the hypothalamus-pituitary-adrenal axis and in the centrally mediated induction of peripheral IL-6 by TNF , but p75, despite having little IL-6 inductive properties by itself, seems to potentiate p55 induction of IL-6
Isumi et al., Biochem Biophys Res Commun 1998 (Inflammation) : Furthermore, AM remarkably potentiated stimulatory effects of tumor necrosis factor-alpha , IL-1 beta and lipopolysaccharide on IL-6 production
Xu et al., Rheumatology (Oxford) 2007 (Arthritis, Rheumatoid) : The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate ( PDTC ), a chemical inhibitor of NF-kappaB ... TNF-alpha induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha
Fernandez et al., Cell Immunol 2001 : We recently found that CGRP induces IL-6 and TNF-alpha in long-term bone marrow cultures and that IL-6 and TNF-alpha also inhibit IL-7 responses
Carter et al., Vet Immunol Immunopathol 1999 (Arthritis, Rheumatoid...) : Analysis of synovial fluids from dogs with osteoarthritis ( OA ) and rheumatoid arthritis ( RA ) showed that IL-1 and TNFalpha bioactivity was not readily detectable at increased levels in diseased joints but that IL-6 was significantly increased in both diseases
Nezu et al., Am J Vet Res 2008 (Reperfusion Injury) : Compared with the control group, serum IL-6 activity increased significantly after 180 minutes of reperfusion in the I-R group ; also, jejunal TNF-alpha mRNA expression increased significantly after 60 ( peak ) and 180 minutes of reperfusion
Xu et al., Int J Tuberc Lung Dis 2008 : Our study demonstrated that after stimulation of alveolar macrophages by Mce4E protein for 48 h, the expression of TNF-alpha was induced , with an enhanced IL-6 mRNA level ( P < 0.05 ) and no changes in IL-12 expression in the macrophages
Huang et al., Int J Cardiol 2009 (Atherosclerosis) : Metformin inhibits TNF-alpha induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K dependent AMPK phosphorylation ... The effects of metformin on TNF-alpha induced IL-6 production were investigated ... TNF-alpha increased IL-6 secretion by HUVEC in a dose dependent manner but inhibitors of NF-kappaB abolished the TNF-alpha induced IL-6 production ... Pre-treatment with metformin ( 100-1000 micromol/L ) also inhibited TNF-alpha induced IL-6 production, phosphorylation of IkappaB kinase (IKK) alpha/beta and IkappaB-alpha degradation ... AICAR, a direct AMPK activator, had inhibitory effects on TNF-alpha induced IL-6 production, similar to that of metformin ... Transfection of siRNA against alpha1-AMPK eradicated the inhibitory effects of metformin on TNF-alpha induced IL-6 , implying the essential role of AMPK ... Metformin had anti-inflammatory effects on endothelial cells and inhibited TNF-alpha induced IKKalpha/beta phosphorylation, IkappaB-alpha degradation and IL-6 production in HUVEC
Vasilescu et al., Eur Surg Res 1996 : Our results indicate that the leukocyte derived production of IL-6 and IL-1 beta in whole blood is stimulated directly by endotoxin and is not mediated by TNF alpha
Yarovinsky et al., J Immunol 2003 (Adenovirus Infections, Human...) : Decreased production of IL-6 and KC in response to exogenous TNF-alpha , in addition to protection from TNF-alpha, suggested that adenoviral infection results in TNF-alpha tolerance
Guo et al., Free Radic Biol Med 2008 : CH3-Avn-c, a synthetically prepared methyl ester derivative of Avn-c with a high biological potency, significantly and dose dependently decreased mRNA expression and secretion of IL-6 , IL-8, and MCP-1 by HAEC as determined by real-time RT-PCR and ELISA, and it inhibited IL-1beta- and TNFalpha stimulated NF-kappaB activation as determined by a NF-kappaB DNA binding assay and a NF-kappaB luciferase reporter assay
Mayne et al., Ann Neurol 1999 (Multiple Sclerosis) : Conversely, treatment of PBMCs with the adenosine A1 receptor agonist R-phenylisopropyladenosine (R-PIA) ( 1 microM ) significantly inhibited mitogen stimulated production of TNF alpha but not IL-6 in control subjects and significantly inhibited production of IL-6 but not TNF alpha in MS patients
Kim et al., Cell Immunol 1990 : The studies suggest that IL-1, IL-4, or TNF-alpha mediate a proliferative signal on murine thymocytes independent of IL-6 and that the proliferative signals provided by these cytokines as well as IL-6 are inhibitable by rHu TGF-beta 1
Hettmannsperger et al., J Invest Dermatol 1992 (Psoriasis) : Unstimulated HDMEC did not produce significant amounts of IL-6, whereas lipopolysaccharide (LPS), TNF , and IL-1 beta were potent inducers of HDMEC derived IL-6 production ... In contrast, LPS and TNF induced prolonged stimulation of IL-6 production by HDMEC as IL-6 mRNA transcripts were still detected after 24 h treatment and IL-6 protein was markedly increased at this timepoint
Wang et al., Invest Ophthalmol Vis Sci 2012 : TNF-a significantly increased the expression of IL-6 , IL-8, and MCP-1 in ARPE-19 cells at both the protein and mRNA levels
Trujillo et al., J Clin Endocrinol Metab 2006 (Obesity) : In contrast, inhibition of p38 MAPK only partially blocked the effect of TNF on IL-6 production
Gambhir et al., Invest Ophthalmol Vis Sci 2012 (Diabetes Mellitus, Experimental...) : TNF-a increased the expression and secretion of IL-6 and Ccl2 in ARPE-19 cells ... In contrast, GPR109A ligands failed to suppress TNF-a induced expression and secretion of IL-6 and Ccl2 in primary RPE cells from Gpr109a ( -/- ) mice, confirming that the observed anti-inflammatory effects were mediated specifically by Gpr109a
Pollard et al., Cell Microbiol 2004 : In an in vitro culture system, the inflammatory response of macrophages to these two different strains of P. aeruginosa was divergent at the protein level, with higher IL-6 and tumour necrosis factor (TNF)-alpha production generated in response to strain P1 and higher IL-1 beta production in response to strain Fc808. Interaction of macrophages with these two bacterial strains induced distinct gene expression patterns as detected by gene array analysis, with prominence of genes encoding pro-inflammatory cytokines, surface receptors, transcription factors and proteins involved in phagocytosis
Berman et al., J Invest Dermatol 1992 : PFN failed to inhibit constitutive or TNF alpha induced IL-6 hybridoma proliferative activity, IL-6 protein, or IL-6-specific m-RNA levels
Becher et al., J Clin Invest 1996 : Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro
Blanchard et al., Dig Dis Sci 2000 (Acute Disease...) : CAPAN-1 cells had concentration dependent production of IL-6 and IL-8 in response to both endotoxin and TNF-alpha ... CAPAN-2 cells had concentration dependent production of IL-6 and IL-8 in response to TNF-alpha
Lin et al., PloS one 2013 : Knocking down WWP1 enhanced the TNF-a and IL-6 production induced by LPS, and over-expression of WWP1 inhibited the TNF-a and IL-6 production induced by LPS, but not by TNF-a
Klausen , Dan Med Bull 1998 : The other proinflammatory cytokines IL-1 beta, and TNF alpha remained unchanged, and the increased serum IL-6 did not induce production of c-reactive protein
Hehlgans et al., J Interferon Cytokine Res 2001 (Anoxia) : Hypoxic upregulation of TNF receptor type 2 expression involves NF-IL-6 and is independent of HIF-1 or HIF-2
Stecenko et al., Inflammation 2001 (Cystic Fibrosis...) : Finally, when CF cells were grown at 27 degrees C ( a culture condition which results in transport of CF transmembrane conductance regulator, CFTR, to the cell membrane and normalization of chloride conductance ) TNFalpha stimulated production of IL-6 and IL-8 reverted to normal
Nakayama et al., Cell Biol Int 2004 (Osteosarcoma) : We used RT-PCR to examine the effects of TNF-alpha on bone sialoprotein ( BSP ), core binding factor a1 (Cbfa1), osterix, alpha 1 ( I ) collagen, cyclooxygenase-2 (COX-2), interleukin-6 (IL-6) , cathepsin B, cathepsin L and tissue inhibitors of metalloproteinase-1 ( TIMP-1 ) ... TNF-alpha ( 10ng/ml ) increased BSP, IL-6 and COX-2 mRNA levels after 3h, reaching maximal levels at 12 h. Cbfa1 mRNA levels increased after 3 h, but decreased by 24 h. Osterix, cathepsin B, cathepsin L and TIMP-1 mRNA levels did not change after stimulation with TNF-alpha
Ma et al., J Pharmacol Sci 2012 : We also demonstrated that pretreatment of cells with this compound prevented TNF-a induced expression of NF-?B target genes, such as interleukin 6, interleukin 8, monocyte chemotactic protein 1, cyclooxygenase-2 and inducible nitric oxide
Koubovec et al., Mol Cell Endocrinol 2004 : We show that MPA, like dexamethasone ( dex ), significantly represses tumour necrosis factor (TNF) stimulated interleukin-6 (IL-6) protein production in mouse fibroblast ( L929sA ) cells
Tomita et al., Gene Ther 2000 (Glomerulonephritis) : Therefore, we examined the effect of NFkappaB decoy ODN transfection on TNF-alpha induced endogenous interleukin (IL)-1alpha, IL-1beta, IL-6 , ICAM-1 and VCAM-1 gene expression as assessed by RT-PCR and Northern blotting
Jeevanandam et al., Nutrition 1999 (Wounds and Injuries) : The plasma levels of TNF-alpha and IL-1 beta in trauma patients are not significantly different from those in healthy volunteers, but plasma IL-6 levels are significantly increased ( five times ) in severely injured patients
Reittie et al., Leukemia & lymphoma 1996 (Leukemia, Lymphocytic, Chronic, B-Cell) : Spontaneous IL-6 protein release was enhanced in the presence of TNF ( 100 U/ml and 250 U/ml ) by CLL cells at 48 hours of culture 143.6 % and 172 % ( p < 0.05, n = 6 ) ... IL-6 ( 100 U/ml or greater ) increased spontaneous DNA synthesis ( 3H-TdR uptake ) but, in the presence of high concentrations of TNF-alpha, inhibited TNF induced DNA synthesis in a dose dependent manner
Brouckaert et al., Lymphokine Res 1989 : We have observed a marked species specificity in the in vivo antitumor, shock inducing and Interleukin-6 (IL-6) inducing activities of human recombinant TNF ( hrTNF ) versus murine rTNF ( mrTNF ) in mouse models
Frering et al., J Thorac Cardiovasc Surg 1994 (Heart Diseases) : A local production of these cytokines can not be excluded, because interleukin-6 and interleukin-8 are produced by stimulated macrophages and monocytes in response to tumor necrosis factor-alpha and interleukin-1 beta
Nasu et al., Arch Pathol Lab Med 1998 (Endometrial Neoplasms...) : Interleukin-1beta, ( 100 pmol/L ), tumor necrosis factor-alpha ( 1 nmol/L ), and lipopolysaccharide ( 1 microg/mL ) each increased the release of IL-6 , IL-8, and monocyte chemoattractant protein-1 by MaMi cells
Schnyder et al., Cytokine 2005 : This inhibitory activity of IL-17 ( IC50=0.2 ng/ml ) was 6-fold more potent than its stimulatory activity on TNF-alpha induced IL-6 secretion ( ED50=1.2 ng/ml ), measured in the same cells
Lisi et al., J Autoimmun 2010 (Sjogren's Syndrome) : The gene silencing technique was used to study the AREG-TNF-alpha-IL-6/IL-8 secretion pathway, demonstrating that : ( i ) TNF-alpha gene silencing provokes a significant decrease of proinflammatory cytokines production and AREG expression in anti-Ro/SSA Abs treated healthy SGEC ; ( ii ) AREG gene silencing has a potent inhibitory effect on TNF-alpha induced IL-6 and IL-8 secretion in healthy SGEC treated with anti-Ro/SSA Abs ... These findings indicate that TACE mediated AREG shedding plays a critical role in TNF-alpha induced IL-6 and IL-8 secretion by the human healthy salivary gland epithelial cells, suggesting that this may be one of the possible intracellular mechanisms involved in the salivary glands inflammatory response in Sjögren 's syndrome
Montfort et al., J Immunol 2009 (Listeriosis...) : Of particular interest, TNF induced expression of cytokines/chemokines, such as IL-6 and CXCL-2, was impaired in FAN-deficient cells
Van Bladel et al., Cytokine 1991 (Carcinoma, Hepatocellular...) : We have studied the effect of interleukin-6 (IL-6) on the binding of tumor necrosis factor (TNF) to various cell lines
Goldbach et al., Eur J Pharmacol 1997 : The results demonstrate that TNF-alpha is a much stronger inducer of fever and interleukin-6 production or of HPA-axis activation than TNF-beta in so far as all the investigated responses can be measured for prolonged time in response to TNF-alpha
Hedges et al., Int J Antimicrob Agents 1994 : Uroepithelial cells also respond to stimulation by cytokines ; IL-1alpha and TNFalpha induce the secretion of IL-6 and IL-8 and the upregulation of mRNAs for IL-1alpha, IL-1beta, IL-6 and IL-8
Matsunaga et al., Mol Med Report 2012 : ?-Tocotrienol attenuates TNF-a induced changes in secretion and gene expression of MCP-1, IL-6 and adiponectin in 3T3-L1 adipocytes ... ?-tocotrienol effectively improved the TNF-a induced adverse changes in MCP-1, IL-6 and adiponectin secretion, and in MCP-1, IL-6 , adiponectin and PPAR? mRNA expression
Cheon et al., J Rheumatol 2004 (Arthritis, Rheumatoid...) : When RA FLS are stimulated with interleukin 1 or tumor necrosis factor-a , WISP3 mRNA is significantly increased
Szeto et al., J Steroid Biochem Mol Biol 2007 : Consistently, induction of IL-6 by TNFalpha or IL-1beta was much more robust in VDR ( -/- ) than in VDR ( +/- ) cells, indicating that VDR ( -/- ) cells are more susceptible to inflammatory stimulation
Ho et al., Shock 2009 (Acute Disease...) : Intravenous LPS ( 10-50 mg/kg ) dose-dependently increased plasma endotoxin and reactive oxygen species in the blood, bile, and liver and increased plasma alanine aminotransferase and aspartate aminotransferase levels as well as TNF-alpha , monocyte chemoattractant protein 1, tissue inhibitor of metalloproteinase 1, IL-1beta, and IL-6 levels in the rats
Yamagishi et al., J Mol Cell Cardiol 2004 : Pigment epithelium derived factor inhibits TNF-alpha induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase mediated reactive oxygen species generation ... PEDF inhibited TNF-alpha induced expression of IL-6 at both mRNA and protein levels ... The results demonstrated that PEDF inhibited TNF-alpha induced NF-kappaB activation and subsequent IL-6 overexpression in HUVEC by suppressing NADPH oxidase mediated ROS generation
Qiu et al., Zhongguo Yao Li Xue Bao 1999 : SMT inhibited LPS induced nitric oxide release and increased IL-1 beta and IL-6 secretions in AM, but the TNF alpha levels remained unchanged
Wang et al., Pflugers Arch 2006 (Inflammation) : In contrast, TNF-alpha induced rapid and substantial increases in expression of the genes encoding IL-6 , MCP-1, NGF and TNF-alpha itself ; IL-6 and TNF-alpha mRNA levels peaked at 2 h with 75-fold and 600-fold increases, respectively ... The adipokine secretion pattern largely paralleled cellular mRNA levels ; IL-6 ( transiently ), MCP-1, NGF and VEGF release were stimulated by TNF-alpha , with an accelerating rate of MCP-1 secretion over 24 h. TNF-alpha has rapid and substantial effects on the synthesis of key inflammation related adipokines in human adipocytes, with highly gene-specific responses
Blasi et al., Infect Immun 1994 : Moreover, pretreatment of macrophages with recombinant TNF for 3 h enhances TNF and induces interleukin-1 production in response to both forms of Candida, while pretreatment for 18 h renders macrophages refractory to any stimuli
Zhang et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2011 : [ Signal transduction pathway for TNF induced IL-6 release from mast cells ] ... To investigate the effect of TNF on release of IL-6 , IL-10 and histamine from mast cells and to explore its potential signal transduction pathway ... Pretreatment of PD98059 or U0126 inhibited TNF induced IL-6 release and ERK phosphorylation in P815 cells ( P < 0.05 ), whereas pretreatment of SB203580 or AG490 hardly affect IL-6 release, with little effect on phosphorylation of p38 and STAT3 respectively ... TNF induced IL-6 release from P815 cells may involve activation of ERK signalling pathway
Durando et al., Am J Vet Res 1994 (Toxemia) : In contrast, compared with effects of endotoxin given without pretreatment, use of antiserum was associated with significantly ( P < 0.05 ) higher respiratory rate, maximal plasma IL-6 activity, and total TNF response ( as determined by areas under curves of plasma TNF vs time )
Dudley et al., J Clin Endocrinol Metab 1992 : Interleukin 1 ( alpha and beta ) and tumor necrosis factor (TNF) all induced a significant concentration dependent stimulation of IL-6 production by decidual cells
Neumark et al., Immunol Lett 2002 (Adenocarcinoma...) : The expression of MCP-1, IL-6 and MMPs in both DA3-high and CSML-high cells was up-regulated by tumor necrosis factor alpha (TNFalpha)
Elbaz et al., J Clin Invest 1991 (Acute Disease...) : The TNF effect does not occur at 0 degrees C and can not be induced by IL-2, IL-6 , or GM-CSF
Ensor et al., Am J Physiol 1994 (Fever) : Our results show that IL-6 expression persisted at incubation temperatures in the upper end of the physiological range that induced heat shock and attenuated the expression of functionally active TNF-alpha in LPS stimulated HuMoM phi
Tanida et al., Cytokine 2009 (Arthritis, Rheumatoid) : Although IL-6 failed to induce CCL20, TNF-alpha induced IL-6 enhanced the production of CCL20 in an autocrine/paracrine manner
Hardyman et al., J Allergy Clin Immunol 2013 (Asthma) : TNF-a lowered transepithelial electrical resistance and increased fluorescent dextran permeability, caused loss of occludin and claudins from tight junctions with redistribution of p120 catenin and E-cadherin from adherens junctions, and also increased endogenous TNF-a, IL-6 , IL-1ß, IL-8, thymic stromal lymphoprotein, and pro-matrix metalloprotease 9 release
Delomenie et al., Exp Cell Res 1993 : IL-6 production by HEC was significantly increased only in the presence of IL-1 beta, TNF alpha, or MECIF activity
Dumas et al., Bioorg Med Chem Lett 2002 (Arthritis) : This compound is orally active in two acute models of cytokine release ( TNF induced IL-6 and LPS induced TNF ) and a chronic model of arthritis ( 20-day murine collagen induced arthritis )
Sawada et al., Brain Res 1992 : TNF alpha induces IL-6 production by astrocytes but not by microglia
Nath et al., J Biol Chem 1999 : IL-1beta and IL-6 production were independent of tumor necrosis factor-alpha production
Taranta et al., Bone 2002 : Furthermore, both compounds were able to inhibit tumor necrosis factor (TNF)-alpha induced IL-1beta, but not IL-6 , increase
Pailla et al., JPEN J Parenter Enteral Nutr 1998 : Hepatocyte monolayers were incubated for 6 hours, with either KIC or octanoic acid ( 1 mmol/L ), in the presence of glucagon and TNF-alpha ( 25 micro/L ) IL-6 ( 15 microg/L ) and/or IL-6
Asschert et al., Int J Cancer 1999 (Ovarian Neoplasms) : Regulation of spontaneous and TNF/IFN induced IL-6 expression in two human ovarian-carcinoma cell lines ... The CAOV-3 cell line spontaneously secreted IL-6 , which was enhanced by tumor necrosis factor-alpha ( 877 +/- 89 vs. 8,452 +/- 1,762 pg/ml, x +/- sd, p < 0.01 )
Gastl et al., Int J Cancer 1993 : LPS, IL-1 alpha, and TNF-alpha strongly enhanced the release of IL-6 by RCC cells, but only marginally affected IL-10 production in colon-carcinoma cells
Hennig et al., Metabolism 2000 : In contrast, cellular preenrichment with 18 : 0, 18 : 1, or 18 : 3 had no effect on TNF-alpha mediated production of IL-6
Gómez et al., Mech Ageing Dev 2006 : Our results indicate that the serum from aged rats significantly impairs the capacity of young macrophages to induce tumor necrosis factor-alpha (TNF-alpha) production, while at the same time it increases the basal levels of interleukin-6 (IL-6)
Lin et al., Crit Care Med 2003 (Hyperoxia) : Endogenous nitric oxide may be an important endogenous inhibitor of hyperoxia + tumor necrosis factor-alpha induced leukocyte recruitment and subsequently tumor necrosis factor-alpha, interleukin-1 beta, and GRO/CINC-1 release
Thorgersen et al., Infect Immun 2013 (Inflammation...) : Interleukin-6 (IL-6) was significantly inhibited in all organs, IL-1ß and IP-10 were significantly inhibited in liver, spleen, and kidneys, and tumor necrosis factor , IL-8, and PAI-1 were inhibited only in the spleen
Andoh et al., Biochim Biophys Acta 2002 : In human pancreatic myofibroblasts, interleukin (IL)-17 markedly enhances tumor necrosis factor (TNF)-alpha induced IL-6 secretion through the induction of IL-6 mRNA stabilization
Okamura et al., J Biol Chem 1991 : Endogenous basic fibroblast growth factor dependent induction of collagenase and interleukin-6 in tumor necrosis factor treated human microvascular endothelial cells ... In the present study, we have examined whether the TNF-alpha induced synthesis of IL-6 or collagenase in HOME cells is mediated by an inducible growth factor
Choi et al., Rheumatol Int 2010 : The level of IL-6 expression was strongly increased in both FLSs and THP-1 macrophages in response to IL-1beta and TNF-alpha , but the level by TNF-alpha was less than that by IL-1beta
Li et al., J Oral Pathol Med 1996 (Mouth Diseases...) : In contrast, both cell types produced IL-6 in response to TNF alpha , IFN gamma or IL-4, and IFN gamma and IL-4 exhibited synergy with TNF alpha
Lee et al., Curr Eye Res 2013 : Purpose : To investigate the effects of rapamycin on the TNF-a induced secretion of interleukin-6 (IL-6) and IL-8 in orbital fibroblasts and its possible mechanism ... Results : Rapamycin significantly enhanced TNF-a induced IL-6 and IL-8 secretion from orbital fibroblasts ... Down-regulation of PDCD4 by PDCD4 siRNA transfection reduced TNF-a induced IL-6 and IL-8 secretion from orbital fibroblasts ... Conclusion : Rapamycin enhances the TNF-a induced secretion of IL-6 and IL-8 by suppressing PDCD4 degradation in orbital fibroblasts
Ichiyama et al., Inflamm Res 2004 : Moreover, the inhibitory effects of IVIG on IkappaBalpha degradation, interleukin-6 (IL-6) production, and E-selectin expression induced by TNF-alpha were evaluated by Western blot analysis, ELISA, and flow cytometry, respectively ... Moreover, IVIG inhibited IkappaBalpha degradation, IL-6 production, and E-selectin expression induced by TNF-alpha in CAEC
Rabinovici et al., Circ Res 1996 : Furthermore, TNF-alpha inhibition prevented the upregulation of lung tissue IL-1 beta, IL-6 , cytokine induced neutrophil chemoattractant, and E-selectin ( ELAM-1 ) but not intercellular adhesion molecule-1 mRNAs in response to IL-2
Morgan et al., J Rheumatol 2004 (Arthritis, Experimental) : In vitro tumor necrosis factor-alpha (TNF-alpha) , interferon-gamma (IFN-gamma), and interleukin 6 (IL-6) responses were detected during reactions to most antigens tested, while IL-4 responses were absent
Costa et al., Pharmacol Res 2010 : In human macrophages THP-1, treatment with different cytokines was able to stimulate by about 3-folds the release of IL-6 and Manidipine 1 microM showed a 25 % inhibition on TNF-alpha induced IL-6 secretion
Hessle et al., Inflammation 2003 (Inflammation) : We have seen that Gram-positives preferentially induce IL-12 and TNF-alpha , whereas Gram-negatives induce more IL-10, IL-6 , and IL-8
Walker et al., J Immunol 1992 (Mycobacterium Infections) : The effect of in vitro exposure of these cells to the immunizing Ag was also investigated ; again, IL-1, IL-2, TNF , and IFN-gamma mRNA were abundant, but in addition, IL-3, IL-6 , and granulocyte-macrophage colony stimulating factor mRNA were greatly increased , suggesting an important role in the recall response
Ghigo et al., Infect Immun 2001 (Endocarditis, Bacterial...) : First, interleukin-10 suppressed C. burnetii stimulated production of TNF
Hofbauer et al., J Bone Miner Res 1999 : Treatment with 5alpha-dihydrotestosterone ( DHT ) dose-dependently inhibited constitutive and TNF-alpha/IL-1beta stimulated IL-6 mRNA steady-state levels in hFOB/AR-6 cells by 70-80 % at 10-7 M ... In addition, testosterone also suppressed TNF-alpha/IL-1beta stimulated IL-6 mRNA levels by 57 %, while the adrenal androgen dehydroepiandrosterone had no effect
Venkataraman , Cryobiology 1997 : In vitro irradiation had an inconsistent effect on TNF-alpha production by the fresh PBMCs. Taken together, these results suggest that the endogenously hypersecreted TNF-alpha is indirectly responsible for the previously reported elevated IL-1-, IL-6- , and IL-10 secreting capabilities of frozen PBMCs
Murray et al., Circulation 2000 : In myocardium from control animals, neither TNF-alpha nor IL-1beta were detected , whereas IL-6 was present at very low levels
Villiger et al., J Immunol 1991 (HTLV-I Infections) : Furthermore, IL-6 expression in HTLV-1 infected cells was enhanced by stimulation with IL-1 beta or TNF-alpha
Heyninck et al., J Cell Biol 1999 : We show that A20 does not inhibit TNF- induced nuclear translocation and DNA binding of NF-kappaB, although it completely prevents the TNF- induced activation of an NF-kappaB dependent reporter gene, as well as TNF induced IL-6 and granulocyte macrophage-colony stimulating factor gene expression
Xu et al., Arthritis Rheum 2006 (Arthritis, Rheumatoid) : SMV prevented the increase in NF-kappaB activation and rise in IL-1beta and IL-6 levels induced by TNFalpha , whereas mevalonate and geranylgeranyl pyrophosphate reversed the inhibitory effects of SMV on activation of NF-kappaB and RhoA
Hoffmann et al., J Hepatol 1994 : Furthermore, lipopolysaccharide, tumor necrosis factor-alpha , interferon-gamma, interleukin-1 beta and phorbol ester induced interleukin-6 production and, at the same time, suppressed the level of interleukin-6 receptor mRNA
Shi et al., Cell Biochem Biophys 2004 (Atherosclerosis) : We observed constitutive expression of interleukin (IL)-6 , IL-8, granulocyte macrophage colony stimulating factor ( GM-CSF ), and monocyte chemoattractant protein (MCP)-1 in both human and baboon endothelial cells, and these cytokines were further induced by TNF-alpha and LPS
Amrani et al., Mol Pharmacol 2001 : Tumor necrosis factor receptor (TNFR) 1, but not TNFR2, mediates tumor necrosis factor-alpha induced interleukin-6 and RANTES in human airway smooth muscle cells : role of p38 and p42/44 mitogen activated protein kinases ... In contrast, PD98059, a p42/44 inhibitor, reduced ICAM-1 expression by 50 % but had no effect on TNF alpha induced RANTES or IL-6 secretion ... Using receptor-specific blocking antibodies, we found that TNFR1 primarily regulates TNF alpha induced IL-6 and RANTES secretion and activation of p38 and p42/44 MAPK pathways
Palmieri et al., Am J Physiol Heart Circ Physiol 2002 : After 20 min, whereas TNF-alpha expression further increased, IL-6 and IGF-1 levels progressively reduced to values lower than those observed under moderate stretch and in unstretched ( 5 mmHg ) control myocardium ( IL-6 )
Miyazawa et al., Am J Pathol 1998 (Arthritis, Rheumatoid...) : Neither anti-human TNF-alpha nor IL-1 antibody affected spontaneous IL-6 production of these FLS clones, suggesting that IL-6 production of the FLSs was endogenously up-regulated
Zhou et al., Malaria journal 2012 (Malaria, Falciparum) : Unopsonized IE induced secretion of IL-6 ( median= 622 pg/ml [ IQR=1,250-240 ], n=9 ) but no IL-1ß or TNF , whereas PPS opsonized IE induced secretion of IL-1ß ( 18.6 pg/mL [ 34.2-14.4 ] ) and TNF ( 113 pg/ml [ 421-17.0 ] ) and increased IL-6 secretion ( 2,195 pg/ml [ 4,658-1,095 ] )
Wanner et al., Shock 1999 (Inflammation...) : These data indicate that TNF-alpha produced early after liver I/R triggers both its own secretion as well as IL-6 release by KC during reperfusion while the release of IL-1alpha occurs independent from TNF-alpha
Van bezooijen et al., J Bone Miner Res 1999 (Bone Resorption) : In addition, IL-17 increased TNF-alpha induced IL-1alpha, IL-1beta, and IL-6 mRNA expression in fetal mouse metatarsals and IL-1alpha and IL-6 mRNA expression in MC3T3-E1 cells
Shalaby et al., Clin Immunol Immunopathol 1989 (Shock, Septic) : Endotoxin, tumor necrosis factor-alpha and interleukin 1 induce interleukin 6 production in vivo ... The ability of Escherichia coli derived lipopolysaccharide (LPS), recombinant ( r ) interleukin 1-beta ( rIL-1 beta ), and r murine tumor necrosis factor-alpha ( rMuTNF-alpha ) to induce interleukin 6 (IL-6) production in vivo was investigated ... The coinjection of antiserum against rMuTNF-alpha with LPS resulted in a reduction of the induced serum IL-6 level, indicating the involvement of endogenous TNF-alpha in LPS induction of IL-6 ... These data demonstrate the abilities of IL-1 beta and TNF-alpha to induce IL-6 production in vivo and indicate that LPS induction of IL-6 may be mediated, at least partially, through TNF-alpha action
Kralisch et al., FEBS Lett 2005 : Moreover, the thiazolidinedione troglitazone partly reversed TNFalpha- but not IL-6 induced TIMP-1 synthesis
Brown et al., J Immunol 1991 : IL-1 alpha and TNF-alpha are also potent inducers of IL-6 production in these cells, the order of potency being IL-1 alpha greater than Onco M greater than TNF-alpha
Poulsen et al., Cytokine 1996 (Dermatitis, Atopic...) : The combination ION + PMA induced the highest levels of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha , whereas maximal production of IL-6 and TNF-beta were induced by PHA and PHA + PMA, respectively
You et al., J Exp Med 2001 : Modulation of the nuclear factor kappa B pathway by Shp-2 tyrosine phosphatase in mediating the induction of interleukin (IL)-6 by IL-1 or tumor necrosis factor ... Production of interleukin (IL)-6 in response to IL-1 alpha or tumor necrosis factor (TNF)-alpha was nearly abolished in homozygous mutant ( Shp-2 ( -/ ) - ) fibroblast cells ... The targeted Shp-2 mutation has no significant effect on the activation of the three types of mitogen activated protein ( MAP ) kinases, extracellular signal regulated kinase ( Erk ), c-Jun NH ( 2 ) -terminal kinase ( Jnk ), and p38, by IL-1/TNF, indicating that Shp-2 does not work through MAP kinase pathways in mediating IL-1/TNF induced IL-6 synthesis
Andoh et al., Int J Mol Med 2002 (Acute Disease...) : Inhibitory effects of somatostatin on tumor necrosis factor-alpha induced interleukin-6 secretion in human pancreatic periacinar myofibroblasts ... To elucidate the mechanisms mediating the therapeutic actions of somatostatin on acute pancreatitis, we investigated how somatostatin affects the tumor necrosis factor (TNF)-alpha induced interleukin (IL)-6 and IL-8 secretion from pancreatic myofibroblasts ... Somatostatin dose-dependently inhibited the TNF-alpha induced IL-6 secretion ... Northern blot analysis demonstrated that somatostatin decreased the TNF-alpha induced IL-6 mRNA expression, and that this effect was completely blocked by the somatostatin antagonist cyclo-somatostatin ... Somatostatin down-regulated the TNF-alpha induced IL-6 secretion in human pancreatic periacinar myofibroblasts
Simeonova et al., Lab Invest 1999 : Furthermore using cell transfection and mobility shift assays, it was found that transcriptional activation of the IL-8 gene required TNF-alpha induced activation and binding of nuclear factor-kappaB (NF-kappaB)- and NF-IL-6 , nuclear transcription factors to regulatory elements in the IL-8 promoter
Kurokouchi et al., J Bone Miner Res 1998 (Bone Neoplasms...) : TNF-alpha increases expression of IL-6 and ICAM-1 genes through activation of NF-kappaB in osteoblast-like ROS17/2.8 cells ... TNF-alpha also increased the mRNA levels of interleukin-6 (IL-6) and intercellular adhesion molecule-1 ( ICAM-1 ) ... An antioxidant, N-acetyl-L-cysteine, significantly attenuated the TNF-alpha dependent increase in these mRNAs, and simultaneously reduced the activation of NF-kappaB by TNF-alpha, indicating that NF-kappaB mediates the TNF-alpha dependent expression of IL-6 and ICAM-1 in ROS17/2.8 cells
Rieckmann et al., Res Exp Med (Berl) 1995 : TNF-alpha , LT, IFN-gamma and IL-6 mRNAs were detected in patients with active multiple sclerosis, whereas TNF-alpha, IL-6 , and endothelin-1 mRNA expression was found frequently in patients with HIV encephalitis
Danis et al., Clin Exp Immunol 1991 : Effects of granulocyte-macrophage colony stimulating factor ( GM-CSF ), IL-2, interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and IL-6 on the production of immunoreactive IL-1 and TNF-alpha by human monocytes ... The effects of GM-CSF, IL-2, IFN-gamma, TNF-alpha and IL-6 on the production of IL-1 ( both secreted and cell associated ) and TNF-alpha by peripheral blood monocytes were studied
Hu et al., J Investig Dermatol Symp Proc 2007 : This study investigated the effects of murine p75-Fc, a soluble TNF receptor protein, on TNF induced IL-6 production in mice ... Mice treated with 5 and 15 mg/kg murine p75-Fc demonstrated complete inhibition of TNF induced IL-6 production ... Murine p75-Fc ( 1.5 mg/kg ) resulted in a partial but significant reduction of TNF induced IL-6 production ... In conclusion, murine p75-Fc completely inhibits TNF induced IL-6 production in mice
Grimble et al., Z Ernahrungswiss 1998 (Arthritis, Rheumatoid...) : We have found that the total C18 : 2 and 20 : 4 diacyl species of phosphatidylethanolamine in peritoneal macrophages relates in a positive curvilinear fashion with dietary linoleic acid intake ; that TNF induced IL1 and IL6 production relate in a positive curvilinear fashion to linoleic acid intake ; that leukotriene B4 production relates positively with dietary linoleic acid intake over a range of moderate intakes and is suppressed at high intakes, while PGE2 production is enhanced
Maeda et al., J Invest Dermatol 2003 : Among T helper 1 cytokines, interleukin-4 mediated suppression of tumor necrosis factor-alpha was not affected by terfenadine, which, however, markedly restored mRNA expression of interferon-gamma or interleukin-2
Deakin et al., Cytokine 1995 : These results indicate that NO can differentially modulate LPS and IFN-gamma induced cytokine release from J774 cells, up-regulating TNF-alpha but down regulating IL-6 , and that NO is cytotoxic to these cells
Jana et al., J Neurochem 2003 : Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophages
Asschert et al., Int J Cancer 1999 (Ovarian Neoplasms) : IL-6-promoter activity was enhanced by TNF-alpha irrespective of the presence of an AP-1 binding site, while the degree of activation differed in the various clones, being most pronounced in the m-175 and m-248 clones
Mong et al., J Immunol 2008 (Pneumonia) : Activation of Rho kinase was required for JNK dependent IL-6 secretion induced by TNF-alpha
Lee et al., Mol Cell Biol 2003 (MAP Kinase Signaling System) : We found TNF-alpha induced p38 MAP kinase activation and interleukin-6 (IL-6) production impaired in rip1 ( -/- ) murine embryonic fibroblasts (MEF) but unaffected in traf2 ( -/- ) MEF
Ikeda et al., IUBMB Life 2009 : TNFalpha , but not TPA, increased IL-6 and MCP-1 mRNA levels, Next, we investigated the effects of ligands which activate c/nPKC
Chen et al., J Leukoc Biol 2001 : The results revealed that TNF-alpha up-regulated NO, PGE2, and IL-6 synthesis ; PGE2 up-regulated NO, but down-regulated TNF-alpha synthesis ; and PGE2 and IL-6 mutually up-regulated reciprocally
Benveniste et al., Int J Dev Neurosci 1995 : In this study, we demonstrate that transforming growth factor-beta ( TGF-beta ), interleukin-10 (IL-10) and interleukin-6 (IL-6) inhibit tumor necrosis factor-alpha expression by primary rat astrocytes ... In this study, we demonstrate that transforming growth factor-beta ( TGF-beta ), interleukin-10 (IL-10) and interleukin-6 (IL-6) inhibit tumor necrosis factor-alpha expression by primary rat astrocytes
Judd et al., Am J Physiol 1995 : ZG cells released IL-6 and TNF , and this release was stimulated by lipopolysaccharide, interleukin-1 alpha, interleukin-1 beta, a protein kinase C activator, and a calcium ionophore without affecting intracellular adenosine 3 ', 5'-cyclic monophosphate ( cAMP ) content
Soboslay et al., Clin Exp Immunol 1992 (Dermatitis...) : Peripheral blood mononuclear cells ( PBMC ) from untreated patients produced IL-1 beta, tumour necrosis factor-alpha (TNF-alpha) and IL-6 in response to mitogenic stimulation with phytohaemagglutinin ( PHA ), only low levels of IL-1 beta, IL-2 and TNF-alpha in response to OvAg, but higher amounts of IL-4 and interferon-gamma (IFN-gamma) in response to OvAg than control individuals
Bilej et al., Int Immunol 2006 : Interestingly, our data suggest that TNF contributes , through lectin-saccharide interaction, to the secretion of IL-6 and NO induced by CCF
Nishida et al., Kidney Int Suppl 1999 : Exposure to VLDL, IDL, LDL, or a high concentration of HDL enhanced the secretion of IL-6 , PDGF-AB, and TGF-beta by mesangial cells, whereas TNF-alpha secretion was stimulated by oxidized LDL
Liu et al., J Biol Chem 2012 (Inflammation...) : With cultured vascular smooth muscle cell, angiotensin II, arachidonic acid, and TNF-a markedly induce increased expression of IL-6 and TNF-a mRNAs, all of which were suppressed by inhibiting iPLA ( 2 ) ß activity or expression with bromoenol lactone, antisense oligonucleotides, and genetic deletion, respectively
Straub et al., FASEB J 2000 (Inflammation...) : Bacteria reversed noradrenergic inhibitory effector mechanisms : Under bacteria-free conditions, TNF-alpha secretion was very low and IL-6 secretion was mainly inhibited by alpha2-adrenoreceptor ligation ... In the presence of bacteria, TNF-alpha and IL-6 secretion were high and IL-6 secretion was mainly inhibited by beta-adrenoreceptor ligation
Blenman et al., Clin Immunol 2004 (Lupus Erythematosus, Systemic) : An endotoxicosis model that utilizes LPS and d-galactosamine to induce mortality by TNFalpha/TNFR1 dependent hepatocyte apoptosis was used to assess TNFalpha production, apoptotic signaling, and effects on the production of IL-6 and IL-10 ... NZM2410 was found to be resistant to endotoxicosis and to produce significantly less TNFalpha induced IL-6 and IL-10
Becker et al., J Immunol 1991 (Respirovirus Infections) : However, TNF , IL-1, and RSV, but not IL-6, induced IL-8 and IL-6 mRNA expression by the bronchial epithelial cells suggesting that cytokines produced by RSV infected AM may be more important in modulating the inflammatory response in infection than directly interfering with virus infection/replication of airway epithelium
Kobayashi et al., Brain Res 1997 : Third, TNF stimulates ACTH synthesis in AtT-20 cells, while TNF increases immunoreactive interleukin (IL)-6 release from TtT/GF cells
Calabrò et al., J Vasc Res 2005 : The two new PPAR-gamma agonists and 15d-PGJ2 also inhibited TNF-alpha induced interleukin-6 (IL-6) and monocyte chemoattractant protein-1 ( MCP-1 ) production in supernatants of TNF-alpha stimulated ECs, whereas ciglitazone and DIM-C-pPhCH ( 3 ) did not decrease TNF-alpha induced expression of these two proteins
Siegel et al., Cytokine 1995 (Cachexia) : cA2 inhibited TNF induced mitogenesis and IL-6 secretion by human fibroblasts, TNF priming of human neutrophils, and the stimulation of human umbilical vein endothelial cells by TNF as measured by the expression of E-selectin, ICAM-1 and procoagulant activity
Phillips et al., Thromb Res 1996 (Carcinoma, Hepatocellular...) : TNF-alpha suppresses IL-1 alpha and IL-6 upregulation of C4b binding protein in HepG-2 hepatoma cells
Hooper et al., Thromb Res 1996 (Carcinoma, Hepatocellular...) : TNF-alpha suppresses IL-6 upregulation of protein S in HepG-2 hepatoma cells
Kohno et al., J Rheumatol 2001 : T-614 suppressed TNF-alpha induced production of IL-6 , IL-8, and monocyte chemoattractant protein 1, and also reduced the accumulation of IL-6 and IL-8 mRNA in a concentration dependent manner
Sopasakis et al., Int J Obes Relat Metab Disord 2005 : TNFalpha increased the mRNA levels of TNFalpha itself as well as IL-6 , IL-8, IL-1beta and PAI-1, but not leptin
Gnant et al., Cytokine 2000 : TNF caused increased secretion of IL-6 , IL-8, ICAM-1, and VCAM-1 with little or no additional effect from HT. Increased E-selectin and RANTES levels were observed with TNF and HT only at 24 h after treatment
Wang et al., Biol Pharm Bull 2006 (Carcinoma, Hepatocellular...) : These results suggest that pitavastatin at a low dose ( 0.1 microM ) inhibits NF-kappaB activation and decreases IL-6 production induced by TNF-alpha , and is therefore expected to be a new strategy for treating HCC
Panja et al., Clin Exp Immunol 1995 : LPS, IFN-gamma or TNF-alpha had no effect on spontaneous IL-6 production, and neither resulted in the secretion of IL-1 beta or TNF-alpha
Li et al., J Clin Endocrinol Metab 1992 : These results suggest that trophoblast derived TNF alpha induced IL-6 release and then activated the IL-6-R system in trophoblasts to release hCG ... Collectively, trophoblast derived TNF alpha and IL-1 synergistically regulated the level of IL-6 secreted by trophoblasts, the magnitude of which determined the level of hCG released by activating the IL-6-R system in trophoblasts
Thomas et al., Leukemia & lymphoma 1998 (Multiple Myeloma) : However, the role of monoclonal antibodies, directed against these factors, confirmed the role of TNF-alpha in the IL-6 production by stromal cells, while any IL-1beta intervention was not shown in our co-culture system
Venza et al., J Periodontol 2010 (Chronic Periodontitis...) : These findings showed that : 1 ) in subjects without diabetes and patients with well controlled diabetes, TNF-alpha , CCR5, and CXCR3 may constitute distinctive biomarkers of P-IM; 2 ) poor glycemic control abolished the differences between CP and P-IM regarding the expression of these mediators ; and 3 ) type 2 diabetes affected the expression of TNF-alpha, IL-6 and -8, CCR5, and CXCR3
Kozawa et al., J Biol Chem 1997 : We investigated the mechanism of interleukin-6 (IL-6) synthesis induced by tumor necrosis factor-alpha (TNF) in osteoblast-like MC3T3-E1 cells ... TNF stimulated the synthesis of IL-6 dose dependently in the range between 1 and 30 ng/ml. Staurosporine and calphostin C, inhibitors of protein kinase C ( PKC ), significantly enhanced the TNF induced synthesis of IL-6 ... 1-Oleoyl-2-acetylglycerol, a specific activator of PKC, inhibited the TNF induced IL-6 synthesis ... The TNF induced IL-6 synthesis was significantly enhanced by D-609 ... These results strongly suggest that sphingosine 1-phosphate may act as a second messenger for TNF induced IL-6 synthesis and that TNF autoregulates IL-6 synthesis due to PKC activation via phosphatidylcholine-specific phospholipase C in osteoblast-like cells
Watanabe et al., Br J Anaesth 2013 (Anoxia...) : /st > Sevoflurane suppressed TNF-a induced IL-6 , IL-8, and MCP-1 gene expression and the production of IL-6 and IL-8 in SAEC under anoxia/reoxygenation conditions
Papasian et al., Infect Immun 2002 (Disease Models, Animal...) : In vitro experiments demonstrated a statistically significant, but modest, inhibitory effect of IL-6 on TNF-alpha production by RAW cells stimulated with E. faecalis
Sinclair et al., Spine (Phila Pa 1976) 2011 (Intervertebral Disc Degeneration) : Across all patients, TNF-a induced large, statistically significant increases in NO, PGE2, and IL6 secretion from IVD cells compared with controls ( 60-, 112-, and 4-fold increases, respectively ; P < 0.0001 )
Libert et al., J Immunother (1991) 1991 : Nevertheless, GalN had no influence on TNF clearance or IL-6 induction after mTNF injection ; however, the induced TNF and IL-6 levels were considerably augmented by the GalN cotreatment when a high dose of LPS was injected ( GalN was given as a single injection together with TNF or LPS ) ... Indomethacin and dexamethasone, either of which shows a clear protection against TNF/LPS lethality in normal mice, did not change the clearance of injected mTNF, but both reduced the TNF induced IL-6 levels
Zhang et al., Mol Cell Biol 1990 (Chromosome Deletion) : Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence ... On the basis of these and other experiments, we conclude that TNF and IL-1 apparently activate IL-6 gene expression by closely related mechanisms involving activation of a NF-kappa B-like factor, whereas the pathway of IL-6 induction by forskolin is, in part, different
Adser et al., Acta Physiol (Oxf) 2011 : In conclusion, IL-6 affects exercise induced glycogen use, AMPK signalling and TNF-a mRNA responses in mouse skeletal muscle
Marotte et al., Arthritis Res Ther 2005 (Arthritis, Rheumatoid...) : TNF-alpha induced IL-6 and OPG production by synoviocytes, which was further increased with patient plasma dilutions and inhibited by infliximab
Jourdan et al., Eur Cytokine Netw 1999 (Multiple Myeloma) : The survival activity of TNF-alpha is not affected by anti-IL-6 or anti-gp130 monoclonal antibodies ( mAbs )
Tagashira et al., Fertil Steril 2009 (Endometriosis...) : Interleukin-10 attenuates TNF-alpha induced interleukin-6 production in endometriotic stromal cells ... We examined the effects of TNF-alpha and IL-10 on the expression of IL-6 or IL-8 by real-time RT-PCR and ELISA ... Addition of IL-10 suppressed the expressions of IL-6 induced by TNF-alpha and IL-10 induced the phosphorylation of STAT3 in endometriotic stromal cells ... Interleukin-10 attenuates TNF-alpha induced IL-6 synthesis via NF-kappaB and MAPK pathways in endometriotic cells
Webb et al., J Dent Res 2002 (Osteosarcoma) : Regulation of TNF-alpha induced IL-6 production in MG-63 human osteoblast-like cells ... Therefore, we tested the hypothesis that TNF-alpha induced IL-6 production in MG-63 osteosarcoma cells occurs via the p38 mitogen activated protein kinase ( MAPK ) pathway ... TNF-alpha activated p38 MAPK and stimulated IL-6 secretion by MG-63 cells, and pre-incubation of cells with the p38 MAPK inhibitor abrogated TNF-alpha dependent IL-6 secretion ... Transfection of IL-6 full-length and 5-deletion gene promoter reporter constructs indicated that p38 MAPK activation by TNF-alpha enhanced IL-6 gene expression, and that the p38 MAPK-responsive region resided in the proximal 260-bp segment ... In conclusion, although p38 MAPK activation by TNF-alpha stimulates IL-6 secretion by MG-63 cells, it has opposing effects on c/EBPbeta and NFkappaB activity
Tseng et al., J Cell Physiol 2010 : FAK activation is required for TNF-alpha induced IL-6 production in myoblasts ... TNF-alpha caused concentration dependent increases in IL-6 production ... TNF-alpha mediated IL-6 production was attenuated by focal adhesion kinase ( FAK ) mutant and siRNA ... Our results suggest that TNF-alpha increased IL-6 production in myoblasts via the FAK/PI3K/Akt and NF-kappaB signaling pathway
Tokuda et al., J Cell Biochem 1999 : In osteoblast-like MC3T3-E1 cells, we have recently reported that sphingosine 1-phosphate among sphingomyelin metabolites acts as a second messenger for tumor necrosis factor-alpha (TNF) induced interleukin-6 (IL-6) synthesis
Oka et al., J Periodontol 2012 (Alveolar Bone Loss...) : IND and EP4A inhibited the upregulation of TNF-a mRNA expression, and only EP4A inhibited IL-6 and RANKL mRNA expressions in ST2 cells with LPS stimulation
Moore et al., Int J Biochem Cell Biol 1997 (Leg Ulcer...) : Co-culture with 0.25 % Iodosorb, Iodosorb conditioned medium or 20 micrograms/ml iodine enhanced TNF alpha secretion ( 48 +/- 3 % cytotoxicity in L929 bioassay to 78 +/- 2 % cytotoxicity, +/-SD ) by U937 cells stimulated with sub-optimal concentrations of LPS ( 0.25 ng/ml ) and inhibited secretion of IL-6 from cells stimulated with 10 ng/ml LPS ( > 750 pg/ml to 267 +/- 52 pg/ml, +/-SD, n = 4 )
Seatter et al., Arch Surg 1994 (Disease Models, Animal) : Tumor necrosis factor and interleukin-1 regulation by lipopolysaccharide pretreatment
Bode et al., J Immunol 2003 : Furthermore, activation of p38 mitogen activated protein kinase is shown to be essential for the inhibitory effect of TNF-alpha on IL-6 signaling and TNF-alpha dependent recruitment of SHP2 to gp130
Novitskiĭ et al., Vestn Ross Akad Med Nauk 2006 (Coronary Disease) : Oxygen dependent killing was controlled mostly by IL-6 during the pre-operative period, and by this plus TNF-alpha 24 hours after surgery
Kumagai et al., Arch Biochem Biophys 2012 (Carcinoma...) : Moreover, we found that DEM pretreatment enhanced the production of IL-6 induced by TNF-a ... Knockdown of ASMase attenuated the enhancement of TNF-a dependent IL-6 production ... On the other hand, enhancement of TNF-a induced IL-6 production was observed in ASMase overexpressing cells without DEM. Fractionation of the lipid raft revealed that the TNF receptor 1 (TNFR1) was migrated into the lipid raft in DEM treated cells or ASMase overexpressing cells ... The TNF-a induced IL-6 expression required the clustering of TNFR1 since IL-6 expression were decreased by the destruction of the lipid raft with filipin ... These results demonstrated a new role for ASMase in the acceleration of the production of TNF induced IL-6 as a pro-inflammatory cytokine and indicated that electrophiles could potentiate inflammation response by up-regulating of ASMase expression following formation of lipid rafts
Danis et al., Clin Exp Immunol 1995 : TNF-alpha also up-regulated production of IL-1 alpha, IL-1 beta, IL-1Ra and IL-6 by monocytes, but the variability in the results of cells cultured from the same individuals on different occasions was greater
Daftarian et al., J Immunol 1996 : IL-12 and/or IL-6 can induce the expression of IL-10 by PHA stimulated T cells, whereas TNF-alpha induces IL-10 production by monocytes
Campbell et al., J Immunol 1989 : The magnitude for the effects of IFN-gamma and TNF-alpha on the production of IL-6 from mouse islets was found to be both time and dose dependent
Palladino et al., Ciba Found Symp 1987 (Neoplasms, Experimental) : Apart from their direct cytotoxic/cytostatic activities against tumours in vitro and in vivo, the in vivo antitumour activities of TNF-alpha or TNF-beta may involve the following biological activities : the induction of interleukin 1 production ; activation of polymorphonuclear neutrophil functions ; modulation of endothelial cell functions ; and augmentation of specific immune functions
Ravindranath et al., J Immunol 2009 (Acute Lung Injury...) : In human pulmonary microvascular ECs, AR activity was required for TNF-alpha induced activation of the Rho kinase/MKK4/JNK pathway and IL-6 production, but not p38 activation or ICAM-1 expression
Liu et al., J Immunol 1990 : Although perforin ( hemolytic ) activity was detected in unstimulated R8i, it was induced 2- to 14-fold in the presence of IL-2, IL-3, IL-4, and IL-6 , and to a lesser degree ( less than 4-fold ) by TNF and IFN-gamma
Martin et al., Cell Immunol 1990 : Thus even though TNF-alpha production precedes that of IL-1 and IL-6, and stimulates IL-6 production in fibroblasts, there is no evidence that TNF-alpha acts to amplify the production of IL-6 or IL-1 by murine macrophage cell lines
Flower et al., Cytokine 2003 : TNFalpha and insulin induced IL-6 production from PBC, but had no effect on adipocytes
Paniagua et al., Perit Dial Int 2004 : Appearance of interleukin-6 increased 17 % and 43 % ( p < 0.01 ), and TNFalpha appearance increased 14 % and 50 % ( p < 0.01 ) when dialysate volumes of 2.5 and 3.0 L were used, compared with 2.0 L
Beyaert et al., Cancer Res 1993 (Fibrosarcoma...) : In the L929 fibrosarcoma cell line, staurosporine also enhanced the transcriptional activation of interleukin 6 synthesis by TNF ( 500-fold stimulation at 56 nM )
Zhang et al., J Ethnopharmacol 2013 (Arthritis, Experimental...) : The results also found that there was significant reduction levels of IL-6, IL-8 and TNF-a in serum of CIA rats treated with ATW and ATW inhibited the expression of IL-6 , IL-8, NF-?B, TNF-a in synovial tissue
de Haij et al., J Am Soc Nephrol 2005 : IL-6 production induced by IL-1, TNF-alpha , and IL-17 was specifically inhibited by the c-jun NH ( 2 ) -terminal kinase ( JNK ) inhibitor SP600125, but not by a selective inhibitor of p38 MAPK, and was moderately increased when the ERK1/2 pathway was inhibited
Vargas et al., J Bone Miner Res 1996 : Receptor deficiency was confirmed by determining the ability of PTH, IL-1 alpha, and TNF-alpha to stimulate IL-6 in the media of primary calvaria derived osteoblastic cell cultures from CD-1 and cytokine receptor-deficient mice ... After 24 h of treatment, IL-1 alpha and TNF-alpha did not stimulate IL-6 production in osteoblasts from IL-1R1-/- and TNFR1-/- mice, respectively
Ortiz-Arduan et al., Am J Physiol 1996 (Endotoxemia) : Lipopolysaccharides (LPS), interleukin-1 beta, interferon-gamma (IFN-gamma), and TNF-alpha increase the levels of Fas mRNA in cultured mesangial and tubular cells
Haynes et al., J Bone Joint Surg Br 1997 (Bone Resorption) : Both IL-1beta and TNFalpha stimulated IL-6 and PGE2 release from the osteoblast-like cells
Wang et al., J Nutr Biochem 2013 : Despite necessary for IL-6, NF-?B activation by TNF-a or other cytokines is not sufficient for IL-6 induction with exception of LPS
Bhat et al., Clin Exp Allergy 2003 : Finally, cockroach extract also increased TNF-alpha induced transcription from the IL-6 promoter
Fan et al., Biochem Biophys Res Commun 2011 : TNF-a induced the expression of IL-6 , IL-8 and sICAM in ECs
von Asmuth et al., Scand J Immunol 1990 (Disease Models, Animal...) : Although IL-6 release during septic shock is partly dependent on TNF , in vitro trigger mechanisms for IL-6 and TNF differ remarkably
Siebert et al., Arthritis Rheum 2005 : Nevertheless, the C43S TRAPS fibroblasts were capable of producing interleukin-6 (IL-6) and IL-8 in response to TNFalpha
Yamamoto et al., J Biol Chem 1995 : Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha dependent induction of cyclooxygenase-2 in MC3T3-E1 cells
Marcinkiewicz et al., Immunology 1994 : However, after chlorination Gram positive bacteria lost their ability to induce NO and TNF-alpha , whereas phagocytosis and IL-6 production were not affected by chlorination
Yoshida et al., Am J Physiol 1999 : In contrast, tumor necrosis factor (TNF)-alpha ( 200 U/ml ) induced IL-6 at the protein and mRNA levels in both airway epithelial cells and lung fibroblasts ... In WI-38-40 cells, DMSO was not able to suppress IL-6 production induced by TNF-alpha
Antonelli et al., Scand J Rheumatol 2011 (Inflammation...) : IFN-? and TNF-a induce a different modulation of interleukin-6 in systemic sclerosis fibroblasts compared to healthy controls
Henrotin et al., Osteoarthritis Cartilage 1996 : IL-beta and TNF alpha highly stimulated IL-6 , LIF and IL-8 productions
Yoshida et al., J Rheumatol 2005 : In addition, MTX significantly inhibited the enhancement by IL-17 of TNF-alpha stimulated IL-6 synthesis
Lee et al., Leuk Res 1993 : Purified T-cells did not produce significant levels of TNF-alpha , even in the presence of IL-1 and IL-6
Funakoshi-Tago et al., Cytokine 2009 : Interestingly, we observed that TNFalpha induced expression of IL-6 , CXCL1 and granulocyte macrophage colony stimulating factor ( GM-CSF ) were significantly enhanced in TRAF6-deficient MEFs
Mancuso et al., Infect Immun 1994 (Streptococcal Infections) : In this model, TNF-alpha is also partially responsible for the induction of interleukin-6 (IL-6) ... The effect of anti-IL-6 monoclonal antibodies and recombinant IL-6 on lethality and TNF-alpha production was investigated ... Collectively, our data are compatible with the hypothesis that IL-6 is involved in negative feedback regulation of plasma TNF-alpha levels in experimental GBS sepsis
Tanabe et al., Journal of neuroinflammation 2010 (Glioma) : Mechanisms of tumor necrosis factor-alpha induced interleukin-6 synthesis in glioma cells ... Tumor necrosis factor (TNF)-alpha induces IL-6 release from rat C6 glioma cells through the inhibitory kappa B ( IkappaB ) -nuclear factor kappa B (NFkappaB) pathway, p38 mitogen activated protein ( MAP ) kinase and stress activated protein kinase ( SAPK ) /c-Jun N-terminal kinase (JNK) ... The present study investigated the mechanism of TNF-alpha induced IL-6 release in more detail than has previously been reported ... TNF-alpha stimulated increases in IL-6 levels were suppressed by wedelolactone ... The Janus family of tyrosine kinase ( JAK ) inhibitor I, an inhibitor of JAK 1, 2 and 3, attenuated TNF-alpha induced phosphorylation of STAT3 and significantly reduced TNF-alpha stimulated IL-6 release ... Apocynin, an inhibitor of NADPH oxidase that suppresses intracellular reactive oxygen species, significantly suppressed TNF-alpha induced IL-6 release and mRNA expression ... These results strongly suggest that TNF-alpha induces IL-6 synthesis through the JAK/STAT3 pathway in addition to p38 MAP kinase and SAPK/JNK in C6 glioma cells, and that phosphorylation of NFkappaB at Ser 536 and Ser 468, and NADPH oxidase are involved in TNF-alpha stimulated IL-6 synthesis
Cubitt et al., Invest Ophthalmol Vis Sci 1995 : These results demonstrate that both IL-1 alpha and TNF-alpha could induce keratocytes to produce nanogram levels of IL-6 but IL-1 alpha was a 30-fold more effective inducer
Vandevoorde et al., FEBS Lett 1992 : TNF mediated IL6 gene expression and cytotoxicity are co-inducible in TNF-resistant L929 cells ... These results confirm our earlier conclusions regarding the close relationship between TNF mediated IL6 gene expression and the pathway leading to cytotoxicity
Lu et al., Invest Ophthalmol Vis Sci 2006 : Lipopolysaccharide (LPS) induced the release of the proinflammatory cytokine IL-6 and that of the chemokines G-CSF, MCP-1, MIP-1beta, and IL-8 as well as surface expression of ICAM-1 by corneal fibroblasts, whereas IL-1beta, TNF-alpha , and GM-CSF were not detected in the culture supernatants of cells incubated with or without LPS
Rogler et al., Scand J Gastroenterol 2001 (Colitis, Ulcerative...) : IL-8 and IL-6 secretion could be stimulated by IL-1alpha, IL-1beta, TNF , PMA and LPS within 6 h of incubation
Foey et al., Biochim Biophys Acta 1997 : Mimicking this ` defect ' on normal mononuclear cells with ouabain has been shown to induce TNF alpha and, in particular, IL-l beta production, whereas IL-6 synthesis was suppressed
Diamant et al., Autoimmunity 1991 : Both tumor necrosis factor-alpha and -beta also augmented interleukin-6 production, but less potently than interleukin-1
Desmet et al., Biochem Pharmacol 2005 : On the contrary, both RSG and TRO significantly potentiated TNF-alpha induced production of granulocyte/macrophage-colony stimulating factor, interleukin (IL)-6 and/or IL-8 in these cells
Kehrl et al., Ann N Y Acad Sci 1992 (HIV Infections) : The secondary rise in IL-6 production is dependent upon the prior production of TNF-alpha
Carlo et al., J Pediatr 2011 (Cerebral Palsy...) : The analyses were focused on 5 cytokines ( interleukin [ IL] 1ß ; IL-8 ; tumor necrosis factor-a ; regulated upon activation, normal T-cell expressed, and secreted ( RANTES ) ; and IL-2 ) reported to be most predictive of CP in term and late preterm infants
Tappia et al., Mol Cell Biochem 1996 : The relationship between altered membrane composition, eicosanoids and TNF induced IL1 and IL6 production in macrophages of rats fed fats of different unsaturated fatty acid composition
Leonardi et al., Clin Exp Allergy 2006 (Conjunctivitis, Allergic) : IL-6 , IL-8, MCP-1, RANTES and eotaxin were detected from fibroblasts cultures, and were all up-regulated by TNF-alpha
Wang et al., Zhong Xi Yi Jie He Xue Bao 2009 (Adenocarcinoma...) : TNF-alpha ( 1 microg/L ) strongly induced the production of IL-6 and IL-8 as compared with the control serum in A549 cells, and the induced cytokine production was significantly suppressed by 15 % serum containing Feiyanning Decoction ( P < 0.01 ) ... Feiyanning Decoction can inhibit IL-6 and IL-8 production induced by TNF-alpha
Qin et al., Invest Ophthalmol Vis Sci 2008 : Finally, with the exception of TNF-alpha induced IL-6 production, adenosine dialdehyde, an inhibitor of S-adenosylhomocysteine hydrolase, was found to block cytokine production and ICAM-1 expression
Kaminska et al., Tumour Biol 2005 (Colorectal Neoplasms) : The levels of circulating interleukin (IL)-6 , IL-8, macrophage colony stimulating factor ( M-CSF ) and interleukin 1 receptor antagonist ( IL-1ra ) significantly increased with the clinical stage of CRC, and the levels of IL-6, soluble tumor necrosis factor ( sTNF ) receptor type I ( RI ), soluble interleukin 2 receptor alpha and TNFalpha with tumor grade, while IL-6, IL-8, M-CSF, IL-1ra and sTNF RI levels significantly rose with bowel wall invasion
Li et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis...) : Inhibitors of JAK, p38, and NF-kappaB revealed that these signaling pathways are indispensable for the plasmin mediated tumor necrosis factor-alpha and IL-6 induction
Utsunomiya et al., Eur J Pharmacol 1994 (Pleurisy) : However, production of tumor necrosis factor (TNF) and interleukin-1 in the pleural exudate was significantly enhanced by the pretreatment with indomethacin, whereas the interleukin-6 level was reduced
Kim et al., J Cardiovasc Pharmacol 2007 : The inhibitors of JNK, NF-kappaB, and STAT-3 produced a statistically significant decrease of the TNF-alpha induced U937 adhesion and IL-6 protein release
Elias et al., Am J Respir Cell Mol Biol 1990 : We determined whether normal human lung fibroblasts expressed cell associated thymocyte stimulating activity in response to recombinant interleukin-1 ( rIL-1 ) ( alpha and beta ) and recombinant tumor necrosis factor ( rTNF )
Legrand-Poels et al., Biochem J 2000 (Adenocarcinoma...) : Analyses of secreted IL-6 by ELISA and of IL-6 mRNA by reverse transcription-PCR revealed that, whereas HeLa cells produced high levels of IL-6 in response to tumour necrosis factor-alpha (TNF-alpha) and IL-1beta, the HTM-29 cell line failed to produce both IL-6 protein and mRNA
Kawakami et al., J Trauma 1998 (Burns...) : TNF-alpha , IL-1alpha, and IL-1beta increased IL-6 production in normal skin ( p < 0.05 )
Ritchie et al., Eur J Endocrinol 1996 : Dopamine increases interleukin 6 release and inhibits tumor necrosis factor release from rat adrenal zona glomerulosa cells in vitro
Zhou et al., Rheumatol Int 2012 (Arthritis, Rheumatoid) : Nicotine inhibits tumor necrosis factor-a induced IL-6 and IL-8 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis ... Nicotine at concentrations of 0.1-10 µM dose reduced the protein and mRNA expression of IL-6 and IL-8 induced by tumor necrosis factor-a (TNFa)
LeVine et al., J Neuroimmunol 1997 : In particular, TNFalpha promotes oligodendrocyte and myelin pathology, and IL-6 expression is induced in astrocyte and microglial cultures that have been incubated with TNFalpha or myelin debris, respectively
Sharma et al., Am J Physiol Lung Cell Mol Physiol 2007 (Inflammation...) : H/R ( 3 h/1 h ) significantly induced KC, MCP-1, macrophage inflammatory protein-2 ( MIP-2 ), RANTES, and IL-6 ( but not TNF-alpha ) by MLE-12 cells, whereas H/R induced TNF-alpha , MCP-1, RANTES, MIP-1alpha, and MIP-2 ( but not KC ) by RAW264.7 cells ... Importantly, using macrophage and epithelial coculture methods, the specific production of TNF-alpha by H/R exposed RAW264.7 cells significantly induced proinflammatory cytokine/chemokine expression ( KC, MCP-1, MIP-2, RANTES, and IL-6 ) by MLE-12 cells
Ulivi et al., Arthritis Res Ther 2011 : We report that MGDG : 1 ) represses the expression of interleukin-6 (IL-6) and interleukin-8 (IL-8) induced by interleukin-1alpha ( IL-1a ) or IL-1a + tumor necrosis factor a (TNFa) interfering with the p38 and NF-kB pathways ; 2 ) is not toxic for the cells and does not affect the cell phenotype ; 3 ) strongly enhances COX-2 expression induced by IL-1a or IL-1a + TNFa ; 4 ) represses mPGES expression induced by IL-1a and the synthesis of PGE ( 2 ) and induces the synthesis of 15-deoxy-d 12,14-prostaglandin J ( 2 ) ( 15dPGJ ( 2 ) )
Sheron et al., Clin Exp Immunol 1990 (Hepatitis B) : Several studies have shown that the cytokine interleukin-6 (IL-6) is produced in response to tumour necrosis factor (TNF) in vitro ... These findings suggest that the very high levels of IL-6 found in certain disease states are not purely the result of circulating TNF
Newman et al., J Surg Res 2003 : Therefore, we tested the hypothesis that elevating cyclic AMP would inhibit TNF-alpha mediated IL-6 expression and VSMC migration ... Further, elevating cyclic AMP inhibited TNF-alpha induced release of IL-6 , and migration of VSMC
Ferreira , Drugs 1993 (Hyperalgesia...) : The release of tumour necrosis factor-alpha (TNF-alpha) initiates the release of interleukin-1 and interleukin-8, which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines, respectively
Rieckmann et al., J Immunol 1991 : In addition, it was shown that IL-6 production by in vitro activated B cells was partially blocked by an anti-TNF-alpha antibody suggesting that TNF-alpha regulates IL-6 production in normal B cells via an autocrine pathway
Wang et al., Shock 2004 (Inflammation...) : We conclude that p38 MAPK is involved in endotoxin induced myocardial contractile dysfunction and myocardial TNF-alpha production ; however, p38 MAPK 's involvement in IL-1 and IL-6 production may be indirectly mediated by TNF-alpha
Shibanuma et al., FEBS Lett 1994 : We found that : ( i ) TNF alpha increased IL-6 mRNA levels and this increase was inhibited by N-acetyl-L-cysteine (NAC), a scavenger of reactive oxygen species
Lee et al., Phytother Res 2006 : In the presence of TNF-alpha , culture with CCE ( 10-100 microg/mL ) for 48 h inhibited the production of IL-6 and nitric oxide in osteoblastic MC3T3-E1 cells
Ng et al., J Biol Chem 1994 : Differential induction of the interleukin-6 gene by tumor necrosis factor and interleukin-1 ... These results suggest that the induction of the IL-6 gene expression in primary human fibroblasts by TNF and IL-1 is differentially regulated at the transcriptional as well as at the post-transcriptional level
Cairns et al., Immunology 1992 (Lymphoma, Large B-Cell, Diffuse) : Up-regulation of TNF receptors by IL-6 is dependent on de novo protein synthesis since receptor induction is abolished in the presence of cycloheximide ... Taken together the data suggest that the potentiation of cell killing observed by a combination of these lymphokines is mediated in part by IL-6 induced changes in TNF receptor expression
Shah et al., Cell Physiol Biochem 2005 (Calcium Signaling) : The antidiabetic agent rosiglitazone upregulates SERCA2 and enhances TNF-alpha- and LPS induced NF-kappaB dependent transcription and TNF-alpha induced IL-6 secretion in ventricular myocytes ... Since NF-kappaB dependent pathways, including the upregulation of IL-6 secretion, were shown to protect neonatal rat ventricular myocytes from apoptosis upon TNFalpha stimulation, additional experiments were designed to determine whether rosiglitazone enhances TNFalpha induced NF-kappaB dependent transcription and IL-6 secretion ... Treatment of neonatal rat ventricular myocytes with 10 micromol/L rosiglitazone enhanced TNF-alpha- and lipopolysaccharide induced NF-kappaB dependent transcription by approximately 1.8- and approximately 1.4-fold respectively, and TNF-alpha induced IL-6 secretion by n1.5-fold
Di Santo et al., Cytokine 1997 : Differential effects of IL-6 on systemic and central production of TNF : a study with IL-6-deficient mice ... Co-administration of soluble IL-6 receptor ( sIL-6R ) did not enhance the effect of IL-6 on brain TNF , so this refractoriness can not be attributed to a lack of IL-6 receptors ... Interestingly, IL-6 potently inhibited LPS induced TNF production by macrophagic cells but not by a microglial cell clone, suggesting that the defective response to IL-6 of the brain lies within the responsiveness TNF producing cells to IL-6
Kanematsu et al., Biochim Biophys Acta 1997 (Melanoma, Experimental) : ( 1 ) Dex decreased the accumulation of tumor necrosis factor-alpha induced by IL-6 , whereas nitric oxide production was enhanced by Dex
Chae et al., Bone 2001 (MAP Kinase Signaling System) : The p38 mitogen activated protein kinase pathway regulates interleukin-6 synthesis in response to tumor necrosis factor in osteoblasts ... When added to MG-63 cells, tumor necrosis factor-alpha (TNF-alpha) had a stimulatory effect on the production of IL-6 , and this elevation was significantly reduced by SB203580, a specific p38 MAPK inhibitor ... These results strongly suggest that both p38 MAPK and NF-kappaB are required in TNF-alpha induced IL-6 synthesis and that these two TNF-alpha activated pathways can be primarily dissociated
Wang et al., J Surg Res 1998 (Endotoxemia) : In addition, we examined the effects of TNF alpha and IL-1 beta on mucosal IL-6 production ... Both TNF alpha and IL-1 beta may be involved in the regulation of gastrointestinal IL-6 production during endotoxemia
Agarwal et al., Gynecol Endocrinol 2000 : TNF alpha also stimulated release of IL-6 by these cells
Damera et al., Am J Physiol Lung Cell Mol Physiol 2009 : Whereas TNF enhanced basal secretion of IL-6 ( 57 +/- 3 % ), ozone exposure at 0.6 ppm for 6 h augmented IL-6 levels in basal ( 41 +/- 3 % ) and TNF- ( 50 +/- 5 % ) primed cocultures compared with that derived from NHBE or ASM monolayers alone
Suh et al., Phytochemistry 2003 : Soybean isoflavones inhibit tumor necrosis factor-alpha induced apoptosis and the production of interleukin-6 and prostaglandin E2 in osteoblastic cells
Harigai et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid...) : CD14+ RA synovial cells stimulated with rsCD154 plus interferon-gamma (IFNgamma) induced significantly higher production of IL-6 , IL-8, and monocyte chemoattractant protein 1 by FLS compared with unstimulated CD14+ synovial cells, through TNFalpha- , IL-1alpha-, and IL-1beta mediated pathways
Bermudez et al., Infect Immun 1992 (Mycobacterium avium-intracellulare Infection) : The effect of IL-6 on TNF receptors was observed after 4 h and was reversible
McKay et al., Am J Respir Cell Mol Biol 2000 : Tumor necrosis factor-alpha enhances mRNA expression and secretion of interleukin-6 in cultured human airway smooth muscle cells
Batey et al., Alcohol Clin Exp Res 1998 (Endotoxemia...) : Decreased IL-1alpha and TNF-alpha production in 24-hr culture supernatants of mononuclear cells isolated from liver perfusate was detected while IL-6 remained unchanged over 20 weeks
Burger et al., Ann Hematol 1994 (Giant Lymph Node Hyperplasia...) : Cell populations from various sites including peripheral blood, bone marrow, lymph nodes, and osteolytic bone lesions were cultured and tested for spontaneous or IL-1 beta/TNF alpha induced IL-6 production in a sensitive bioassay
Andoh et al., Int J Mol Med 2000 : EMSAs indicated that trichostatin A weakly suppressed TNF-alpha induced NF-kappaB and NF-IL6 activation
Takahashi et al., J Exp Med 2008 (Shock...) : Serum levels of TNF induced IL-6 and nitric oxide metabolites were significantly reduced in mice deficient in the IL-17R
Yeung et al., AIDS 1995 : ELISA and RT-PCR studies revealed that rgp120SF2 induced IL-6 and tumor necrosis factor (TNF)-alpha in brain cultures ; IL-6 could also be induced by TNF-alpha added to brain cultures
Haynes et al., Agents Actions 1993 : In contrast, DHB stimulated production of interleukin (IL)-1 and tumour necrosis factor (TNF) but inhibited IL-6 production by rat macrophages
Pedersen et al., Scand J Immunol 2005 (Breast Neoplasms) : The lymph node homing chemokine receptor CCR-7 expression was induced by TNF-alpha + IL-1beta + IL-6 + prostaglandin E2 but was not induced by Poly I:C + TNF-alpha
Ito et al., Arthritis Res Ther 2011 (Arthritis, Rheumatoid...) : Exogenous addition of IL-17 dramatically enhanced the spontaneous production of IL-6 and prostaglandin E2 ( PGE2 ) by the ST-derived inflammatory cells, while it had no effect on the production of tumor necrosis factor (TNF)-a and macrophage colony stimulating factor ( M-CSF )
Hojo et al., Cancer Lett 1996 (Lung Neoplasms...) : The IL-6 production was greatly enhanced by IL-1 alpha, but not by IL-6, tumor necrosis factor-alpha or interferon-gamma
Sheng et al., Acta Cardiol 2009 (Dilatation, Pathologic...) : The expression of TLR4, TNF-alpha and IL-6 in the myocardium significantly increased in the MI group and simvastatin markedly inhibits the expression of TLR4, TNF-alpha , and IL-6 in the myocardium after MI. Serum TNF-alpha and IL-6 levels between the MI group and the simvastatin group remained unchanged
Ribel-Madsen et al., Arthritis 2012 : TNF-a stimulation caused similar IL-1ß, IL-6 , and IL-8 release in all groups
Zhang et al., J Biol Chem 1988 : Synthesis of IL-6 is stimulated by interleukin 1 (IL-1), tumor necrosis factor (TNF), or platelet derived growth factor ... IL-1 and TNF too increased IL-6 mRNA levels by a protein kinase C-independent mechanism ... Our results suggest a role for the cAMP dependent pathway ( s ) in IL-6 gene activation by TNF and IL-1
Vallés et al., Biomaterials 2008 : Experiments employing neutralising antibodies indicate that exposure of co-cultured macrophages to both Ti-based particles induces the release of M-CSF, GM-CSF, IL-6 and PGE2 through up-regulation of IL-1beta and TNF-alpha
Hausman et al., Am J Obstet Gynecol 2003 : Uterine and cervical interleukin-1beta and interleukin-6 were decreased, and uterine tumor necrosis factor-alpha increased in celecoxib-B
Atanackovic et al., Cancer Immunol Immunother 2002 (Neoplasms) : This first phase was followed by a marked but short lived increase in the patients ' serum levels of interleukin-6 ( IL-6 ; P < 0.01 ) during the first 5 h following treatment, with a subsequent decrease to baseline levels at 24 h and significantly increased serum levels of tumor necrosis factor-alpha (TNF-alpha) at 0 h ( P < 0.01 ), 3 h ( P < 0.05 ), 5 h ( P < 0.05 ) and 24 h ( P < 0.01 ) post-WBH-CT
Shi et al., Arthritis Res Ther 2006 (Osteoarthritis) : HNE dose-dependently decreased basal and tumour necrosis factor-alpha (TNF-alpha) induced IL-6 expression while inducing COX-2 expression and prostaglandin E2 ( PGE2 ) release ... Overexpression of IKKalpha increased TNF-alpha induced IL-6 production
Bauer et al., Blood 1988 : Tumor necrosis factor , interferon-gamma and interleukin-2 (IL-2) had no effect on IL-6 synthesis in monocytes or macrophages
Cunningham et al., Neuropathol Appl Neurobiol 2002 (Prion Diseases) : The aim of this study was to determine whether, in the absence of IL-1beta and IL-6 , tumour necrosis factor (TNF)-alpha may play an equivalent pro-inflammatory role, or if an anti-inflammatory cytokine profile dominates
Yoshida et al., J Immunol 1999 (Arthritis, Rheumatoid...) : Involvement of thioredoxin in rheumatoid arthritis : its costimulatory roles in the TNF-alpha induced production of IL-6 and IL-8 from cultured synovial fibroblasts ... We thus examined the effect of TRX on the TNF-alpha induced IL-6 and IL-8 production using rheumatoid synovial fibroblast cultures
Schlüter et al., Infect Immun 2001 : Neuronal expression of some cytokines ( IL-6 , TGF-beta1 ) and chemokines ( MIP-1beta ) was regulated by infection and/or by IFN-gamma and TNF
Sparacio et al., J Neuroimmunol 1992 : These results suggest that TNF-alpha and IL-1 beta activate IL-6 gene expression in astrocytes by a mechanism ( s ) involving activation of an NF-kappa B-like protein
Vandekerckhove et al., Lymphokine Cytokine Res 1991 : Of the other cytokines tested, TNF-alpha and IFN-gamma weakly induced IL-6
Gunaydın et al., J Pediatr Surg 2012 (Acute Lung Injury...) : Aspiration of gastrointestinal decontamination agents produced histopathologic changes, elevated levels of malondialdehyde and surfactant protein D, reduced levels of antioxidant enzymes, and increased expression of inflammatory cytokines interleukin-1ß and tumor necrosis factor a. Curcumin treatments effectively attenuated the rats ' pulmonary inflammation responses ( as shown by reduced alveolar damage ), decreased serum malondialdehyde and surfactant protein D levels, and inhibited the expressions of tumor necrosis factor a and interleukin-1ß
Fiedler et al., Am J Respir Cell Mol Biol 1998 : The working hypothesis of the studies described herein was that inhibition of proteasome mediated IkappaB degradation would inhibit TNF-alpha induced nuclear factor-kappaB (NF-kappaB) activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells
van Maanen et al., Arthritis Rheum 2009 (Arthritis, Rheumatoid) : Specific alpha7nAChR agonists reduced tumor necrosis factor alpha induced IL-6 and IL-8 production by FLS
Rifas et al., Endocrinology 1995 : To investigate this hypothesis in a human model, we have examined 12 separate strains of normal human osteoblasts ( HOB ) and 11 separate strains of human bone marrow stromal cells ( HBMSC ) and determined whether ovarian steroids regulate the induction of IL-6 by interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha) or IL-1 + TNF
Tsuji et al., Am J Pathol 1995 (Granuloma...) : Thus, interleukin-1 alpha and inducible nitric oxide synthase were induced mostly in the cells accumulated around the beads and also in some bronchiolar epithelial cells during the early phase ( 1 to 3 days ), whereas tumor necrosis factor-alpha was induced in the cells around the beads at the later resolution phase ( 3 to 7 days )
Greenberg et al., Cancer Res 1992 : Since tumor necrosis factor increases circulating IL-6 , some of its effects may be mediated or potentiated by IL-6
Lin et al., J Endod 2002 (Pulpitis) : To gain further insight into the molecular pathogenesis of pulpitis, we investigated the effects of IL-1alpha or TNF-alpha and PGE2, either alone or in combination on IL-6 and cyclooxygenase (COX)-2 messenger RNA ( mRNA ) production in cultured human dental pulp ( HDP ) fibroblasts
Kuroiwa et al., J Immunol 1999 (Glomerulonephritis) : The addition of plasma membrane enhanced TNF-alpha induced mesangial IL-6 production by approximately 4-fold
Abu-Amer et al., J Biol Chem 1998 : Consistent with the pivotal role played by c-Src in TNF induced Ikappa Balpha tyrosine phosphorylation, NF-kappaB activation, by the cytokine, is markedly delayed and reduced in c-src-/- BMMs. Underscoring the physiological significance of c-Src activation of NF-kappaB, TNF induction of IL-6 , which is an NF-kappaB mediated event, is substantially diminished in c-src-/- BMMs
Song et al., Mol Immunol 2009 (Inflammation) : Ablation of IRAK-4 expression in human umbilical vein endothelial cells ( HUVEC ) with siRNA suppressed IL-1beta induced IL-6 and IL-8 production whereas IRAK-1 siRNA suppressed TNFalpha induced but not IL-1beta induced cytokine production
Kim et al., Naunyn Schmiedebergs Arch Pharmacol 2005 : VSMCs were exposed to 44 degrees C for 15-60 min, and subjected to interleukin-1beta (IL-1beta) or tumor necrosis factor alpha (TNFalpha) , which induced interleukin-6 (IL-6) production
Hashimoto et al., Biochem Biophys Res Commun 1999 : The results showed that TNF-alpha induced p38 MAP kinase activation and interleukin-6 (IL-6) production by TRX 14 were less than those by the parental L cells and the control transfected L cells ( Neo-1 ) ... SB 203580 as the specific inhibitor for p38 MAP kinase activity inhibited TNF-alpha induced IL-6 production by the parental L cells, indicating that TNF-alpha activated p38 MAP kinase regulates IL-6 production by the cell lines used in this study
Jiao et al., Clin Dev Immunol 2012 (Arthritis, Rheumatoid) : Notch signaling mediates TNF-a induced IL-6 production in cultured fibroblast-like synoviocytes from rheumatoid arthritis ... Blockage of Notch signaling by a ?-secretase inhibitor ( DAPT ) inhibited IL-6 secretion of RA FLSs in response to TNF-a while treatment with recombinant fusion protein of Notch ligand Delta-like 1 promoted such response ... TNF-a stimulation also induced IL-6 secretion in OA FLSs ; however, the Hes-1 level remained unaffected
Liby et al., Clin Cancer Res 2007 (Breast Neoplasms...) : Low nanomolar concentrations of 4204 blocked the ability of lipopolysaccharide and tumor necrosis factor-alpha to induce the release of nitric oxide and interleukin 6 and the degradation of IKBalpha in RAW264.7 macrophage-like cells
Yamagishi et al., Nihon Jibiinkoka Gakkai Kaiho 2000 (Rhinitis, Allergic, Perennial) : [ IL-1 and TNF-alpha mediated regulation of IL-6 , IL-8, and GM-CSF release from cultured nasal epithelial cells ]
Judd et al., Endocrine 1995 : Tumor necrosis factor increases interleukin-6 release from adrenal zona glomerulosa cellsin vitro
Yoon et al., Acta Otolaryngol 1999 : Effects of TNF-alpha and IL-1 beta on mucin, lysozyme, IL-6 and IL-8 in passage-2 normal human nasal epithelial cells
Gallucci et al., Int Immunol 1998 (Inflammation) : We found that IL-1beta, tumor necrosis factor (TNF)-alpha and lipopolysaccharide (LPS) stimulated myoblast IL-6 secretion in a dose- and time dependent manner, whereas forskolin and cholera toxin did not ... HA1004 at 10 microM did not significantly affect the IL-1beta- and TNF-alpha induced IL-6 secretion, suggesting that cAMP and protein kinase A are not sufficient to stimulate this process
Chan et al., Int J Oncol 1997 : Involvement of interleukin-1 in the differentiation inducing activity of tumor necrosis factor-alpha on a murine myeloid leukemia ( WEHI-3B JCS )
Sugawara et al., J Hepatol 1998 (Reperfusion Injury) : Endotoxin and interleukin-6 levels increased in a similar manner to nitrate levels, but tumor necrosis factor-alpha and interleukin-1 beta levels did not
Guerne et al., J Clin Invest 1989 (Arthritis, Rheumatoid) : In vitro, synoviocytes spontaneously released IL-6 , which was increased by IL-1 and tumor necrosis factor-alpha
Havell et al., J Immunol 1991 (Listeriosis) : J. Exp. Med. 170 : 1627 ), experiments were undertaken to determine whether IL-6 production elicited by the Gram positive bacterium, L. monocytogenes, was also TNF dependent
Beyaert et al., Eur J Immunol 1992 (Psoriasis) : Synergistic induction of interleukin-6 by tumor necrosis factor and lithium chloride in mice : possible role in the triggering and exacerbation of psoriasis by lithium treatment
Drescher et al., Invest Ophthalmol Vis Sci 1996 (Eye Infections, Viral...) : Peak TNF alpha mRNA levels were detected 4 hours after exposure to HSV, whereas IL-6 peaked 4 hours later ( increases of 10.3 and 8.7 times over baseline, respectively )
Kikumori et al., Biochem J 2001 : We have recently demonstrated that nuclear factor kappaB (NF-kappaB) mediates the tumour necrosis factor alpha (TNF-alpha) dependent expression of the gene encoding interleukin 6 (IL-6) in rat thyroid FRTL-5 cells cultured in the presence of thyrotropin ( TSH ) ... Accordingly, TNF-alpha activated the expression of the IL-6 gene in the presence of TSH but not in its absence
Rigby et al., Oncogene 2007 (Colonic Neoplasms...) : In vitro, SOCS3 overexpression reduced proliferation, IL-6 mediated STAT3 activation and tumor necrosis factor (TNF) alpha mediated NF-kappaB activation
Takahashi et al., Drugs Exp Clin Res 1998 (Arthritis, Rheumatoid) : KE-298 significantly suppressed TNF-alpha induced production of promatrix metalloproteinase-1 and IL-6 , in a dose dependent manner, but not that of tissue inhibitor-1 of metalloproteinases
Li et al., Microvasc Res 2001 : Histamine induced production of interleukin-6 and interleukin-8 by human coronary artery endothelial cells is enhanced by endotoxin and tumor necrosis factor-alpha
Zhang et al., J Leukoc Biol 2005 : In the present study, incubation of AM with unopsonized Pneumocystis organisms was not associated with release of interleukin (IL)-1beta, IL-6 , or tumor necrosis factor (TNF)-alpha ( important cytokines in the host response to Pneumocystis ) and did not induce IL-1beta, IL-6, or TNF-alpha mRNA transcripts
Wang et al., Vet Res 2003 : The TNF-alpha in plasma may partially induce transcription of IL-6 and IL-8, which contribute to the CD14 independent increase in level of mRNA for IL-6 and IL 8
Andoh et al., J Immunol 2002 : IL-17 enhances the TNF-alpha induced IL-6 and IL-8 secretion in human colonic subepithelial myofibroblasts
Sitaraman et al., J Clin Invest 2001 : In addition, Salmonella typhimurium, TNF-alpha , and forskolin, known inducers of IL-6 secretion in intestinal epithelial cells, also stimulate IL-6 secretion into the apical compartment
Schreml et al., Int Immunopharmacol 2007 : Taking everything into account, we conclude that EC-proliferation is inhibited at concentrations needed to suppress TNF stimulated IL-6 synthesis
Martner et al., Infect Immun 2009 : If pneumococcal LytA was inactivated by mutation or by culture in a medium containing excess choline, the pneumococci induced production of significantly more TNF , IFN-gamma, and IL-12 in PBMC, whereas the production of IL-6 , IL-8, and IL-10 was unaffected ... Further, adding autolyzed pneumococci to intact bacteria inhibited production of TNF , IFN-gamma, and IL-12 in a dose dependent manner but did not inhibit production of IL-6 , IL-8, and IL-10 in response to the intact bacteria
Hamilton et al., Mol Cancer Res 2011 (Colonic Neoplasms) : TNF receptor (TNFR) 2 expression is increased in inflammatory bowel diseases, the azoxymethane/dextran sodium sulfate ( AOM/DSS ) model of colitis associated cancer, and by combined interleukin (IL) 6 and TNFa
Kunisch et al., Ann Rheum Dis 2007 (Arthritis, Rheumatoid...) : In contrast, inhibition of p38 reversed TNFalpha effects on proliferation and IL6/PGE ( 2 ) secretion ( but not on IL8 and MMP-3 secretion )
Ye et al., Nan Fang Yi Ke Da Xue Xue Bao 2009 : TNF-alpha induced the activation of NF-kappaB and increased the expressions of IL-6 and sICAM-1 in HUVECs ... Astragalus Membranaceus Injection can inhibit the TNF-alpha induced expression of IL-6 and sICAM-1 by suppressing NF-kappabeta activation, suggesting its protective effect on the endothelial function
Bryson et al., Arch Biochem Biophys 1998 : It potently inhibited interleukin 1- and tumor necrosis factor stimulated proteoglycan release from both nasal and articular cartilage
Ding et al., Cytokine 2000 : Blocking protein tyrosine kinase ( PTK ) activation by herbimycin A or genistein, or blocking NF-kappaB activation by pyrrolidinedithiocarbamate, reduced the IL-6 expression induced by TNF-alpha , IL-1beta and OSM
Shahar et al., Clin Immunol Immunopathol 1996 (Lung Diseases, Interstitial...) : Tumor necrosis factor-alpha (TNFalpha) and interleukin-1 (IL-1) enhanced IL-6 secretion and IL-6 mRNA transcription in AFb of SA patients
Barut et al., J Clin Invest 1993 (Leukemia, Hairy Cell) : In addition, IL-6 secretion by HCs was markedly augmented by TNF ... Finally, although neither IL-6 nor anti-IL-6 antibody altered TNF induced DNA synthesis by HCs, IL-6 antisense oligonucleotide inhibited TNF induced DNA synthesis and IL-6 secretion by HCs
Carter et al., Br J Haematol 1990 (Multiple Myeloma) : This study investigates the capacity of interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta) and tumour necrosis factor-alpha (TNF-alpha) to induce interleukin-6 (IL-6) production in freshly isolated myeloma cells ( MC ) and bone marrow derived stromal cells (MSC) ... Recombinant human ( rh ) IL-1 alpha, IL-1 beta and TNF-alpha augmented production of IL-6 in human MC. IL-6 was determined on a factor dependent Cess cell line ... Next we found that IL-1 alpha, IL-1 beta and TNF-alpha induced MSC to produce IL-6
Arcangeli et al., Sci Total Environ 2001 (Silicosis) : Our data show that TNF-alpha and TGF-beta are able to stimulate the proliferation of human lung fibroblasts in culture, to increase the collagen production of the cells and are both able to increase IL-6 production by lung fibroblasts of patients with silicosis
Chevrel et al., Ann Rheum Dis 2005 (Translocation, Genetic) : TNFalpha and IL1beta induced IL6 production by normal muscle samples and myoblasts, the action of TNFalpha being more potent on muscle samples
Hideshima et al., Oncogene 2001 (MAP Kinase Signaling System...) : TNFalpha also activates NF-kappaB and markedly upregulates ( fivefold ) secretion of interleukin-6 (IL-6) , a myeloma growth and survival factor, in bone marrow stromal cells ( BMSCs )
Shivers et al., Life Sci 1994 : Furthermore, supernatant interleukin-6 (IL-6) levels were decreased, but tumor necrosis factor ( TNF-alpha ) levels were increased by THC treatment
Abe et al., Nihon Rinsho Meneki Gakkai Kaishi 2013 : We also found that high-dose IgG specifically and completely inhibited accelerated expression of KD-related cytokines such as G-CSF, IL-6 and IL-1ß by HCAEC in response to TNF-a
Everaerdt et al., J Immunol 1994 (Neoplasms, Experimental) : However, the induction of high levels of circulating IL-6 by murine TNF was not affected, although IL-1ra almost completely blocked the induction of IL-6 by exogenously administered IL-1
Girasole et al., J Clin Invest 1992 (Osteoporosis) : Addition of 17 beta-estradiol in the cultures exerted a dose dependent inhibition of IL-1-, TNF-, and IL-1 + TNF induced production of bioassayable IL-6 ... In addition, estradiol inhibited both TNF induced IL-6 production and osteoclast development in primary bone cell cultures derived from neonatal murine calvaria
Duan et al., Clin Cancer Res 2004 (Glioma) : However, in the resistant cells, the production of IL-1beta and IL-6 were specifically impaired in response to TNF-alpha
Goldberg et al., Mol Immunol 2007 : In contrast, both IL-1beta and TNFalpha highly induced IL-6 secretion in chorion derived cells, demonstrating the overall responsiveness of these cells to these stimuli
Petersen et al., J Appl Physiol 2005 (Inflammation) : IL-6 stimulates the appearance in the circulation of other anti-inflammatory cytokines such as IL-1ra and IL-10 and inhibits the production of the proinflammatory cytokine TNF-alpha
Sethu et al., J Immunol 2008 (Calcium Signaling...) : Furthermore, use of antisense oligonucleotides to reduce expression of PLD1 or PLD2 demonstrated that PLD1 is required for TNF-alpha induced production of several important cytokines, such as IL-1beta, IL-5, IL-6 , and IL-13, in human monocytes
Turner et al., Cardiovasc Res 2007 (Coronary Disease) : Mechanism of TNFalpha induced IL-1alpha, IL-1beta and IL-6 expression in human cardiac fibroblasts : effects of statins and thiazolidinediones ... TNFalpha ( 0.1-10 ng/ml ) stimulated IL-6 , IL-1alpha and IL-1beta mRNA expression in cardiac fibroblasts in a concentration dependent manner ... Pharmacological inhibitors and receptor neutralizing antibodies established that both TNFalpha induced IL-6 and IL-1beta expression was mediated via the TNFRI receptor and p38 mitogen activated protein kinase ( MAPK ), phosphoinositide 3-kinase (PI3K)/Akt and nuclear factor (NF)-kappaB pathways ... Neither statins ( simvastatin, fluvastatin ) nor TZDs ( ciglitazone, rosiglitazone, troglitazone ) had inhibitory effects on TNFalpha induced IL-6 secretion or IL-1alpha/beta mRNA expression ; indeed, cytokine expression was increased in response to TZDs
Zoja et al., Am J Pathol 1991 : Interleukin-1 beta and tumor necrosis factor-alpha induce gene expression and production of leukocyte chemotactic factors, colony stimulating factors, and interleukin-6 in human mesangial cells ... Similarly IL-1 beta and TNF-alpha induced the interleukin-6 (IL-6) gene and active secretion of its mature protein
Dijsselbloem et al., J Immunol 2007 : We previously demonstrated that genistein suppresses TNF-alpha induced NF-kappaB dependent IL-6 gene expression in cancer cells by interfering with the mitogen- and stress activated protein kinase 1 activation pathway
Keslacy et al., Mol Pharmacol 2007 (Inflammation) : In contrast to these studies, we found that IFNgamma ( 1000 U/ml ) markedly inhibited TNFalpha induced expression of interleukin (IL)-6 , IL-8, and eotaxin by 66.29+/-3.33, 43.86+/-7.11, and 63.25+/-6.46 %, respectively ... These genes were also found to be NF-kappaB dependent in that TNFalpha induced expression of IL-6 , IL-8, and eotaxin was dose-dependently inhibited by the selective IKKbeta inhibitor 4- ( 2'-aminoethyl ) amino-1,8-dimethylimidazo [ 1,2-a ] quinoxaline ( BMS-345541 ) ( 1-30 microM )
Huang et al., J Biomed Sci 2005 : G-protein coupled receptor agonists differentially regulate basal or tumor necrosis factor-alpha stimulated activation of interleukin-6 and RANTES in human airway smooth muscle cells ... More importantly, such calcium mobilizing agents significantly enhanced TNF-alpha induced IL-6 secretion while RANTES secretion was abrogated ... We also found that Go-6976, a selective calcium dependent PKC isozyme inhibitor, did not inhibit IL-6 secretion in response to GPCR agonist and TNF-alpha ; whereas Rottlerlin, a PKC-delta inhibitor, inhibited both Thr- and TNF-alpha induced expression of IL-6 , while BK-induced IL-6 secretion was not affected
Damås et al., Basic Res Cardiol 2001 : ( ii ) In contrast, TNFalpha had no effect on IL-10 and only a modest effect on IL-1beta and IL-6 levels in these cells
Bandyopadhyay et al., Biochem Pharmacol 2006 : In MC3T3-E1 cells, apigenin dose-dependently ( from 5 to 20 microM ) inhibits TNFalpha induced production of the osteoclastogenic cytokines, IL-6 ( interleukin-6 ), RANTES ( regulated upon activation, normal T cell expressed and -secreted ), monocyte chemoattractant protein-1 ( MCP-1 ) and MCP-3
Klein et al., Hematol Oncol Clin North Am 1992 (Multiple Myeloma) : IFN-alpha and TNF induce an autocrine production of IL-6 in myeloma-cell lines and make possible the autonomous growth of these cell lines
Griesinger et al., J Soc Gynecol Investig 2001 (Bacterial Infections...) : The pathogenic microorganisms induced a dose- and time dependent release of IL-1beta, IL-6 , IL-8, and IL-10, whereas TNF-alpha secretion was not elevated
Lou et al., J Neuroimmunol 1997 : TBP I completely abolished TNF induced IL-6 production and E-selectin induction, while it partially inhibited TNF induced IL-8 production and up-regulation of ICAM-1 and VCAM-1
Gutteberg et al., APMIS 1991 (Sepsis) : Using a whole blood in vitro model, we have investigated the effect of Escherichia coli ( E. coli ), Streptococcus agalactiae ( group B streptococci, GBS ) and tumor necrosis factor alpha (TNF) on the generation of lactoferrin (LF), interleukin-1 beta (IL-1) and tissue thromboplastin (TPL) in healthy newborns at term and their mothers
Sayah et al., J Neurochem 1999 (Astrocytoma) : Whereas IL-1beta, tumor necrosis factor-alpha , and transforming growth factor-beta mRNA levels remained unchanged, stimulation of astrocytoma cells ( T98G, CB193, U118MG ) by C3a, C5a, and peptidic C3aR and C5aR agonists induced an increase in the IL-6 mRNA level
Baouz et al., Int Immunol 2005 (Asthma) : Finally, SMl decreases TNF- alpha induced production of the inflammatory cytokine IL-6
Sun et al., Acta Orthop 2006 (Bone Resorption...) : At a concentration of 88 particles/cell, bone cement particles yielded a 2-fold increase ( 327 pg/mL ) in soluble receptor activator for nuclear factor kappa B ligand secretion, a 5-fold ( 239 pg/mL ) increase in interleukin-6 secretion and 4-fold ( 129 pg/mL ) increase in tumor necrosis factor-alpha secretion
Zhu et al., Mol Med 2009 (Disease Models, Animal...) : The protective effects were associated with a significant reduction in peritoneal and serum levels of several surrogate markers of sepsis ( for example, Interleukin-6 [IL-6 ], keratinocyte derived chemokine [ KC ], monocytes chemoattractant protein-1 [MCP-1 ], macrophage inflammatory protein-2 [ MIP-2 ], tissue inhibitor of metalloproteinase-1 [ TIMP-1 ], soluble tumor necrosis factor-alpha receptor I [ sTNFRI ], and soluble tumor necrosis factor-alpha receptor II [ sTNFRII ] ) during a late stage of sepsis
Jones , BMC complementary and alternative medicine 2001 : IL6 increased at 7 weeks and TNFalpha increased in unstimulated cultures at 3 and 7 weeks but decreased at these times in LPS and SAC stimulated cultures
Neta et al., J Exp Med 1992 (Hypoglycemia...) : Thus, it is difficult to identify the cytokine primarily responsible for a particular biologic effect, since IL-1 and TNF stimulate one another, and both IL-1 and TNF stimulate IL-6
Hedges et al., Scand J Immunol 1993 : E. coli Hu734, IL-1 alpha and TNF-alpha stimulated an IL-6 response in the two epithelial cell lines
Ulich et al., J Immunol 1991 : IL-6 in turn inhibited TNF and IL-1 expression, suggesting that IL-6 may be part of a negative feedback mechanism in the cytokine cascade
Hierl et al., Exp Clin Endocrinol Diabetes 1998 : We observed that ( 1 ) IL-1beta and TNFalpha induced IL-6 in a dose and time dependent fashion, ( 2 ) TGFbeta 1 and 2 enhanced basal and IL-1beta and TNFalpha induced IL-6 expression, ( 3 ) ET-1 elicited a dose dependent stimulatory effect on IL-6 expression
Moscovis et al., FEMS Immunol Med Microbiol 2004 (Genetic Predisposition to Disease...) : The second objective was to assess effects of human recombinant IL-10 on interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) responses of human leukocytes to staphylococcal toxins implicated in SIDS
Minamitani et al., Mol Cell Endocrinol 2010 : p70 S6 kinase limits tumor necrosis factor-alpha induced interleukin-6 synthesis in osteoblast-like cells ... In the present study, we investigated whether p70 S6 kinase is involved in TNF-alpha stimulated IL-6 synthesis in MC3T3-E1 cells ... Rapamycin, an inhibitor of p70 S6 kinase, which attenuated the phosphorylation of p70 S6 kinase induced by TNF-alpha, significantly amplified the TNF-alpha stimulated IL-6 synthesis ... The amplification by rapamycin of TNF-alpha induced IL-6 synthesis was reduced by PD98059, a specific inhibitor of MEK1/2, or Akt inhibitor ... Taken together, these results strongly suggest that p70 S6 kinase limits the TNF-alpha stimulated IL-6 synthesis at a point upstream from p44/p42 MAP kinase and Akt in osteoblast-like cells
Sethu et al., PloS one 2010 (Disease Models, Animal...) : Similarly TNFalpha caused an increase in the serum levels of IL-6 , MIP-1alpha and MIP-1beta : this increase in cytokine/chemokine levels was inhibited in mice where PLD1 had been silenced
Thomsen et al., Scand J Clin Lab Invest 2011 : We have shown that tumor necrosis factor a (TNF-a) up-regulates CUNS and increases interleukin 6 expression (IL-6) within hours of administration ... IL-6 may also mediate TNF-a effects on acute phase protein gene expression
Spooren et al., Cell Signal 2010 : We have observed that treatment of human 1321N1 astrocytes with the beta-adrenergic agonist isoproterenol synergistically enhanced TNF-alpha induced expression of the cytokine IL-6
Todo et al., J Neurosurg 1994 (Meningeal Neoplasms...) : Interleukin-6 secretion was remarkably stimulated by tumor necrosis factor-alpha , IL-1 beta, and IL-4, and was also influenced by a combination of epidermal growth factor and bromocriptine
Verhoog et al., J Biol Chem 2011 (Inflammation) : Glucocorticoid independent repression of tumor necrosis factor (TNF) alpha stimulated interleukin (IL)-6 expression by the glucocorticoid receptor : a potential mechanism for protection against an excessive inflammatory response
Roger et al., Am J Physiol Lung Cell Mol Physiol 2004 (Adenocarcinoma...) : Exaggerated IL-8 and IL-6 responses to TNF-alpha by parainfluenza virus type 4-infected NCI-H292 cells
Tsukamoto et al., Inflamm Bowel Dis 2013 : : Enzyme linked immunosorbent assay and AP assay showed interleukin-1ß induced TNF-a shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells
Hata et al., Am J Physiol Gastrointest Liver Physiol 2002 (Inflammatory Bowel Diseases) : The combination of either IL-17 + IL-1beta or IL-17 + tumor necrosis factor (TNF)-alpha enhanced cytokine secretion ; in particular, the effects of IL-17 + TNF-alpha on IL-6 secretion were much stronger than the other responses
Li et al., Eur J Pharmacol 1998 (Multiple Sclerosis) : Production of tumor necrosis factor-alpha and the lysosomal cysteine proteinase cathepsin B were markedly inhibited, but production of interleukin-1 increased
Brieva et al., Int Immunopharmacol 2001 (Inflammation) : The drug increased the levels of TNF-alpha regulators such as IL-10 and corticosteroids, whereas it inhibited TNF-alpha dependent IL-6 production
Funakoshi-Tago et al., J Biol Chem 2003 : Interestingly, TNF induced interleukin (IL)-6 production was nearly abolished in FAK-/- fibroblasts, whereas a normal level of production was obtained in FAK+/- or FAK+/+ fibroblasts ... Similarly, TNF induced activation of activator protein 1 or NF-IL-6 was not impaired in FAK-/- cells
Zabłocka et al., Int Immunopharmacol 2007 : NP induced TNF-alpha only while PRP induced IL-6 , IL-10 and TNF-alpha
Kamijo et al., J Immunol 1990 (Leukemia, Myeloid) : Although IFN-gamma, IL-6 , granulocyte CSF, and granulocyte-macrophage CSF induced nitroblue tetrazolium reducing activity of U-937 cells, only IFN-gamma, and TNF induced it synergistically in combination with TGF-beta 1
Kato et al., Glycoconj J 2010 : Engagement of SIGNR1 on PEMs with an anti-SIGNR1-specific rat IgM antibody, ERTR9, induced production of IL-12 and tumor necrosis factor (TNF)-alpha from PEMs, while secretion of IL-6 and IL-1beta was not detected with the same treatment
Campuzano et al., J Neurosci Res 2009 (Brain Injuries) : The adult injured striatum exhibited a rapid induction of all cytokines analyzed, but the aged injured striatum showed a weak induction of cytokine expression : IL-1beta showed no injury induced changes at any time, TNF-alpha presented a late induction at 5 days after lesioning, and IL-6 was only induced at 6 hr after lesioning
Hou et al., Wei Sheng Yan Jiu 2012 : To investigate the effects of citreoviridin (CIT) on the expression of MCP-1, IL-1beta, IL-6 and IL-8 induced by TNF-alpha in human umbilical vein endothelial cells ( HUVECs )
Stebulis et al., J Rheumatol 2005 (Arthritis...) : Tumor necrosis factor-alpha (TNF-alpha) induced interleukin 6 (IL-6) , IL-8, and cyclooxygenase 2 (COX-2) mRNA levels were assessed ... TNF-a induced increases in IL-6 , IL-8, and COX-2 mRNA were suppressed by dexamethasone in both fd-FLS and td-FLS
Grooteman et al., ASAIO J 1995 : Interleukin 1 beta and interleukin 6 could not be detected at all, whereas tumor necrosis factor alpha levels were marginally elevated before and after HD with both membranes
Suzumura et al., Brain Res 1996 : Given that IL-1 and TNF alpha , monokines derived from microglia, induce IL-6 production in astrocytes, but not in microglia, results indicate that astrocytes and microglia may mutually regulate IL-6 production by different cytokines
Busam et al., J Hepatol 1990 : The secretion of IL-6 could also be induced by interleukin (IL)-1 beta and tumor necrosis factor ( TNF-alpha )
Schulze-Osthoff et al., EMBO J 1993 : This depletion of the mitochondrial oxidative metabolism resulted in resistance towards TNF cytotoxicity, as well as in inhibition of NF kappa B activation and interleukin-6 gene induction by TNF
Kramer et al., Am J Physiol Lung Cell Mol Physiol 2007 (Chorioamnionitis) : Recombinant TNF-alpha induced IL-6 production by lung monocytic cells exposed to intra-amniotic endotoxin but not in control cells
Ulich et al., Am J Pathol 1993 (Acute Disease...) : On the other hand, co-injection of sTNFrI and LPS decreased IL-6 levels in BAL fluid, most likely by interfering with the induction of IL-6 by TNF
Takeda et al., Int Immunopharmacol 2011 (Orthomyxoviridae Infections) : On day 2, tumor necrosis factor (TNF)-a production in BALF was also reduced significantly, but interferon-a, interleukin-12 , and interferon-? productions were augmented and natural killer ( NK ) cell activity was significantly elevated
Tliba et al., Mol Pharmacol 2004 : 8-Bromo-cADPr, a cADPr antagonist, significantly augmented TNFalpha induced interleukin-6 secretion, whereas regulated on activation normal T cell expressed and secreted secretion was suppressed
Grimstein et al., J Gene Med 2010 (Arthritis, Experimental) : In addition, the effects of hAAT and doxycycline on lipopolysaccharide (LPS)- or tumor necrosis factor-alpha induced interleukin (IL)-6 production from mouse fibroblast cells were also determined
Zachrisson et al., Cytokine 2001 : TNF-alpha induced the release of IL-8 ( P < 0.01 ) and IL-6 ( P < 0.05 ) from the duodenal explants
Samal et al., Leuk Res 1990 (Leukemia, Myeloid, Acute) : Recombinant interleukin 6 did not have the activity but it could significantly increase the activity of recombinant TNF
Granger et al., Biochim Biophys Acta 2000 : Whilst the expression of JunD was not affected by any of the mediators, the mRNA levels of c-fos and JunB were induced by LPS, IL-6 , IFN-gamma, PDGF and TNF-alpha, and that of c-jun by LPS, IFN-gamma, PDGF and TNF-alpha
Rougier et al., Cytokine 1998 : IL-1 alpha, IL-1 beta, and IL-3, tumour necrosis factor alpha (TNF-alpha) , Stem cell factor (SCF) and granulocyte-macrophage colony stimulating factor ( GM-CSF ) ( at 10 ng/ml ) stimulated IL-6 and IL-8 production in 0 % and 10 % FCS
Harris et al., Prostate 2000 (Disease Models, Animal...) : After 4 weeks of treatment with E ( 2 ) + DHT, a significant increase in transcript levels of IL-4, IL-5, IL-6 , MIP-2, eotaxin, and iNOS was detected , while IL-1beta and TNF-alpha transcript levels only increased slightly
Patestos et al., Biochimie 1993 (Fibrosarcoma) : Activation of the nuclear factor kappa B is not sufficient for regulation of tumor necrosis factor induced interleukin-6 gene expression ... Also activation of NF-kappa B as a function of time following TNF treatment did not reveal a correlation between the abundance of the protein/DNA complex and the TNF induced IL-6 mRNA levels
Takahashi et al., Indian J Dermatol 2009 : Furthermore, TNF-alpha induced secretion of IL-6 , IL-8, EGF, HGF, TGF-alpha, epiregulin, and amphiregulin were compared among these keratinocytes ... The significant induction of TNF-alpha increased IL-6 , IL-8, EGF, HGF, TGF-alpha, epiregulin, and amphiregulin, but the increase in these cytokines and growth factors were not different among normal skin, uninvolved, and involved psoriasis
Benveniste et al., J Neuroimmunol 1990 : IL-6 induction by LPS/Ca2+ ionophore is more sensitive to the suppressive effects of dexamethasone than is IL-6 induction by TNF-alpha/IL-1 beta
De Bosscher et al., Proc Natl Acad Sci U S A 1997 : Upon investigating DEX mediated repression of interleukin-6 expression induced by tumor necrosis factor , DEX treatment was found to act directly on NF-kappaB dependent transcription, without changing the expression level of IkappaB
Zarantonelli et al., Infect Immun 2006 (Meningococcal Infections...) : Although tumor necrosis factor alpha production was reduced in mice infected with the mutant of devoid LOS, both LOS mutants induced production of other proinflammatory cytokines, such as interleukin-1beta (IL-1beta), IL-6 , and the murine IL-8 homolog KC. Together, these results suggest that meningococcal LOS plays a role during the early infectious and invasive process, and they further confirm that other, nonlipopolysaccharide components of Neisseria meningitidis may significantly contribute to the inflammatory reaction of the host
Vermes et al., J Bone Joint Surg Am 2001 (Osteolysis) : Exogenous tumor necrosis factor-alpha also enhanced the release of interleukin-6 ( p < 0.01 ) and transforming growth factor-beta1 ( p < 0.05 ), whereas the secretion of transforming growth factor-beta1 was increased by insulin-like growth factor-I and prostaglandin E2 as well
Roldán et al., J Immunol 1992 : Finally, IL-1 beta plus TNF-alpha induced the production of IL-6 , but not of Ig, by adherent BM cells ... These results suggest that IL-1 beta and TNF-alpha produced by adherent BM cells synergistically induce early IL-6 generation, which, in turn, drives BM B cell producers into the high rate Ig-secreting state
Wei et al., Exp Neurol 2013 (Disease Models, Animal...) : Furthermore, inhibition of TNF-a synthesis by intraperitoneal thalidomide prevented both mechanical allodynia and the up-regulation of IL-6 in DRGs following L5-VRT ... These data suggested that the increased IL-6 in afferent neurons and spinal cord contribute to the development of neuropathic pain following motor fiber injury, and that TNF-a is responsible for the up-regulation of IL-6
Silacci et al., J Biol Chem 1998 : Given the high levels of soluble receptor in synovial fluid and the marked induction of IL-6 by IL-1 or TNF-alpha , it is likely that IL-6 and its soluble receptor are critical in controlling the catabolic effects of pro-inflammatory cytokines
Moe et al., J Cell Mol Med 2011 (Ventricular Remodeling) : Nox2 and Nox4 siRNA were used to determine whether or not Nox2 and Nox4 mediated TNF-a induced ROS and upregulation of IL-1ß and IL-6 in adult human cardiomyocytes ... Nox2 and Nox4 siRNA significantly attenuated TNF-a induced ROS and upregulation of IL-1ß and IL-6 in cardiomyocytes
Fernandes et al., J Neuroimmunol 2004 : UCB leads to an increase of extracellular glutamate and highly enhances the release of TNF-alpha and IL-1beta, while inhibiting the production of IL-6
Krady et al., J Neurosci Res 2008 : We show that CNTF reduces COX-2 levels, whereas IL-6 increases the expression of IL-1beta, TNFalpha , and Cox-2
Giuliani et al., Scand J Rheumatol 1998 : Spontaneous and IL-1 + TNF-alpha stimulated IL-6 release was measured in supernatants of cultures of human osteoblastic osteosarcoma cells MG-63, pretreated for 4 hours with different doses of etidronate, clodronate or alendronate using a specific bioassay
Yap et al., Biochim Biophys Acta 1991 : Tumor necrosis factor (TNF) inhibits interleukin (IL)-1 and/or IL-6 stimulated synthesis of C-reactive protein (CRP) and serum amyloid A (SAA) in primary cultures of human hepatocytes
Tyagi et al., Mol Cell Endocrinol 2010 : In addition, like 17beta-estradiol, presence of medicarpin inhibited TNFalpha induced upregulation of interleukin-1 , and -6 mRNA levels in osteoblasts
Robinson et al., Infect Immun 2009 (Disease Susceptibility...) : Cellular tumor necrosis factor , gamma interferon, and interleukin-6 responses as correlates of immunity and risk of clinical Plasmodium falciparum malaria in children from Papua New Guinea
Xu et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2006 (Liver Failure, Acute) : As compared with the control group, the degree of liver injury in the therapy group significantly decreased ( P < 0.05 ), and the levels of TNF-alpha and IFN-gamma mRNA in the hepatic tissue also reduced remarkably ( P < 0.01, respectively ), while the levels of IL-6 and IL-10 mRNA increased ( P < 0.01, respectively ) at 6 h after the D-GalN/LPS injection
Libby et al., Am J Pathol 1986 : Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells
Fan et al., Immunology 2007 : LPS induced production of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), IL-10 and interferon-gamma-inducible protein-10 (IP-10); SA induced TNF-alpha , and IL-1beta production ; and GBS induced TNF-alpha, IL-6 , IL-1beta, macrophage inflammatory protein-1alpha ( MIP-1alpha ) and keratinocyte chemoattract ( KC ) production were all decreased ( P < 0.05 ) in Galpha ( i2 ) ( -/- ) or Galpha ( i1/3 ) ( -/- ) mice compared with WT mice
Harigai et al., J Clin Lab Immunol 1991 (Arthritis, Rheumatoid) : Interleukin 1 and tumor necrosis factor-alpha synergistically increase the production of interleukin 6 in human synovial fibroblast ... In this paper, we examined the effects of tumor necrosis factor-alpha (TNF-alpha) on IL-6 production by human synovial fibroblasts ... Both IL-1 and TNF-alpha induced IL-6 production by synovial fibroblasts in a dose dependent manner
Mentzel et al., Clin Exp Rheumatol 1998 (Arthritis, Reactive) : Finally, TNF-alpha increased the levels of IL-6 and NO in the supernatants of synoviocytes ; the extent of stimulation was dependent on the course of AIA
Wu et al., Mol Cell 2004 : Different combinations of site-specific phosphorylations of SRC-3 are required for induction of IL-6 gene expression by TNF-alpha as compared to oncogenic transformation of MEFs
Boue et al., J Immunol 1992 (HIV Infections) : HIV induced IL-6 production ( 500 to 1500 pg ) in the presence of IL-4, with a slight production of TNF-alpha
Alsalameh et al., J Rheumatol 2003 (Arthritis, Rheumatoid...) : TNF-a stimulation induced IL-6 secretion by RA SFB ( 3-fold ) and OA SFB ( 4-fold ), as well as MMP-1 secretion ( RA, 85-fold ; OA, 29-fold ), with significant differences between RA and OA
Lee et al., Scand J Rheumatol 2008 (Arthritis, Experimental) : TNFalpha , IL-1beta, and MMP-3 expression decreased, but IL-6 expression in AD-treated joint tissues increased
Procházková et al., Vnitr Lek 2006 (Rheumatic Diseases) : In the treatment of rheumatic diseases are currently used TNFalpha inhibitors and blockade of the IL-1, in phase of clinical trials or actual registration are agents blocking IL-6 , the antibodies against B cell and inhibition of activation of T-cells by costimulating blockade with CTLA4Ig
Djafarzadeh et al., PloS one 2012 : Furthermore, prior remifentanil incubation prevented TNF-a induced IL-6 release of HepG2 cells, and attenuated fragmentation of pro-caspase-3 into cleaved active caspase 3 ( an early marker of apoptosis )
Shimizu et al., Mol Cell Biol 1990 (Chromosome Deletion...) : We demonstrate that a common IL-6 promoter element, termed inflammatory lymphokine-responsive element ( ILRE ), is important for induction of IL-6 gene expression by IL-1 and TNF-alpha despite possible differences in the mechanisms of action of these lymphokines ... In addition, mutations of the ILRE sequence which impair the binding of this nuclear factor abolished the induction of IL-6 gene expression by IL-1 and TNF-alpha in vivo ... These results indicate that a nuclear factor indistinguishable from NF-kappa B is involved in the transcriptional activation of the IL-6 gene by IL-1 and TNF-alpha
Pang et al., Clin Exp Immunol 1994 : TNF-alpha stimulated the release of GM-CSF, IL-6 and IL-8 and, combined with IL-1 alpha, cytokine production was enhanced synergistically
Shi et al., Inflamm Res 2004 (Chondrosarcoma...) : IL-1, but not TNF-alpha , can induce IL-6 , bone morphogenic protein 2 (BMP-2), and cyclooxygenase ( COX-2 ) expression in SW1353 cells
Tsan et al., Am J Physiol 1992 (Anoxia) : IL-6 enhances TNF-alpha- and IL-1 induced increase of Mn superoxide dismutase mRNA and O2 tolerance
Sanceau et al., J Immunol 1991 : Sequential stimulation of THP-1 cells by IFN-gamma and subsequently by TNF-alpha did not allow IL-6 gene induction, suggesting that IFN-gamma and TNF-alpha induced or activated different signaling factors which should act together to trigger IL-6 gene transcription ... Taken together, results reported here provide evidence that functional interaction between IFN-gamma and TNF-alpha is involved in the regulation of IL-6 and IL-6R expression in monocytic cells
Matthys et al., Infect Immun 1995 (Body Weight...) : The data obtained with anti-IL-6 antibody indicate that endogenous IL-6 is involved in regulating the levels of TNF and IFN-gamma in serum
De Caterina et al., Am J Clin Nutr 2000 (Arteriosclerosis) : Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ), E-selectin, intercellular adhesion molecule 1 ( ICAM-1 ), interleukin 6 (IL-6), and IL-8 in response to IL-1, IL-4, tumor necrosis factor , or bacterial endotoxin, with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations
Ammit et al., Am J Respir Cell Mol Biol 2002 : Tumor necrosis factor-alpha induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells : modulation by glucocorticoids and beta-agonists ... We found that TNF-alpha induced IL-6 gene expression in ASM cells via a nuclear factor (NF)-kappaB dependent pathway, whereas RANTES gene expression was mediated via activation of activator protein (AP)-1 and nuclear factor of activated T cells ( NF-AT ) ... TNF-alpha induced IL-6 secretion was only partially inhibited by dexamethasone, yet TNF-alpha induced RANTES secretion was abolished ... beta-Agonists augmented TNF-alpha induced IL-6 secretion, reflecting an additive effect of NF-kappaB and CRE response elements on IL-6 gene expression ... Collectively, these data elucidate transcriptional mechanisms mediating TNF-alpha induced IL-6 and RANTES secretion from ASM cells, and identify the specific cis- or trans acting elements that determine the differential effects of glucocorticoids and cAMP elevating agents on the expression of these genes
Loppnow et al., Cell Immunol 1989 : LPS, lipid A, and TNF increased IL6 release modestly ( 5 to 20-fold ), while recombinant IL1s ( rIL1s ) stimulated this process 100 to 400-fold
Platz et al., Oligonucleotides 2005 : The tumor necrosis factor- alpha (TNF-alpha) induced release of interleukin-6 (IL-6) and IL-8 was significantly inhibited by the application of siRNA.p65
Beyaert et al., Cytokine 1991 : This study shows the in vitro effect of LiCl on the TNF induced or interleukin 1 (IL-1) induced expression of IL-6 , granulocyte-macrophage colony stimulating factor ( GM-CSF ), IL-3, IL-2, and the IL-2 receptor-alpha ( IL-2R alpha )
Fleisher et al., Exp Eye Res 2000 : Tumor necrosis factor-alpha , although ineffective alone, increased interleukin-1beta induced interleukin-6 release in a concentration dependent manner when co-incubated with interleukin-1betafor 18 hr ... However, tumor necrosis factor-alphadid not enhance interleukin-1beta induced interleukin-6 release if co-incubated with interleukin-1betafor a shorter time ( 6 hr )
Van De Walle et al., Toxicol In Vitro 2010 : The effects of TNF-alpha on IL-8 and IL-6 or NO production were stronger upon combination with IL-1beta or IFN-gamma, respectively, whereas cells were unaffected by the presence of LPS
Leonard et al., Kidney Int 1999 (MAP Kinase Signaling System) : The aim of this study was to examine the role of the p38 and extracellular signal regulated kinase ( ERK ) mitogen activated protein kinase ( MAPK ) pathways in regulating TNF-alpha mediated IL-6 production from both primary human mesangial cells ( HMCs ) and human proximal tubular (HPT) cells ... TNF-alpha ( 0.1 to 100 ng/ml ) stimulated a dose dependent increase in IL-6 production in both renal cell types ... The role of these activations in IL-6 production was confirmed by the ability of both inhibitors SB203580 ( 1 to 30 microM ) and PD98059 ( 0.01 to 10 microM ) to inhibit basal and TNF-alpha stimulated IL-6 production in both cell types ... In response to TNF-alpha , the activation of both pathways leads to IL-6 production
Ritchie et al., Cytokine 1997 : Adenosine increased IL-6 release and inhibited TNF release from ovarian cells ... Thus, in immune and endocrine tissues, adenosine increases IL-6 release, but inhibits TNF release
Yamamoto et al., J Immunol 1995 (Sarcoma, Experimental) : Moreover, IFN-gamma/TNF production was negatively regulated by IL-6
Andoh et al., Clin Exp Immunol 1999 : The EMSAs indicated that sodium butyrate suppressed TNF-alpha induced nuclear factor (NF)-kappaB- and activation protein (AP)-1-DNA binding activity, but enhanced TNF-alpha induced activation of CCAAT/enhancer binding protein ( C/EBP)beta (NF-IL-6 ) -DNA binding activity
Aikawa , Nihon Geka Gakkai Zasshi 1996 (Multiple Organ Failure...) : In response to surgical insults, macrophages produce and release TNF and IL-1 which subsequently induce the production of other cytokines ( IL-6 , IL-8, etc. ) and other endogenous chemical mediators ( growth factors, adhesion molecules, complement cleavage products, thrombin, eicosanoids, PAF, nitric oxides, oxygen-free radicals, granulocyte elastase, etc. )
Werth et al., J Invest Dermatol 2003 : Although interleukin-12 is considered to act primarily on lymphocytes, provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha, we hypothesized that interleukin-12 might also affect tumor necrosis factor alpha secretion from skin cells ... Remarkably, the exogenous interleukin-12 totally blocked ultraviolet-B induced tumor necrosis factor alpha production ... Thus, interleukin-12 strongly inhibits tumor necrosis factor alpha production by noninflammatory skin cells, mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter
Tada , Hokkaido Igaku Zasshi 1992 (Brain Neoplasms...) : TNF at a low dose ( 10 U/ml ) stimulated production of prostaglandin E2, Mn-superoxide dismutase, interleukin (IL)-6 and IL-8 by glioblastoma cells
Juarranz et al., Rheumatology (Oxford) 2004 (Arthritis, Rheumatoid...) : The effects of VIP on basal or tumour necrosis factor alpha (TNF-alpha) stimulated production of CCL2 ( MCP-1, monocyte chemotactic protein 1 ), CXCL8 [ interleukin (IL)-8 ], IL-6 and TNF-alpha were studied by specific ELISAs ( enzyme linked immunosorbent assays )
Aggarwal et al., FEBS Lett 1995 : The difference in the signaling was further evident from our observation that TNF induced the expression of interleukin-6 but anti-Fas did not
Gomaraschi et al., Biochim Biophys Acta 2005 : Human plasma HDL caused a concentration dependent inhibition of TNFalpha induced IL-6 production in human endothelial cells ( by 58.5+/-1.5 % at 2 mg of HDL-protein/ml )
Bersinger et al., Arch Gynecol Obstet 2011 : The release of ENA-78, IL-8 and IL-6 by the isolated and monolayer cultured stromal cell fraction in the presence of IL-1ß ( 0.08 to 50 ng/mL ), TNF-a , and interferon-? ( both 20 to 500 ng/mL ) was determined
Miyazawa et al., J Allergy Clin Immunol 1999 (Arthritis, Rheumatoid...) : Enhanced IL-6 production by high producing clones was independent of cytokines from other cell populations or autocrine production of tumor necrosis factor-alpha and IL-1
Ikeda et al., Hepatology research : the official journal of the Japan Society of Hepatology 2008 : In cultured BEC, TNF-alpha, interleukin (IL)-1beta, IL-6 , and interferon-gamma induced the expression of CDX2 mRNA, though only TNF-alpha additionally induced the expression of MUC2 mRNA
Gould et al., Kidney Int 2002 : BMP-7 represses the basal and TNF-alpha stimulated expression of the pro-inflammatory cytokines IL-6 and IL-1beta, the chemokines MCP-1 and IL-8, and the vasoconstrictor ET-2 in PTEC
Tsuchiya et al., J Pharmacol Exp Ther 2010 (Arthritis, Rheumatoid) : TNFalpha stimulation induced production of inflammatory cytokines such as IL-6 and IL-8 in RSF, and the extent of IL-6 and IL-8 induction was dramatically reduced by CHPD under noncytotoxic concentrations
Kolasa et al., Chem Biol Interact 2013 : BZA/TNF-a mediated IL-6 induction in MCF-7 cells was counteracted by silencing aryl hydrocarbon receptor (AhR), known to mediates most of PAH effects
Iho et al., Scand J Immunol 1993 : IL-6 , as previously reported, acts at late stages of low-dose IL-2 culture to enhance LAK, but does not stimulate TNF-alpha production
Mustafa et al., Eur J Oral Sci 1998 : In contrast to its effect on IL-1beta, triclosan did not influence the mRNA expression or the production of IL-6 induced by TNFalpha
Chida et al., Biochem Biophys Res Commun 2007 (Fever) : Only IL-1alpha, but not TNFalpha , induced IL-6 in the IL-1alpha/beta/TNFalpha KO mouse brain, while both cytokines induced cyclooxygenase (Cox)-2
Richards et al., Cytokine 1991 : IL-1 alpha and tumor necrosis factor markedly induced steady state levels of IL-6 at 20 h in serum-free conditions, whereas transforming growth factor-beta ( TGF-beta ), epidermal growth factor, and 10 % fetal calf serum did not
Das et al., Laryngoscope 2005 (Otitis Media...) : Secondary TNF-alpha stimulation following well established ( i.e., 72 h ) RSV infection induced marked increases in IL-6 , IL-8, and RANTES when compared with both RSV infection alone and TNF-alpha stimulation alone
Hauschildt et al., Eur J Immunol 1990 : IL 6 and TNF-alpha secretion increased from day 6 to day 20 whereas IL 1 secretion increased until day 13 and decreased on day 20
Butler et al., Eur Cytokine Netw 1994 (Arthritis, Rheumatoid) : TNF-alpha stimulated synovial fibroblast DNA synthesis and the release of IL-6 , IL-8 and PGE2 was inhibited by antagonist monoclonal antibodies against either the p55 or the p75 TNF receptor, although the blockade of the p55 TNF receptor had a more potent effect than inhibition of the p75 TNF receptor alone ... Both p55 and p75 TNF receptors on dermal and gingival fibroblasts were also involved in TNF-alpha mediated DNA synthesis and IL-6 , IL-8 and PGE2 release, although differences in the levels of DNA synthesis and release of inflammatory cytokines and PGE2 were observed between the three fibroblast types
Spangelo et al., Neuroimmunomodulation 1995 : Similarly, IL-1 and TNF alpha affect granulosa cell steroidogenesis and IL-6 production
Reiter et al., Cell Immunol 1990 : The protective effect of TNF-alpha and IL-1 alpha is not mediated by the induction of IFN-beta 2/IL-6
Ishii-Yonemoto et al., Am J Physiol Endocrinol Metab 2010 (Inflammation...) : In contrast, overexpression of 11 beta-HSD1 further augmented TNF-alpha induced iNOS, IL-6 , and MCP-1 expression
Seidel et al., Am J Physiol Lung Cell Mol Physiol 2009 (Chronic Disease...) : TNFalpha induced eotaxin, RANTES, and IL-6 as well as PDGF-BB induced IL-6 expression was inhibited by DMF and by dexamethasone from asthmatic and nonasthmatic ASMC, but the combination of both drugs showed no glucocorticoid sparing effect in either of the two groups
Hosokawa et al., Arch Biochem Biophys 2010 (Diabetes Complications...) : In differentiating 3T3-F442A adipocytes, fucoxanthinol, which is a fucoxanthin metabolite found in WAT, attenuated TNF-a induced MCP-1 and IL-6 mRNA overexpression and protein secretion into the culture medium
Bae et al., J Cell Physiol 2010 : In this study, we show that HK-2 cells express endothelial protein C receptor ( EPCR ) and that the occupancy of this receptor by protein C switches the signaling specificity of thrombin so that the activation of PAR-1 by thrombin inhibits the TNF-alpha mediated synthesis of IL-6 and IL-8 and down-regulates the TGF-beta mediated expression of ECM proteins
De Bosscher et al., Proc Natl Acad Sci U S A 2000 : Previously, we have shown that GCs repress tumor necrosis factor induced IL-6 gene expression by an NF-kappaB dependent nuclear mechanism without changing the DNA binding capacity of NF-kappaB or the expression levels of the cytoplasmic inhibitor of NF-kappaB ( IkappaB-alpha )
Van Molle et al., J Immunol 1997 : The observation that these acute phase proteins did not affect the induction by TNF of IL-6 , nitric oxide, or serum amyloid P excludes a nonselective inhibition of the TNF activated pathways
Ruef et al., Am J Pathol 1992 : IL-6 secretion is stimulated in a dose dependent manner by IL-1 alpha, TNF-alpha , and PDGF
Scamurra et al., J Interferon Cytokine Res 1996 : IL-6 expression in transformed swine testicular (TST) fibroblasts was enhanced by TNF and IL-1 beta and to a lesser extent by poly ( I ). ( C ) and LPS
Rühl et al., Am J Physiol Gastrointest Liver Physiol 2001 : Stimulation with TNF-alpha did not affect IL-6 mRNA expression, whereas IL-1beta stimulated IL-6 mRNA and protein synthesis in a time- and concentration dependent fashion
Alvarez et al., Biochim Biophys Acta 2002 : Previous studies from our laboratory have shown that TNF induces IL-6 mRNA expression in cultured skeletal muscle cells ... These findings indicate that the effects of TNF on muscle protein synthesis are mediated by IL-6 , but that TNF exerts IL-6 independent effects on proliferation of murine skeletal myoblasts
Totlandsdal et al., Toxicological sciences : an official journal of the Society of Toxicology 2008 : In lung cell cultures both particle types induced release of IL-6 and IL-1beta, whereas TNF-alpha was only detected upon exposure to St Louis particles
Desai et al., Am J Obstet Gynecol 2013 (Inflammation...) : Finally, metformin dose-dependently reduced TNF-a induced IL-6 and I?Ba levels in cultured placental JAR cells ... Similarly, metformin treatment of a placental cell line suppressed TNF-a induced IL-6 levels by NF?B inhibitor
Henness et al., J Allergy Clin Immunol 2004 : IL-17A augments TNF-alpha induced IL-6 expression in airway smooth muscle by enhancing mRNA stability ... However, IL-17A ( 10 ng/mL ) significantly augmented TNF-alpha induced IL-6 secretion 12-fold ( TNF-alpha, 2.3 +/- 0.4 ng/mL ; IL-17A and TNF-alpha, 27.5 +/- 4.8 ng/mL ; P < .05 ) while having no effect on IL-1beta induced IL-6 ... Although IL-17A had no effect on nuclear factor kappaB mediated transcriptional regulation of IL-6 gene expression induced by TNF-alpha , IL-17A significantly augmented TNF-alpha induced IL-6 mRNA stability ... Collectively, these results demonstrate that IL-17A amplifies the synthetic function of ASM cells, acting via a posttranscriptional pathway, rather than transcriptional mechanisms, to augment TNF-alpha induced secretion of IL-6 from ASM cells
Lee et al., J Biochem 2001 : TNF-alpha gene expression was also dramatically reduced by SNP, but IL-6 gene expression was inhibited much less
Matsui et al., J Ethnopharmacol 2009 : Aqueous extract of Vitex trifolia leaves showed significant dose- and time dependent inhibitory activity on interleukin (IL)-1 beta, IL-6 and iNOS mRNA synthesis, but slight effect on tumor necrosis factor (TNF)-alpha , all of which are involved in the inflammatory response
Matsumura et al., Biochem Biophys Res Commun 2010 : Our study showed, for the first time, that RNAi mediated selective depletion of BCAP- ( L ) enhanced IL-6 and IL-10 production but not TNF-a production in TLR ligand stimulated macrophages
Aderka et al., Blood 1993 (Cell Transformation, Viral...) : Because TNF induces production of interleukin-6 (IL-6) , which has been shown to be a growth factor for myeloma and other transformed B cells, we examined the possibility that IL-6 mediates the growth-stimulatory effect of TNF on B-CLL cells
Elias et al., J Immunol 1990 : IL-1 and tumor necrosis factor synergistically stimulate fibroblast IL-6 production and stabilize IL-6 messenger RNA
Lin et al., Virology 2007 : Wild-type PIV5 infection induces little, if any, expression of cytokines such as IL-6 or TNF-alpha , whereas infection by a mutant PIV5 lacking the conserved C-terminal cysteine rich domain ( rPIV5VDeltaC ) induced high levels of IL-6 expression
Suarez-Cuervo et al., Breast Cancer Res Treat 2003 (Breast Neoplasms) : Tumor necrosis factor-alpha induces interleukin-6 production via extracellular regulated kinase 1 activation in breast cancer cells ... We show here, that while basal, TGF-beta and IL-1beta induced IL-6 production was similar in parental cells and in pcDNA3 control, ERK1K71R and p38/AF clones, TNF-alpha induced IL-6 production was blunted in the ERK1K71R clones ... In conclusion, TNF-alpha induced IL-6 production is mediated via ERK1 activation in MDA-MB-231 cells
Papa et al., J Clin Virol 2006 (Hemorrhagic Fever, Crimean) : Statistically significant differences between the groups were obtained for TNF-alpha and IL-6 : TNF-alpha was detected in 3 cases in group A, and in none of the other groups, while IL-6 was elevated in 10/16 patients in group A, 4/9 in group B, and 4/26 in group C. sTNF-R was not significantly different for the three groups
Fischer et al., Eur J Immunol 1997 (Toxoplasmosis, Animal) : The IL-6 response of parasitized astroglia was up-regulated by external tumor necrosis factor (TNF)-alpha and transforming growth factor (TGF)-beta 1, with only TNF-alpha enhancing simultaneous release of IL-1
Oda et al., J Gastrointest Surg 2002 (Liver Failure, Acute) : During the 24-hour postoperative period, GGA significantly suppressed the release of aspartate or alanine aminotransferase and elevation of the serum interleukin-6 level, and completely inhibited an increase in the serum level of tumor necrosis factor-alpha
Feldmann et al., Annu Rev Immunol 2001 (Arthritis, Rheumatoid...) : Clinical investigations in which the activity of TNF alpha in RA patients was blocked with intravenously administered infliximab, a chimeric anti-TNF alpha monoclonal antibody ( mAB ), has provided evidence that TNF regulates IL-6 , IL-8, MCP-1, and VEGF production, recruitment of immune and inflammatory cells into joints, angiogenesis, and reduction of blood levels of matrix metalloproteinases-1 and -3
Nagy et al., J Bone Miner Res 2001 : In contrast to these findings, the stimulatory effects of PTH, TNF-alpha , and IL-1beta on the IL-6 promoter expression were enhanced by staurosporine
Wu et al., Kidney Int 2005 : In the present studies, we examine whether LXA ( 4 ) have inhibitory effects on tumor necrosis factor-alpha (TNF-alpha) induced productions of IL-1beta and IL-6 and proliferation of glomerular mesangial cells of rat, and explore the molecular mechanisms of signal pathway of LXA ( 4 ) ... LXA ( 4 ) also antagonized TNF-alpha stimulated IL-1beta and IL-6 synthesis, and these antagonisms were related to SHP-2 and NF-kappaB pathway dependent signal transduction
Herseth et al., Toxicol In Vitro 2009 : In this study we investigated the role of IL-1 beta, TNF-alpha and COX2 in silica induced regulation of IL-6 release and pneumocyte loss in various mono- and co-cultures of monocytes, pneumocytes and endothelial cells
Kehlen et al., Arthritis Res Ther 2003 (Arthritis, Rheumatoid) : Among these genes we identified the following : tumor necrosis factor stimulated gene-6 ( TSG-6 ), IL-6 , IL-8, GRO-beta, and bone morphogenetic protein-6 with an expression 3.6-10.6-fold that in the unstimulated control
Utsunomiya et al., Cytokine 1998 (Pleural Effusion...) : Generation of inflammatory cytokines in zymosan induced pleurisy in rats : TNF induces IL-6 and cytokine induced neutrophil chemoattractant ( CINC ) in vivo ... These results suggest that CINC produced in the pleural exudate may participate in neutrophil infiltration, that IL-6 induced in the plasma stimulates T-kininogen production, and that endogenous TNF may be partly involved in the induction of CINC and IL-6 in this zymosan inflammation
Yan et al., J Leukoc Biol 2001 (Corneal Diseases...) : Inclusion of IL-10 neutralizing antibody in the culture medium significantly ( p < 0.05 ) enhanced TNF-alpha induced IL-6 and MIP-2 production by both corneal cell types
Galatowicz et al., Clin Exp Allergy 2007 (Conjunctivitis, Allergic...) : For conjunctival biopsy derived cultures ( n=11 ), FcepsilonR1 stimulation increased histamine, TNF-alpha , TNF-beta, IL-5 and IL-8 levels and the production of IL-5, IL-6 ( P < 0.05 ), histamine and IL-8 ( P < 0.01 ) was inhibited by epinastine
Kawasaki et al., Anesth Analg 1999 : Therefore, in this study, we investigated the efficacy of ketamine on LPS induced TNF-alpha, IL-6, and IL-8 production and recombinant human ( rh ) TNF-a induced IL-6 and IL-8 production in human whole blood ... IMPLICATIONS : We found that ketamine suppressed lipopolysaccharide induced tumor necrosis factor alpha, interleukin (IL)-6, and IL-8 production and recombinant human tumor necrosis factor induced IL-6 and IL-8 production in human whole blood
Fukuzawa et al., Immunol Lett 1997 : Lipopolysaccharide (LPS) induced in vitro TNF-alpha production by human peripheral blood mononuclear cells, measured by enzyme linked immunosorbent assay ( ELISA ), was significantly inhibited with more than 1 x 10 ( -3 ) mol/l of nicotinamide, while interleukin-1-beta was not inhibited and interleukin-6 was slightly inhibited even with 10 ( -2 ) mol/l. Oral administration of nicotinamide with more than 62.5 mg/kg also significantly inhibited LPS induced serum TNF-alpha production measured by ELISA and bioassay in Balb/c mice
Ruan et al., Curr Alzheimer Res 2009 (Alzheimer Disease...) : Expression of TNF-alpha was detected at 8 months of age, while IL-1 beta, IL-6 and MCP-1 at 10 months
Lieb et al., J Neurochem 1996 (Astrocytoma) : Whereas activation of protein kinase A was able to induce expression of the IL-6 gene, it did not induce TNF alpha gene expression and was not involved in IL-1 beta induced IL-6 and TNF alpha gene expression
Yamamoto et al., Eur J Pharmacol 1996 (Disseminated Intravascular Coagulation) : Plasma interleukin-1 and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) inhibited the increased plasma interleukin-1 ( 100.0 % ) and plasma TNF-alpha ( 89.2 % ) levels
Mane et al., Gene Ther 2006 (Thrombocytopenia) : Moreover, we also demonstrated that TNFalpha blockade via antibody or huTNFR : Fc pretreatment attenuates both thrombocytopenia ( > 40 % increase in platelet count ) and IL-6 expression ( > 80 % reduction ) without affecting interleukin 12, liver enzymes, hematological indices or vector transduction in a murine model
Pedersen , Essays Biochem 2006 (Atherosclerosis...) : IL-6 stimulates the appearance in the circulation of other anti-inflammatory cytokines such as IL-1ra ( interleukin-1 receptor antagonist ) and IL-10 ( interleukin-10 ) and inhibits the production of the pro-inflammatory cytokine TNF-alpha ( tumour necrosis factor-alpha )
Dai et al., Bone 2006 : The more extensive effect of TNFalpha likely reflects that TNFalpha stimulates IL-6 production and bone resorption in pathological situations
Wilbrink et al., Br J Rheumatol 1991 : TNF alpha induced no detectable amounts of IL-1 ( less than 0.01 U ) in young or old cartilage but did induce IL-6 production
Vermes et al., J Bone Joint Surg Br 2004 : In this study, we tested the effects of calcitriol ( 1alpha,25-dihydroxy-vitamin-D3 ) and the bisphosphonate pamidronate on titanium-particle- and TNF-alpha induced release of interleukin-6 and suppression of osteoblast-specific gene expressions in bone-marrow derived stromal cells with an osteoblastic phenotype
Murakami et al., Eur J Pharmacol 2007 (Insulin Resistance) : As a result, the IL-6 produced by RAW264.7 cells is an inducer of TNFalpha expression in 3T3-L1 adipocytes, and the IL-6 secretion is inhibited by the activation of PPARalpha
Alshorafa et al., Tohoku J Exp Med 2012 (Psoriasis) : Exogenous H ( 2 ) S inhibited the TNF-a mediated upregulation of NO, IL-6 and IL-8 in a dose dependent manner
Xu et al., Stem Cells 2009 : Furthermore, while STAT1 is critical in IFNgamma signaling, we found that STAT1 knockdown in MSCs did not affect C/EBPbeta expression or the synergistic induction of IL-6 and CXCL1 by IFNgamma and TNFalpha
Hamanaka et al., J Biol Chem 1992 : We have previously reported that tumor necrosis factor-alpha (TNF-alpha) enhances expression of interleukin-6 , collagenase, plasminogen activator inhibitor-1, and basic fibroblast growth factor genes in human omental microvascular endothelial ( HOME ) cells in culture
Hashizume et al., Rheumatology (Oxford) 2008 (Arthritis, Rheumatoid) : On the other hand, TNF-alpha and IL-17 did not induce RANKL expression, although TNF-alpha, IL-17 or IL-1beta stimulated cell growth and IL-6 production
Natsume et al., Int J Mol Med 2010 : Synergistic effect of vasoactive intestinal peptides on TNF-alpha induced IL-6 synthesis in osteoblasts : amplification of p44/p42 MAP kinase activation ... In the present study, we investigated the effect of vasoactive intestinal peptide (VIP) on TNF-alpha induced IL-6 synthesis in these cells ... VIP, which by itself slightly stimulated IL-6 synthesis, synergistically enhanced the TNF-alpha induced IL-6 synthesis in MC3T3-E1 cells ... The synergistic effect of VIP on the TNF-alpha induced IL-6 synthesis was concentration dependent in the range between 1 and 70 nM ... Forskolin, a direct activator of adenylyl cyclase, or 8-bromoadenosine-3',5'-cyclic monophosphate ( 8bromo-cAMP ), a plasma membrane-permeable cAMP analogue, markedly enhanced the TNF-alpha induced IL-6 synthesis as well as VIP ... PD98059, a specific inhibitor of MEK1/2, significantly suppressed the enhancement of TNF-alpha induced IL-6 synthesis by VIP ... These results strongly suggest that VIP synergistically enhances TNF-alpha stimulated IL-6 synthesis via up-regulating p44/p42 MAP kinase through the adenylyl cyclase-cAMP system in osteoblasts
Beyaert et al., EMBO J 1996 : Under the same conditions, SB203580 also completely inhibited TNF induced synthesis of interleukin (IL)-6 and expression of a reporter gene that was driven by a minimal promoter containing two NF-Kappa B elements
Suzaki et al., Acta Otolaryngol 2003 (Nasal Polyps) : Addition of RXM at a concentration of 10.0 microg/ml to cell cultures suppressed both IL-6 and RANTES ( but not IL-8 ) production in response to stimulation with 25.0 ng/ml tumor necrosis factor (TNF)-alpha ... In the second part of the study, we examined the influence of RXM on cytokine mRNA expression in NPFs. Addition of RXM at a concentration of 10.0 mg/ml to cell cultures caused reduction of the mRNA expressions of both IL-6 and RANTES, which were enhanced by TNF-alpha stimulation in vitro
Mullen et al., J Surg Res 1994 (Bacteremia...) : We conclude that although TNF-alpha plays an important role in synthesis and release of IL-6 , there is a TNF-alpha independent pathway for release of IL-6 in sepsis
Nakamura et al., Kidney Int 1999 : Using renal resident macrophage cells treated with endotoxin, lipopolysaccharide (LPS), and beta2-adrenoceptor agonist, terbutaline, we investigated the role of cAMP pathway, tumor necrosis factor (TNF)-alpha and mitogen activated protein kinase ( MAPK ) pathway ( p42/p44 ) in regulating IL-6 production
García-Criado et al., J Interferon Cytokine Res 2009 (Reperfusion Injury) : Administration of LA-803, LA-807 and, in a lower proportion, LA-810 prevented from the enhanced production of tumor necrosis factor (TNF), interferon-gamma (IFN-gamma), and interleukin-1beta (IL-1beta), the decrease in interleukin-6 (IL-6) and interleukin-10 (IL-10), the increase in tissue level of superoxide anion ( SOA ) and superoxide dismutase ( SOD ), and the increase in neutrophil infiltration induced by warm I/R. Treatment with LA-803 in animals with renal transplantation after cold ischemia was also associated with reduced plasma levels of TNF , IFN-gamma, and IL-1beta, increased plasma levels of IL-6 and IL-10, reduced renal levels of SOA and SOD, and reduced neutrophil infiltration
Andoh et al., Ther Apher Dial 2005 (Colitis, Ulcerative...) : TNF-alpha induced IL-8 secretion was also significantly decreased after apheresis, but there was no significant difference in TNF-alpha induced IL-6 secretion ( P = 0.052 )
Bartoccioni et al., Immunol Lett 1994 : In the present study we investigated the effects of tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on the secretion of interleukin-6 (IL-6) by myoblasts ... The secretion of IL-6 was greatly increased by TNF-alpha ; the increase was both time- and dose dependent
Palmqvist et al., J Dent Res 2008 (MAP Kinase Signaling System...) : IL-6-type cytokine expression and regulation by IL-1beta and tumor necrosis factor-alpha (TNF-alpha) were studied in fibroblasts from the non inflamed gingiva of healthy individuals ... Constitutive mRNA expression of IL-6, IL-11, and leukemia inhibitory factor (LIF), but not of oncostatin M (OSM), was demonstrated, as was concentration dependent stimulation of IL-6 and LIF mRNA and of protein by IL-1beta and TNF-alpha
Palma et al., Glia 1997 : SP also enhanced the small inducing effect of tumor necrosis factor-alpha (TNF-alpha) on IL-6 and PGE2 secretion and that of transforming growth factor-beta on PGE2 secretion
Muñoz et al., Blood 1996 : Both PDTC and NAC inhibited, in a dose dependent manner, the synthesis of IL-6 , IL-8, and GM-CSF induced by tumor necrosis factor (TNF)-alpha or bacterial lipopolysaccharides (LPS) in human umbilical vein endothelial cells ( HUVEC )
Seatter et al., Shock 1995 : LPS1 significantly increased LPS2 triggered monocyte secretion of IL-1, IL-6 , and PGE2, but inhibited TNF release
Ellaban et al., Cell Immunol 2004 (Cecal Diseases...) : While production of IL-6 and KC was reduced, secretion of TNF-alpha and MIP-1alpha was enhanced in those cells isolated from mice with mild sepsis
Hoffman , Lymphokine Res 1986 : The effects of tumor necrosis factor on the production of interleukin-1 by macrophages
Kita et al., Nat Immun 1992 : CK-M stimulated thioglycollate induced peritoneal macrophages to produce interleukin 1 (IL-1) and tumor necrosis factor alpha (TNF-alpha) at concentrations of 1-100 ng/ml, and it also induced IL-2 and interferon-gamma (IFN-gamma) as well as IL-6 production by splenocytes
Wilson et al., Mil Med 1993 : The purpose of this study was to determine if endotoxin, tumor necrosis factor (TNF) , and interleukin 6 (IL-6) increased in patients during or after total hip arthroplasty
Huang et al., Int Immunopharmacol 2005 : MPA markedly inhibited tumor necrosis factor-alpha (TNFalpha) induced intercellular adhesion molecule-1 ( ICAM-1 ) mRNA and surface expression, suppressed TNFalpha induced neutrophils adhesion to endothelial cells, and reduced TNFalpha induced interleukin-6 (IL-6) secretion
Grund et al., Mol Pharmacol 2008 (Endometriosis...) : Interestingly, MEK, p38, and IKK inhibitors block TNF-alpha induced IL-8, IL-6 , and GM-CSF secretion and 12z invasion, whereas the PI3K inhibitors do not
Majetschak et al., Blood 2003 (Critical Illness...) : In contrast, the TNF-alpha response to zymosan or Staphylococcus aureus as well as the interleukin-6 (IL-6) and IL-8 responses to endotoxin were unaffected by ubiquitin
Norris et al., J Immunol 1994 (Second Messenger Systems) : Signal transduction pathways mediating astrocyte IL-6 induction by IL-1 beta and tumor necrosis factor-alpha ... We have focused on signal transduction related to the stimulation of IL-6 gene expression by IL-1 beta and TNF-alpha ... Our results indicate that stimuli related to protein kinase C ( PKC ), such as PMA and calcium ionophore A23187, increase IL-6 expression, whereas pharmacologic inhibitors of PKC inhibit IL-6 induction by IL-1 beta and TNF-alpha ... However, inhibition of the cAMP pathway effector, protein kinase A, did not reduce the induction of astrocyte IL-6 gene expression in response to IL-1 beta or TNF-alpha , and an ELISA for cAMP detected only very small increases in cAMP synthesis in response to these cytokines ... These data suggest that although cAMP does activate astrocyte IL-6 gene expression, it is the PKC pathway that plays a primary role in the stimulation of astrocyte IL-6 gene expression by IL-1 beta and TNF-alpha
Delneste et al., Clin Exp Immunol 1994 : Tumour necrosis factor-alpha (TNF-alpha) induced IL-6 production was also potentiated in a dose dependent manner by histamine, without modification of the time course of IL-6 secretion
Kammouni et al., Infect Immun 1997 (Cystic Fibrosis) : In addition, dexamethasone was found to stimulate IL-6 and IL-8 secretion ( in the presence or absence of LPS ) but did not induce any secretion of TNF-alpha
Shanley et al., Am J Pathol 1997 (Immune Complex Diseases) : Recombinant IL-6 instilled intratracheally at commencement of injury led to substantial reductions in lung vascular permeability, neutrophil accumulation, and levels of tumor necrosis factor (TNF)-alpha and macrophage inflammatory protein (MIP)-2 in bronchoalveolar lavage fluids ... Conversely, blocking of intrinsic IL-6 by a neutralizing antibody resulted in increases in lung vascular permeability, neutrophil content, and TNF-alpha levels in bronchoalveolar lavage fluids
Aderka et al., J Immunol 1989 : IL-6 inhibits lipopolysaccharide induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice
Koo et al., Cancer Immunol Immunother 1992 (Carcinoma, Renal Cell...) : TNF alpha also significantly stimulated the production of biologically active IL-6 ( P less than 0.01 )
Thomsen et al., Scand J Clin Lab Invest 2010 (Inflammation) : TNF-alpha increased interleukin 6 (IL-6) ( p < 0.001 ) ; circulating acute phase proteins were unchanged
Quante et al., Am J Respir Cell Mol Biol 2008 : We have found that corticosteroids do not act at the transcriptional level to reduce TNF-alpha induced IL-6 gene expression ... Rather, corticosteroids inhibit TNF-alpha induced IL-6 secretion by reducing the stability of the IL-6 mRNA transcript ... Moreover, TNF-alpha acts via a p38 MAPK dependent pathway to stabilize the IL-6 mRNA transcript ( TNF-alpha, t(1/2) = 9.6 h ; SB203580 + TNF-alpha, t(1/2) = 1.5 h ), exogenous expression of MKP-1 significantly inhibits TNF-alpha induced IL-6 secretion and MKP-1 siRNA reverses the inhibition of TNF-alpha induced IL-6 secretion by dexamethasone
Ambarish et al., Indian J Physiol Pharmacol 2012 (Inflammation) : Plasma IL-6 and TNF-alpha increase with acute moderate exercise and IL-6 increases further with acute strenuous exercise
Grunfeld et al., Cancer Res 1990 : These data suggest that interleukin 6 , but not platelet activating factor, prostaglandins, or catecholamines, could potentially mediate the lipogenic effects of TNF
Hideshima et al., Blood 2003 (Multiple Myeloma) : Tumor necrosis factor alpha (TNF-alpha) induced IL-6 secretion in BMSCs is also inhibited by VX-745
Elias et al., Chest 1990 (Pneumonia...) : To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the effects of recombinant interleukin-1, tumor necrosis factor , and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production, interleukin-1-beta production, and interleukin-6 production
Satoh et al., J Cell Physiol 1992 : Tumor necrosis factor stimulates DNA synthesis of mouse hepatocytes in primary culture and is suppressed by transforming growth factor beta and interleukin 6
Klegeris et al., Brain Res 1997 (Alzheimer Disease) : First, it was shown that THP-1 cells could be induced to secrete significant amounts of TNF-alpha by interleukin-1 , lipopolysaccharide, interferon-gamma (IFN-gamma) and PMA alone or in combination with each other
Bachert , Clin Exp Allergy 1998 (Hypersensitivity) : It also increases TNF alpha induced IL-6 production and expression of adhesion molecules
Bouchelouche et al., J Urol 2006 : We investigated whether HDSMCs are capable of expressing and releasing MCP-1, IL-6 and SCF in response to IL-4, IL-13, IL-1beta and tumor necrosis factor-alpha ... Furthermore, IL-1beta and tumor necrosis factor-alpha alone induced significant release of MCP-1, IL-6 and SCF but in combination with IL-4 or IL-13 it induced greater secretion of MCP-1, IL-6 and SCF
Yamauchi et al., Fertil Steril 2004 (Endometriosis) : Tumor necrosis factor-alpha induced the release of interleukin-6 from endometriotic stromal cells by the nuclear factor-kappaB and mitogen activated protein kinase pathways ... To examine the involvement of nuclear factor-kappaB (NF-kappaB) and mitogen activated protein kinase ( MAPK ) in the induction of interleukin-6 (IL-6) by tumor necrosis factor-alpha (TNF-alpha) in endometriotic stromal cells ( ESC ) ... We determined the effect of TNF-alpha on the production of IL-6 and the effect of inhibitors for NF-kappaB and the MAPK pathway on IL-6 production using ELISA ... The NF-kappaB inhibitor ( TPCK ) and MAPK inhibitor ( U0126 ) blocked the TNF-alpha induced IL-6 expression ... These findings demonstrate that NF-kappaB and AP-1 activation is critical for TNF-alpha induced IL-6 expression in endometriotic stromal cells
Vanden Berghe et al., J Biol Chem 1999 : Expression of the pleiotropic cytokine interleukin (IL)-6 can be stimulated by the proinflammatory cytokine tumor necrosis factor (TNF) and the microbial alkaloid staurosporine (STS) ... We conclude that, within an `` enhanceosome-like '' structure, NF-kappaB is the central mediator of TNF induced IL-6 gene expression, involving CBP/p300 and requiring histone acetyltransferase activity
Makó et al., Cytometry A 2010 : Moreover, expression of E-selectin, IL-6 , and IL-8 was induced most efficiently by IL-1ß, while LPS and TNF-a had less effect, whereas we did not find such a difference in ICAM-1 and MCP-1 expression
Shimada et al., J Immunol 2002 : IL-6 secretion was rapidly induced by IL-17, IL-1beta, and TNF-alpha ... EMSAs demonstrated that IL-17, IL-1beta, and TNF-alpha induced NF-kappaB activation within 1.5 h after stimulation, and a blockade of NF-kappaB activation by the pyrrolidine derivative of dithiocarbamate and tosyl-phe-chloromethylketone markedly reduced the IL-17-, IL-1beta-, or TNF-alpha induced IL-6 gene expression ... Furthermore, IL-17, IL-1beta, and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs, and specific MAPK inhibitors ( SB203580, PD98059, and U0216 ) significantly reduced IL-17-, IL-1beta-, or TNF-alpha induced IL-6 secretion, indicating the role of MAPKs in the induction of IL-6
Schultz et al., Antimicrob Agents Chemother 1998 : Inhibition of TNF contributed to erythromycin induced inhibition of IL-6 synthesis
Le et al., J Immunol 1987 : Induction of membrane associated interleukin 1 by tumor necrosis factor in human fibroblasts
Fujisawa et al., Placenta 2000 (Choriocarcinoma...) : IL-6 transcription and secretion were dose-dependently enhanced by stimulation with IL-1beta, tumour necrosis factor (TNF)-alpha , transforming growth factor (TGF)-beta1 and 12-O-tetradecanoyl phorbol-13-acetate ( TPA ) ... The TNF-alpha induced secretion of IL-6 was inhibited by dexamethasone
Platel et al., Cytokine 1996 : That IL-6 increased the binding of TNF-alpha on the surface of the hepatic cells, whereas TNF-alpha alone downregulated its own specific binding capacity is reported ... Furthermore, this upregulatory effect of IL-6 was mainly attributable to an increase in the number of plasma membrane TNF-alpha specific receptors, with little change in their affinity
Lee et al., J Cell Biochem 2012 (Insulin Resistance...) : In addition to the interference of artemisinic acid with adipogenesis, artemisinic acid significantly attenuated tumor necrosis factor-a induced secretion of interleukin-6 by undifferentiated hAMSCs, thus influencing insulin resistance and the inflammatory state characterizing obesity
Adams et al., Neurosurgery 1994 (Neuroma, Acoustic) : Tumor necrosis factor-alpha , interleukin-1-beta, and cholera toxin all stimulated IL-6 secretion
Lappas et al., J Clin Endocrinol Metab 2004 (Diabetes, Gestational) : Stimulation of placenta, adipose tissue, and skeletal muscle with LPS and TNF-alpha resulted in greater release of IL-6 and IL-8, whereas only LPS increased TNF-alpha release from all three tissues
Hashimoto et al., Inflammation 1992 : Both IL-1 and TNF induced PCA, reduced TM, and induced IL-6 production in a dose dependent manner ... IFN-gamma, however, when added in combination with either IL-1 or TNF, modulated the effects of these cytokines ; INF-gamma inhibited the PCA expression and enhanced the reduction of TM and the production of IL-6 , which were induced by either IL-1 or TNF
Berg et al., Cytokine 1994 (Cachexia...) : D-factor and TNF increased IL-6 production in 3T3-L1 cells
Brissette et al., Cytokine 1995 (Leukopenia) : In addition, TNF induced IL-6 production was also enhanced
Takei et al., J Biomed Mater Res 2000 : Combined effect of titanium particles and TNF-alpha on the production of IL-6 by osteoblast-like cells
Kikumori et al., Endocrinology 1998 : The present study examined the effects of TNF-alpha on the activation of nuclear factor-kappa B (NF-kappaB) and on the expression of interleukin (IL)-6 gene in rat thyroid FRTL-5 cells ... These results strongly suggest that TNF-alpha increases the IL-6 gene expression through the activation of NF-kappaB in the thyroid cells, and that antioxidants suppress the TNF-alpha dependent IL-6 expression by inhibiting the activation of the transcriptionally active NF-kappaB
Shembade et al., J Virol 2007 : Mouse fibroblasts lacking Ubc13 exhibit impaired Tax activation of NF-kappaB despite normal tumor necrosis factor- and interleukin-1 mediated NF-kappaB activation
Kim et al., Phytother Res 2012 (Endometriosis) : In addition, treatment of endometriotic stromal cells with curcumin markedly inhibited TNF-a induced secretion of IL-6 , IL-8 and MCP-1
Fioravanzo et al., Curr Alzheimer Res 2010 (Alzheimer Disease...) : Moreover RHAs secrete IL-1ß and, only after the Aß1-42 treatment, TNF-a promotes RCEC release of IL-1ß, IL-6 and TNF-a
Nishida et al., Am J Kidney Dis 1997 : Exposure to VLDL, IDL, LDL, or a high concentration of HDL enhanced the secretion of interleukin-6 , platelet derived growth factor, and transforming growth factor-beta by mesangial cells, whereas tumor necrosis factor-alpha secretion was stimulated by oxidized LDL
Kim et al., Phytother Res 2009 : We then examined the effect of PE on the TNF-alpha induced production of interleukin-6 (IL-6) and nitric oxide ( NO ) in osteoblasts
Inagaki et al., J Biol Chem 2008 : Tumor necrosis factor- and interleukin-1 induced activation of TAK1 was entirely normal in Tab1-deficient MEFs and could activate both mitogen activated protein kinases and NF-kappaB
Leal-Berumen et al., J Immunol 1996 : Forskolin, an agent known to increase intracellular cAMP levels, also induced a significant increase in IL-6 production, whereas TNF-alpha production was decreased
Schell et al., Endocrinology 2008 : TNF-alpha furthermore strongly enhanced expression and/or synthesis of other inflammatory molecules, namely IL-6 and cyclooxygenase-2
Gowen et al., Endocrinology 1990 : Human osteoblast cultures derived as out-growths from trabecular bone released tumor necrosis factor ( TNF alpha ) upon stimulation of the cells with human recombinant interleukin 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ), human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ), and bacterial lipopolysaccharide ( 5-500 ng/ml )
Wang et al., FEBS Lett 2001 : Further, IkappaB-alphaM suppressed TNF-alpha stimulated release of interleukin-6 and -8 ( IL-6 and IL-8 )
Kiu et al., Growth Factors 2007 : Mechanism of crosstalk inhibition of IL-6 signaling in response to LPS and TNFalpha ... Analysis of suppressor of cytokine signalling 3 ( SOCS3 ) -deficient macrophages reveal that SOCS3 is necessary but surprisingly, not sufficient for the complete crosstalk inhibition of IL-6 signaling induced by LPS and TNFalpha
Ueo et al., J Am Coll Surg 1994 : The IL-6 secretion by skin explants was significantly enhanced either by tumor necrosis factor or interleukin-1, while it was inhibited by corticosteroids
Guerne et al., J Immunol 1990 : The inflammatory cytokines IL-1, and, to a lesser extent, TNF-alpha and IFN-gamma increased IL-6 production
Thorn et al., Amyloid 2002 : The Saa1 and Saa2 promoters are strongly induced by IL-6 , with synergistic upregulation of Saa2, but not of Saa1, by IL-1 or TNF
Mascarenhas et al., Immunol Invest 1996 : In contrast, stimulation of the cells with TNF-alpha resulted in an equal level of IL-6 secretion to the apical and basal surfaces, regardless of whether the cells were stimulated by the apical or basal route
Cenni et al., Toxicol In Vitro 1999 : Chromium extract did not impair TNFalpha release significantly, but inhibited IL-6 release significantly in stimulated PBMC
McClellan et al., Cytokine 2012 (Adenomatous Polyposis Coli...) : Gene expression ( mRNA ) of MCP-1, IL-1ß, IL-6 and TNF-a was increased in sections 2 and 3 starting at week 12 ( P < 0.05 ), with further increases in MCP-1, IL-1ß and IL-6 at 16 weeks ( P < 0.05 )
Mastorakos et al., J Clin Endocrinol Metab 1994 (Inappropriate ADH Syndrome) : Plasma IL-1 beta and tumor necrosis factor-alpha concentrations, assayed by specific enzyme linked immunosorbent assays during the 4 h after the first IL-6 injection, were either within the normal range or undetectable, confirming in vitro observations that IL-6 does not stimulate IL-1 beta or tumor necrosis factor-alpha secretion and suggesting that it exerts its effect on the HPA axis and AVP secretion independently of them
Kim et al., Osteoarthritis Cartilage 2009 (Low Back Pain) : SB202190 successfully suppressed IL-6 , IL-8, PGE2, and PGF2alpha secretion in macrophage exposed AF cells in response to TNF-alpha
Jia et al., J Cell Physiol 2013 (MAP Kinase Signaling System...) : Silencing constitutive AnxA1 expression in NLF using small interfering RNA ( siRNA ) was associated with moderate but significant increases in tumor necrosis factor (TNF) induced proliferation and interleukin (IL)-6 production, accompanied by reduction of ERK and NF-?B activity ... Blocking FPR2 using the specific antagonist WRW4 mimicked the effects of AnxA1 silencing on TNF induced proliferation, IL-6 , ERK, and NF-?B activation
Choi et al., FEMS Immunol Med Microbiol 2007 (Candidiasis) : CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving tumor necrosis factor-alpha dependent interleukin-12 induction
Altan et al., J Pharmacol Exp Ther 2010 (Endometriosis) : TBP and TNF-SHARC dose-dependently inhibited TNFalpha induced secretion of interleukin (IL)-6 , IL-8, granulocyte macrophage-colony stimulating factor, and monocyte chemoattractant protein-1 in immortalized human endometriotic cells
Anstead et al., J Leukoc Biol 2003 (Malnutrition) : Thus, in macrophages from the malnourished mice, initial deficits in NF-kappaB activity probably lead to decreased TNF-alpha , which results in decreased NO ; however, IL-6 is regulated independently from NF-kappaB and TNF-alpha
Strle et al., J Neuroimmunol 2007 : This protection occurs without decreasing global activity of TNF receptors since IL-10 does not impair TNFalpha induced IL-6 synthesis or ERK1/2 phosphorylation
Yasukawa et al., Nat Immunol 2003 : In macrophages lacking the Socs3 gene or carrying a mutation of the SOCS3 binding site in gp130, the lipopolysaccharide induced production of tumor necrosis factor (TNF) and IL-12 is suppressed by both IL-10 and IL-6
Delerive et al., EMBO Rep 2001 (Inflammation) : We demonstrated that ROR alpha is expressed in human primary smooth-muscle cells and that ectopic expression of ROR alpha1 inhibits TNFalpha induced IL-6 , IL-8 and COX-2 expression in these cells
Baker et al., Wound Repair Regen 2006 (Colorectal Neoplasms...) : Daily profiles of IL-6 and TNF-alpha were similar in drain fluid and plasma ; IL-6 levels peaked on POD 1 decreasing to POD 7, and TNF-alpha levels increased from PODs 1 to 7
Kurebayashi et al., Br J Cancer 1999 (Body Weight...) : Both basal and TNF-alpha induced IL-6 mRNA levels were dose-dependently lowered by MPA
Smith et al., Clin Exp Immunol 1992 : IL-1 beta was the more potent inducer for SAA production, but for CRP production IL-1 alpha and IL-1 beta were equivalent ; ( iii ) prednisolone enhances the production of SAA by HepG2 cells, but does not enhance the production of CRP ; ( iv ) TNF-alpha in the presence or absence of IL-6 and/or prednisolone did not induce the production of SAA or CRP by HepG2 cells
Li et al., Zhonghua Nan Ke Xue 2013 : TNF-alpha + CAPE induced statistically lower expressions of IL-6 and p-STAT3 than TNF-alpha alone ( P < 0.05 ) ... CAPE can inhibit IL-6 secretion induced by TNF-alpha in PC-3 cells and thus suppress STAT3 translocation
Brach et al., FEBS Lett 1990 : We show that the capacity of TNF alpha and LT to induce IL-6 mRNA accumulation increases as monocytic differentiation proceeds with TNF alpha being more potent than LT, suggesting that alternate pathways may be used by differentiating cells to control expression of IL-6 ... In contrast, in monocytes which constitutively synthesize IL-6 transcripts, TNF alpha and LT treatment had opposite effects on levels of IL-6 mRNA accumulation ... In these cells TNF alpha enhanced steady state levels of IL-6 transcripts due to mRNA stabilization, whereas LT shortened IL-6 mRNA half-life, most likely due to induction of a RNA destabilizer since LT-mediated downregulation of levels of IL-6 mRNA in monocytes could be prevented by inhibition of protein synthesis
Slack et al., Blood 1990 (Cell Transformation, Viral) : Nuclear run-on analyses showed that IL-1 alpha transcriptionally activated the genes for IL-6, GM-CSF, and IL-1 beta, while TNF alpha transcriptionally induced expression of IL-6 and IL-1 beta
Aggarwal et al., Exp Cell Res 1995 : Diminished responsiveness of senescent normal human fibroblasts to TNF dependent proliferation and interleukin production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B
Schoeniger-Skinner et al., Brain Behav Immun 2007 (Pain) : While the literature predominantly documents the cascade of pro-inflammatory cytokines as beginning with TNF, followed by the stimulation of IL-1, and finally TNF plus IL-1 stimulating the release of IL-6 , the present findings indicate that a blockade of IL-6 inhibits the gp120 induced elevations of TNF, IL-1, and IL-6 mRNA in dorsal spinal cord, elevation of IL-1 protein in lumbar dorsal spinal cord, and TNF and IL-1 protein release into the surrounding lumbosacral cerebrospinal fluid
Alter et al., J Biol Chem 2008 : Expression of IL-6 and leukemia inhibitory factor (LIF) was induced by TNFalpha in wild-type and JNK2-null myoblasts
Han et al., J Gerontol A Biol Sci Med Sci 2000 (Orthomyxoviridae Infections...) : Pulmonary interleukin (IL)-6 , IL-1beta, and tumor necrosis factor (TNF)-alpha levels increased significantly postinfection
Phillips et al., Gut 2003 : MMP2 secretion by PSCs was significantly increased by TGF-beta1 and IL-6 , but was not affected by TNF-alpha
Erinjeri et al., J Vasc Interv Radiol 2013 (Neoplasms) : There was a significant increase in the plasma level of IL-6 after ablation compared with before ablation ( 9.6-fold±31-fold, P < .002 ). IL-10 also showed a significant increase after ablation ( 1.9-fold±2.8-fold, P < .02 ). Plasma levels of IL-1a, IL-2, and TNF-a were not significantly changed after ablation. Cryoablation resulted in the largest change in IL-6 level ( > 54-fold ), whereas radiofrequency ablation and microwave ablation showed 3.6-fold and 3.4-fold changes, respectively
Shinmei et al., J Rheumatol Suppl 1991 (Osteoarthritis) : IL-6 production was induced by IL-1 alpha and TNF-alpha
Libert et al., J Immunol 1991 : In addition, we demonstrate that the IL-1 induced desensitization was only observed when a functioning liver was present, that IL-1 pretreated animals did not show decreased numbers of hepatocyte TNF receptors, and that the amount of TNF induced IL-6 was not reduced
Morton et al., J Periodontol 1999 (Gingival Overgrowth) : We have also demonstrated that GF IL-6 responses to bacterial challenge or TNFalpha are downregulated by CsA
von Scheele et al., Inhal Toxicol 2010 : Endotoxin, TNF , and dust stimulated the release of IL-6 and IL-8 in a time dependent manner
Nakajima et al., Prostate 1996 (Prostatic Neoplasms) : These data suggest that the lack of an antiproliferative effect of rTNF on the androgen independent PCA cell lines PC-3 and JCA-1 is not due to the failure of these cells to express TNF-R, but may be related to the differences in TNF mediated IL-6 expression by these PCA cell lines
Pope et al., J Clin Invest 1994 : We present data to show that the expression of TNF alpha is regulated by the transcription factor C/EBP beta ( NF-IL6 )
Wirtz et al., Life Sci 2004 (Arteriosclerosis) : Our findings suggest that elevated plasma levels of TNF-alpha might enhance LPS stimulated IL-6 release from circulating monocytes
Schlaepfer et al., J Biol Chem 2007 : TNFalpha stimulated FAK catalytic activation and IL-6 production were inhibited by FAK N-terminal but not FAK C-terminal domain overexpression ... Constitutively activated MAPK kinase-1 ( MEK1 ) expression in FAK ( -/- ) and A549 FAK short hairpin RNA expressing cells rescued TNFalpha stimulated IL-6 production ... Inhibition of Src protein-tyrosine kinase activity or mutation of Src phosphorylation sites on FAK ( Tyr-861 or Tyr-925 ) did not affect TNFalpha stimulated IL-6 expression ... Moreover, analyses of Src ( -/- ), Yes ( -/- ), and Fyn ( -/- ) fibroblasts showed that Src expression was inhibitory to TNFalpha stimulated IL-6 production
Vesanen et al., J Gen Virol 1992 (Neuroblastoma) : In addition, based on a thymidine incorporation assay, TNF-alpha inhibited, but IL-6 strongly increased , the DNA synthesis in SK-N-MC cells, whereas in the SH-SY5Y cell line no such differences were seen
Linker-Israeli et al., Clin Immunol 1999 (Lupus Erythematosus, Systemic) : We found that ( 1 ) exogenous rIL-10 and rIL-4 mediated reduction of constitutive and lectin induced IL-6 in monocytes of SLE patients as effectively as that of controls ; ( 2 ) IL-6 mRNA decay was significantly delayed in SLE with active disease ( P < 0.001 ) ; ( 3 ) adding rIL-10 or neutralizing endogenous IL-1 beta and TNF-alpha down-regulated IL-6 mainly by destabilizing IL-6 transcripts, whereas exogenous IL-4 and TGF beta 1 down-regulated IL-6 transcriptionally ; ( 4 ) time kinetics and levels of IL-10 were lower than those of IL-6 and IL-1 beta
Kang et al., Cell Immunol 1996 (Disease Models, Animal...) : When human monocytes/macrophages stimulated with silica were treated with 0.1-10 microg/ml acanthoic acid, the production of IL-1 and TNF-alpha was inhibited up to 90 %, but the production of interleukin-6 (IL-6) was not inhibited at all
Shinoda et al., Cell Signal 1999 : In other studies, we demonstrated that thrombin stimulates IL-6 synthesis, which depends on intracellular Ca2+ mobilisation in these cells and that tumour necrosis factor-alpha (TNF) induces IL-6 synthesis through sphingosine 1-phosphate, a product of sphingomyelin turnover ... On the contrary, C2-ceramide enhanced the TNF induced IL-6 synthesis
Kremlev et al., Nat Immun 1998 (Inflammation) : We also showed that regardless of the presence or absence of CSF-1 or FN, IL-6 inhibits GM-CSF and TNF-alpha gene expression in an autocrine manner
Kempf et al., J Mol Med (Berl) 2007 (Hyperglycemia...) : Using quantitative real-time PCR, we could show that the expression of intercellular adhesion molecule 1 ( ICAM-1 ), tumor necrosis factor alpha (TNF-alpha) , and interleukin 6 (IL-6) significantly increased in peripheral blood leukocytes from `` MetS '' subjects ( n=39 ) compared to `` no MetS '' subjects ( n=35 ) 2 h after an oral glucose tolerance test ( ICAM-1 +52 %, TNF-alpha +107 %, and IL-6 +38 % ) and also in vitro after 72 h cultivation in high-glucose medium ( ICAM-1 +74 %, TNF-alpha +71 %, and IL-6 +44 % )
Marshall et al., J Immunol 1999 : We have observed that NGF at doses as low as 10 ng/ml will induce IL-6 production and inhibit TNF-alpha release from rat peritoneal mast cells in the presence of lysophosphatidylserine as a cofactor
Tliba et al., J Biol Chem 2003 (Inflammation) : Secreted IFNbeta acted as a negative regulator of TNFalpha induced interleukin-6 expression, while IFNbeta augmented TNFalpha induced RANTES ( regulated on activation normal T cell expressed and secreted ) secretion but had little effect on TNFalpha induced intercellular adhesion molecule-1 expression
Yao et al., J Surg Res 1997 (Ischemia) : The current study was designed to determine the potential effects of TNF blockade, by means of monoclonal antibody ( TNF MoAb ) treatment, on plasma interleukin 6 (IL-6) in rats after acute intestinal I/R injury ... The present study demonstrates that the activation and/or release of IL-6 in the setting of acute gut I/R may, at least in part, be mediated via TNF dependent mechanisms, providing further evidence that a complex interaction exists between TNF and IL-6
Ritchie et al., Endocrine 1996 : Serotonin ( 1-1000 nM ) increased basal IL-6 release from zona glomerulosa cells, but inhibited basal TNF release from these cells ... Serotonin potentiated IL-6 release stimulated by endotoxin and IL-1ß, but inhibited TNF release stimulated by these agents
Zhu et al., J Biol Chem 2005 (Inflammation) : The ERK signaling pathway is not involved in TNF-alpha and nitric oxide production, but, interestingly, negatively regulates the expression of IL-6 and IL-12
Starkie et al., FASEB J 2003 : Exercise and IL-6 infusion inhibit endotoxin induced TNF-alpha production in humans
Choi , Pharmazie 2007 : Apigenin increases osteoblastic differentiation and inhibits tumor necrosis factor-alpha induced production of interleukin-6 and nitric oxide in osteoblastic MC3T3-E1 cells ... The effect of apigenin on the TNF-alpha induced production of IL-6 and nitric oxide ( NO ) in osteoblasts was examined ... Treatment with apigenin ( 10 microM ) decreased the TNF-alpha induced production of IL-6 and NO in osteoblasts
Noguchi et al., J Periodontal Res 2001 (Periodontal Diseases) : IL-1beta and tumor necrosis factor alpha (TNFalpha) , proinflammatory cytokines, induced IL-6 production in a time dependent manner, and PGF2alpha synergistically enhanced IL-6 production induced by IL-1beta and TNFalpha ... IL-6 mRNA was expressed in PGF2alpha stimulated HGF, and PGF2alpha increased IL-6 mRNA levels induced by IL-1beta and TNFalpha
Persson et al., Biochem Biophys Res Commun 2005 : The IL-6 protein release from calvarial osteoblasts was also stimulated by the osteoclastogenic, proinflammatory cytokines IL-11, LIF, OSM, IL-17, TGF-beta, and TNF-alpha
Ikemoto et al., Oncol Rep 2003 (Carcinoma, Renal Cell...) : Tumor necrosis factor alpha (TNFalpha) and TNFalpha receptor mRNA expression, the effects of TNFalpha on DNA synthesis and cell proliferation as well as its effects on interleukin-6 (IL-6) production and expression in renal cell carcinoma (RCC) were studied using RCC cell lines ... The effects of TNFalpha on DNA synthesis and IL-6 production were also studied using short-term established RCC cell lines ... When the effects of TNFalpha on IL-6 production were studied by ELISA, IL-6 production was induced in RC-2, RGB, 14T, OCUU-1, OCUU-2 and OCUU-5 while not in 4T and OCUU-4
Fransson et al., Arch Dermatol Res 1999 (Psoriasis) : The production of IL-6 in the fibroblast cultures was stimulated by TNF-alpha ( 0.01-10 nm/ml medium ) in a dose dependent way
Sanders et al., J Bone Miner Res 2000 : PDB pretreatment reduced IL-6 responses to 5 nM and 10 nM PTH by 61 % and 33 %, respectively, reduced IL-6 responses to 5nM and 10 nM TNF-a by 54 % and 42 %, respectively, and failed to inhibit the IL-6 responses to 0.1-10 nM IL-1beta
Gayle et al., Brain Res Bull 1998 (Brain Neoplasms...) : The data show that ( 1 ) IL-1beta induced a significant upregulation of TNF-alpha mRNA ; ( 2 ) the effect of IL-1beta on TNF-alpha mRNA expression was completely blocked by the concomitant application of IL-1Ra, which suggests specificity of IL-1beta action through the IL-1 signaling receptor ; ( 3 ) no detectable modulation of TNF-alpha mRNA expression was observed with the individual applications of TNF-alpha, IL-6, or IFN-alpha; (4) the concomitant treatments of TNF-alpha + IL-1beta or TNF-alpha + IL-1beta + IL-6 strongly upregulated TNF-alpha mRNA expression, whereas the concomitant application of TNF-alpha + IL-6 or IL-1beta + IL-6 induced a moderate increase ; and ( 5 ) IFN-alpha significantly attenuated induction of TNF-alpha mRNA by TNF-alpha + IL-1beta + IL-6
Ogawara et al., Arthritis Res Ther 2006 : RGD targeted adenovirus delivered the dnIkappaB via alphavbeta3 to become functionally expressed, leading to complete abolishment of TNF-alpha induced up-regulation of E-selectin, ICAM-1, VCAM-1, IL-6 , IL-8, VEGF-A and Tie-2
Oxholm et al., Acta Derm Venereol 1991 (Dermatitis, Contact) : These results demonstrate that enhancement of keratinocyte bound IL-6 does not induce TNF alpha , IL-1 alpha/beta or IL-6 expression by LC during APR or IPR, and that enhanced keratinocyte expression of IL-6 fails to distinguish between these two reactions
Kent et al., Infect Immun 1998 : Although TNF-alpha stimulated IL-6 production by HGF, > 10-fold-larger amounts were induced with IL-1alpha and IL-1beta
Sheikh et al., J Ayub Med Coll Abbottabad 2011 : TNF-alpha increased release of pro-inflammatory cytokines, IL-6 , IL-8, and also GM-CSF from the model mucosa after 24 hours, but had no effect on the release of IL-1alpha, IL-6, IL-8, and GM-CSF after 5 minutes and 24 hours respectively
Machelon et al., Mol Cell Endocrinol 1997 : Hence, IL-6 is induced by TNF alpha via activation of PTK
Radeff et al., Exp Cell Res 2001 (Bone Resorption) : Involvement of PKC-beta in PTH, TNF-alpha , and IL-1 beta effects on IL-6 promoter in osteoblastic cells and on PTH stimulated bone resorption
Tokuda et al., J Endod 2002 : IL-10 inhibited IL-8 mRNA expression, which is normally stimulated by PiLPS, IL-1alpha, and tumor necrosis factor-alpha and inhibited IL-6 mRNA expression, which is normally stimulated by IL-1alpha
Cousens et al., Proc Natl Acad Sci U S A 1997 (Cytomegalovirus Infections...) : Effects were selective, as induction of tumor necrosis factor was unaffected and induction of IL-6 was enhanced
Borgatti et al., J Biomed Biotechnol 2010 (Cystic Fibrosis) : Induction by TNF-a of IL-6 and IL-8 in cystic fibrosis bronchial IB3-1 epithelial cells encapsulated in alginate microbeads
Schwingshackl et al., Am J Physiol Lung Cell Mol Physiol 2013 (Acute Lung Injury) : We hypothesized that Trek-1 regulates tumor necrosis factor-a (TNF-a) induced IL-6 release via NF-?B-, p38-, and PKC dependent pathways
Erroi et al., Infect Immun 1993 : Whereas IL-6 had no effect, IL-1 alpha or TNF induced partial tolerance to LPS in terms of inhibition of LPS stimulated TNF and IL-6 production
Jones et al., Eur J Endocrinol 1997 (Goiter, Nodular...) : The secretion of IL-6 can be stimulated by interleukin-1 (IL-1), tumour necrosis factor-alpha (TNF) , serum, TSH and agents which increase intracellular cyclic AMP levels
Gouin et al., Ann Behav Med 2012 : Childhood abuse history moderated IL-6 levels but not TNF-a and CRP responses to daily stressors
Monick et al., Am J Physiol 1994 : Dexamethasone blocks the induction of IL-6 and IL-8 by IL-1 or TNF ... Both IL-1 and TNF increased release of IL-6 and IL-8 from the cells in a dose dependent manner and dexamethasone inhibited this effect ... Dexamethasone also inhibited the induction of IL-6 and IL-8 RNA by IL-1 and TNF
Spratte et al., Mol Hum Reprod 2013 : Unfractionated heparin significantly suppressed the TNF-a induced and NF-?B mediated secretion and expression of IL-8 and -6 as well as other molecules in decidualized and undifferentiated human ESCs
Ronda et al., Clin Exp Immunol 2003 (Arteriosclerosis) : IgG prevented TNFalpha induced CD106 membrane expression and an increase in [ Ca++]i, and inhibited the secretion of interleukin-6 (IL-6) and macrophage-colony stimulating factor ( M-CSF )
Sancéau et al., J Biol Chem 1995 : Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1, NF kappa B, and Sp1 transcription factors ... We investigated the molecular basis of the synergistic induction by interferon-gamma (IFN-gamma)/tumor necrosis factor-alpha (TNF-alpha) of human interleukin-6 (IL-6) gene in THP-1 monocytic cells, and compared it with the basis of this induction by lipopolysaccharide (LPS) ... Functional studies with IL-6 promoter demonstrated that three regions are the targets of the IFN-gamma and/or TNF-alpha action , whereas only one of these regions seemed to be implicated in LPS activation ... Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha , in monocytic cells, involved cooperation between the IRF-1 and NF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter
Takai et al., Horm Metab Res 2006 : Phosphatidylinositol 3-kinase/Akt plays a part in tumor necrosis factor-alpha induced interleukin-6 synthesis in osteoblasts ... In the present study, we investigated whether phosphatidylinositol 3-kinase ( PI3-kinase ) /protein kinase B ( Akt ) is involved in TNF-alpha stimulated IL-6 synthesis in MC3T3-E1 cells ... Akt inhibitor, 1L-6-hydroxymethyl-CHIRO-inositol 2- ( R ) -2- O-methyl-3-O-octadecylcarbonate, significantly suppressed the TNF-alpha stimulated IL-6 synthesis, but the inhibitory effect was partial ... Wortmannin and LY294002 significantly reduce the TNF-alpha induced IL-6 synthesis ... A combination of Akt inhibitor and PD98059 suppressed the TNF-alpha induced IL-6 synthesis in an additive manner ... These results strongly suggest that PI3-kinase/Akt plays a role in the TNF-alpha stimulated IL-6 synthesis mainly independent of p44/p42 MAP kinase in osteoblasts
Schindler et al., Blood 1990 : IL-6 did not stimulate IL-1 beta or TNF production, but suppressed IL-1 beta and TNF production induced by LPS or PHA by 30 % ( P less than .01 )
Rompe et al., Hypertension 2010 (Inflammation) : C21 dose-dependently ( 1 nM to 1 micromol/L ) reduced tumor necrosis factor-alpha induced interleukin 6 levels in primary human and murine dermal fibroblasts
Lee et al., Mol Med 2013 : Recombinant AAT-Fc protein was tested for antiinflammatory function and AAT-Fc sufficiently suppressed tumor necrosis factor (TNF)-a induced interleukin (IL)-6 in human peripheral blood mononuclear cells ( PBMCs ) and inhibited cytokine induced TNFa by different cytokines in mouse macrophage Raw 264.7 cells
Morohoshi et al., Diabetes 1996 (Carcinoma, Hepatocellular...) : The results of this study demonstrate that hyperglycemia stimulated IL-6 and TNF synthesis and secretion by human peripheral monocytes in vitro and that the IL-6 response to hyperglycemia may be mediated by TNF
Kawada et al., Jpn J Cancer Res 1999 (Prostatic Neoplasms) : In the conditioned medium, marked IL-6 secretion was induced from WI-38 cells by IL-1beta or TNF-alpha
Passeri et al., Bone Miner 1994 : Prompted by this evidence, we have now examined whether TNF and/or IL-1 are produced by murine calvarial cells, and whether these cytokines are involved in IL-6 production and osteoclast formation ... These findings suggest that TNF, but not IL-1, is produced by murine bone cells and that endogenous TNF induces the IL-6 production, osteoclast formation, and bone resorption exhibited by these cultures under basal conditions
Krizanac-Bengez et al., J Cell Physiol 2006 (Brain Ischemia) : These cells induce release of TNF-alpha early after ischemia/reperfusion ; TNF-alpha triggers release of IL-6 , since blockade of TNF-alpha prevents IL-6 release, whereas blockade of IL-6 induces TNF-alpha release
Hildebrand et al., Unfallchirurg 2005 (Inflammation...) : TNF-alpha and IL-1beta are early regulators of the immune response and both induce the release of secondary cytokines, such as IL-6 and IL-8
Sun et al., Am J Physiol Endocrinol Metab 2006 : Consequently, these alterations combined led to a marked increase in nuclear p65 DNA binding and NF-kappaB transcriptional activity ; consistently, induction of IL-6 by TNF-alpha or IL-1beta was much more robust in VDR-/- than in VDR+/- cells, indicating that VDR-/- cells are more susceptible to inflammatory stimulation
Seidel et al., Schweiz Med Wochenschr 2010 : We determined the effect of DMF on platelet derived growth factor (PDGF)-BB induced proliferation, as well as on PDGF-BB and tumor necrosis factor (TNF)-a induced interleukin (IL)-6 secretion and on activation of activated protein (AP)-1 and nuclear factor kappaB ( NF-?B ) ... PDGF-BB and TNF-a induced IL-6 secretion by lung fibroblasts and this was inhibited by DMF in a dose dependent manner ... Our data suggest that DMF down-regulates TNF-a induced IL-6 secretion and proliferation by inhibiting NF-?B and AP-1 activity, indicating its potential beneficial use for the treatment of inflammatory lung diseases
Plomgaard et al., J Clin Endocrinol Metab 2008 : Plasma TNF-alpha levels increased from 0.7 +/- 0.04 to 16.7 +/- 1.8 pg/ml, and plasma IL-6 increased from 1.0 +/- 0.2 to 9.2 +/- 1.0 pg/ml ( P < 0.05 ) after 4-h rhTNF-alpha infusion
Bodine et al., Endocrinology 1996 : Finally, interleukin-1 beta and tumor necrosis factor-alpha ( 1-1000 pM ) stimulated dose dependent increases in the secretion of interleukin-6 and monocyte chemoattractant protein-1 at 34 C and 40C
Hawkins et al., Am J Vet Res 1995 (Horse Diseases...) : The induction of IL-1, IL-1 inhibitory activity IL-6 , WBC, and total protein concentration responses are largely independent of TNF activity in synovial fluid of horses receiving endotoxin intra-articularly
Buonaguro et al., J Virol 1992 (Inflammation) : As TNF can increase the production of IL-1 and IL-6 and these inflammatory cytokines all enhance HIV-1 gene expression and affect the immune, vascular, and central nervous systems, the activation of TNF by Tat may be part of a complex pathway in which HIV-1 uses viral products and host factors to increase its own expression and infectivity and to induce disease
Xu et al., Endocrinology 2001 : We therefore examined the effects of the PPARalpha activator fenofibrate and the GR activator dexamethasone on TNFalpha stimulated expression of IL-6 and vascular cell adhesion molecule-1 in vascular endothelial cells ... Both fenofibrate and dexamethasone reduced TNFalpha induced IL-6 production in human vascular endothelial cells, but only fenofibrate reduced TNFalpha stimulated vascular cell adhesion molecule-1 expression in these cells
Kawasaki et al., J Neurosci 2008 (Hyperalgesia...) : Consistently, TNFalpha and IL-1beta enhanced AMPA- or NMDA induced currents, and IL-1beta and IL-6 suppressed GABA- and glycine induced currents
Cesaratto et al., PloS one 2013 : E3330 treatment prevented the functional activation of NF-?B via the alteration of APE1 subcellular trafficking and reduced IL-6 and IL-8 expression induced by TNF-a and FAs accumulation through blockage of the redox mediated activation of NF-?B
Ren et al., Immunol Lett 2011 (Pneumonia) : Similarly, LPS induced increases in TNF-a , IL-1ß and IL-6 protein levels in NR8383 cell supernatants was significantly inhibited by MD-2 silencing
Tomita et al., J Hypertens 1998 (Inflammation) : Transcription factor decoy for nuclear factor-kappaB inhibits tumor necrosis factor-alpha induced expression of interleukin-6 and intracellular adhesion molecule-1 in endothelial cells ... Also nuclear factor-kappaB decoy oligodeoxynucleotides but not scrambled oligodeoxynucleotides inhibited tumor necrosis factor induced expression of interleukin-6 and intracellular adhesion molecule-1 both at the messenger RNA and at protein level ( assessed by reverse transcription-polymerase chain reaction and enzyme linked immunosorbent assay )
Villacres et al., J Infect Dis 2012 (HIV Infections...) : Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß), interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 12 (IL-12), and tumor necrosis factor a (TNF-a) responses to Toll-like receptor (TLR) 3 and TLR4 stimulation ... Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß), interleukin 6 (IL-6) , interleukin 10 (IL-10), interleukin 12 (IL-12), and tumor necrosis factor a (TNF-a) responses to Toll-like receptor (TLR) 3 and TLR4 stimulation
Gruchlik et al., Acta Pol Pharm 2012 : Effect of Gly-Gly-His, Gly-His-Lys and their copper complexes on TNF-alpha dependent IL-6 secretion in normal human dermal fibroblasts ... GGH, GHK, CuCl2 and their copper complexes decreased TNF-alpha dependent IL-6 secretion in fibroblasts
Gruchlik et al., Acta Pol Pharm 2012 : After 24 h incubation TNF-alpha dependent IL-6 secretion was determined with ELISA kit ( RandD Systems ) .The influence of magnetic field and its effect on cell proliferation were determined with TOX-2 ( In Vitro Toxicology Assay Kit XTT Based, TOX-2, Sigma ) and CyQUANT NF cell proliferation assay kit ( Molecular Probes ) ... It was shown that SMF inhibited TNF-alpha dependent IL-6 secretion
Ruddy et al., J Biol Chem 2004 : Because C/EBP family members are known to control IL-6, we examined whether enhanced C/EBPdelta expression is involved in the cooperative up-regulation of IL-6 by IL-17 and TNFalpha
Faber et al., Nutrition & diabetes 2012 : Gene expression analyses showed that TNF-a and IL-1ß stimulate the adipocyte expression of TNF-a, IL-1ß and IL-6
Lee et al., Am J Pathol 2009 (Tracheitis) : In addition, HO-1 overexpression inhibited TNF-alpha induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression, adherence of THP-1 cells, generation of interleukin-6 , p47(phox) translocation, and nuclear factor-kappaB activation
Papini et al., Br J Plast Surg 1997 (Bacteremia...) : There was little change in TNF levels between preoperative and recovery samples but IL-6 concentrations increased three-fold, particularly in those with large recent burns or bacteraemia, and were correlated with poor clinical outcome
Noah et al., Am J Respir Cell Mol Biol 1996 : In the same cultures, tumor necrosis factor-alpha induced marked increases in release of both IL-8 and IL-6 at 24 and 48 h after stimulation
Matsuzaki , Nihon Sanka Fujinka Gakkai Zasshi 1994 (Chorioamnionitis) : IL-1 and tumor necrosis factor-alpha (TNF-alpha) synergistically augmented IL-6 production to stimulate hCG production
Li et al., Eur J Pharmacol 2013 : THC inhibited the production of TNF-a and IL-6 by down regulating LPS induced IL-6 and TNF-a mRNA expression
Parikh et al., Shock 1997 : The regulation of IL-6 production in the enterocyte may be specific for IL-1 beta, since neither TNF nor IL-6 stimulated IL-6 production
Antonelli et al., J Rheumatol 2012 (Scleroderma, Systemic) : We evaluated the effect of interferon-? ( IFN-? ) and/or tumor necrosis factor-a (TNF-a) on the secretion of prototype proinflammatory cytokine interleukin 6 (IL-6) , compared to T-helper 1 [ Th1 ; chemokine (C-X-C motif) ligand 10 ( CXCL10 ) ] or Th2 [ chemokine (C-C motif) ligand 2 ( CCL2 ) ] chemokines, in primary cultured fibroblasts from patients with systemic sclerosis ( SSc ) at an early stage of the disease
Xu et al., J Steroid Biochem Mol Biol 2002 : In this investigation, we showed that RU486, already proved to be an active anti-glucocorticoid and anti-progesterone agent, blocked the inhibition of tumor necrosis factor (TNF)-alpha stimulated interleukin-6 (IL-6) production by the PPARalpha activator fenofibrate in human umbilical vein ECs ... Transient transfection of bovine aortic ECs with an IL-6 promoter construct demonstrated that RU486 blocked the inhibitory effect of fenofibrate on TNF-alpha induced IL-6 promoter activity
Lorré et al., Eur Cytokine Netw 1992 : IL-4, IL-6 , GM-CSF and IFN-gamma had no effect on TNF-alpha production by T cells activated via either pathway
Woiciechowsky et al., Med Sci Monit 2004 (Gliosis) : Accordingly, TNF-alpha , which did not induce IL-6 release, also did not induce gliosis
Männel et al., Rev Infect Dis 1987 : No TNF induced production of interleukin 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures
Hines et al., Vet Microbiol 1999 : MIF-A3 does induce secretion of IL-6 , but does not induce secretion of TNFalpha , IL-1beta, and GM-CSF
Moutzouris et al., Biochim Biophys Acta 2010 (Asthma) : Investigating the effect of MG-132 on secretion of the cytokine IL-6 we show that while short-term pretreatment with MG-132 ( 30min ) partially reduced TNFalpha induced IL-6 via inhibition of IkappaB-alpha degradation and the NF-kappaB pathway, longer-term proteasome inhibition ( up to 24h ) robustly upregulated MKP-1 and was temporally correlated with repression of p38 mediated IL-6 secretion from ASM cells
Cho et al., Int J Mol Med 2007 : However, it was unknown whether curcumin, showing inhibitory effects on NF-kappaB and MAPKs, attenuates the expression of TNF-alpha induced IL-1beta, IL-6 , IL-8, and TNF-alpha as well as cyclin E expression in HaCaT cells ... We found that curcumin inhibited the expression of TNF-alpha induced IL-1beta, IL-6 , and TNF-alpha, but not IL-8, in TNF-alpha treated HaCaT cells as well as the TNF-alpha induced cyclin E expression
Lee et al., mBio 2012 : Replacement of the IKK?/NEMO S377 residue by alanine ( S377A ) or glutamic acid ( S377E ) resulted in a significant increase or decrease of NF-?B activity and TNF-a mediated IL-6 cytokine production, respectively
Bergeron et al., Antimicrob Agents Chemother 1998 (Pneumonia, Pneumococcal) : The drug also prevented IL-6 release in lung homogenates and partly inhibited TNF-alpha , but it did not interfere with IL-1alpha secretion in the lungs of infected mice
Wei et al., Biochimie 2006 : Promutoxin is also able to stimulate the release of IL-12, TNFalpha , IL-6 and IL-1beta from human monocytes, and induce IL-2, TNFalpha and IL-6 release from T cells, indicating that this snake venom group IIA PLA(2) is actively involved in the inflammatory process in man caused by snake venom poisoning
Billingsley et al., Ann Surg Oncol 1996 (Cachexia...) : 4JK tumor was further tested to determine if IL-1, tumor necrosis factor (TNF) , or cocultivation with RAW 264 cells augmented IL-6 or LIF production
Noris et al., J Immunol 2009 (Acute Disease...) : In vitro, Tir8 ( -/- ) dendritic cell precursors acquired higher allostimulatory activity and released more IL-6 upon stimulation with a TLR4 ligand and TNF-alpha than Tir8 ( +/+ ) cells, which may explain the increased frequency of antidonor-reactive T cells and the block of regulatory T cell formation in recipients of a Tir8 ( -/- ) kidney
Taniguchi et al., Mol Cell Endocrinol 2009 (Endometriosis) : By transfection of TAK1 siRNA, TNFalpha induced phosphorylation of IkappaBalpha, JNK1/2, and p38MAPK, as well as IL-6 or IL-8 expression, were repressed
Vitkus et al., In Vitro Cell Dev Biol Anim 1998 : We have determined that the human colonic carcinoma cell line Caco-2 is capable of secreting IL-6 when stimulated by the inflammatory cytokines IL-1beta or tumor necrosis factor-alpha (TNF-alpha), and stimulation of these cells with IL-1beta plus TNF-alpha induced a synergistic enhancement of IL-6 secretion
De Cesaris et al., J Biol Chem 1998 : Tumor necrosis factor-alpha induces interleukin-6 production and integrin ligand expression by distinct transduction pathways ... Our data strongly support the hypothesis that, in response to TNF-alpha , activation of p38 leads to IL-6 production, whereas ICAM-1 and VCAM-1 expression could be induced by activation of the c-Jun N-terminal protein kinase/stress activated protein kinase pathway
Vanden Berghe et al., J Biol Chem 1998 : In the mouse fibrosarcoma cell line L929, the nuclear factor (NF)-kappaB plays a crucial role in IL-6 gene expression mediated by tumor necrosis factor (TNF) ... We observed that the p38 mitogen activated protein kinase ( MAPK ) inhibitor SB203580 was able to repress TNF stimulated expression of the IL-6 gene, as well as of a kappaB dependent reporter gene construct, without affecting the levels of NF-kappaB binding to DNA ... Therefore, we conclude that, in addition to cytoplasmic activation and DNA binding of NF-kappaB, the p38 and extracellular signal regulated kinase MAPK pathways act as necessary cooperative mechanisms to regulate TNF induced IL-6 gene expression by modulating the transactivation machinery
Van Damme et al., J Invest Dermatol 1990 : This study focuses on interferon-beta (IFN-beta), interleukin-6 (IL-6), and interleukin-8 (IL-8) production by fibroblasts and epithelial cells in response to interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha)
Nemunaitis et al., Gene Ther 2001 (Adenocarcinoma...) : IL-6 , gamma-IFN, TNF-alpha and IL-10 increased within 24 h following treatment
Gerritsen et al., Am J Pathol 1995 (Inflammation) : Apigenin also inhibited IL-1 alpha induced prostaglandin synthesis and TNF-alpha induced IL-6 and IL-8 production, suggesting that the hydroxyflavones may act as general inhibitors of cytokine induced gene expression
Gahring et al., Alcohol Clin Exp Res 1999 : Alcohol also affected the paracrine/autocrine induction of cytokine transcripts in neuronal cell cultures, which included enhancing the ability of TNFalpha to stimulate IL-6 transcripts
Katz et al., J Immunol 1989 : IL-1 and TNF induced concentration related increases in the synthesis of factor B, C3, and IFN-beta 2/IL-6 in human skin fibroblasts ... In contrast to the similarities between the effects of IL-1 and TNF on synthesis of factor B, C3, and IFN-beta 2/IL-6 , only TNF increased synthesis of factor H ... An autocrine action of TNF through IL-1 is possible for TNF induced synthesis of IFN-beta 2/IL-6 , but the effects of TNF on synthesis of factor B, C3, and factor H indicated that TNF has effects on fibroblasts separate from IL-1
Fujimoto-Ouchi et al., Int J Cancer 1995 (Cachexia...) : Neither TNF alpha , IL-1 alpha nor IFN gamma was detected in the serum of mice bearing either clone, while IL-6 was detected in mice bearing both clones by ELISA and a bioassay