Gene interactions and pathways from curated databases and text-mining

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IL8 — TNF

Text-mined interactions from Literome

Ou et al., Scand J Immunol 2009 (Colonic Neoplasms) : TNF-alpha induced significantly increased levels of IL-8 and TNF-alpha itself in both cell lines suggesting recruitment and activation of immune cells in the underlying mucosa in vivo
Choi et al., FEMS Immunol Med Microbiol 2007 (Candidiasis) : CpG oligodeoxynucleotides protect mice from lethal challenge with Candida albicans via a pathway involving tumor necrosis factor-alpha dependent interleukin-12 induction
Fulton et al., J Infect Dis 1998 : Regulation of interleukin-12 by interleukin-10, transforming growth factor-beta, tumor necrosis factor-alpha , and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra
Broaddus et al., Am Rev Respir Dis 1992 (Empyema, Pleural...) : Because tumor necrosis factor alpha (TNF-alpha) is a strong inducer of IL-8 , we also asked whether TNF-alpha was present
Yoshida et al., Invest Ophthalmol Vis Sci 2001 : IL-4 and -13, but not IL-10, enhanced constitutive and TNF-alpha induced HRPE IL-8 and MCP-1 secretion ... IL-13 potentiated TNF-alpha induced MCP-1, but not IL-8 secretion by cocultures
Elner et al., Exp Eye Res 1997 : Substantial dose- and time dependent RPE secretion of IL-8 was observed following stimulation with IL-1 beta or TNF-alpha , but cell associated IL-8 was detectable only after high dose ( 20 ng ml-1 ) IL-1 beta stimulation and comprised less than 1 % of the total IL-8 induced
Kang et al., Stem Cells Dev 2007 : In agreement with this observation, induction of interleukin-8 (IL-8) in response to TNF-alpha was seen only in differentiated SNUhES3 cells ... On the basis of an IkappaB kinase (IKK) inhibitor study, expression of IL-8 induced by TNF-alpha was dependent on NF-kappaB activity
Robson et al., J Immunol 2001 : In contrast, IFN-gamma inhibited basal and IL-1beta-, and TNF-alpha induced production of IL-8
Ma et al., J Pharmacol Sci 2012 : We also demonstrated that pretreatment of cells with this compound prevented TNF-a induced expression of NF-?B target genes, such as interleukin 6, interleukin 8, monocyte chemotactic protein 1, cyclooxygenase-2 and inducible nitric oxide
Yoshida et al., Mol Cell Biol 1997 : Administration of a NF-kappaB antisense oligonucleotide almost completely inhibited TNF-alpha dependent IL-8 production and partially abrogated TNF-alpha dependent VEGF production, and an Sp1 antisense sequence partially inhibited TNF-alpha dependent production of VEGF
Mazor et al., Cytokine 2000 : Pretreatment with either isohelenin or parthenolide inhibited TNF-alpha mediated IL-8 gene expression in a concentration dependent manner ... Pretreatment with either compound inhibited TNF-alpha mediated activation of the IL-8 promoter and TNF-alpha mediated nuclear translocation of NF-kappaB
Denizot et al., Cytokine 1999 : PGE ( 2 ) ( 1 microM or 10 nM ) reduces marrow stromal cell IL-8 synthesis in response to IL-1alpha or TNF-alpha
Mizuno et al., Oncology 1994 (Lung Neoplasms) : TNF-alpha and IL-1 beta significantly augmented the levels of mRNA expression for IL-8 and its production
Bachwich et al., Biochem Biophys Res Commun 1986 : Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages ... We have investigated the effect of tumor necrosis factor on the release of interleukin-1 and PGE2 from murine resident peritoneal macrophages ... Tumor necrosis factor causes an increase in the production of interleukin-1 and PGE2 with a maximum induction for both noted at 5.9 X 10 ( -8 ) M
Holden et al., Br J Pharmacol 2007 : Similarly, H ( 3 ) and H ( 4 ) receptor agonists did not affect TNFalpha induced NF-kappaB dependent transcription, or IL-6 and IL-8 release at concentrations below 10 microM
Tajima et al., Clin Exp Immunol 2007 (Staphylococcal Infections) : This factor ( s ) in the bacterial culture supernatant inhibited both basal and tumour necrosis factor (TNF)-alpha induced IL-8 production
Savidge et al., Pediatr Res 2006 (Enteritis) : IL-8 production in response to activation by unrelated TNF-alpha and PMA signaling pathways is also inhibited, indicating a broad spanning tolerance
Maruyama et al., J Dermatol 1995 (Carcinoma, Squamous Cell...) : On the other hand, it enhanced IL-1 alpha- and TNF alpha induced IL-8 secretion in NHKs
Bouchelouche et al., Urology 2006 : TNF-alpha and IL-1beta ( 0.01 to 100 ng/mL ) induced secretion of IL-8 , IL-6, and RANTES in a dose and time dependent manner
Fan et al., Respir Res 2009 : For both NCI-H292 and NHBE cells, low arginine concentrations enhanced basal epithelial IL-6 and IL-8 production and synergized with TNF-alpha induced IL-6 and IL-8 production
Casola et al., J Immunol 2000 : Promoter deletion and mutagenesis experiments indicate that although the region from -99 to -54 nt is sufficient for TNF induced IL-8 transcription, this region alone is not sufficient for RSV induced IL-8 transcription
Sheth et al., Virology 1996 : Secretion of TNF alpha or IL-1 beta, cytokines which themselves increase IL-8 secretion, was not induced by rotavirus, nor was that of TNF alpha, IFN alpha, IFN gamma, or IL-6
Théâtre et al., Am J Respir Cell Mol Biol 2009 (Calcium Signaling) : A P2X ion channel triggered NF-kappaB pathway enhances TNF-alpha induced IL-8 expression in airway epithelial cells
Bai et al., J Immunol 2010 (Tuberculosis) : Inhibition of endogenous IL-32 production in THP-1 cells that express one of three distinct shRNA-IL-32 constructs significantly decreased M. tuberculosis induction of TNF-alpha by approximately 60 %, IL-1beta by 30-60 %, and IL-8 by 40-50 % and concomitantly increased the number of cell associated M. tuberculosis bacteria compared with THP-1 cells stably expressing a scrambled shRNA
Hachicha et al., J Immunol 1998 : In contrast, while IL-8 production in response to S. cerevisiae and zymosan was enhanced in the presence of TNF-alpha , no MIP-1alpha was produced
Lockwood et al., Am J Pathol 2006 (Chorioamnionitis) : Tumor necrosis factor-alpha and interleukin-1beta regulate interleukin-8 expression in third trimester decidual cells : implications for the genesis of chorioamnionitis
Xu et al., Rheumatology (Oxford) 2007 (Arthritis, Rheumatoid) : The production of IL-1beta, IL-6 and IL-8 induced by TNF-alpha was decreased by pyrrolidine dithiocarbamate ( PDTC ), a chemical inhibitor of NF-kappaB ... TNF-alpha induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha
Goh et al., J Immunol 2001 : In parallel experiments involving human colonic mucosa ex vivo, LXA ( 4 ) potently attenuated TNF-alpha stimulated release of the C-X-C chemokine IL-8 , and the C-C chemokines monocyte-chemoattractant protein-1 ( MCP-1 ) and RANTES
Hashimoto et al., Eur Respir J 1999 : Inhibition of TNF-alpha- and IL-1alpha induced p38 MAP kinase activity by SB 203580 inhibited TNF-alpha- and IL-1alpha induced IL-8 protein production as well as IL-8 messenger ribonucleic acid ( mRNA ) expression, indicating that SB 203580 was effective at the transcriptional level
John et al., Am J Respir Cell Mol Biol 1998 (Bronchial Neoplasms) : TNF-alpha stimulated IL-8 mRNA expression and protein release in a time- and dose dependent manner, whereas IFN-gamma alone had no effect ... IL-8 release induced by TNF-alpha and IFN-gamma was partly inhibited by the Th-2 derived cytokines IL-4, IL-10, and IL-13, as well as by dexamethasone
Kim et al., Int Immunopharmacol 2005 : Inhibitory effect of luteolin on TNF-alpha induced IL-8 production in human colon epithelial cells ... In this study, we investigated the role of luteolin, a major flavonoid of Lonicera japonica, on TNF-alpha induced IL-8 production in human colonic epithelial cells ... Luteolin suppressed TNF-alpha induced IL-8 production in dose dependent manner ... These results suggest that luteolin has the inhibitory effects on TNF-alpha induced IL-8 production in the intestinal epithelial cells through blockade in the phosphorylation of MAPKs, following IkappaB degradation and NF-kappaB activation
Horie et al., Fertil Steril 2005 : To investigate whether and how P, dienogest ( synthetic progestin ), and danazol affected tumor necrosis factor alpha (TNFalpha) induced interleukin-8 (IL-8) expression in endometriotic stromal cells
Guo et al., Free Radic Biol Med 2008 : CH3-Avn-c, a synthetically prepared methyl ester derivative of Avn-c with a high biological potency, significantly and dose dependently decreased mRNA expression and secretion of IL-6, IL-8 , and MCP-1 by HAEC as determined by real-time RT-PCR and ELISA, and it inhibited IL-1beta- and TNFalpha stimulated NF-kappaB activation as determined by a NF-kappaB DNA binding assay and a NF-kappaB luciferase reporter assay
Yamagishi et al., Nihon Jibiinkoka Gakkai Kaiho 2000 (Rhinitis, Allergic, Perennial) : [ IL-1 and TNF-alpha mediated regulation of IL-6, IL-8 , and GM-CSF release from cultured nasal epithelial cells ]
Chandru et al., Gene 2007 : The role of sphingosine 1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells ... Interleukin-8 (IL-8) , a C-X-C chemokine, is induced by TNF-alpha and initiates injury by acting as a chemoattractant for neutrophils and other immune cells ... Although sphingolipids such as ceramide and sphingosine 1-phosphate ( S1-P ) have been shown to serve as signaling molecules in the TNF-alpha inflammatory response, their role in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells is not known ... We investigated the role of sphingolipids in the TNF-alpha induction of IL-8 gene expression in H441 lung epithelial cells ... We found that TNF-alpha induced IL-8 mRNA levels by increasing gene transcription, and the stability of IL-8 mRNA was not affected ... Dimethylsphingosine, an inhibitor of sphingosine kinase, partially inhibited TNF-alpha induction of IL-8 mRNA levels indicating the importance of intracellular increases in S1-P in the IL-8 induction ... These data show that increases in the intracellular S1-P partly mediate TNF-alpha induction of IL-8 gene expression in H441 lung epithelial cells via ERK and p38 MAPK signaling pathways and increased AP-1 DNA binding
Remacle-Bonnet et al., Cancer Res 2000 (Adenocarcinoma...) : We further report that TNF induced IL-8 production was indeed strongly enhanced upon IGF-I addition, and this effect was totally abrogated by both MAPK and NF-kappaB inhibitors
Beigi et al., Br J Pharmacol 2003 (Inflammation) : Attenuation of TNF-alpha stimulated IL-8 secretion by oATP was similar in wild-type HEK cells or HEK cells stably expressing recombinant P2X7R ... However, inhibition of P2Y1 receptors with the specific antagonist MRS2216 did not mimic the effects of oATP on TNF-alpha stimulated IL-8 secretion
Brunius et al., Regul Pept 2005 : The stimulatory effect of BK on the IL-1beta- or TNFalpha stimulated IL-8 production was reduced in the presence of BK B2 receptor antagonist HOE 140, whereas the B1 receptor antagonist Lys- ( des-arg9, Leu8 ) -BK had no effect ... Similar to BK, the calcium ionophore A23187 also upregulated the stimulatory effect of IL-1beta and TNFalpha on IL-8 production ... The protein kinase C ( PKC ) inhibitor bisindolylmaleimide, BIS, significantly reduced the stimulatory effect of BK on IL-1beta and TNFalpha increased IL-8 production but did not affect the production of IL-8 stimulated by cytokines alone ... In conclusion, this study shows that BK upregulates IL-1beta- and TNFalpha stimulated IL-8 production via BK B2 receptor and that PKC signal pathway seems to be involved in the upregulation of the cytokine induced IL-8 production in gingival fibroblasts
Dyrøy et al., Arterioscler Thromb Vasc Biol 2005 (Psoriasis) : Our main findings were as follows : ( 1 ) TTA suppressed the tumor necrosis factor alpha induced expression of vascular cell adhesion molecule 1 ( VCAM-1 ) and interleukin 8 (IL-8) in HUVECs
Blanchard et al., Dig Dis Sci 2000 (Acute Disease...) : CAPAN-1 cells had concentration dependent production of IL-6 and IL-8 in response to both endotoxin and TNF-alpha ... CAPAN-2 cells had concentration dependent production of IL-6 and IL-8 in response to TNF-alpha
Mercado et al., PloS one 2012 (Asthma) : Corticosteroid sensitivity was determined by measuring dexamethasone inhibition of CD3/28 and TNF-a induced IL-8 production in PBMCs by using ELISA
Sheikh et al., J Ayub Med Coll Abbottabad 2011 : TNF-alpha increased release of pro-inflammatory cytokines, IL-6, IL-8 , and also GM-CSF from the model mucosa after 24 hours, but had no effect on the release of IL-1alpha, IL-6, IL-8, and GM-CSF after 5 minutes and 24 hours respectively
Stecenko et al., Inflammation 2001 (Cystic Fibrosis...) : Finally, when CF cells were grown at 27 degrees C ( a culture condition which results in transport of CF transmembrane conductance regulator, CFTR, to the cell membrane and normalization of chloride conductance ) TNFalpha stimulated production of IL-6 and IL-8 reverted to normal
Matsuki et al., Oncol Rep 1996 : Stimulation of cells with both TNF-alpha and IFN-gamma increased the biosynthesis of IL-8 or endothelins significantly ( p < 0.05 )
Cui et al., Ophthalmic Res 2005 : alpha-MSH inhibited IL-1beta or TNF-alpha stimulated IL-8 and MCP-1 protein levels in the media
Park et al., Scand J Immunol 2003 (Heart Failure...) : Tumour necrosis factor-alpha (TNF-alpha) and IL-1beta induced mesothelial cell IL-8 mRNA expression, and neutralizing anti-TNF-alpha antibody and IL-1 receptor antagonist nearly completely obliterated CoMTB induced mesothelial cell IL-8 mRNA expression and protein secretion
Wang et al., Zhonghua Gan Zang Bing Za Zhi 2011 (Carcinoma, Hepatocellular...) : TNF-a could increase the production of IL-8 in MHCC-97H cells and p38 MAPK- NF-kB pathways seem to play a central role in the regulation of IL-8 production
Sangiovanni et al., PloS one 2013 : ETs inhibited IL-8 secretion induced by TNF-a and IL-1ß at low concentrations ( IC50 range of 0.7-4 µg/mL )
Fujisawa et al., J Allergy Clin Immunol 2000 : Both IL-4 and IL-13 synergistically enhanced TNF-alpha induced eotaxin production, whereas IL-8 production induced by TNF-alpha was significantly down-regulated by the T ( H ) 2-derived cytokines
Shimizu et al., Adv Exp Med Biol 2009 (Disease Models, Animal...) : Taurine also inhibited the TNF-alpha induced secretion of IL-8 ( a human homologue of MIP-2 ) from human intestinal epithelial Caco-2 cells
Rathanaswami et al., Arthritis Rheum 1993 (Arthritis, Rheumatoid) : TNF alpha and IL-1 beta induced a time- and dose dependent release of immunoreactive IL-8
Frishman et al., J Infect Dis 2000 : Tumor necrosis factor (TNF)-alpha induced interleukin-8 in human blood cultures discriminates neutralization by the p55 and p75 TNF soluble receptors ... In this study, neutralization of TNF-alpha induced interleukin (IL)-8 by p75-Fc in whole human blood exhibited a U-shaped inhibition curve, whereas the TNF-soluble p55 receptor, linked to polyethylene glycol ( p55-PEG ), exhibited a dose dependent inhibition ... Native soluble p75 increased TNF-alpha induced IL-8 , versus a 61 % reduction by native p55
Gallelli et al., Int J Immunopathol Pharmacol 2010 : Effects of budesonide on P38 MAPK activation, apoptosis and IL-8 secretion, induced by TNF-alpha and Haemophilus influenzae in human bronchial epithelial cells
Sarir et al., Biochem Pharmacol 2010 (Emphysema) : CSM and TNF-alpha induce a dose- and time dependent increase in IL-8 production
Steube et al., Leuk Res 2003 (Leukemia, Promyelocytic, Acute) : Besides the staurosporines, also 12-O-tetradecanoyl phorbol acetate ( TPA ) and tumor necrosis factor-alpha (TNFalpha) strongly increased the IL-8 and MCP-1 secretion of NB-4 cells
Lisi et al., J Autoimmun 2010 (Sjogren's Syndrome) : The gene silencing technique was used to study the AREG-TNF-alpha-IL-6/IL-8 secretion pathway, demonstrating that : ( i ) TNF-alpha gene silencing provokes a significant decrease of proinflammatory cytokines production and AREG expression in anti-Ro/SSA Abs treated healthy SGEC ; ( ii ) AREG gene silencing has a potent inhibitory effect on TNF-alpha induced IL-6 and IL-8 secretion in healthy SGEC treated with anti-Ro/SSA Abs ... These findings indicate that TACE mediated AREG shedding plays a critical role in TNF-alpha induced IL-6 and IL-8 secretion by the human healthy salivary gland epithelial cells, suggesting that this may be one of the possible intracellular mechanisms involved in the salivary glands inflammatory response in Sjögren 's syndrome
Fukumoto et al., J Leukoc Biol 1998 (Pleurisy) : These results indicate important roles of IL-8 in LPS induced delayed VP and that TNF-alpha causes the delayed VP through the production of IL-8
Ungerstedt et al., Clin Exp Immunol 2003 (Endotoxemia) : At a concentration of 40 mmol/l, the IL-1 beta, IL-6 and TNF alpha responses were reduced by more than 95 % and the IL-8 levels reduced by 85 %
Andrew et al., Biochem Biophys Res Commun 1995 (Melanoma) : The nitric oxide synthase inhibitor, NG-amino-L-homoarginine ( NAHA ), inhibited TNF-alpha stimulated IL-8 promoter activity by 60 %
McCracken et al., Experimental biology and medicine (Maywood, N.J.) 2002 : However, TNF-alpha induced IL-8 mRNA expression, and co-culture of TNF-alpha treated HT-29 cells with L. plantarum 299v significantly increased IL-8 mRNA expression above levels induced by TNF-alpha alone in an adhesion dependent manner
Cheng et al., J Immunol 2002 : We found that incubation of human dermal microvascular endothelial cells with recombinant eotaxin/CCL11 suppresses TNF-alpha induced production of the neutrophil-specific chemokine IL-8/CXCL8
Barshishat et al., Clin Exp Metastasis 2002 (Adenocarcinoma...) : These results suggest that the effect of TNFalpha on IL-8 is responsible for the regulation of the expression of CD44 isoforms
Cheon et al., J Rheumatol 2004 (Arthritis, Rheumatoid...) : When RA FLS are stimulated with interleukin 1 or tumor necrosis factor-a , WISP3 mRNA is significantly increased
Feldmann et al., Annu Rev Immunol 2001 (Arthritis, Rheumatoid...) : Clinical investigations in which the activity of TNF alpha in RA patients was blocked with intravenously administered infliximab, a chimeric anti-TNF alpha monoclonal antibody ( mAB ), has provided evidence that TNF regulates IL-6, IL-8 , MCP-1, and VEGF production, recruitment of immune and inflammatory cells into joints, angiogenesis, and reduction of blood levels of matrix metalloproteinases-1 and -3
Fitzgerald et al., Vet Immunol Immunopathol 2007 (Mastitis, Bovine) : Tumour necrosis factor-alpha (TNF-alpha) increases nuclear factor kappaB (NFkappaB) activity in and interleukin-8 (IL-8) release from bovine mammary epithelial cells ... TNF-alpha induced primarily serosal IL-8 release in the cell culture model ... Pre-treatment with anti-TNF or dexamethasone inhibited TNF-alpha induced IL-8 release ... These data support a role for TNF-alpha in activation of NFkappaB and release of IL-8 from bovine mammary epithelial cells
Smirnova et al., Acta Otolaryngol 2002 (Otitis Media with Effusion) : IL-1beta and TNF-alpha stimulated the secretion of IL-8 in HT29-MTX goblet cells
Shin et al., Inflammation 2011 (MAP Kinase Signaling System) : Synergistic effect of tumor necrosis factor-alpha and hydrogen peroxide on the induction of IL-8 production in human intestinal Caco-2 cells ... The IL-8 production ( secretion, mRNA expression, and transcriptional activity ) induced by both TNF-a and H ( 2 ) O ( 2 ) was significantly higher than that by single stimulation ... Oxidative stress and TNF-a may cooperatively enhance IL-8 production via NF-?B in Caco-2 cells
Jijon et al., Am J Physiol Cell Physiol 2002 : In contrast, ERK and p38 inhibition resulted in the accelerated degradation of the IL-8 mRNA, suggesting that in HT-29 cells, p38 and ERK contribute to TNF-alpha stimulated IL-8 secretion by intestinal epithelial cells via a posttranscriptional mechanism that involves stabilization of the IL-8 transcript
Miyauchi et al., J Dairy Sci 2009 (Colitis) : Among the 4 lactobacilli studied, Lactobacillus rhamnosus OLL2838 most effectively suppressed barrier impairment and increased IL-8 secretion induced by tumor necrosis factor-alpha in Caco-2 cells ; however, the conditioned medium from OLL2838 did not show any effect on barrier functions
Rahman et al., Mol Cell Biochem 2002 (Inflammation) : Both H2O2 and TNF-alpha significantly increased IL-8 release, which was further enhanced by pre-treatment of A549 cells with TSA compared to the individual treatments
Brand et al., Arterioscler Thromb 1994 : In contrast, oxLDL did not alter LPS mediated production of interleukin-8 and actually inhibited LPS induced secretion of tumor necrosis factor-alpha , suggesting that some aspects of the signaling pathways for TF induction differ from those of other LPS-responsive monocyte/macrophage gene products
Carpenter et al., BMC infectious diseases 2002 (Lung Neoplasms) : In this study, we examined the NF-kappaB mediated effects of RSV and the proinflammatory cytokine TNFalpha on the induction of IL-8 , MCP-1 and RANTES chemokine gene expression in A549 epithelial cells
Hardyman et al., J Allergy Clin Immunol 2013 (Asthma) : TNF-a lowered transepithelial electrical resistance and increased fluorescent dextran permeability, caused loss of occludin and claudins from tight junctions with redistribution of p120 catenin and E-cadherin from adherens junctions, and also increased endogenous TNF-a, IL-6, IL-1ß, IL-8 , thymic stromal lymphoprotein, and pro-matrix metalloprotease 9 release
Bonnans et al., Biomed Pharmacother 2007 : Exogenous LXA ( 4 ) significantly inhibited tumor necrosis factor-alpha (TNF-alpha) induced interleukin-8 (IL-8) release in the different epithelial cell types and the potency of inhibition was dependent of the accessibility of the specific LXA(4) receptor, formyl-peptide receptor like-1 (FPRL-1) expressed by all these cells
Singh et al., Am J Respir Cell Mol Biol 2008 (Fever) : HS markedly enhanced TNF-alpha induced IL-8 secretion in human A549 respiratory epithelial-like cells and in primary human small airway epithelial cells ... Furthermore, depletion of HSF-1 using siRNA also reduced the effects HS on TNF-alpha induced IL-8 expression, demonstrating that HSF-1 could also act to regulate IL-8 gene transcription
Li et al., Journal of inflammation (London, England) 2008 : Our results demonstrated that, in human pulmonary alveolar epithelial cells, the overexpression of PBEF significantly augmented basal and TNFalpha stimulated IL-8 secretion by more than 5 to 10-fold and increased cell permeability by > 30 % ; the knockdown of PBEF expression with siRNA significantly inhibited basal and TNFalpha stimulated IL-8 secretion by 70 % and IL-8 mRNA levels by 74 %
Lin et al., Crit Care Med 2003 (Hyperoxia) : Endogenous nitric oxide may be an important endogenous inhibitor of hyperoxia + tumor necrosis factor-alpha induced leukocyte recruitment and subsequently tumor necrosis factor-alpha, interleukin-1 beta, and GRO/CINC-1 release
Temkin et al., J Immunol 2002 (MAP Kinase Signaling System) : HMC-1 induced IL-8 release was significantly reduced by the tryptase inhibitors GW-45 and GW-58 ( 90 and 87 %, respectively, at an optimal concentration ) but not by anti-stem cell factor, anti-TNF-alpha , or anti-IFN-gamma neutralizing Abs or by the antihistamine drugs pyrilamine and cimetidine
Choi et al., Rheumatol Int 2010 : In contrast, the expression of IL-8 in both cell types was strongly stimulated by both IL-1beta and TNF-alpha
Parilla et al., Respir Res 2006 : In addition, CpG synergistically upregulated TNFalpha induced IL-8 expression
Ichiyama et al., Inflamm Res 2004 : Moreover, the inhibitory effects of IVIG on IkappaBalpha degradation, interleukin-6 (IL-6) production, and E-selectin expression induced by TNF-alpha were evaluated by Western blot analysis, ELISA, and flow cytometry, respectively
Oltmanns et al., Respir Res 2005 : TNFalpha enhanced CSE induced IL-8 release and expression
Aherne et al., Mol Immunol 2009 (Arthritis) : Ectopic expression of NR4A2 leads to robust changes in endogenous IL-8 mRNA levels and co-treatment with TNF-alpha results in significant ( p < 0.001 ) secretion of IL-8 protein ... Transcriptional effects of NR4A2 on the human IL-8 promoter are enhanced in the presence of TNF-alpha , suggesting molecular crosstalk between TNF-alpha signalling and NR4A2
Hill et al., Alcohol Clin Exp Res 1998 (Liver Diseases, Alcoholic...) : Inactivation of the NF-kappaB and 3'NF-IL-6 DNA binding sites decreased IL-8 gene transcriptional activation in response to TNF while inactivation of the 5'NF-IL-6 binding site increased IL-8 gene transcriptional activity in response to TNF ... This system may be useful to assess the effects of ethanol on TNF induced hepatocyte IL-8 production
Sakamoto et al., J Clin Endocrinol Metab 2003 (Endometriosis) : Tumor necrosis factor-alpha induced interleukin-8 (IL-8) expression in endometriotic stromal cells, probably through nuclear factor-kappa B activation : gonadotropin releasing hormone agonist treatment reduced IL-8 expression ... We hypothesize that TNFalpha may induce IL-8 production in endometriotic cells through nuclear factor-kappa B (NF-kappa B) activation ... These findings demonstrate that NF-kappa B activation is critical for TNFalpha induced IL-8 expression in endometriotic stromal cells
Altman et al., Vascul Pharmacol 2008 (Inflammation) : TNF-alpha induced upregulation of the expression of inflammatory genes interleukin (IL)-8 and intracellular adhesion molecule (ICAM)-1 was attenuated by incubation with DHEAS
Jordan et al., Br J Pharmacol 1997 : In contrast approximately three fold more IL-8 was induced by IL-1alpha than by TNFalpha whereas significant RANTES production was induced only by TNFalpha ... IL-13, but not IL-10, significantly enhanced IL-8 and MCP-1 release in response to IL-1alpha or TNFalpha
Ghigo et al., Infect Immun 2001 (Endocarditis, Bacterial...) : First, interleukin-10 suppressed C. burnetii stimulated production of TNF
Zeineh et al., Am J Reprod Immunol 2003 : This study investigated the possible effects of IL-1alpha, tumor necrosis factor-alpha (TNF-alpha), protein kinase C ( PKC ) activators ( TPA ), and db-cyclic adenosine monophosphate ( cAMP ) on IL-8 and GRO-alpha production by immortalized GC1a and granulosa-lutein cells
Yang et al., Cancer Res 2011 (Carcinoma, Squamous Cell...) : Depletion of RelA or dNp63 by small interfering RNA ( siRNA ) significantly inhibited NF-?B-specific, or TNF-a induced IL-8 reporter activation
Vilela et al., Int Immunopharmacol 2006 : As fenretinide is a ceramide up-regulating drug that inhibits the activation of the pro-inflammatory transcriptional factor, nuclear factor (NF)-kappaB, the impact of fenretinide on unstimulated and tumor necrosis factor (TNF)-alpha stimulated production of NF-kappaB dependent interleukin (IL)-8 was studied in immortalized wild-type ( non-CF ; 9HTEo- ) and mutant DeltaF508 CFTR ( CF ; CFTE29o- ) tracheal epithelial cells ... Clinically relevant concentrations of fenretinide ( 1.25, 2.5 and 5 microM ) inhibited TNF-alpha induced IL-8 production of CF cells by up to 73 % but had no effect or increased the IL-8 production in non-CF cells
Zhao et al., J Agric Food Chem 2008 : 5-caffeoylquinic acid and caffeic acid down-regulate the oxidative stress- and TNF-alpha induced secretion of interleukin-8 from Caco-2 cells ... We investigated in this study the down-regulative effects of 5-caffeoylquinic acid ( CQA ), the predominant isomer of CHA, on the H ( 2 ) O ( 2- ) or TNF-alpha induced secretion of interleukin (IL)-8 , a central pro-inflammatory chemokine involved in the pathogenesis of inflammatory bowel diseases, in human intestinal epithelial Caco-2 cells ... Both CQA and CA suppressed the TNF-alpha induced IL-8 secretion as well ... However, CQA and CA did not suppress the TNF-alpha induced increase in the IL-8 mRNA expression, indicating that the suppressive mechanisms are different between TNF-alpha induced and H ( 2 ) O ( 2 ) -induced IL-8 production models
Nie et al., J Biol Chem 2005 : We reported here that the PPARgamma agonists 15-deoxy-Delta ( 12,14 ) -PGJ ( 2 ) ( 15d-PGJ ( 2 ) ) and troglitazone, but not PPARalpha agonist WY-14643, inhibited TNFalpha induced production of eotaxin and monocyte chemotactic protein-1 (MCP-1) but not IL-8
Shi et al., Cell Biochem Biophys 2004 (Atherosclerosis) : We observed constitutive expression of interleukin (IL)-6, IL-8 , granulocyte macrophage colony stimulating factor ( GM-CSF ), and monocyte chemoattractant protein (MCP)-1 in both human and baboon endothelial cells, and these cytokines were further induced by TNF-alpha and LPS
Asagoe et al., J Immunol 1998 : To assess the interactions of multiple cytokines at the level of inflammatory effector cells, we examined the effects of TNF-alpha on the expression of two IL-8Rs ( CXCR1 and CXCR2 ) on polymorphonuclear leukocytes ( PMNs )
Ko et al., World J Gastroenterol 2007 (Adenocarcinoma...) : Lactobacillus plantarum inhibits epithelial barrier dysfunction and interleukin-8 secretion induced by tumor necrosis factor-alpha ... TNF-alpha induced IL-8 secretion was reduced by L. plantarum ... Induction of epithelial barrier dysfunction and IL-8 secretion by TNF-alpha is inhibited by L. plantarum
Möhler et al., Melanoma Res 1996 (Melanoma) : A pronounced increase of IL-8 mRNA expression and protein production was induced by tumour necrosis factor-alpha (TNF alpha) ... Interferon-gamma (IFN gamma) partially inhibited TNF alpha induced IL-8 secretion, whereas no influence on IL-8 mRNA levels was detected
Sato et al., J Rheumatol 1996 (Arthritis, Rheumatoid) : Antioxidants inhibit tumor necrosis factor-alpha mediated stimulation of interleukin-8 , monocyte chemoattractant protein-1, and collagenase expression in cultured human synovial cells ... TNF-alpha increased the expression of IL-8 , MCP-1, and collagenase mRNA in human synovial cells ... Our data suggest that TNF-alpha induces expression of proinflammatory cytokines such as IL-8 and MCP-1 through generation of reactive oxygen intermediates and subsequent activation of NF-kappa B in human synovial cells, and the antioxidants may inhibit, at least in part, the activation of NF-kappa B by TNF-alpha
Marie et al., Mediators Inflamm 1996 : IL-8 induction by TNFalpha was, unlike its induction by LPS, resistant to the inhibitory effects of IL-10, IL-4, IL-13 and TGFbeta ... Despite the capacity of IL-4, IL-10, and IL-13 to limit the production of TNFalpha induced IL-8 in a whole blood assay, none was able to inhibit this production when studying isolated human polymorphonuclear cells
Wilmer et al., Cell Biol Toxicol 1995 : However, PMA and TNF alpha induced IL-8 production that coincided with significant cell cycle inhibition ... At all concentrations tested, TNF alpha reduced the mitotic index by approximately 45 %, slowed cell cycle progression by approximately 3.5 h, and induced a flat, albeit large, IL-8 response at concentrations > or = 12.5 ng/ml
Goldstein et al., Mediators Inflamm 1996 : TNF induced IL-8 and MCP-1 production in the eosinophilic cell line, EOL-1 ... Initial studies demonstrated that TNF-alpha induced the upregulation of IL-8 and MCP-1 mRNA and protein
Cowburn et al., Eur J Immunol 2004 : In human neutrophils, TNF-alpha ( 200 U/ml ) induced rapid I kappa B-alpha degradation, NF-kappa B activation and IL-8 release ( 31.8+/-5.4 pg/10 ( 5 ) cells/2 h ), whereas GM-CSF ( 10 ng/ml ) stimulated an equivalent IL-8 release ( 26.5+/-4.5 pg/10 ( 5 ) cells/2 h ) without enhanced I kappa B-alpha degradation or NF-kappa B activation compared to control
Hirano et al., Eur J Pharmacol 2007 : Synergistic effect of PGD2 via prostanoid DP receptor on TNF-alpha induced production of MCP-1 and IL-8 in human monocytic THP-1 cells ... In addition, the selective prostanoid DP receptor antagonist, pinagladin ( ( Z ) -7- [ ( 1R,2R,3S,5S ) -2- ( benzothiophen-3-ylcarbonylamide ) -10-norpinan-3-yl ] hept-5-enoic acid ) inhibited the production of MCP-1 and IL-8 upon combined stimulation with PGD2 and TNF-alpha ... Our findings suggest that activation of the prostanoid DP receptor on THP-1 cells enhances TNF-alpha induced MCP-1 and IL-8 production via the cAMP/PKA signaling pathway
Dunican et al., Shock 2000 : An enzyme linked immunoassay was used to measure levels of the anti-apoptotic cytokine IL-8 , induced by TNFalpha-stimulation
Strieter et al., Am J Respir Cell Mol Biol 1990 : The induction of AMO derived IL-8 by tumor necrosis factor (TNF) , lipopolysaccharide (LPS), and interleukin-1 ( IL-1 beta ) was shown to be both dose and time dependent
Andoh et al., Int J Mol Med 2002 (Acute Disease...) : To elucidate the mechanisms mediating the therapeutic actions of somatostatin on acute pancreatitis, we investigated how somatostatin affects the tumor necrosis factor (TNF)-alpha induced interleukin (IL)-6 and IL-8 secretion from pancreatic myofibroblasts
Hachicha et al., J Exp Med 1995 (Gout...) : Both TNF-alpha and GM-CSF stimulated IL-8 production ; however, only TNF-alpha exerted a significant effect on MIP-1 alpha secretion in neutrophils ... IL-8 production induced by TNF-alpha and GM-CSF was synergistically enhanced in the presence of MSU or CPPD, whereas MIP-1 alpha secretion induced by TNF was completely inhibited in the presence of either MSU or CPPD
Simeonova et al., Lab Invest 1999 : Redox dependent regulation of interleukin-8 by tumor necrosis factor-alpha in lung epithelial cells ... IL-8 induction by TNF-alpha was redox sensitive, as indicated by electron spin resonance analysis and inhibition with membrane permeable hydroxyl scavengers ... Furthermore using cell transfection and mobility shift assays, it was found that transcriptional activation of the IL-8 gene required TNF-alpha induced activation and binding of nuclear factor-kappaB (NF-kappaB)- and NF-IL-6, nuclear transcription factors to regulatory elements in the IL-8 promoter
Oliveira et al., Proc Natl Acad Sci U S A 1992 : Tumor necrosis factor (TNF) and IL-1 are potent inducers of IL-8 expression ... Earlier we showed that TNF induced stimulation of IL-8 mRNA accumulation in human FS-4 fibroblasts was inhibited by interferon beta (IFN-beta) or IFN-gamma ... Treatment with IFN-beta also decreased TNF induced IL-8 protein accumulation ... Nuclear run-on assays demonstrated that IFN-beta caused a marked inhibition of TNF induced IL-8 gene transcription ; the transcriptional activation of several other TNF induced genes was not inhibited by IFN-beta
Westra et al., Arthritis Res Ther 2004 (MAP Kinase Signaling System) : Strong inhibition of TNF-alpha production and inhibition of IL-8 and COX-2 mRNA expression in monocyte derived macrophages by RWJ 67657, a p38 mitogen activated protein kinase ( MAPK ) inhibitor
Jana et al., J Neurochem 2003 : Induction of tumor necrosis factor-alpha (TNF-alpha) by interleukin-12 p40 monomer and homodimer in microglia and macrophages
Sopasakis et al., Int J Obes Relat Metab Disord 2005 : TNFalpha increased the mRNA levels of TNFalpha itself as well as IL-6, IL-8 , IL-1beta and PAI-1, but not leptin
Garrouste et al., Cell Death Differ 2002 : Correspondingly, IGF-I markedly enhanced the TNF- and IFN/TNF induced NF-kappaB dependent interleukin-8 production
Paik et al., Lab Invest 2006 (Fibrosis...) : These findings suggest that TNF-alpha or IL-1beta primed HSCs enhance the production of IL-8 in response to PGN and LTA through augmentation of the TLR2 system
Kim et al., Mol Immunol 2007 (Ovarian Neoplasms) : TNF-alpha induced IL-8 promoter activation that is inhibited by saxatilin treatment was dependent on activating protein-1 (AP-1) instead of nuclear factor-kappa B (NF-kappaB)
Fujiwara et al., Lab Invest 2002 (Arthritis, Experimental) : GROalpha does not seem to initiate TNFalpha , IL-1beta, and IL-8 in an early phase, but induces IL-1beta and IL-8 in a late phase
Benveniste et al., Int J Dev Neurosci 1995 : In this study, we demonstrate that transforming growth factor-beta ( TGF-beta ), interleukin-10 (IL-10) and interleukin-6 (IL-6) inhibit tumor necrosis factor-alpha expression by primary rat astrocytes
Judd et al., Am J Physiol 1995 : ZG cells released IL-6 and TNF , and this release was stimulated by lipopolysaccharide, interleukin-1 alpha, interleukin-1 beta, a protein kinase C activator, and a calcium ionophore without affecting intracellular adenosine 3 ', 5'-cyclic monophosphate ( cAMP ) content
Pera et al., Am J Physiol Lung Cell Mol Physiol 2012 (MAP Kinase Signaling System) : In various cell types, transforming growth factor-ß activated kinase 1 ( TAK1 ) plays a crucial role in MAP kinase and NF-?B activation, as well as IL-8 release induced by IL-1ß, TNF-a , and lipopolysaccharide
Kamada et al., Infect Immun 2008 : Enzyme linked immunosorbent assays and real-time quantitative PCR showed that Nissle 1917 treatment suppressed TNF-alpha induced IL-8 transcription and production ... In conclusion, these data indicate that the nonpathogenic E. coli strain Nissle 1917 expresses a direct anti-inflammatory activity on human epithelial cells via a secreted factor which suppresses TNF-alpha induced IL-8 transactivation through mechanisms different from NF-kappaB inhibition ... To determine the effect of E. coli Nissle 1917, the human colonic epithelial cell line HCT15 was incubated with or without E. coli Nissle 1917 or another nonpathogenic E. coli strain, K-12, and then tumor necrosis factor alpha (TNF-alpha) induced interleukin-8 (IL-8) production from HCT15 cells was assessed
Siebert et al., Arthritis Rheum 2005 : Nevertheless, the C43S TRAPS fibroblasts were capable of producing interleukin-6 (IL-6) and IL-8 in response to TNFalpha
Minami et al., J Dent Res 2007 (MAP Kinase Signaling System...) : Stimulation of gingival fibroblasts with tumor necrosis factor-alpha , IL-1alpha, and lipopolysaccharide markedly induced IL-8 production, and the IL-8 production was synergistically augmented in the presence of or pre-treatment with histamine
Becker et al., J Immunol 1991 (Respirovirus Infections) : However, TNF , IL-1, and RSV, but not IL-6, induced IL-8 and IL-6 mRNA expression by the bronchial epithelial cells suggesting that cytokines produced by RSV infected AM may be more important in modulating the inflammatory response in infection than directly interfering with virus infection/replication of airway epithelium
Zhou et al., Rheumatol Int 2012 (Arthritis, Rheumatoid) : Nicotine inhibits tumor necrosis factor-a induced IL-6 and IL-8 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis ... Nicotine at concentrations of 0.1-10 µM dose reduced the protein and mRNA expression of IL-6 and IL-8 induced by tumor necrosis factor-a (TNFa)
Kohno et al., J Rheumatol 2001 : T-614 suppressed TNF-alpha induced production of IL-6, IL-8 , and monocyte chemoattractant protein 1, and also reduced the accumulation of IL-6 and IL-8 mRNA in a concentration dependent manner
Kurtz et al., Invest Ophthalmol Vis Sci 1997 : In contrast, CSA significantly inhibited TNF-alpha stimulated , but not IL-1 beta stimulated, HRPE MCP-1 and IL-8 secretion ... IL-1 beta induced chemokine secretion is sensitive to DEX, whereas MCP-1 and IL-8 induced by TNF-alpha are inhibited by CSA
Gnant et al., Cytokine 2000 : TNF caused increased secretion of IL-6, IL-8 , ICAM-1, and VCAM-1 with little or no additional effect from HT. Increased E-selectin and RANTES levels were observed with TNF and HT only at 24 h after treatment
Schulz et al., Respiration 2003 (Pulmonary Disease, Chronic Obstructive) : The unstimulated and TNFalpha induced IL-8 release was measured by enzyme linked immunosorbent assay
Abreu-Martin et al., J Immunol 1995 (Second Messenger Systems) : This study shows that the pathways leading to cell death and IL-8 production in response to Fas Ag ligation and TNF-alpha were similar with regard to their requirements for new gene expression, protein synthesis, and protein kinase activity
Nita et al., Int J Biochem Cell Biol 2007 : In contrast, longer term incubation ( 18 h ) of monocytes with combined AAT/LPS results in a significant reduction in expression of both CD14 and TLR4, inhibition of LPS induced TNFalpha , IL-1 beta and IL-8 mRNA and protein expression
Catley et al., Br J Pharmacol 2005 (Asthma) : Similarly, IKK beta ( KA ) and I kappa B alpha delta N overexpression also inhibited IL-1beta- and TNF alpha dependent increases in ICAM-1, IL-8 and GM-CSF in addition to IL-1beta mediated increases in cyclooxygenase-2 expression, whereas IKK alpha ( KM ) overexpression had little effect on these outputs
Fukui et al., Microbiol Immunol 2013 : Moreover, TLR agonists differentially regulated tumor necrosis factor-alpha induced IL-8 and CXCL10 production by the tested cell types
Patel et al., J Surg Res 2006 : Addition of exogenous Ub ( equaling day 42 concentration ) to day 0-4 plasma inhibited TNF-alpha production by one-third of the effect detected for day 42 plasma, but also inhibited IL-8 production by 40 %
Banerjee et al., Shock 2013 (Acute Lung Injury) : Hyperosmolarity alone had no effect on either basal IL-8 release or ICAM-1 surface expression but did lead to concentration dependent decreases in TNF-a induced IL-8 release, ICAM-1 surface expression, and PMN-HMVEC adhesion ... Despite this basal activation, hyperosmolar incubation attenuated TNF-a stimulated IL-8 release and ICAM-1 surface expression and subsequent PMN adherence, while p38 MAPK inhibition did not further influence the effects of hyperosmolar conditions on ICAM-1 surface expression
Bian et al., Lab Invest 1998 : Collectively, these results suggest specific potentiation of TNF-alpha induced HRPE IL-8 by human serum albumin that has been glycated either during circulation or locally within tissue
Hashimoto et al., Br J Pharmacol 2001 : However, the effect of N-acetylcysteine (NAC), which acts as a precursor of glutathione ( GSH ) synthesis, on TNF-alpha induced activation of p38 MAP kinase pathway and p38 MAP kinase mediated IL-8 production by human pulmonary vascular endothelial cells has not been determined ... 6. These results indicate that the cellular reduction and oxidation ( redox ) regulated by intracellular GSH is critical for TNF-alpha induced activation of p38 MAP kinase pathway and p38 MAP kinase mediated IL-8 production by human pulmonary vascular endothelial cells, and we emphasize that anti-oxidant therapy is an important strategy for the treatment of acute lung injury
Rafiee et al., Am J Physiol Gastrointest Liver Physiol 2003 (Esophagitis) : TNF-alpha/LPS activation of HEMEC resulted in upregulation of the cell adhesion molecules (CAM) ICAM-1, VCAM-1, E-selectin, and mucosal addressin CAM-1 (MAdCAM-1), increased IL-8 production, and enhanced leukocyte binding
Grob et al., J Biol Chem 1990 : The binding of MDNCF/IL-8 to human neutrophils is not inhibited by interleukin-1 alpha, tumor necrosis factor-alpha , insulin, or epidermal growth factor
Quaid et al., J Trauma 2001 (Wounds, Nonpenetrating) : At 40 minutes, IL-8 and GROalpha significantly inhibited TNFalpha adherence dependent peroxide production in normal neutrophils ( 35 % +/- 4 % and 45 % +/- 3 %, respectively ; p < 0.05 )
Sato et al., J Rheumatol 1997 (Arthritis, Rheumatoid) : Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha in cultured human synovial cells ... Based on our recent finding that reactive oxygen intermediates play important roles in mediating TNF-alpha action, we examined the effect of an antioxidant bioflavonoid, quercetin, on TNF-alpha induced expression of interleukin 8 (IL-8) and monocyte chemoattractant protein-1 ( MCP-1 ) in cultured human synovial cells ... Quercetin suppresses TNF-alpha mediated stimulation of IL-8 and MCP-1 expression, at least in part, by inhibiting the activation of NF-kappa B
Tagashira et al., Fertil Steril 2009 (Endometriosis...) : We examined the effects of TNF-alpha and IL-10 on the expression of IL-6 or IL-8 by real-time RT-PCR and ELISA
Hattar et al., J Immunol 2001 : IL-1RA and sTNFRs, accumulating under these circumstances, seem to be centrally involved in this regulatory mechanism by interfering with the IL-1beta- and TNF-alpha dependent IL-8 generation
Dong et al., J Interferon Cytokine Res 1998 : Using human Hep G2 cells, it was demonstrated that, in contrast to lipopolysaccharides (LPS), both tumor necrosis factor-alpha ( TNF-beta ) and H2O2 are potent inducers of IL-8 , presumably acting via protein kinase C ( PKC ) -dependent pathways ... Furthermore, in vitro TNF-alpha neutralization experiments and transfection of Hep G2 cells with an IL-8 construct confirmed that TNF-alpha and H2O2 directly stimulate IL-8 secretion
To et al., Am J Respir Crit Care Med 2010 (Pulmonary Disease, Chronic Obstructive) : Corticosteroid sensitivity was determined as the 50 % inhibitory concentration of dexamethasone on tumor necrosis factor-a induced interleukin-8 release in peripheral blood mononuclear cells from patients with COPD ( n = 17 ) and compared with that of nonsmoking ( n = 8 ) and smoking ( n = 7 ) control subjects
O'Hara et al., Cytokine 2009 : Tumor necrosis factor (TNF)-alpha induced IL-8 expression in gastric epithelial cells : role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1 ... Overexpression of Ref-1 enhanced IL-8 gene transcription at baseline and after TNF-alpha treatment whereas Ref-1 suppression and antioxidant treatment inhibited TNF-alpha stimulated IL-8 expression
Seatter et al., Arch Surg 1994 (Disease Models, Animal) : Tumor necrosis factor and interleukin-1 regulation by lipopolysaccharide pretreatment
Tada , Hokkaido Igaku Zasshi 1992 (Brain Neoplasms...) : TNF at a low dose ( 10 U/ml ) stimulated production of prostaglandin E2, Mn-superoxide dismutase, interleukin (IL)-6 and IL-8 by glioblastoma cells ... TNF at a low dose ( 10 U/ml ) stimulated production of prostaglandin E2, Mn-superoxide dismutase, interleukin (IL)-6 and IL-8 by glioblastoma cells
Subauste et al., Int Immunopharmacol 2001 : Effects of tumor necrosis factor-alpha , epidermal growth factor and transforming growth factor-alpha on interleukin-8 production by, and human rhinovirus replication in, bronchial epithelial cells
Tsaprouni et al., Clin Exp Immunol 2007 : To investigate this, we studied the effect of two glucocorticoids ( dexamethasone and triamcinolone acetonide ) on reducing lipopolysaccharide (LPS)- and tumour necrosis factor (TNF)-alpha induced interleukin (IL)-8 release in a monocytic cell line and two lymphocytic cell lines ( HUT-78 and Jurkat ) ... The effect of the histone deacetylase inhibitor trichostatin A (TSA) on LPS- and TNF-alpha induced IL-8 release and its repression by glucocorticoids was also examined ... LPS and TNF-alpha induced IL-8 release in all three cell lines and this induction was inhibited by both dexamethasone and triamcinolone
Boldrini et al., Int J Mol Med 2006 (Carcinoma, Non-Small-Cell Lung...) : TNF-alpha can stimulate the expression of many molecules, including interleukin-8 (IL-8) and endothelin-1 (ET-1) ; in our study, the expression of TNF-alpha was significantly associated with high IL-8 mRNA levels ( p=0.008 ) and ET-1 mRNA positivity ( p=0.03 )
Palladino et al., Ciba Found Symp 1987 (Neoplasms, Experimental) : Apart from their direct cytotoxic/cytostatic activities against tumours in vitro and in vivo, the in vivo antitumour activities of TNF-alpha or TNF-beta may involve the following biological activities : the induction of interleukin 1 production ; activation of polymorphonuclear neutrophil functions ; modulation of endothelial cell functions ; and augmentation of specific immune functions
van Deventer et al., J Infect Dis 1993 : Endotoxin and tumor necrosis factor-alpha induced interleukin-8 release in humans ... These data indicate that IL-8 is released in humans after injection of endotoxin and TNF alpha and suggest that endotoxin induced IL-8 release is mediated by TNF alpha
Drake et al., Lab Invest 1992 : However, alpha-thrombin synergistically enhanced the PMNL infiltration induced by IL-1 alpha, TNF-alpha , but not that induced by zymosan activated plasma ( C5a ) or IL-8 ( neutrophil activating peptide-1 )
Kohsaka et al., Hepatology 2002 (Alagille Syndrome...) : The increase of interleukin 8 (IL-8) production induced by tumor necrosis factor alpha (TNF-alpha) in Huh 7 cells was suppressed by the coexistence of JAG1 protein
Ashburner et al., Mol Cell Biol 2001 : Finally, we show that inhibition of HDAC activity with TSA causes an increase in both basal and TNF induced expression of the NF-kappaB regulated interleukin-8 (IL-8) gene
Moon et al., Spine (Phila Pa 1976) 2012 (Fibrosis...) : Prior macrophage exposure increased the secretion of IL-8 and VEGF in response to TNF-a/IL-1ß stimulation whereas IL-6 production was increased in response to IL-1ß
Ortiz-Arduan et al., Am J Physiol 1996 (Endotoxemia) : Lipopolysaccharides (LPS), interleukin-1 beta, interferon-gamma (IFN-gamma), and TNF-alpha increase the levels of Fas mRNA in cultured mesangial and tubular cells
Yasumoto et al., J Biol Chem 1992 (Stomach Neoplasms) : These results indicated that IFN gamma synergistically enhanced TNF alpha induced IL-8 production in a human gastric cancer cell line through synergistic activation of transcription factors without up-regulating TNF alpha receptor
Ihenetu et al., Eur J Pharmacol 2003 : We have investigated the effects of cannabinoid agonists and antagonists on tumour necrosis factor-alpha (TNF-alpha) induced secretion of interleukin-8 from the colonic epithelial cell line, HT-29 ... The cannabinoid receptor agonists [ ( - ) -3- [ 2-hydroxy-4- ( 1,1-dimethyl-heptyl ) -phenyl ] 4- [ 3-hydroxypropyl ] cyclo-hexan-1-ol ] ( CP55,940 ) ; Delta-9-tetrahydrocannabinol ; [ R ( + ) - [ 2,3-dihydro-5-methyl-3- [ ( morpholinyl ) methyl ] pyrrolo [ 1,2,3-de ] 1,4-benzoxazin-6-yl ] ( 1-naphthyl ) methanone mesylate ] ( WIN55,212-2 ) and 1-propyl-2-methyl-3-naphthoyl-indole ( JWH 015 ) inhibited TNF-alpha induced release of interleukin-8 in a concentration dependent manner ... The less active enantiomer of WIN55212-2, [ S ( - ) - [ 2,3-dihydro-5-methyl-3- [ ( morpholinyl ) methyl ] pyrrolo [ 1,2,3-de ] 1,4-benzoxazin-6-yl ] ( 1-naphthyl ) methanone mesylate ( WIN55212-3 ), and the cannabinoid CB(1) receptor agonist arachidonoyl-2-chloroethylamide ( ACEA ) had no significant effect on TNF-alpha induced release of interleukin-8 ... We conclude that in HT-29 cells, TNF-alpha induced interleukin-8 release is inhibited by cannabinoids through activation of cannabinoid CB(2) receptors
Bhat et al., Clin Exp Allergy 2003 : We found that crude cockroach extract induced a synergistic increase in TNF-alpha induced transcription from the IL-8 promoter ... The synergistic effect was observed with as little as 0.3 micro g/mL of crude cockroach extract, while larger concentrations ( 30 micro g/mL ) approximately doubled TNF-alpha induced IL-8 promoter activity ... Addition of endotoxin at concentrations found in the cockroach extract had no effect on TNF-alpha mediated IL-8 expression ... Addition of recombinant Bla g 2, Bla g 3 and Bla g 5 had no effect on TNF-alpha induced IL-8 promoter activation
Fan et al., Biochem Biophys Res Commun 2011 : TNF-a induced the expression of IL-6, IL-8 and sICAM in ECs
Taniguchi et al., Gynecol Obstet Invest 2013 (Endometriosis...) : GnRH agonists or antagonists did not repress TNF-a induced IL-8 production in endometriotic stromal cells
Ding et al., Hum Exp Toxicol 2012 : On day 21, the uric acid ( UA ) content of group IV was increased in serum ( p < 0.05 ) ; on day 42, the serum aspartate aminotransferase (AST) activity and the level of tumor necrosis factor (TNF)-a and interleukin (IL)-8 increased in group IV ( p < 0.05 ) ; 100 mg/kg MEL alone increased the level of TNF-a and the rate of renal apoptosis ( p < 0.05 ) ; and 33.3 mg/kg CYA alone increased the level of IL-8 and the rate of renal apoptosis ( p < 0.05 )
Goebeler et al., J Invest Dermatol 1997 : Upon stimulation with interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) , both HDMECs and HMEC-1 expressed high levels of IL-8 , GRO, and monocyte chemoattractant protein-1 ( MCP-1 )
Mueller et al., Am J Pathol 2007 (Colorectal Neoplasms...) : In vitro analyses revealed a striking induction of IL-8 expression in CAFs and LFs by tumor necrosis factor-alpha (TNF-alpha) ... In conclusion, these data raise the possibility that the majority of CAFs in CLM originate from resident LFs. TNF-alpha induced up-regulation of IL-8 via nuclear factor-kappaB in CAFs is an inflammatory pathway, potentially permissive for cancer invasion that may represent a novel therapeutic target
Bergmann et al., Hypertension 2010 : RT-PCR showed a strong tumor necrosis factor alpha mRNA increase with IL-8 that was blocked by aldosterone, excluding the possibility that the tumor necrosis factor alpha increase was merely a consequence of secretion
Henrotin et al., Osteoarthritis Cartilage 1996 : IL-beta and TNF alpha highly stimulated IL-6, LIF and IL-8 productions
Thomas et al., FASEB J 1998 (Inflammation) : Induction of the stress response with PGA1 and concomitant induction of I-kappaBalpha were associated with inhibition of TNF-alpha mediated secretion of interleukin 8 and with inhibition of TNF-alpha mediated nuclear translocation and activation of NF-kappaB
Storey et al., J Invest Dermatol 2005 (Dermatitis...) : Eicosapentaenoic acid and docosahexaenoic acid reduce UVB- and TNF-alpha induced IL-8 secretion in keratinocytes and UVB induced IL-8 in fibroblasts ... In addition, TNF-alpha induced IL-8 secretion by keratinocytes was reduced by 54 % and 42 %, respectively, by EPA and DHA ( p < 0.001 ) ... Hence both n-3 PUFA inhibit production of UVB- and TNF-alpha induced IL-8 in skin cells ; this may be important in the photoprotective and other anti-inflammatory effects conferred by these agents
Yamashita et al., Int Arch Allergy Immunol 1999 : In that regard, the transcription factor, nuclear factor, Kappa B ( NF-kappaB ), is an important activator of tumor-necrosis-factor-alpha (TNF-alpha) induced IL-8 gene expression in monocytes, lymphocytes and neutrophils ... Stimulation of eosinophils with GM-CSF + TNF-alpha induced significant increases in the synthesis and secretion of IL-8 which were associated with translocation of NF-kappaB p50 into the nucleus
Page et al., Am J Respir Cell Mol Biol 2005 : German cockroach extract synergistically regulates tumor necrosis factor-alpha (TNF-alpha) induced interleukin (IL)-8 expression in human airway epithelial cells ... We conclude that proteases in German cockroach extract regulate PAR-2 and ERK to increase NF-IL6 activity and synergistically regulate TNF-alpha induced IL-8 promoter activity in human airway epithelium
Aneja et al., Crit Care Med 2004 : We determined the effects of theaflavin, a black tea derived polyphenol, on tumor necrosis factor-alpha mediated expression of the interleukin-8 gene in A549 cells ... A549 cells were exposed to varying concentrations of theaflavin and analyzed for tumor necrosis factor-alpha mediated interleukin-8 gene expression ... Theaflavin inhibited tumor necrosis factor-alpha mediated interleukin-8 gene expression, as measured by luciferase assay and Northern blot analysis, at concentrations of 10 and 30 microg/mL ... This effect appears to primarily involve inhibition of interleukin-8 transcription because theaflavin inhibited tumor necrosis factor-alpha mediated activation of the interleukin-8 promoter in cells transiently transfected with an interleukin-8 promoter-luciferase reporter plasmid
Desmet et al., Biochem Pharmacol 2005 : On the contrary, both RSG and TRO significantly potentiated TNF-alpha induced production of granulocyte/macrophage-colony stimulating factor, interleukin (IL)-6 and/or IL-8 in these cells ... On the contrary, both RSG and TRO significantly potentiated TNF-alpha induced production of granulocyte/macrophage-colony stimulating factor, interleukin (IL)-6 and/or IL-8 in these cells
Kasahara et al., Immunology 1991 (Astrocytoma) : IL-1 and TNF-alpha induction of IL-8 and monocyte chemotactic and activating factor ( MCAF ) mRNA expression in a human astrocytoma cell line ... Several human astrocytoma and glioblastoma cell lines expressed high levels of IL-8 and MCAF mRNA in vitro upon stimulation with IL-1 and TNF-alpha ... These data suggest that IL-1 and TNF-alpha induce astrocytes to produce IL-8 and MCAF transcriptionally and post-transcriptionally, both of which may be responsible for leucocytosis seen in inflammation of the CNS
Summers et al., Life Sci 2003 (Colitis, Ulcerative) : Nicotine significantly inhibited TNFalpha induced IL-8 release in a concentration related manner with peak inhibition occurring at 10 ( -7 ) M ( 2.39 +/- 0.78 ng ml(-1), n = 5 )
Ma et al., Infect Immun 2004 : Our experiments were designed to explore the mechanism of effect of L. reuteri in the human epithelial cell lines T84 and HT29 on cytokine and NGF synthesis and IL-8 response to tumor necrosis factor alpha (TNF-alpha) ... Epithelial cells were cultured for various times with live and killed L. reuteri and examined by reverse transcription-PCR for NGF, IL-10, and TNF-alpha induced IL-8 expression ... Neither cellular lysates nor media supernatants had any effect on TNF-alpha induced IL-8
Choi et al., World J Gastroenterol 2006 : DA-9601, a standardized extract of Artemisia asiatica, blocks TNF-alpha induced IL-8 and CCL20 production by inhibiting p38 kinase and NF-kappaB pathways in human gastric epithelial cells ... Treatment of AGS cells with DA-9601 reduced TNF-alpha induced IL-8 and CCL20 promoter activities, as well as their gene expression and protein release
Abe et al., Am J Respir Cell Mol Biol 2000 : Northern blot analyses showed that CAM inhibited tumor necrosis factor (TNF)-alpha induced IL-8 gene expression in a dose- and incubation time dependent manner
Findlay et al., PloS one 2013 : Three lipopeptides induced high levels of IL-8 production, above that of equivalent concentrations of cathelicidin LL-37, while no compound induced production of the pro-inflammatory cytokine TNF-a at or below 100 µM
Leonardi et al., Clin Exp Allergy 2006 (Conjunctivitis, Allergic) : IL-6, IL-8 , MCP-1, RANTES and eotaxin were detected from fibroblasts cultures, and were all up-regulated by TNF-alpha
Wang et al., Zhong Xi Yi Jie He Xue Bao 2009 (Adenocarcinoma...) : TNF-alpha ( 1 microg/L ) strongly induced the production of IL-6 and IL-8 as compared with the control serum in A549 cells, and the induced cytokine production was significantly suppressed by 15 % serum containing Feiyanning Decoction ( P < 0.01 ) ... Feiyanning Decoction can inhibit IL-6 and IL-8 production induced by TNF-alpha
Kaminska et al., Tumour Biol 2005 (Colorectal Neoplasms) : The levels of circulating interleukin (IL)-6, IL-8 , macrophage colony stimulating factor ( M-CSF ) and interleukin 1 receptor antagonist ( IL-1ra ) significantly increased with the clinical stage of CRC, and the levels of IL-6, soluble tumor necrosis factor ( sTNF ) receptor type I ( RI ), soluble interleukin 2 receptor alpha and TNFalpha with tumor grade, while IL-6, IL-8, M-CSF, IL-1ra and sTNF RI levels significantly rose with bowel wall invasion
Zouki et al., J Leukoc Biol 2001 : The NO synthase inhibitors aminoguanidine and N ( G ) -nitro-L-arginine methyl ester blocked nuclear accumulation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB in both polymorphonuclear ( PMN ) and mononuclear leukocytes and inhibited IL-8 mRNA expression and IL-8 release by approximately 90 % in response to IL-1beta and TNF-alpha
Elias et al., Am J Respir Cell Mol Biol 1990 : We determined whether normal human lung fibroblasts expressed cell associated thymocyte stimulating activity in response to recombinant interleukin-1 ( rIL-1 ) ( alpha and beta ) and recombinant tumor necrosis factor ( rTNF )
Wu et al., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2001 : and Their time courses were similar, thus suggesting that the induction of IL-8 gene expression by TNF-alpha is probably due to the activation of NF-kappa B
Bheekha-Escura et al., Blood 2000 : In purified eosinophils primed with granulocyte-macrophage colony stimulating factor, both tumor necrosis factor alpha (TNF-alpha) and HrHRF induced increased secretion of interleukin (IL) 8
Nukada et al., J Toxicol Sci 2008 : Production of IL-8 in THP-1 cells following contact allergen stimulation via mitogen activated protein kinase activation or tumor necrosis factor-alpha production ... In conclusion, IL-8 production was predominantly induced in THP-1 cells following allergen stimulation, and MAPK pathways and TNF-alpha were involved in the IL-8 production induced by DNCB and NiSO ( 4 )
Ulivi et al., Arthritis Res Ther 2011 : We report that MGDG : 1 ) represses the expression of interleukin-6 (IL-6) and interleukin-8 (IL-8) induced by interleukin-1alpha ( IL-1a ) or IL-1a + tumor necrosis factor a (TNFa) interfering with the p38 and NF-kB pathways ; 2 ) is not toxic for the cells and does not affect the cell phenotype ; 3 ) strongly enhances COX-2 expression induced by IL-1a or IL-1a + TNFa ; 4 ) represses mPGES expression induced by IL-1a and the synthesis of PGE ( 2 ) and induces the synthesis of 15-deoxy-d 12,14-prostaglandin J ( 2 ) ( 15dPGJ ( 2 ) )
Ohama et al., Fertil Steril 2008 (Endometriosis) : Peroxisome proliferator activated receptor-gamma ligand reduced tumor necrosis factor-alpha induced interleukin-8 production and growth in endometriotic stromal cells ... To evaluate the influence of peroxisome proliferator activated receptor-gamma ( PPAR gamma ) ligand ( pioglitazone ) on tumor necrosis factor-alpha (TNF-alpha) induced interleukin-8 (IL-8) expression in endometriotic stromal cells ( ESCs ) and on proliferation of ESCs ... Measurement of IL-8 protein by ELISA showed that adding TNF-alpha ( 100 pg/mL ) significantly increased IL-8 protein ... Treating ESCs with 0.1-10 microM of pioglitazone significantly reduced the TNF-alpha induced IL-8 production
Hedges et al., Int J Antimicrob Agents 1994 : Uroepithelial cells also respond to stimulation by cytokines ; IL-1alpha and TNFalpha induce the secretion of IL-6 and IL-8 and the upregulation of mRNAs for IL-1alpha, IL-1beta, IL-6 and IL-8
Ferreira , Drugs 1993 (Hyperalgesia...) : The release of tumour necrosis factor-alpha (TNF-alpha) initiates the release of interleukin-1 and interleukin-8, which in turn liberate cyclo-oxygenase metabolites and sympathomimetic amines, respectively
Ng et al., J Biol Chem 1994 : Although tumor necrosis factor (TNF) and interleukin-1 ( IL ) induce the expression of the IL-8 , TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested
Lakshminarayanan et al., J Biol Chem 1998 : H2O2 and tumor necrosis factor-alpha induce differential binding of the redox-responsive transcription factors AP-1 and NF-kappaB to the interleukin-8 promoter in endothelial and epithelial cells ... We previously demonstrated that tumor necrosis factor-alpha (TNFalpha) and H2O2 differentially regulate interleukin-8 (IL-8) and intercellular adhesion molecule ( ICAM-1 ) gene expression in endothelial and epithelial cells ... Unlike H2O2, the proinflammatory cytokine TNFalpha induced IL-8 and ICAM-1 in both cell types ... These data indicate that the cell type-specific induction of IL-8 gene expression by H2O2 and TNFalpha in HMEC-1 and A549 cells can be explained by the differential binding of AP-1 and NF-kappaB to the IL-8 promoter
Bekeredjian-Ding et al., Immunology 2009 (Head and Neck Neoplasms) : Here we demonstrate that tumour derived prostaglandin E2 ( PGE ( 2 ) ) and transforming growth factor-beta ( TGF-beta ) increase interleukin-8 (IL-8) but synergistically inhibit interferon-alpha ( IFN-alpha ) and tumour necrosis factor (TNF) production of Toll-like receptor 7 (TLR7)- and Toll-like receptor 9 (TLR9) stimulated PDC
Kawano et al., Clin Exp Obstet Gynecol 2012 (MAP Kinase Signaling System) : Regulation of interleukin-1alpha and tumor necrosis factor-alpha induced interleukin-8 production by amnion derived ( WISH ) cells ... The production of IL-8 was significantly increased by IL-1alpha or TNF-alpha , and the increase of IL-8 stimulated by IL-1alpha was suppressed by IL-1 ra in a dose dependent manner ... The results of this study demonstrate that the production of IL-8 induced by IL-1alpha and TNF-alpha is enhanced by C2-ceramide, and suppressed by MEK inhibitor or P38 MAP kinase inhibitor
Mahanonda et al., J Immunol 2007 : TNF-alpha enhanced TLR ligand induced IL-8 production in HGFs, whereas IFN-gamma enhanced TLR ligand induced IDO expression
Hashimoto et al., Life Sci 2000 : Grepafloxacin inhibits tumor necrosis factor-alpha induced interleukin-8 expression in human airway epithelial cells
Harigai et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid...) : CD14+ RA synovial cells stimulated with rsCD154 plus interferon-gamma (IFNgamma) induced significantly higher production of IL-6, IL-8 , and monocyte chemoattractant protein 1 by FLS compared with unstimulated CD14+ synovial cells, through TNFalpha- , IL-1alpha-, and IL-1beta mediated pathways
Nyhlén et al., Cytokine 2000 : IFN-gamma as well as the GCs, Dexamethasone and Budesonide, inhibited TNF-alpha induced IL-8 secretion in a dose dependent manner ... IFNs may have a general modulating effect, since IFN-alpha also inhibited the TNF-alpha induced IL-8 secretion
DeForge et al., J Immunol 1992 : The early, local production of TNF and IL-1 may therefore contribute to the subsequent expression of IL-8
Pang et al., Am J Respir Cell Mol Biol 2000 (Asthma) : Synergistic inhibition by beta ( 2 ) -agonists and corticosteroids on tumor necrosis factor-alpha induced interleukin-8 release from cultured human airway smooth-muscle cells ... Here, we tested the effects of the beta ( 2 ) -agonists salbutamol ( Salbu ) and salmeterol ( Salme ) on IL-8 release and tumor necrosis factor (TNF)-alpha induced IL-8 release from ASM cells ... We found that TNF-alpha strongly enhanced IL-8 release in a time- and concentration dependent manner, whereas Salbu, Salme, the direct adenylyl cyclase activator forskolin ( FSK ), and the cyclic monophosphate ( cAMP ) analogue 8-bromoadenosine 3',5'-cAMP ( 8-Br-cAMP ) alone weakly stimulated IL-8 release
Létuvé et al., Am J Pathol 2010 (Asthma...) : Tumor necrosis factor-alpha stimulated ChTRase release only from alveolar macrophages from smokers with COPD, and exposure of these cells to ChTRase promoted the release of IL-8 , monocyte-chemoattractant protein-1, and metalloproteinase-9
Gronert et al., J Exp Med 1998 : When lipoxins and LXA4 stable analogs were evaluated for enterocyte functional as well as immune responses, lipoxins sharply inhibited TNF-alpha induced IL-8 release but did not alter either barrier function or agonist stimulated chloride secretion
Bowie et al., J Immunol 2000 : The induction of a NF-kappaB dependent gene, IL-8 , by TNF was also inhibited
Page et al., J Allergy Clin Immunol 2003 : We have shown that serine proteases in German cockroach extract increase TNF-alpha induced expression of IL-8 in human bronchial epithelial cells ... Cockroach proteases and PAR-2 activation synergistically increase TNF-alpha induced IL-8 transcription via activation of ERK
Elner et al., Invest Ophthalmol Vis Sci 1997 : IFN-gamma induced dose dependent increases in HRPE MCP-1, but not IL-8, IFN-gamma potentiated IL-1 beta and TNF-alpha induced MCP-1 production, but showed little modulation of IL-1 beta and TNF-alpha induced IL-8 production
Ribel-Madsen et al., Arthritis 2012 : TNF-a stimulation caused similar IL-1ß, IL-6, and IL-8 release in all groups
Bian et al., Curr Eye Res 1999 : IL-4 potentiates IL-1beta- and TNF-alpha stimulated IL-8 and MCP-1 protein production in human retinal pigment epithelial cells ... It has been shown in this and other laboratories that interleukin-1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) are potent inducers of HRPE IL-8 and MCP-1 secretion ... IL-1beta and TNF-alpha induced dose dependent increases in HRPE IL-8 and MCP-1 secretion with maximal stimulation observed at 2-5 ng/ml. IL-4 alone ( 100 ng/ml ) resulted in a slight increase of MCP-1 and IL-8 secretion ... HRPE IL-8 and MCP-1 gene expression and protein production are stimulated by IL-1beta or TNF-alpha through pathways differentially modulated by IL-4 and GM-CSF
Kwong et al., J Clin Immunol 1998 (Hyaline Membrane Disease) : Differential regulation of IL-8 by IL-1beta and TNFalpha in hyaline membrane disease ... Bronchoalveolar lavage cell cytokine relationships were evaluated and the differential regulation of IL-8 by IL-1beta and TNFalpha was studied in a short-term culture system
Sheron et al., Clin Exp Immunol 1992 (Chronic Disease...) : The cytokine IL-8 -- predominantly an activator and chemotactic factor for circulating polymorphonuclear neutrophil leucocytes -- is produced in response to TNF-alpha in vitro, and high circulating levels of IL-8 are found in septic primates
Gross et al., Gastroenterology 1995 : TNF-alpha and IL-1 beta dose-dependently induced IL-8 production in HT-29 cells ... However, induction of IL-8 by IL-1 beta or TNF-alpha was reduced by the PTK inhibitors herbimycin ( by 79 % or 89 %, respectively ) and genistein ( by > 95 % ) ... The synthesis of IL-8 is stimulated in HT-29 cells by IL-1 beta or TNF-alpha
King et al., J Biol Chem 2009 : Repression of TNFalpha induced p38 MAPK phosphorylation, NF-kappaB dependent transcription, and IL-8 expression by dexamethasone are sensitive to transcriptional or translational inhibitors ... Thus, MKP-1 attenuates TNFalpha dependent activation of p38 MAPK, induction of IL-8 expression, and NF-kappaB dependent transcription
Yoshida et al., J Immunol 1999 (Arthritis, Rheumatoid...) : Involvement of thioredoxin in rheumatoid arthritis : its costimulatory roles in the TNF-alpha induced production of IL-6 and IL-8 from cultured synovial fibroblasts ... We thus examined the effect of TRX on the TNF-alpha induced IL-6 and IL-8 production using rheumatoid synovial fibroblast cultures
Black et al., Am J Respir Cell Mol Biol 1998 (Cystic Fibrosis) : Again, TNF-alpha stimulated IL-8 production did not differ significantly between cell lines with and without functioning CFTR
Lang et al., Clin Nutr 2004 : The spontaneous and TNF-alpha stimulated secretion of IL-1beta, IL-8 , IP-10 and MIG from HT-29 and Caco-2 cells was tested with, or without pretreatment with allicin
Gunaydın et al., J Pediatr Surg 2012 (Acute Lung Injury...) : Aspiration of gastrointestinal decontamination agents produced histopathologic changes, elevated levels of malondialdehyde and surfactant protein D, reduced levels of antioxidant enzymes, and increased expression of inflammatory cytokines interleukin-1ß and tumor necrosis factor a. Curcumin treatments effectively attenuated the rats ' pulmonary inflammation responses ( as shown by reduced alveolar damage ), decreased serum malondialdehyde and surfactant protein D levels, and inhibited the expressions of tumor necrosis factor a and interleukin-1ß
Fiedler et al., Am J Respir Cell Mol Biol 1998 : Inhibition of TNF-alpha induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132 ... The working hypothesis of the studies described herein was that inhibition of proteasome mediated IkappaB degradation would inhibit TNF-alpha induced nuclear factor-kappaB (NF-kappaB) activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells ... The working hypothesis of the studies described herein was that inhibition of proteasome mediated IkappaB degradation would inhibit TNF-alpha induced nuclear factor-kappaB (NF-kappaB) activation, interleukin-8 (IL-8) gene transcription, and IL-8 protein release in A549 cells ... Mutational analysis of the 5 ' flanking region of the IL-8 gene confirmed that an intact NF-kappaB site is necessary for TNF-alpha induced IL-8 gene transcription ... These studies show that inhibition of proteasome mediated IkappaB degradation results in inhibition of TNF-alpha induced IL-8 production in A549 cells by limiting NF-kappaB mediated gene transcription
van Maanen et al., Arthritis Rheum 2009 (Arthritis, Rheumatoid) : Specific alpha7nAChR agonists reduced tumor necrosis factor alpha induced IL-6 and IL-8 production by FLS
Tsuji et al., Am J Pathol 1995 (Granuloma...) : Thus, interleukin-1 alpha and inducible nitric oxide synthase were induced mostly in the cells accumulated around the beads and also in some bronchiolar epithelial cells during the early phase ( 1 to 3 days ), whereas tumor necrosis factor-alpha was induced in the cells around the beads at the later resolution phase ( 3 to 7 days )
Pechkovsky et al., Eur Cytokine Netw 2000 : TNF-alpha increased both IL-8 mRNA expression and protein production, whereas IL-1 beta slightly increased IL-8 release but did not change mRNA expression in AEC-II
Lee et al., Int Immunopharmacol 2007 (Colitis) : Simvastatin ( 50 micro M ) significantly inhibited TNF-alpha induced IL-8 gene expression in COLO 205 cells
Thuong et al., Arch Pharm Res 2005 : Inhibitory effect on TNF-alpha induced IL-8 production in the HT29 cell of constituents from the leaf and stem of Weigela subsessilis
Patel et al., Immunology 1998 (Respiratory Syncytial Virus Infections) : IL-1beta and TNF-alpha induced the synthesis of IL-8 at 24 hr, but partially inhibited the synthesis at 48 hr
Andoh et al., J Gastroenterol 2004 (Colitis, Ulcerative) : IL-1beta- and TNF-alpha induced IL-8 and IL-6 secretion was significantly decreased after the first and second LCAP treatments
Nakamura et al., J Biol Chem 1991 : As in other epithelium, TNF markedly increased the level of the 1.8-kilobase IL-8 mRNA transcripts in both bronchial epithelial cell lines ... The half-life of IL-8 mRNA transcripts in these cells was approximately 40 min and did not change after TNF stimulation, suggesting that TNF up-regulated IL-8 gene expression mainly at the transcriptional level
Yoon et al., Acta Otolaryngol 1999 : Effects of TNF-alpha and IL-1 beta on mucin, lysozyme, IL-6 and IL-8 in passage-2 normal human nasal epithelial cells
Kim et al., Exp Mol Med 2009 : Repression of TNF-alpha induced IL-8 expression by the glucocorticoid receptor-beta involves inhibition of histone H4 acetylation ... We investigated the functional role of GRbeta expression in the suppressive effect of glucocorticoids on tumor necrosis factor (TNF)-alpha induced IL-8 release in an airway epithelial cell line ... The suppressive effect of dexamethasone on TNF-alpha induced IL-8 transcription was not affected by GRbeta overexpression, rather GRbeta had its own weak suppressive activity on TNF-alpha induced IL-8 expression
Perez et al., Am J Physiol Lung Cell Mol Physiol 2008 (Cystic Fibrosis...) : In vitro, PPARgamma agonists reduced IL-8 and MMP-9 release from airway epithelial cells in response to PAO1 or TNFalpha/IL-1beta stimulation
Chan et al., Int J Oncol 1997 : Involvement of interleukin-1 in the differentiation inducing activity of tumor necrosis factor-alpha on a murine myeloid leukemia ( WEHI-3B JCS )
Dorn et al., J Invest Dermatol 2007 (Dermatitis, Contact...) : Interestingly, both CpG-1-PTO and Non-CpG-5-PTO suppressed basal and tumor necrosis factor alpha induced IL-8 levels measured in cell culture supernatants
Iwabe et al., J Clin Endocrinol Metab 2000 (Endometriosis) : TNFalpha induced the gene and protein expression of IL-8 in endometriotic stromal cells in a dose dependent fashion
Hobert et al., J Biol Chem 2002 : In Madin-Darby canine kidney monolayers expressing dominant negative Rac1 or Cdc42, both Salmonella- and tumor necrosis factor alpha induced activation of NFkappaB and mitogen activated protein kinase signaling cascades proceeded normally, but IL-8 secretion was inhibited
Li et al., Microvasc Res 2001 : Histamine induced production of interleukin-6 and interleukin-8 by human coronary artery endothelial cells is enhanced by endotoxin and tumor necrosis factor-alpha
Wang et al., Invest Ophthalmol Vis Sci 2012 : TNF-a significantly increased the expression of IL-6, IL-8 , and MCP-1 in ARPE-19 cells at both the protein and mRNA levels
Wang et al., Vet Res 2003 : The TNF-alpha in plasma may partially induce transcription of IL-6 and IL-8 , which contribute to the CD14 independent increase in level of mRNA for IL-6 and IL 8
Andoh et al., J Immunol 2002 : IL-17 enhances the TNF-alpha induced IL-6 and IL-8 secretion in human colonic subepithelial myofibroblasts
Fredriksson et al., Inflammation 2003 : IL-8 release from fibroblasts was significantly increased when cultured with RBC or RBC-CM and both tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) further stimulated this IL-8 secretion
Snyder et al., Am J Physiol Heart Circ Physiol 2008 (Inflammation) : Overexpression of SP-D by adenoviral mediated gene transfer in HCASMCs inhibited both LPS- and TNF-alpha induced IL-8 release
Martner et al., Infect Immun 2009 : If pneumococcal LytA was inactivated by mutation or by culture in a medium containing excess choline, the pneumococci induced production of significantly more TNF , IFN-gamma, and IL-12 in PBMC, whereas the production of IL-6, IL-8 , and IL-10 was unaffected ... Further, adding autolyzed pneumococci to intact bacteria inhibited production of TNF , IFN-gamma, and IL-12 in a dose dependent manner but did not inhibit production of IL-6, IL-8 , and IL-10 in response to the intact bacteria
Rolfe et al., Am J Respir Cell Mol Biol 1991 : PF-derived IL-8 expression was dependent upon stimulation by either tumor necrosis factor (TNF) or IL-1 but not lipopolysaccharide (LPS)
Mormina et al., Eur J Pharmacol 2006 : Release of IL-8 induced by tumor necrosis factor-alpha (TNF-alpha) was determined by enzyme linked immunosorbent assay ( ELISA )
Boonkaewwan et al., J Agric Food Chem 2008 : Stevioside ( 2 mM ) potentiated TNF-alpha mediated IL-8 release in T84 cells ... However, steviol ( 0.01-0.2 mM ) significantly suppressed TNF-alpha induced IL-8 release in all three cell lines ... Two biological effects of steviol in the colon are demonstrated for the first time : stimulation of Cl ( - ) secretion and attenuation of TNF-alpha stimulated IL-8 production
Bryson et al., Arch Biochem Biophys 1998 : It potently inhibited interleukin 1- and tumor necrosis factor stimulated proteoglycan release from both nasal and articular cartilage
Jamaluddin et al., Cell Signal 2007 : Consistently, a site mutation of Rel A ( Ser ( 276 ) to Ala ) in RelA-deficient embryonic fibroblasts failed to activate IL-8 Luciferase activity in response to TNF-alpha ... These results indicate that the ROS mediated TNF-alpha induced IL-8 transcription is regulated by NF-kappaB/RelA phosphorylation at the critical Ser ( 276 ) residue by PKAc, resulting in stable enhanceosome formation on target genes
Baba et al., Crit Care Med 2000 (Adenocarcinoma, Bronchiolo-Alveolar...) : Perfluorocarbon blocks tumor necrosis factor-alpha induced interleukin-8 release from alveolar epithelial cells in vitro ... To determine whether tumor necrosis factor (TNF)-alpha induced interleukin (IL)-8 production by pulmonary alveolar epithelial cells is blocked by perfluorocarbon (PFC) ... To determine TNF-alpha induced IL-8 production, IL-8 was measured by using a human IL-8 kit in both control and experimental groups ... TNF-alpha stimulation induced a large increase in IL-8 ... When added to the lower chamber, TNF-alpha also induced IL-8 production unaffected by the addition of PFC to the upper chamber ... The decrease in TNF-alpha induced IL-8 production depended on the time of PFC administration after the initiation of TNF-alpha stimulation
Chokki et al., Life Sci 2006 : Metalloprotease dependent amphiregulin release mediates tumor necrosis factor-alpha induced IL-8 secretion in the human airway epithelial cell line NCI-H292 ... Since recent studies demonstrated that the stimulation of epidermal growth factor receptor (EGFR) could induce IL-8 secretion, the involvement of EGFR in TNF-alpha induced IL-8 secretion in airway epithelium-like NCI-H292 cells was investigated in this study ... TNF-alpha and epidermal growth factor (EGF) stimulated IL-8 secretion in a time- and concentration dependent manner ... Inhibition of the EGFR by either an anti-EGFR neutralizing antibody or by its specific inhibitor AG1478 ( 1 microM ) blocked TNF-alpha induced IL-8 secretion ... Further, TNF-alpha induced IL-8 secretion was completely inhibited by the neutralizing antibody against amphiregulin (AR), an EGFR ligand, suggesting that TNF-alpha induced IL-8 secretion was mediated by the AR-EGFR pathway ... Finally, both AR and IL-8 release induced by TNF-alpha were eliminated by pretreatment with either GM6001, a broad-spectrum inhibitor for metalloprotease, or TAPI-1, relatively selective inhibitor for TNF-alpha converting enzyme (TACE) ... These findings indicate that metalloprotease mediated AR shedding and subsequent activation of EGFR play a critical role in TNF-alpha induced IL-8 secretion from the human airway epithelium-like NCI-H292 cells, and that TACE is one of the most possible candidates for metalloprotease responsible for TNF-alpha induced AR shedding
Raingeaud et al., FEBS Lett 2005 : Interleukin-4 downregulates TNFalpha induced IL-8 production in keratinocytes ... IL-4 regulation of TNFalpha induced IL-8 expression is cell-type specific ... In this study, we show that in the keratinocyte cell line HaCaT, IL-4 decreases TNFalpha induced IL-8 mRNA expression ... We then investigated the mechanism of IL-4 effect and showed that IL-4 downregulates TNFalpha induced IL-8 promoter activity in luciferase reporter assays ... Overall our results suggest that IL-4 regulates TNFalpha induced IL-8 expression at a transcriptional level and this mechanism involves STAT6 and NF-kappaB transcription factors
Storey et al., Carcinogenesis 2007 : Additionally, t10, c12-CLA and tt-CLA inhibited TNF-alpha induced IL-8 from 11 669 +/- 1692 pg/ng protein in control cells to 5540 +/- 191 ( P < 0.001 ) and 8082 +/- 1298 pg/ng ( P < 0.01 ) protein, respectively
Weber et al., J Biol Chem 2003 : Pretreatment of monocytic cells for 72 h with low TNF doses inhibited TNF induced ( restimulation with a high dose ) IL-8 promoter dependent transcription as well as IL-8 production ... Finally, overexpression of C/EBPbeta, but not p65 or Oct-1, markedly prevented TNF induced IL-8 promoter dependent transcription
Maeda et al., J Invest Dermatol 2003 : Among T helper 1 cytokines, interleukin-4 mediated suppression of tumor necrosis factor-alpha was not affected by terfenadine, which, however, markedly restored mRNA expression of interferon-gamma or interleukin-2
Facchini et al., J Cell Physiol 2005 : TNFalpha also increased the level and extracellular release of interleukin-8 (IL-8) , a CXC chemokine that can have a role in arthritis, in an NF-kappaB dependent manner
Osawa et al., Infect Immun 2002 : Tumor necrosis factor alpha induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes
Breton et al., J Pharmacol Exp Ther 1997 : Investigation into the mechanism of action of hymenialdisine showed that it was not due to inhibition of protein kinase C because the selective protein kinase C inhibitor RO 32-0432 was inactive against tumor necrosis factor-alpha stimulated luciferase and IL-8 production
Saitoh et al., J Gastroenterol 1997 : CsA ( 1, 5, and 10ng/ml ) significantly reduced IL-1 beta induced IL-8 production ( by 32 %, 41 %, and 48 %, respectively ), and reduced TNF alpha induced IL-8 production ( by 21 %, 42 %, and 50 %, respectively ) ... FK506 or DEX had no effect on IL-1 beta- or TNF alpha induced IL-8 production
Ishikawa et al., Antimicrob Agents Chemother 2009 (Inflammation) : The tumor necrosis factor alpha (TNF-alpha) induced production of IL-8 was synergistically augmented by SLIGKIV-NH ( 2 ), and that synergistic increase in the production of IL-8 was suppressed by 100 nM PAR2-specific small interfering RNA
Nanua et al., Am J Respir Cell Mol Biol 2006 : Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha induced IL-8 and monocyte chemoattractant protein (MCP)-1 ( also called CCL2 ) expression in cultured human airway epithelial cells ... Quercetin also inhibited TNF-alpha induced PI 3-kinase activity, Akt phosphorylation, intracellular H ( 2 ) O ( 2 ) production, NF-kappaB transactivation, IL-8 promoter activity, and steady-state mRNA levels, consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt dependent pathway
Keslacy et al., Mol Pharmacol 2007 (Inflammation) : In contrast to these studies, we found that IFNgamma ( 1000 U/ml ) markedly inhibited TNFalpha induced expression of interleukin (IL)-6, IL-8 , and eotaxin by 66.29+/-3.33, 43.86+/-7.11, and 63.25+/-6.46 %, respectively ... These genes were also found to be NF-kappaB dependent in that TNFalpha induced expression of IL-6, IL-8 , and eotaxin was dose-dependently inhibited by the selective IKKbeta inhibitor 4- ( 2'-aminoethyl ) amino-1,8-dimethylimidazo [ 1,2-a ] quinoxaline ( BMS-345541 ) ( 1-30 microM )
Thapa et al., J Pharmacol Exp Ther 2008 (Colitis) : In a cellular model of colitis using tumor necrosis factor (TNF)-alpha stimulated HT29 colon epithelial cells, treatment with CLT significantly suppressed TNF-alpha mediated IL-8 induction and NF-kappaB transcriptional activity revealed by a luciferase reporter gene assay
Griesinger et al., J Soc Gynecol Investig 2001 (Bacterial Infections...) : The pathogenic microorganisms induced a dose- and time dependent release of IL-1beta, IL-6, IL-8 , and IL-10, whereas TNF-alpha secretion was not elevated
Becher et al., J Clin Invest 1996 : Soluble tumor necrosis factor receptor inhibits interleukin 12 production by stimulated human adult microglial cells in vitro
Gutteberg et al., APMIS 1991 (Sepsis) : Using a whole blood in vitro model, we have investigated the effect of Escherichia coli ( E. coli ), Streptococcus agalactiae ( group B streptococci, GBS ) and tumor necrosis factor alpha (TNF) on the generation of lactoferrin (LF), interleukin-1 beta (IL-1) and tissue thromboplastin (TPL) in healthy newborns at term and their mothers
Boost et al., Int J Mol Med 2009 : We demonstrated inhibition of TNF-alpha induced gene expression and release of IL-8 and HO-1 in human monocytic THP-1 cells exposed to both volatile anesthetics
Kim et al., Atherosclerosis 2010 (Inflammation) : We found that 5'-NIO inhibited TNF-alpha induced MCP-1 and IL-8 expression at the RNA and protein levels in HUVECs
Stríz et al., Inflammation 1999 : IL-13 did not affect the release of IL-8 induced by TNF ( 111 +/- 9 pM )
Yang et al., Am J Gastroenterol 2002 (Colitis, Ulcerative) : Further, the secretion of interleukin 8 , GROalpha, epithelial cell derived neutrophil activator 78, and monocyte chemotactic protein 1 was higher in UC patients than in normal controls, induced significantly by TNFalpha , and down-regulated by dexamethasone
Langeggen et al., Inflammation 2001 : Whereas IL-1alpha and TNFalpha significantly increased the levels of IL-8 , C5a decreased the IL-8 production after 48 h
Okuno et al., Scand J Gastroenterol 2002 : IL-1beta and TNF-alpha both induced a dose- and time dependent increase in IL-8 , MCP-1 and MMP-1 secretion, and weakly stimulated MMP-2 secretion
Mulayim et al., Am J Obstet Gynecol 2003 : Interleukin-1alpha and TNF-alpha treatments induced a concentration dependent increase in interleukin-8 messenger RNA expression in both epithelial and stromal cells
Morita et al., Eur Cytokine Netw 1993 (Astrocytoma...) : The glioma cell lines tested exhibited high levels of IL-8 and MCAF mRNA expression upon stimulation with IL-1 or TNF-alpha , while none of the neuroblastoma cell lines expressed these cytokine mRNA
Kustermans et al., Biochem Pharmacol 2008 : In the present study, we demonstrated that reorganization of actin cytoskeleton induced by Cytochalasin D ( CytD ), an actin-polymerization inhibitor, enhanced il-8 gene expression induced by TNFalpha and LPS in HL-60 monocyte-like cells
Chaudhary et al., Calcif Tissue Int 1994 (Bone Neoplasms...) : Dexamethasone regulates IL-1 beta and TNF-alpha induced interleukin-8 production in human bone marrow stromal and osteoblast-like cells
Lee et al., Cytokine 2006 (Tooth Migration) : In this study, we investigated the role of mitogen activated protein ( MAP ) kinases in dexamethasone- and TNF-alpha induced IL-8 and ICAM-1 expression in hPDL cells ... TNF-alpha increased IL-8 mRNA expression and protein secretion in a dose- and time dependent manner ... Dexamethasone suppressed TNF-alpha induced IL-8 production in a dose dependent manner ... Selective inhibitors for ERKs and p38 attenuated TNF-alpha induced IL-8 and ICAM-1 expression in the presence and absence of dexamethasone, indicating that MAP kinases play a role in the response of hDPL cells to TNF-alpha
Takano et al., Br J Ophthalmol 1999 : Simultaneous addition of IL-4 inhibited TNF-alpha induced IL-8 production in both corneal epithelial cells and keratocytes
von Scheele et al., Inhal Toxicol 2010 : Endotoxin, TNF , and dust stimulated the release of IL-6 and IL-8 in a time dependent manner
Beales et al., Cytokine 1997 : Stimulation of IL-8 production in human gastric epithelial cells by Helicobacter pylori, IL-1beta and TNF-alpha requires tyrosine kinase activity, but not protein kinase C
Watanabe et al., Br J Anaesth 2013 (Anoxia...) : /st > Sevoflurane suppressed TNF-a induced IL-6, IL-8 , and MCP-1 gene expression and the production of IL-6 and IL-8 in SAEC under anoxia/reoxygenation conditions
Gormand et al., Pulm Pharmacol 1995 (Asthma) : Spontaneous and TNFalpha induced GM-CSF or IL-8 released levels increased significantly with time ... TNFalpha potentiated GM-CSF and IL-8 release in control subjects and only the IL-8 production in asthmatics ... Nedocromil sodium, at the concentration of 10 ( -6 ) M, reduced the TNF induced increase in GM-CSF but not the IL-8 release
Roger et al., Am J Physiol Lung Cell Mol Physiol 2004 (Adenocarcinoma...) : Exaggerated IL-8 and IL-6 responses to TNF-alpha by parainfluenza virus type 4-infected NCI-H292 cells
Tsukamoto et al., Inflamm Bowel Dis 2013 : : Enzyme linked immunosorbent assay and AP assay showed interleukin-1ß induced TNF-a shedding in HCT116 and HT29 cells and TPA induced TNF-a release in U937 cells
Zhao et al., Biochem Biophys Res Commun 2005 : TNF-alpha induces interleukin-8 and endothelin-1 expression in human endothelial cells with different redox pathways ... We investigated the effect of TNF-alpha on interleukin-8 (IL-8) and endothelin-1 (ET-1) expression, and their different signal transduction pathways ... By Northern blot analysis, TNF-alpha at 50, 100, 200, and 400 U/ml significantly induced IL-8 mRNA expression by 206 %, 252 %, 211 %, and 158 %, respectively, as compared to controls ( p < 0.05 ) ... Overexpression of human superoxide dismutase ( SOD ) by adenovirus mediated gene transfer or addition of exogenous hydrogen peroxide ( H ( 2 ) O ( 2 ) ) significantly enhanced TNF-alpha induced IL-8 mRNA expression ... Thus, TNF-alpha significantly induces both IL-8 and ET-1 gene expression in HMECs possibly through different redox signaling pathways ... H ( 2 ) O ( 2 ) enhances TNF-alpha induced IL-8 expression, but inhibits TNF-alpha induced ET-1 expression
Li et al., Eur J Pharmacol 1998 (Multiple Sclerosis) : Production of tumor necrosis factor-alpha and the lysosomal cysteine proteinase cathepsin B were markedly inhibited, but production of interleukin-1 increased
Lakshminarayanan et al., J Biol Chem 1997 : Differential regulation of interleukin-8 and intercellular adhesion molecule-1 by H2O2 and tumor necrosis factor-alpha in endothelial and epithelial cells ... Northern blot analysis revealed that TNFalpha induced both ICAM-1 and IL-8 expression in either the A549 lung epithelial cell line or the human microvessel endothelial cell line ( HMEC-1 ) ... TNFalpha induced greater IL-8 gene expression as compared with H2O2, but the kinetics of induction were similar
Hirota et al., Rheumatol Int 1992 : Production of interleukin 8 by cultured synovial cells in response to interleukin 1 and tumor necrosis factor ... Both interleukin 1 alpha (IL-1 alpha) and tumor necrosis factor alpha (TNF alpha) stimulated the production of interleukin 8 (IL-8) by synovial cells in time and dose dependent manners
Kawasaki et al., Anesth Analg 1999 : Therefore, in this study, we investigated the efficacy of ketamine on LPS induced TNF-alpha, IL-6, and IL-8 production and recombinant human ( rh ) TNF-a induced IL-6 and IL-8 production in human whole blood ... IMPLICATIONS : We found that ketamine suppressed lipopolysaccharide induced tumor necrosis factor alpha, interleukin (IL)-6, and IL-8 production and recombinant human tumor necrosis factor induced IL-6 and IL-8 production in human whole blood
Sharma et al., Am J Physiol Gastrointest Liver Physiol 2006 : The anti-inflammatory effect extends to both bacterial and host derived proinflammatory stimuli, since prior infection with EPEC suppressed the IL-8 response to tumor necrosis factor-alpha , IL-1beta, and enterohemorrhagic E. coli flagellin
Park et al., Chem Biol Interact 2012 (Colitis...) : Among the derivatives, 1,3-diphenylpropenone ( DPhP ) was most efficacious, and it significantly suppressed TNF-a induced production of IL-8 which is a proinflammatory and proangiogenic cytokine
Kwon et al., Am J Physiol 1994 : Tumor necrosis factor induced interleukin-8 expression in cultured human airway epithelial cells ... The effects of tumor necrosis factor-alpha (TNF-alpha) on interleukin-8 (IL-8) expression and generation were examined in primary cultured human airway epithelial cells ( HAEC ) and a human lung epithelial cell line ( A549 ) ... There was no change in the stability of IL-8 mRNA, and a nuclear run-on assay confirmed that TNF-alpha increased IL-8 gene transcription ... TNF-alpha induced IL-8 mRNA expression showed a biphasic response in HAEC, with an early increase at 2 h followed by a sustained increase from 8 h, which was abolished by the addition of cycloheximide, suggesting that the synthesis of another protein was involved
Song et al., Mol Immunol 2009 (Inflammation) : Ablation of IRAK-4 expression in human umbilical vein endothelial cells ( HUVEC ) with siRNA suppressed IL-1beta induced IL-6 and IL-8 production whereas IRAK-1 siRNA suppressed TNFalpha induced but not IL-1beta induced cytokine production
Venza et al., J Periodontol 2010 (Chronic Periodontitis...) : These findings showed that : 1 ) in subjects without diabetes and patients with well controlled diabetes, TNF-alpha , CCR5, and CXCR3 may constitute distinctive biomarkers of P-IM; 2 ) poor glycemic control abolished the differences between CP and P-IM regarding the expression of these mediators ; and 3 ) type 2 diabetes affected the expression of TNF-alpha, IL-6 and -8 , CCR5, and CXCR3
Li et al., Am J Physiol Lung Cell Mol Physiol 2002 (MAP Kinase Signaling System) : Using a combination of chemical and dominant negative inhibitors, we found that inhibition of NF-kappaB, ERK, and JNK, but not p38, each decreased TNF-alpha induced transcription from the IL-8 promoter
Hou et al., Wei Sheng Yan Jiu 2012 : To investigate the effects of citreoviridin (CIT) on the expression of MCP-1, IL-1beta, IL-6 and IL-8 induced by TNF-alpha in human umbilical vein endothelial cells ( HUVECs )
Stebulis et al., J Rheumatol 2005 (Arthritis...) : Tumor necrosis factor-alpha (TNF-alpha) induced interleukin 6 (IL-6), IL-8 , and cyclooxygenase 2 (COX-2) mRNA levels were assessed
Jobin et al., J Immunol 1998 : Induction of inducible nitric-oxide synthase (iNOS), IL-1beta, and IL-8 genes by IL-1beta, TNF-alpha , or PMA was blocked in Ad5 IkappaB infected cells but not in Ad5 LacZ controls as assayed by RT-PCR and ELISA
Oliveira et al., Mol Cell Biol 1994 : Earlier we demonstrated that beta interferon ( IFN-beta ) can inhibit tumor necrosis factor (TNF) induced IL-8 gene expression at the transcriptional level, apparently by a novel mechanism
Roebuck , Int J Mol Med 1999 : In contrast, the pro-inflammatory cytokine TNFalpha , whose activity is dependent on the generation of intracellular ROS, induces IL-8 and ICAM-1 in both cell types ... The differential induction of IL-8 and ICAM-1 by H2O2 and TNFalpha suggest that the two inflammatory stimuli target distinct redox responsive signaling pathways to activate cell type-specific gene expression
Takeda et al., Int Immunopharmacol 2011 (Orthomyxoviridae Infections) : On day 2, tumor necrosis factor (TNF)-a production in BALF was also reduced significantly, but interferon-a, interleukin-12 , and interferon-? productions were augmented and natural killer ( NK ) cell activity was significantly elevated
Luecke et al., Genes Dev 2005 : To investigate the determinants of promoter-specific gene regulation by the glucocorticoid receptor ( GR ), we compared the composition and function of regulatory complexes at two NFkappaB-responsive genes that are differentially regulated by GR. Transcription of the IL-8 and IkappaBalpha genes is stimulated by TNFalpha in A549 cells, but GR selectively represses IL-8 mRNA synthesis by inhibiting Ser2 phosphorylation of the RNA polymerase II (pol II) C-terminal domain (CTD)
Murugesan et al., J Mol Cell Cardiol 2003 : LPC did not augment TNFalpha induction of MCP-1 or IL-8
Miyamoto et al., Inflamm Res 1997 (Inflammation) : IL-8 is involved in homologous TNF alpha- , but not in IL-1 beta induced neutrophil infiltration in rabbits ... We examined the involvement of IL-8 in TNF alpha and IL-1 beta neutrophil infiltration, using homologous reagents ... The involvement of IL-8 in TNF alpha- and IL-1 beta induced neutrophil infiltration is limited
Zachrisson et al., Cytokine 2001 : TNF-alpha induced the release of IL-8 ( P < 0.01 ) and IL-6 ( P < 0.05 ) from the duodenal explants
Asgeirsdóttir et al., Biochem Pharmacol 2003 : Relative and competitive RT-PCR analysis verified downregulation of TNFalpha mediated expression of CD40L and IL-8 by Dexa and Dexa-Ab ( hEsel ), respectively
Li et al., Infect Immun 1999 : IL-8 gene transcription in L5F11 cells could also be induced by the cytokine tumor necrosis factor alpha (TNF-alpha) without exposure to H. pylori ... This TNF-alpha induced IL-8 transcription was inhibited by the protein kinase A inhibitor H7, which had no significant effect on H. pylori induced IL-8 transcription
Schreml et al., Int Immunopharmacol 2007 : mTOR-inhibitors failed to suppress basal/TNF induced secretion of IL-8 and MCP-1, but IL-6 synthesis after TNF-induction was reduced to 35 %
Roussel et al., Arch Biochem Biophys 2000 : Here, we investigated whether arsenic, which has been shown to inhibit the ubiquitin-proteasome pathway, could inhibit TNF-alpha mediated increases in IL-8 expression
Gkoumassi et al., Br J Pharmacol 2007 : In the absence of agonist, SR144528 by itself reduced TNF-alpha induced IL-8 release ... Stimulation of the dominant CB(2) receptor signalling pathway diminished cAMP accumulation and TNF-alpha induced IL-8 release
Zu et al., J Immunol 1998 : Inhibition of the cellular p38 MAP kinase activation almost completely abolished the TNF-alpha stimulated IL-8 production and superoxide generation of human neutrophils
Lund et al., Thromb Res 2004 : The effect of TNF-alpha , PMA, and LPS on plasma and cell associated IL-8 in human leukocytes ... IL-8 release by PMN was much more strongly induced by TNF-alpha , increasing by 1050 % in the presence of 10 ng/ml TNF-alpha ( P < 0.005 ), whereas MNC or MNC/PMN subjected to this stimulus alone did not significantly enhance their IL-8 release
Qiu et al., FASEB J 2011 : Thymosin beta4 inhibits TNF-alpha induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK ... We find that enforced expression of Tß ( 4 ) interferes with TNF-a mediated NF-?B activation, as well as downstream IL-8 gene transcription
Chen et al., Inflammation 2002 : Herein we determined the effects of epigallocatechin-3-gallate ( EGCG ), a green tea derived polyphenol, on tumor necrosis factor-alpha (TNF-alpha) mediated expression of the IL-8 gene in A549 cells ... EGCG inhibited TNF-alpha mediated IL-8 gene expression in a dose response manner, as measured by ELISA and Northern blot analysis ... This effect appears to primarily involve inhibition of IL-8 transcription because EGCG inhibited TNF-alpha mediated activation of the IL-8 promoter in cells transiently transfected with an IL-8 promoter-luciferase reporter plasmid
Kim et al., Clin Chim Acta 2004 : Acanthoic acid suppressed TNF-alpha induced IL-8 production in a dose dependent manner ... Acanthoic acid might inhibit TNF-alpha mediated IL-8 production by blocking in both the MAPKs and NF-kappaB pathways in HT29 cells
Chowers et al., Gastroenterology 2001 (Enteritis) : Spontaneous and tumor necrosis factor (TNF)-alpha stimulated interleukin (IL)-8 and IL-1 beta secretion and mRNA expression were assessed in HT-29 and Caco-2 intestinal epithelial cell lines in the presence of a panel of heparin and heparan sulfate disaccharides
Zhou et al., J Clin Immunol 2004 : IL-8 induction by hyperforin required the activation of AP-1 but not the NF-kappaB transcription factor, thereby distinguishing it from the NF-kappaB dependent IL-8 induction mediated by tumor necrosis factor alpha (TNFalpha)
Kocbach et al., Toxicol Appl Pharmacol 2008 (Inflammation) : TNF-alpha and IL-1 antagonists reduced the release of IL-8 induced by particles from both sources
Yoneda et al., Am J Physiol Lung Cell Mol Physiol 2004 : In response to hrHRF, these cells induced IL-8 mRNA expression within 4 h. H2O2, but not IL-1 beta or tumor necrosis factor-alpha , stimulated secretion of HRF p23 by BEAS-2B cells, suggesting that oxidative stress may trigger the release of HRF p23 from bronchial epithelial cells
Sebastiani et al., Arch Dermatol Res 2002 (Dermatitis, Contact) : Chemokines are produced in a coordinated and sequential manner, with IL-8 and RANTES induced by TNF-alpha during early stages, and MCP-1, IP-10, Mig, I-TAC, I-309 and MDC induced by IFN-gamma during later stages
Tyagi et al., Mol Cell Endocrinol 2010 : In addition, like 17beta-estradiol, presence of medicarpin inhibited TNFalpha induced upregulation of interleukin-1 , and -6 mRNA levels in osteoblasts
Tahan et al., Clin Exp Allergy 2008 : We examined the inhibitory effects of montelukast on TNF-alpha induced IL-8 production in PMA differentiated U-937 cells ... The effect of signalling pathways on TNF-alpha induced IL-8 release was examined pharmacologically using selective NF-kappaB/IKK2 ( AS602868, 3 microm ), ( PD98059, 10 microm ) and p38 mitogen activated protein kinase ( MAPK ) ( SB203580, 1 microm ) inhibitors ... TNF-alpha induced IL-8 release was suppressed by an NF-kappaB inhibitor but not by MEK or p38 MAPK inhibitors ... Montelukast induced a concentration dependent inhibition of TNF-alpha induced IL-8 release and mRNA expression that reached a plateau at 0.1 microm without affecting cell viability ... Montelukast inhibits TNF-alpha stimulated IL-8 expression through changes in NF-kappaB p65 associated HAT activity
Libby et al., Am J Pathol 1986 : Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells
Jijon et al., Mediators Inflamm 2012 : The EGF receptor and HER2 participate in TNF-a dependent MAPK activation and IL-8 secretion in intestinal epithelial cells ... As the epidermal growth factor receptor (EGFR) is a known transducer of proliferative signals and a potent activator of MAPKs, we hypothesized that the EGFR participates in TNF dependent MAPK activation and IL-8 secretion by intestinal epithelial cells ( IECs ) ... TNF-a treatment of IECs resulted in an association between EGFR and HER2 and inhibition of HER2 using a specific inhibitor AG879 in combination with AG1478 suppressed TNF-a dependent ERK phosphorylation and IL-8 release
Loghmani et al., Inflammation 2002 : Our results show that pleural fluid isolated human fibroblasts release IL-8 and MCP-1 upon stimulation with IL-1 beta, TNF-alpha , and LPS in both a concentration- and time dependent manner ... TNF-alpha induced a 95-fold increase in IL-8 and an 84-fold increase in MCP-1 levels, as compared to the controls
Yao et al., Am J Respir Cell Mol Biol 2005 (Lung Neoplasms...) : Human recombinant tumor necrosis factor (TNF)-alpha and IL-1alpha could induce IL-8 expression in lung cancer cells in a dose dependent manner
Sica et al., Immunology 1990 : Tumour necrosis factor (TNF) and LPS, unlike the inflammatory monokine IL-6, also induced IL-8 expression
Ehrlich et al., J Immunol 1998 : We found that IL-8 protein levels increased in response to LPS or IL-1 beta, or to TNF-alpha , which also corresponded to elevated IL-8 mRNA levels by RT-PCR
Lee et al., The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 2012 : Pretreatment of HT-29 cells with LGG significantly blocked TNF-a , and LPS induced IL-8 activation at both mRNA and protein level ( p < 0.05 )
Meda et al., Cell Immunol 1994 : Addition of anti-TNF and anti-IL-1 beta antibodies to IFN-gamma plus LPS treated PMN indicated that the LPS induced production of endogenous TNF and IL-1 beta, which was further potentiated by IFN-gamma pretreatment, mediated in autocrine fashion the enhanced LPS induced IL-8 accumulation observed at 18 hr
Wang et al., J Rheumatol 2008 (Fibromyalgia...) : High IL-8 levels remained consistent during the followup, but TNF-alpha was already reduced after 10 days and until 6 months after therapy
Weisbach et al., Vox Sang 1999 (Hemolysis) : At the end of storage, we detected IL-8 in 1 of 16 units of WB tested, in 10 of 16 standard PAGGS-M RBCs and in 15 of 16 temporarily warmed SAG-M RBCs. Prestorage filtration of RBCs prevented the accumulation of IL-1beta and TNF-alpha
Frering et al., J Thorac Cardiovasc Surg 1994 (Heart Diseases) : A local production of these cytokines can not be excluded, because interleukin-6 and interleukin-8 are produced by stimulated macrophages and monocytes in response to tumor necrosis factor-alpha and interleukin-1 beta
Pang et al., Clin Exp Immunol 1994 : TNF-alpha stimulated the release of GM-CSF, IL-6 and IL-8 and, combined with IL-1 alpha, cytokine production was enhanced synergistically
Gewirtz et al., J Clin Invest 2000 : IL-8 secretion induced by both the prototypical proinflammatory cytokine TNF-alpha and S. typhimurium was NF-kappaB dependent ... However, NF-kappaB activation and IL-8 secretion induced by S. typhimurium, but not by TNF-alpha , was preceded by and required an increase in intracellular [ Ca ( 2+ ) ]
Lambert et al., J Biol Chem 2007 (Respiratory Tract Infections) : The alpha, beta unsaturated aldehydes in cigarette smoke ( acrolein and crotonaldehyde ) inhibited production of interleukin-2 (IL-2), IL-10, granulocyte-macrophage colony stimulating factor, interferon-gamma, and tumor necrosis factor-alpha by human T cells but did not inhibit production of IL-8
Fujihara et al., Eur J Immunol 2002 : Prior to morphological signs of apoptosis, TNF-alpha induced IL-8 synthesis is abrogated by inhibition of NF-kappaB
De Caterina et al., Am J Clin Nutr 2000 (Arteriosclerosis) : Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ), E-selectin, intercellular adhesion molecule 1 ( ICAM-1 ), interleukin 6 (IL-6), and IL-8 in response to IL-1, IL-4, tumor necrosis factor , or bacterial endotoxin, with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations
Jiang et al., Free radical research 2004 : The mRNA accumulation of IL-8 , MCP-1, RANTES, and eotaxin, and activation of NF-kappaB were induced by TNF-alpha for 2 h ; all were suppressed significantly by the above two pretreatments
Platz et al., Oligonucleotides 2005 : The tumor necrosis factor- alpha (TNF-alpha) induced release of interleukin-6 (IL-6) and IL-8 was significantly inhibited by the application of siRNA.p65
Grund et al., Mol Pharmacol 2008 (Endometriosis...) : Interestingly, MEK, p38, and IKK inhibitors block TNF-alpha induced IL-8 , IL-6, and GM-CSF secretion and 12z invasion, whereas the PI3K inhibitors do not
Radomska-Leśniewska et al., J Physiol Pharmacol 2006 : NAC inhibited the TNF-alpha/IL-1 beta stimulated ICAM-1 expression and IL-8 release from both cell lines in a concentration dependent manner
Mercado et al., Mol Pharmacol 2011 (Asthma) : Corticosteroid ( dexamethasone ) sensitivity was determined on tumor necrosis factor-a (TNF-a) induced interleukin (IL)-8 production ... In vitro corticosteroid sensitivity on TNF-a induced IL-8 production was significantly lower in patients with severe asthma than in healthy volunteers and patients with mild asthma
Kuno et al., Int Immunol 1994 (Niemann-Pick Diseases) : Unexpectedly, IL-1 alpha and TNF-alpha efficiently induced IL-8 production and IL-8 mRNA in NPD type A fibroblasts as in normal fibroblasts
Laham et al., Biol Reprod 1997 : These studies establish that the amnion, choriodecidua, and placenta are a source of IL-8 and demonstrate tissue-specific and differential regulation of IL-8 release by LPS, IL-1alpha, and TNF-alpha
Sun et al., World J Gastroenterol 2006 : VacA alone induced expression of TNF-alpha, IL-8 and IL-1beta, while NaCl alone induced expression of TNF-alpha and IL-1beta
Henriksen et al., J Immunol 2004 (Arteriosclerosis) : Elafin and murine SLPI also reduced endothelial IL-8 release in response to oxidized low density lipoprotein, LPS, and TNF-alpha and macrophage TNF-alpha production in response to LPS
Han et al., Int Immunopharmacol 2007 (Dermatitis, Irritant) : Moreover, TNF-alpha induced expression of cytokines, such as TNF-alpha and IL-1beta, and a chemokine, IL-8 , were suppressed by silymarin treatment in human keratinocyte cell line, HaCaT
Andoh et al., Clin Exp Immunol 1999 : In the intestinal epithelial cell lines HT-29, T84 and Caco-2, sodium butyrate enhanced TNF-alpha induced C3 secretion, but suppressed TNF-alpha induced factor B and IL-8 secretion
Biswas et al., Antioxid Redox Signal 2005 : Curcumin inhibited both H2O2- and TNF-alpha mediated activation of NF-kappaB and AP-1, and IL-8 release
Valacchi et al., Antioxid Redox Signal 2005 (Inflammation) : To investigate how acrolein affects respiratory tract cell activation, we exposed either primary ( NHBE ) or immortalized human bronchial epithelial cells ( HBE1 ) to 0-25 microM acrolein, and determined effects on basal and tumor necrosis factor-alpha (TNFalpha) induced production of the chemokine interleukin (IL)-8
Relvas et al., Invest Ophthalmol Vis Sci 2009 : TNFalpha induction of IL-8 secretion was also increased by ATPgammaS, UTP, and UDP ... ATPgammaS, UTP, and UDP stimulate both basal and TNFalpha induced IL-8 secretion in RPE cells through an ERK 1/2 dependent pathway
Brat et al., Neuro Oncol 2005 (Brain Neoplasms...) : In addition to hypoxia/anoxia stimulation, increased IL-8 in gliomas occurs in response to Fas ligation, death receptor activation, cytosolic Ca ( 2+ ), TNF-alpha , IL-1, and other cytokines and various cellular stresses
Sadik et al., Int J Biochem Cell Biol 2008 (Lyme Disease) : Systematic analysis highlights the key role of TLR2/NF-kappaB/MAP kinase signaling for IL-8 induction by macrophage-like THP-1 cells under influence of Borrelia burgdorferi lysates
Steube et al., Mol Cell Biol Res Commun 2000 (Leukemia) : Besides TPA, tumor necrosis factor-alpha (TNF alpha) also distinctively enhanced IL-8 and MCP-1 production
Bersinger et al., Arch Gynecol Obstet 2011 : The release of ENA-78, IL-8 and IL-6 by the isolated and monolayer cultured stromal cell fraction in the presence of IL-1ß ( 0.08 to 50 ng/mL ), TNF-a , and interferon-? ( both 20 to 500 ng/mL ) was determined
Jagels et al., Immunopharmacology 2000 : TNF-alpha induced expression of both IL-8 and GM-CSF, without detectable production of RANTES
Roumeguère et al., Eur Urol 2010 (Inflammation) : Two-way ANOVA analysis showed that TNF-alpha alone ( p < 0.001 ) or Mox-LDL alone ( p < 0.001 ) increased IL-8 production
Matsuda et al., Allergy 2008 : TNF-alpha significantly induced growth related oncogene alpha ( GRO-alpha ), interleukin 8 (IL-8), regulated on activation, normal T-cell expressed and secreted ( RANTES ) and interferon-inducible protein 10 (IP-10) productions and cell surface expressions of intracellular adhesion molecule 1 ( ICAM-1 ) and vascular cell adhesion molecule 1 ( VCAM-1 ) on HMVEC-LBl. TNF-alpha induced GRO-alpha and IL-8 were slightly attenuated by DEX treatment ( reaches to 89 % and 79 %, respectively ), whereas expressions of IP-10, ICAM-1 and VCAM-1 were significantly enhanced by the same treatment ( up to 172 %, 152 % and 139 %, respectively )
Cassatella et al., Immunology 1993 : Stimulation of human polymorphonuclear leucocytes ( PMN ) with phagocytosable particles [ yeast-IgG ( Y-IgG ) ], lipopolysaccharide (LPS), tumour necrosis factor (TNF) or formyl-methionyl-leucyl-phenyl-alanine ( FMLP ) results in an increase of the interleukin-8 (IL-8) mRNA accumulation and a subsequent release of the protein ... Preincubation of PMN with IFN-gamma significantly inhibited their ability to release IL-8 upon stimulation with TNF , LPS, FMLP and Y-IgG, but enhanced the respiratory burst capability in response to FMLP and TNF
Das et al., Laryngoscope 2005 (Otitis Media...) : Secondary TNF-alpha stimulation following well established ( i.e., 72 h ) RSV infection induced marked increases in IL-6, IL-8 , and RANTES when compared with both RSV infection alone and TNF-alpha stimulation alone
Ghadimi et al., Inflamm Bowel Dis 2010 : Our study indicates that TLR9 signaling mediates, at least in part, the anti-inflammatory effects of natural commensal-origin DNA on the gut because TLR9 silencing abolished the inhibitory effect of natural commensal-origin DNA on TNF-alpha induced IL-8 secretion in polarized IECs
Rodríguez et al., Life Sci 2002 : The results showed a 35 % decrease in the adhesion of U-937 monocyte cells to TNF-alpha stimulated HUVECs, and a 54 % and 65 % inhibition of TNF-alpha induced IL-8 and MCP-1 secretion by physiological and physiologically high doses of 17beta-estradiol
Vallée et al., Biochem Biophys Res Commun 2003 (Adenocarcinoma...) : Pretreatment of HT29-D4 epithelial adenocarcinoma colic cells with des-IGF-1 upregulated TNF alpha mediated activation of IL-8 expression at different levels ( protein, mRNA, and hnRNA )
Chen et al., Zhonghua Yi Xue Za Zhi 1996 : The effects of IL-1 beta and TNF alpha on the production of IL-8 by glomerular endothelial cells were also observed
Butler et al., Eur Cytokine Netw 1994 (Arthritis, Rheumatoid) : TNF-alpha stimulated synovial fibroblast DNA synthesis and the release of IL-6, IL-8 and PGE2 was inhibited by antagonist monoclonal antibodies against either the p55 or the p75 TNF receptor, although the blockade of the p55 TNF receptor had a more potent effect than inhibition of the p75 TNF receptor alone ... Both p55 and p75 TNF receptors on dermal and gingival fibroblasts were also involved in TNF-alpha mediated DNA synthesis and IL-6, IL-8 and PGE2 release, although differences in the levels of DNA synthesis and release of inflammatory cytokines and PGE2 were observed between the three fibroblast types
Lin et al., Arterioscler Thromb Vasc Biol 2008 (Inflammation) : FIR radiation also inhibited tumor necrosis factor (TNF)-alpha mediated expression of E-selectin, vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1, monocyte chemoattractant protein-1, interleukin-8 , and the cytokine mediated adhesion of monocytes to ECs
Ahmad et al., Am J Respir Cell Mol Biol 2003 (Lung Diseases...) : Tumor necrosis factor-alpha , IL-1beta, and lipopolysaccharide stimulated IL-8 production from epithelial cells in a dose- and time dependent manner, and these effects were abrogated by specific antibodies or inhibitors
Bae et al., J Cell Physiol 2010 : In this study, we show that HK-2 cells express endothelial protein C receptor ( EPCR ) and that the occupancy of this receptor by protein C switches the signaling specificity of thrombin so that the activation of PAR-1 by thrombin inhibits the TNF-alpha mediated synthesis of IL-6 and IL-8 and down-regulates the TGF-beta mediated expression of ECM proteins
Majetschak et al., Blood 2003 (Critical Illness...) : In contrast, the TNF-alpha response to zymosan or Staphylococcus aureus as well as the interleukin-6 (IL-6) and IL-8 responses to endotoxin were unaffected by ubiquitin
Jinquan et al., J Immunol 1997 (HIV Infections) : The IL-8R on N-B cells can be down-regulated by IFN-gamma, IL-2, and TNF-alpha ( selectively on IL-8RA ), and up-regulated by IL-4 and IL-13, whereas IL-10 has no influence
Lee et al., Int Immunopharmacol 2009 (Dermatitis, Atopic) : Hirsutenone attenuated the TNF-alpha induced production of cytokine IL-8 , prostaglandin E ( 2 ) and chemokine CCL27, and the formation of reactive oxygen/nitrogen species in keratinocytes
Vlahopoulos et al., Blood 1999 : TNFalpha is a rapid activator of IL-8 gene expression by U937, producing a 50-fold induction of mRNA within 1 hour of treatment
Ruprecht et al., J Neuropathol Exp Neurol 2001 (Multiple Sclerosis) : Combined application of tumor necrosis factor (TNF)-alpha and OSM synergistically enhanced IL-6 and MCP-1 production, but downregulated TNF-alpha induced IL-8
Adiseshaiah et al., J Immunol 2006 (MAP Kinase Signaling System) : We found that short interfering RNA mediated silencing of FRA-1 enhances TNF-alpha induced IL-8 expression, whereas overexpression causes an opposite effect
Andoh et al., JPEN J Parenter Enteral Nutr 1999 (Adenocarcinoma...) : In the in vitro experiment, sodium butyrate dose-dependently inhibited tumor necrosis factor (TNF)-alpha induced IL-8 secretion in HT-29 cells
Harant et al., Eur J Biochem 1997 : 1alpha,25-Dihydroxyvitamin D3 ( calcitriol ) repressed IL-8 promoter activity induced by tumor necrosis factor-alpha (TNF-alpha) by 50 %, compared to 30 % inhibition using dexamethasone, an effect consistent with its effect on TNF-alpha induced IL-8 release and IL-8 mRNA levels ... Furthermore, overexpression of VDR in the parental G-361 cell line enhanced the repressive effect of calcitriol on activation of the IL-8 promoter by either TNF-alpha stimulation or overexpression of the NF-kappaB subunit p65
Henness et al., Am J Physiol Lung Cell Mol Physiol 2006 (Lung Neoplasms) : Here, we perform an in vitro study to show that although IL-17A did not induce secretion of the CXC chemokine IL-8 from ASM cells, IL-17A significantly potentiates TNF-alpha induced IL-8 protein secretion and gene expression in a concentration- and time dependent manner ( P < 0.05 ) ... We found that IL-17A significantly augmented TNF-alpha induced IL-8 mRNA stability ... Collectively, these results demonstrate that IL-17A amplifies the synthetic function of ASM cells, acting via a p38 MAPK dependent posttranscriptional pathway to augment TNF-alpha induced secretion of the potent neutrophil chemoattractant IL-8 from ASM cells
Bian et al., Invest Ophthalmol Vis Sci 2011 : Caspase-5 knockdown reduced caspase-1 protein expression and activation and inhibited TNF-a induced IL-8 and MCP-1
Kuo et al., Br J Pharmacol 1997 : 4. Neutrophil depletion by cyclophosphamide pretreatment failed to modify TNF-alpha induced human IL-8 equivalent release
Lee et al., The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 2005 : Induction of interleukin-8 (IL-8) expression by tumor necrosis factor-alpha (TNF-alpha) , interleukin-1beta (IL-1beta), or lipopolysaccharide (LPS) was assessed by RT-PCR
Rougier et al., Cytokine 1998 : IL-1 alpha, IL-1 beta, and IL-3, tumour necrosis factor alpha (TNF-alpha) , Stem cell factor (SCF) and granulocyte-macrophage colony stimulating factor ( GM-CSF ) ( at 10 ng/ml ) stimulated IL-6 and IL-8 production in 0 % and 10 % FCS
Friedland et al., Eur J Immunol 1992 : IL-8 production was independent of TNF and of virulence of the strain of M. tuberculosis
Wurz et al., Bioorg Med Chem Lett 2009 : These inhibitors were evaluated for their ability to inhibit the p38alpha enzyme, the secretion of TNFalpha in a LPS challenged THP1 cell line and TNFalpha induced production of IL-8 in 50 % human whole blood
Mazzarella et al., Allergy 2000 (Asthma) : Phenotypic features of alveolar monocytes/macrophages and IL-8 gene activation by IL-1 and TNF-alpha in asthmatic patients
Hedges et al., Infect Immun 1994 : IL-1 alpha and TNF-alpha induced significantly higher levels of IL-8 secretion than did E. coli Hu734
Kehlen et al., Arthritis Res Ther 2003 (Arthritis, Rheumatoid) : Among these genes we identified the following : tumor necrosis factor stimulated gene-6 ( TSG-6 ), IL-6, IL-8 , GRO-beta, and bone morphogenetic protein-6 with an expression 3.6-10.6-fold that in the unstimulated control
Hu et al., J Biomed Biotechnol 2009 : In this study, we found that ticlopidine dose-dependently decreased the mRNA and protein levels of TNF-alpha stimulated MCP-1, IL-8 , and vascular cell adhesion molecule-1 ( VCAM-1 ) in human umbilical vein endothelial cells ( HUVECs )
Galatowicz et al., Clin Exp Allergy 2007 (Conjunctivitis, Allergic...) : For conjunctival biopsy derived cultures ( n=11 ), FcepsilonR1 stimulation increased histamine, TNF-alpha , TNF-beta, IL-5 and IL-8 levels and the production of IL-5, IL-6 ( P < 0.05 ), histamine and IL-8 ( P < 0.01 ) was inhibited by epinastine
Baraldo et al., Am J Physiol Lung Cell Mol Physiol 2003 : IL-9 alone had no effect on IL-8 release, but at concentrations of > or =30 ng/ml, IL-9 significantly increased IL-8 release induced by TNF-alpha
Andoh et al., Pancreas 2000 (Pancreatic Neoplasms) : IL-1beta and tumor necrosis factor (TNF)-alpha both induced a marked increase in C3 and IL-8 secretion
Zhang et al., J Nutr 2005 : Alive and dead Lactobacillus rhamnosus GG decrease tumor necrosis factor-alpha induced interleukin-8 production in Caco-2 cells ... We hypothesized that Lactobacillus rhamnosus GG ( LGG ) are capable of downregulating tumor necrosis factor-alpha (TNFalpha) induced interleukin (IL)-8 production under all 3 of these conditions, and that LGG act through the nuclear factor kappaB (NFkappaB)/inhibitor of kappaB ( IkappaB ) pathway ... TNFalpha induced production of IL-8 by Caco-2 cells was modulated by LGG under all 3 conditions ... Heat killed LGG also blunted the TNFalpha induced IL-8 production ( P < 0.01 ), but by itself did not increase IL-8 production at higher doses as markedly as live LGG ( P < 0.05 ) ... LGG reduced TNFalpha induced IL-8 production by affecting the NFkappaB/IkappaB pathway in Caco-2 cells
Hou et al., Yao Xue Xue Bao 2001 : TNF alpha promoted IL-8 production and mRNA expression in HSC ... Iso inhibited IL-8 production and mRNA expression induced by TNF alpha ( 0.25 U.mL-1 )
Yamamoto et al., Eur J Pharmacol 1996 (Disseminated Intravascular Coagulation) : Plasma interleukin-1 and TNF-alpha levels were elevated by lipopolysaccharide administration and the treatment with FR167653 ( 0.31 mg/kg/h for 4 h ) inhibited the increased plasma interleukin-1 ( 100.0 % ) and plasma TNF-alpha ( 89.2 % ) levels
Lou et al., Eur J Immunol 1996 : Inhibitors of TNF diminished ( < or = 45 % ), but did not abolish the expression of cell adhesion molecules and IL-6 induced by S-PM, IL-8 production being insignificantly affected ( < or = 10 % )
Fiedler et al., Am J Physiol 1995 (Lung Neoplasms...) : We hypothesized that RSV directly induces interleukin (IL)-8 gene expression in airway epithelial cells, independent of IL-1 beta and tumor necrosis factor-alpha (TNF-alpha) production
Yagyu et al., J Clin Endocrinol Metab 2005 (Endometriosis) : Thalidomide inhibits tumor necrosis factor-alpha induced interleukin-8 expression in endometriotic stromal cells, possibly through suppression of nuclear factor-kappaB activation ... TNF-alpha induces IL-8 production in endometriotic cells through nuclear factor-kappaB (NF-kappaB) activation ... We examined whether Thal abrogates TNF-alpha induced up-regulation of IL-8 expression in endometriotic stromal cells ... Thal did not enhance the N-tosyl-L-phenylalanine chloromethyl ketone 's action ; and 4 ) Pretreatment with Thal reduced TNF-alpha induced IL-8 protein production as well as mRNA expression
Sakai et al., Curr Eye Res 2013 : TNF-a induced NF?B activation in rat and human conjunctival fibroblasts and epithelial cells, and caused production and release of cytokines IL-8 and RANTES
Lee et al., Biochem Pharmacol 2007 (Colitis...) : Pretreatment of human intestinal epithelial HT-29 cells with TMMC also significantly inhibited the IL-8 and extracellular matrix metalloproteinase-7 levels induced by TNF-alpha
Enesa et al., J Biol Chem 2008 : Quantitative reverse transcription-PCR and enzyme linked immunosorbent assay revealed that H ( 2 ) O ( 2 ) enhanced the induction of IL-8 by TNFalpha or IL-1beta
Lee et al., Life Sci 2007 : Butein blocks tumor necrosis factor alpha induced interleukin 8 and matrix metalloproteinase 7 production by inhibiting p38 kinase and osteopontin mediated signaling events in HT-29 cells ... Butein significantly inhibited TNF-alpha induced interleukin 8 (IL-8) secretion and mRNA expression ... Using specific kinase inhibitors, we also found that blocking the p38 pathway is critical for, and blocking of OPN mediated I-kappaBalpha phosphorylation pathway is at least for, the inhibitory effect by butein on TNF-alpha induced IL-8 and MMP-7 expression
Alshorafa et al., Tohoku J Exp Med 2012 (Psoriasis) : Exogenous H ( 2 ) S inhibited the TNF-a mediated upregulation of NO, IL-6 and IL-8 in a dose dependent manner
Inoue et al., Am J Respir Crit Care Med 2000 (Bronchial Hyperreactivity...) : In addition, tumor necrosis factor-alpha (TNF-alpha) plus IL-1beta plus interferon-gamma (IFN-gamma) increased IL-8 in culture supernatant of epithelial cells ; the combination of NO synthase (NOS) inhibitors, aminoguanidine ( AG ) plus N ( G ) -nitro-L-arginine methyl ester ( L-NAME ) attenuated the cytokine induced IL-8 production in epithelial cells
Noah et al., Am J Respir Cell Mol Biol 1996 : In the same cultures, tumor necrosis factor-alpha induced marked increases in release of both IL-8 and IL-6 at 24 and 48 h after stimulation
Blasi et al., Infect Immun 1994 : Moreover, pretreatment of macrophages with recombinant TNF for 3 h enhances TNF and induces interleukin-1 production in response to both forms of Candida, while pretreatment for 18 h renders macrophages refractory to any stimuli
Standiford et al., J Clin Invest 1990 : This interaction appears to occur via the ability of human alveolar macrophage ( AM ) -derived monokines, tumor necrosis factor (TNF) , and interleukin-1 (IL-1) to induce gene expression of IL-8 from pulmonary type II-like epithelial cells ( A549 )
Verhagen et al., Cytokine 2001 (Colonic Neoplasms) : TNF and CD95 promote IL-8 gene transactivation via independent elements in colon carcinoma cells ... We examined the pathway for CD95 induced IL-8 secretion using two luciferase reporter constructs ; the first comprising approximately 500 bp of the IL-8 promotor that includes the nuclear factor kappa B (NFkappaB), C/EBP and AP-1 sites known to be involved in TNF mediated IL-8 induction ; the second that encompasses these elements but extends approximately 1.1 kb further upstream
Portielje et al., Clin Cancer Res 2003 (Carcinoma, Renal Cell) : Repeated administrations of interleukin (IL)-12 are associated with persistently elevated plasma levels of IL-10 and declining IFN-gamma, tumor necrosis factor-alpha , IL-6, and IL-8 responses
Andoh et al., Ther Apher Dial 2005 (Colitis, Ulcerative...) : TNF-alpha induced IL-8 secretion was also significantly decreased after apheresis, but there was no significant difference in TNF-alpha induced IL-6 secretion ( P = 0.052 )
Muñoz et al., Blood 1996 : Both PDTC and NAC inhibited, in a dose dependent manner, the synthesis of IL-6, IL-8 , and GM-CSF induced by tumor necrosis factor (TNF)-alpha or bacterial lipopolysaccharides (LPS) in human umbilical vein endothelial cells ( HUVEC )
Hoffman , Lymphokine Res 1986 : The effects of tumor necrosis factor on the production of interleukin-1 by macrophages
O'Gorman et al., Am J Physiol Gastrointest Liver Physiol 2010 : The induction of the chemokine interleukin-8 and the antiapoptotic protein cFLIP by tumor necrosis factor-alpha were markedly less in HCT116 cells lacking DNMT than in parental cells
Su et al., Biochim Biophys Acta 2008 (MAP Kinase Signaling System) : Post-transcriptional regulation of TNF induced expression of ICAM-1 and IL-8 in human lung microvascular endothelial cells : an obligatory role for the p38 MAPK-MK2 pathway dissociated with HSP27 ... We evaluated the role of p38 MAPK, MK2 and HSP27 in regulating the TNF induced expression of ICAM-1 and IL-8 in human lung MVECs ... Our study demonstrates for the first time that MK2 mediates post-transcriptional regulation by p38 MAPK of the TNF induced expression of ICAM-1 and IL-8 in human lung MVECs, and that this regulation by the p38 MAPK/MK2 pathway is dissociated from HSP27 phosphorylation
Takahashi et al., Indian J Dermatol 2009 : Furthermore, TNF-alpha induced secretion of IL-6, IL-8 , EGF, HGF, TGF-alpha, epiregulin, and amphiregulin were compared among these keratinocytes ... The significant induction of TNF-alpha increased IL-6, IL-8 , EGF, HGF, TGF-alpha, epiregulin, and amphiregulin, but the increase in these cytokines and growth factors were not different among normal skin, uninvolved, and involved psoriasis
Lotz et al., J Immunol 1992 (Arthritis) : By using a specific RIA, we demonstrate that not only IL-1 beta, but also TNF-alpha and LPS can induce abundant IL-8 secretion from chondrocytes
Berry et al., Int J Gynecol Cancer 2001 (Carcinoma, Papillary...) : Further, the treatment of endometrial carcinoma cells with inflammatory cytokines, IL-1beta and tumor necrosis factor-alpha (TNF-alpha), demonstrated that IL-1beta and TNF-alpha induced IL-8 expression in endometrial cancer cells
Tada et al., J Neurooncol 1993 (Brain Neoplasms...) : The IL-8 secretion increased with the stimulation by TNF-alpha
Kammouni et al., Infect Immun 1997 (Cystic Fibrosis) : In addition, dexamethasone was found to stimulate IL-6 and IL-8 secretion ( in the presence or absence of LPS ) but did not induce any secretion of TNF-alpha
Yamagishi et al., J Cardiovasc Pharmacol 2004 : Azelnidipine, a newly developed long acting calcium antagonist, inhibits tumor necrosis factor-alpha induced interleukin-8 expression in endothelial cells through its anti-oxidative properties ... In this study, we investigated whether and how azelnidipine, a newly developed long acting calcium antagonist, could inhibit TNF-alpha induced IL-8 expression in human umbilical vein endothelial cells ( HUVEC ) ... An inhibitor of AP-1, curcumin, or an anti-oxidant, N-acetylcysteine, also inhibited the TNF-alpha induced IL-8 expression in HUVEC ... These results demonstrated that azelnidipine inhibited TNF-alpha induced IL-8 expression in HUVEC by blocking NADPH oxidase mediated ROS generation and subsequent AP-1 activation
Nasu et al., Arch Pathol Lab Med 1998 (Endometrial Neoplasms...) : Interleukin-1beta, ( 100 pmol/L ), tumor necrosis factor-alpha ( 1 nmol/L ), and lipopolysaccharide ( 1 microg/mL ) each increased the release of IL-6, IL-8 , and monocyte chemoattractant protein-1 by MaMi cells
Trevino et al., Angiogenesis 2006 (Adenocarcinoma...) : Pharmacologic inhibition of NF-kappaB activity significantly reduced basal IL-8 expression and tumor necrosis factor induced IL-8 expression ( P < 0.05 for both ), yet NF-kappaB activity was not dependent on Src
Kudo et al., J Steroid Biochem Mol Biol 2012 (Mucocutaneous Lymph Node Syndrome) : Pretreatment with 1a,25- ( OH ) ( 2 ) D ( 3 ) significantly inhibited TNF-a induced VCAM-1 expression and IL-8 production in HCAECs
Schratzberger et al., Immunopharmacology 1999 : Upon stimulation with TNF or LPS, HUVEC produced IL-8 and PTX affected this process in opposing fashions, with inhibition of the effects of TNF and augmentation of those of LPS
Elias et al., Chest 1990 (Pneumonia...) : To understand the processes regulating inflammation and fibrosis in the human lung, we characterized the effects of recombinant interleukin-1, tumor necrosis factor , and gamma interferon on fibroblast proliferation, collagen production, interleukin-1-alpha production, interleukin-1-beta production, and interleukin-6 production
Henriquet et al., Lung Cancer 2007 (Adenocarcinoma...) : An AP-1 and a NF-kappaB recognition sites were necessary for full induction of IL-8 promoter activity by TNF-alpha and TPA
Hallberg et al., J Affect Disord 2010 : IL-8 , IL-6 and TNF-alpha increased , and IL-4 decreased during the challenge in both groups
Klegeris et al., Brain Res 1997 (Alzheimer Disease) : First, it was shown that THP-1 cells could be induced to secrete significant amounts of TNF-alpha by interleukin-1 , lipopolysaccharide, interferon-gamma (IFN-gamma) and PMA alone or in combination with each other
Yeh et al., Arterioscler Thromb Vasc Biol 2001 : Increased transcription of IL-8 in endothelial cells is differentially regulated by TNF-alpha and oxidized phospholipids ... To elucidate the molecular mechanisms of Ox-PAPC induced gene expression and to determine whether Ox-PAPC and other inflammatory mediators such as TNF-alpha utilize common signaling pathways, we examined the transcriptional regulation of IL-8 by Ox-PAPC and TNF-alpha in human aortic endothelial cells ... In contrast, TNF-alpha induced IL-8 mRNA synthesis was elevated at 30 minutes, peaked at 2 hours, and reached basal/undetectable levels by 6 hours ... Actinomycin D experiments suggested that both Ox-PAPC and TNF-alpha regulate the expression of IL-8 at the transcriptional level
Ebert et al., Am J Physiol Gastrointest Liver Physiol 2009 (MAP Kinase Signaling System) : Although both TNF-alpha and IFN-gamma increased IL-8 synthesis and CD58 expression by the HT-29 cells, only IFN-gamma reduced IL-8 production by IELs
Allen et al., Am J Physiol Lung Cell Mol Physiol 2000 (Hyperoxia) : Hyperoxia synergistically increases TNF-alpha induced interleukin-8 gene expression in A549 cells ... Hyperoxia alone had a minimal effect on IL-8 gene expression, and TNF-alpha alone increased IL-8 gene expression in a time dependent manner ... Experiments involving IL-8 promoter-reporter assays, electromobility shift assays, and Western blot analyses demonstrated that hyperoxia augmented TNF-alpha mediated activation of the IL-8 promoter by a nuclear factor (NF)-kappaB dependent mechanism and increased the duration of NF-kappaB nuclear translocation after concomitant treatment with TNF-alpha ... We conclude that hyperoxia alone has a minimal effect on IL-8 gene expression but synergistically increases IL-8 gene expression in the presence of TNF-alpha by a mechanism involving cooperative interaction between the transcription factors NF-kappaB and NF-IL-6
Makó et al., Cytometry A 2010 : Moreover, expression of E-selectin, IL-6, and IL-8 was induced most efficiently by IL-1ß, while LPS and TNF-a had less effect, whereas we did not find such a difference in ICAM-1 and MCP-1 expression
Paleolog et al., Blood 1994 : TNF-alpha induced expression of tissue factor and adhesion molecules, and release of IL-8 and GM-CSF, are decreased by antibodies with antagonistic activities for either receptor, although the effect of anti-p55 antibodies is markedly greater than that of anti-p75 antibodies
Le et al., J Immunol 1987 : Induction of membrane associated interleukin 1 by tumor necrosis factor in human fibroblasts
Nishida et al., J Clin Endocrinol Metab 2004 (Endometrial Stromal Tumors...) : Using ELISA, TNF-alpha significantly enhanced the production of IL-8 , growth related oncogene alpha, and epithelial neutrophil activating peptide-78 in all cases of ECSC ( n = 10 ), ESCwE ( n = 6 ), and, NESC ( n = 10 )
Lappas et al., J Clin Endocrinol Metab 2004 (Diabetes, Gestational) : Stimulation of placenta, adipose tissue, and skeletal muscle with LPS and TNF-alpha resulted in greater release of IL-6 and IL-8 , whereas only LPS increased TNF-alpha release from all three tissues
Peterlin et al., Cephalalgia 2007 (Migraine Disorders) : The anti-inflammatory activities of adiponectin include inhibition of IL-6 and TNF induced IL-8 formation, as well as induction of the anti-inflammatory cytokines IL-10 and IL-1 receptor antagonist
Van De Walle et al., Toxicol In Vitro 2010 : The effects of TNF-alpha on IL-8 and IL-6 or NO production were stronger upon combination with IL-1beta or IFN-gamma, respectively, whereas cells were unaffected by the presence of LPS
Shimada et al., Dig Dis Sci 1999 : N-Acetylcysteine (NAC) or dimethylsulfoxide inhibited IL-8 expression induced by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta)
Lisignoli et al., Int J Clin Lab Res 1998 (Tonsillitis) : Activation by tumor necrosis factor-alpha induced interleukin-8 production by B lymphocytes
Lee et al., Dig Dis Sci 2009 (Colitis) : Saccharomyces boulardii blocked tumor necrosis factor-alpha (TNF-alpha) regulation of PPAR-gamma and IL-8 through disruption of TNF-alpha mediated nuclear factor kappa B (NF-kappaB) activation
Peltier et al., Am J Reprod Immunol 2008 (Premature Birth) : P4 enhanced the production of IL-1beta and IL-8 , but inhibited TNF-alpha production by monocytes stimulated with either organism
Shembade et al., J Virol 2007 : Mouse fibroblasts lacking Ubc13 exhibit impaired Tax activation of NF-kappaB despite normal tumor necrosis factor- and interleukin-1 mediated NF-kappaB activation
Wurz et al., Bioorg Med Chem Lett 2010 : A structure activity relationship ( SAR ) investigation was conducted driven by the ability of these compounds to inhibit the p38alpha enzyme, the secretion of TNFalpha in a LPS challenged THP1 cell line and TNFalpha induced production of IL-8 in the presence of 50 % human whole blood ( hWB )
Inagaki et al., J Biol Chem 2008 : Tumor necrosis factor- and interleukin-1 induced activation of TAK1 was entirely normal in Tab1-deficient MEFs and could activate both mitogen activated protein kinases and NF-kappaB
Kamohara et al., Int J Oncol 2007 (Inflammation...) : Induction of interleukin-8 ( CXCL-8 ) by tumor necrosis factor-alpha and leukemia inhibitory factor in pancreatic carcinoma cells : Impact of CXCL-8 as an autocrine growth factor
Son et al., FEBS Lett 2005 : Histidine inhibits oxidative stress- and TNF-alpha induced interleukin-8 secretion in intestinal epithelial cells ... We investigated the effect of several amino acids on the secretion of such inflammatory cytokines as interleukin-8 (IL-8) induced by hydrogen peroxide or tumor necrosis factor-alpha (TNF-alpha) in intestinal epithelial-like Caco-2 and HT-29 cells ... We found that histidine, one of the conditionally essential amino acids, significantly inhibited both hydrogen peroxide- and TNF-alpha induced IL-8 secretion and mRNA expression in Caco-2 cells and HT-29 cells ... TNF-alpha increased the transcriptional activity of the IL-8 promoter which was significantly inhibited by treating Caco-2 cells with histidine ... These results indicate that histidine inhibited the hydrogen peroxide- and TNF-alpha induced IL-8 secretion at the transcriptional level in intestinal epithelial cells, suggesting that histidine has the potential to attenuate intestinal inflammation
Smart et al., Am J Physiol 1994 : This facilitation is dependent on TNF-alpha stimulated production of IL-8
Chaudière et al., C R Seances Soc Biol Fil 1995 : TNF-alpha alone induces the endothelial release of Interleukin-8 (Il-8) as well as the expression of P- and E-selectin
Satsu et al., J Nutr Sci Vitaminol (Tokyo) 2009 : Suppressive effect of an isoflavone fraction on tumor necrosis factor-alpha induced interleukin-8 production in human intestinal epithelial Caco-2 cells ... This study demonstrates the effect of soybean components on the tumor necrosis factor-alpha (TNF-alpha) induced production of interleukin-8 (IL-8) , one of the major inflammatory chemokines, in intestinal epithelial-like Caco-2 cells ... Among the soybean components, an isoflavone fraction ( IFF ) suppressed the TNF-alpha induced IL-8 secretion by Caco-2 cells in a dose dependent manner, whereas a soyasaponin fraction and soypeptide fraction had no significant effect on TNF-alpha induced IL-8 secretion ... The IL-8 secretion induced by hydrogen peroxide and by IL-1beta was not suppressed by IFF, suggesting that the inhibitory effect of isoflavone was specific for the TNF-alpha induced regulation of IL-8 ... These results indicate that IFF suppressed TNF-alpha induced IL-8 production at the transcriptional level in human intestinal Caco-2 cells, suggesting IFF of soybean as a promising food component for preventing intestinal inflammation such as inflammatory bowel disease
Kang et al., Int J Mol Med 2005 : We investigated the role of 18 beta-glycyrrhetinic acid ( GA ), a saponin isolated from licorice roots, on TNF-alpha induced IL-8 production in human colonic epithelial cells ... GA suppressed TNF-alpha induced IL-8 production in a concentration dependent manner ... These results suggest that GA has the inhibitory effects on TNF-alpha induced IL-8 production in the intestinal epithelial cells through blockade in the phosphorylation of MAPKs, following I kappa B alpha degradation and NF-kappa B activation
Wang et al., FEBS Lett 2001 : Further, IkappaB-alphaM suppressed TNF-alpha stimulated release of interleukin-6 and -8 ( IL-6 and IL-8 )
Cesaratto et al., PloS one 2013 : E3330 treatment prevented the functional activation of NF-?B via the alteration of APE1 subcellular trafficking and reduced IL-6 and IL-8 expression induced by TNF-a and FAs accumulation through blockage of the redox mediated activation of NF-?B
Bates et al., Exp Cell Res 2004 (Colonic Neoplasms...) : Using a novel model of EMT in colon carcinoma in which the inflammatory cytokine TNF-alpha accelerates this TGF-beta directed process, we report that TNF-alpha stimulation upregulates expression of the chemokine IL-8 , and that this upregulation is dependent on the transcription factor NF-kappaB
Kim et al., Osteoarthritis Cartilage 2009 (Low Back Pain) : SB202190 successfully suppressed IL-6, IL-8 , PGE2, and PGF2alpha secretion in macrophage exposed AF cells in response to TNF-alpha
Ferran et al., Biochem Biophys Res Commun 1995 : We show that pyrrolidine dithiocarbamate strongly reduces the TNF alpha mediated induction of E-selectin, VCAM-1, ICAM-1, PAI-1, tissue factor, IL-8 and I kappa B-alpha
Zijlstra et al., Eur Respir J 2012 (Asthma) : We investigated whether interleukin (IL)-17A induces GC insensitivity in airway epithelium by studying its effects on responsiveness of tumour necrosis factor (TNF)-a induced IL-8 production to budesonide in human bronchial epithelial 16HBE cells ... We demonstrated that IL-17A induced IL-8 production is normally sensitive to GCs, while IL-17A pre-treatment significantly reduced the sensitivity of TNF-a induced IL-8 production to budesonide
Kobashi et al., Circ Res 2005 (Atherosclerosis) : Adiponectin also inhibited IL-8 mRNA expression induced by TNF-alpha ... The inhibitory effect of adiponectin on TNF-alpha induced IL-8 synthesis was inhibited by pretreatment with Rp-cAMP, a PKA inhibitor ... The inhibitory effect of adiponectin on TNF-alpha induced IL-8 synthesis was abrogated in part by pretreatment with the PI3 kinase inhibitor LY294002 or by Akt siRNA transfection, suggesting that Akt activation might inhibit IL-8 synthesis induced by TNF-alpha
Krakauer , J Infect Dis 1998 : Interleukin-8 production by human monocytic cells in response to staphylococcal exotoxins is direct and independent of interleukin-1 and tumor necrosis factor-alpha
Nakamura et al., Med Hypotheses 2005 (Arteriosclerosis...) : In the process of the search for such a unique anti-hypertensive drug, we have recently found that azelnidipine, a newly developed and commercially used long acting dihydropyridine based calcium antagonist ( DHP ), inhibited TNF-alpha induced activator protein-1 activation and interleukin-8 expression in human umbilical vein endothelial cells by suppressing NADPH oxidase mediated reactive oxygen species generation
Altan et al., J Pharmacol Exp Ther 2010 (Endometriosis) : TBP and TNF-SHARC dose-dependently inhibited TNFalpha induced secretion of interleukin (IL)-6, IL-8 , granulocyte macrophage-colony stimulating factor, and monocyte chemoattractant protein-1 in immortalized human endometriotic cells
Delerive et al., EMBO Rep 2001 (Inflammation) : We demonstrated that ROR alpha is expressed in human primary smooth-muscle cells and that ectopic expression of ROR alpha1 inhibits TNFalpha induced IL-6, IL-8 and COX-2 expression in these cells
Xu et al., J Immunol 2013 (Psoriasis) : Specific inhibition of miR-31 suppressed NF-?B-driven promoter luciferase activity and the basal and TNF-a induced production of IL-1ß, CXCL1/growth related oncogene-a, CXCL5/epithelial derived neutrophil activating peptide 78, and CXCL8/IL-8 in human primary keratinocytes
Aggarwal et al., Exp Cell Res 1995 : Diminished responsiveness of senescent normal human fibroblasts to TNF dependent proliferation and interleukin production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B
Betjes et al., J Infect Dis 1993 : In this study, human peritoneal mesothelial cells were shown to produce high levels of interleukin-8 (IL-8) in response to IL-1 beta and tumor necrosis factor-alpha (TNF alpha) but not lipopolysaccharide or S. epidermidis
Chaly et al., Cytokine 2000 : In this study, we investigated TNF-alpha- and IL-1 mediated regulation of IL-8 gene expression in non fractionated PBMC, and purified monocyte ( MO ) and lymphocyte ( LY ) fractions ... Our analysis revealed that purified human MO did not respond to exogenous TNF-alpha with the induction of IL-8 mRNA or protein, nor require endogenous TNF-alpha for IL-8 expression ... In contrast with MO, purified LY and non fractionated PBMC expressed IL-8 in response to exogenous TNF-alpha , similar to exogenous IL-1alpha and IL-1beta
Elner et al., Exp Eye Res 1996 : Interleukin-7 potentiated tumor necrosis factor-alpha induced RPE monocyte chemotactic protein-1 steady-state mRNA expression at all doses of interleukin-7 while only high dose interleukin-7 ( 100 ng ml-1 ) enhanced tumor necrosis factor-alpha induced RPE interleukin-8 steady-state gene expression ... These studies suggest that interleukin-7 potentiation of interleukin-1 beta and tumor necrosis factor-alpha induced RPE monocyte chemotactic protein-1 and IL-8 may be important for the elicitation of leukocyte chemotaxins in diseased retinal tissue when only low ambient levels of individual pro-inflammatory cytokines are present
Cui et al., Ophthalmic Res 2006 : These findings indicate that berberine dose-dependently inhibited the expression of IL-8 and MCP-1 induced by IL-1beta or TNF-alpha
Iskandar et al., Br J Nutr 2013 (Cystic Fibrosis...) : Neither hydrolysate suppressed IL-8 production induced by TNF-a or IL-1ß, suggesting an effect on the Toll-like receptor (TLR) 4 pathway, the cellular sensor for LPS
Sukedai et al., J Oral Pathol Med 2004 (Arthritis, Experimental...) : TNF-alpha was particularly related with angiogenesis and cartilage destruction and IL-8 was involved in the acute stage of inflammation
Saint-Criq et al., Eur J Pharmacol 2012 (Cystic Fibrosis...) : More, our data showed no effect of azithromycin on IL-1ß- or TNF-a induced IL-8 secretion and NF-?B pathway activation
Su et al., Exp Cell Res 2006 (MAP Kinase Signaling System) : Differential regulation of interleukin-8 gene transcription by death receptor 3 (DR3) and type I TNF receptor ( TNFRI )
Podolin et al., J Immunol 2002 (Acute Disease...) : In addition, in the more robust LPS- and OVA induced arthritis models, which were characterized by increased levels of proinflammatory mediators in the synovial fluid, TNF-alpha , IL-8, PGE ( 2 ), leukotriene B ( 4 ), and leukotriene C ( 4 ) levels were significantly reduced, as was erythrocyte sedimentation rate, possibly as a result of the observed decreases in serum TNF-alpha and IL-8 levels
Bird , Acta Gastroenterol Belg 1994 (Acute-Phase Reaction...) : The potent neutrophil activator and chemotaxin interleukin-8 (IL-8) is released in response to TNF and recent interest has focussed on its possible role in producing the characteristic peripheral blood neutrophilia and liver neutrophil infiltrate in alcoholic hepatitis
Lou et al., J Neuroimmunol 1997 : TBP I completely abolished TNF induced IL-6 production and E-selectin induction, while it partially inhibited TNF induced IL-8 production and up-regulation of ICAM-1 and VCAM-1
Perng et al., Tissue Eng Part A 2012 : miRNA-146a Expression Positively Regulates Tumor Necrosis Factor-a Induced Interleukin-8 Production in Mesenchymal Stem Cells and Differentiated Lung Epithelial-Like Cells ... Overexpression of miRNA-146a, which positively regulates TNF-a induced IL-8 release, may enhance the inflammatory response in both BM-MSC and MSC-EC
Topley et al., Am J Pathol 1993 : Stimulation of HPMC with IL-1 beta or TNF-alpha resulted in a time- and dose dependent IL-8 generation ; after 24 hours the levels induced by IL-1 beta and TNF-alpha ( both at 1000 pg/ml ) were ( mean +/- SEM, n = 5 ) 101 +/- 26.6 ( z = 2.023 ; P < 0.01 ) and 35 +/- 8.09 ( z = 2.023 ; P < 0.01 ) respectively
Andoh et al., J Nutr 2000 : The addition of MCFA ( 5 mmol/L ) induced a 40 % increase in IL-1beta induced IL-8 secretion and a 35 % increase in tumor necrosis factor (TNF)-alpha induced IL-8 secretion, respectively ... The addition of LCFA ( 5 mmol/L ) induced a 140 % increase in IL-1beta induced IL-8 secretion and a 110 % increase in TNF-alpha induced IL-8 secretion, respectively
Brasier et al., J Biol Chem 1998 : A promoter recruitment mechanism for tumor necrosis factor-alpha induced interleukin-8 transcription in type II pulmonary epithelial cells
Kim et al., Eur J Pharmacol 2009 (Inflammatory Bowel Diseases) : TNF-alpha induced mRNA induction of the chemokines, monocyte chemoattractant protein (MCP)-1 and interleukin (IL)-8 , and the intercellular cell adhesion molecule ( ICAM)-1, which are involved in adhesion between leukocytes and epithelial cells, was suppressed by M1-M4, and M1 was the most efficacious
Mitsuyama et al., J Bone Miner Res 2004 (Calcium Signaling) : Ion/PMA and TNF-alpha induced IL-8 mRNA expression
Kim et al., Mol Cells 2012 (Inflammation) : The human colon cell line, HT-29, increased interleukin (IL)-8 expression in response to recombinant human tumor necrosis factor (TNF)-alpha , but not in response to bacterial ligands and interferon (IFN)-gamma
Snoeks et al., Lab Invest 2009 (Colitis...) : In FOXO3 silenced HT-29 cells, TNFalpha induced IL-8 expression is increased approximately 83 % ... In summary, TNFalpha inactivates FOXO3 in intestinal epithelia through the PI3K and IKK pathways and FOXO3 inactivation leads to the upregulation of IL-8 in vitro ; in vivo Foxo3 is in the cytosol of inflamed colonic epithelia and Foxo3 deficiency leads to severe intestinal inflammation
Lafleur et al., Infect Immun 1998 : Our findings support a role for P. haemolytica LPS and TNF-alpha in the induction of IL-8 from bovine alveolar macrophages
Redl et al., J Infect Dis 1993 (Escherichia coli Infections...) : Interleukin-8 release in baboon septicemia is partially dependent on tumor necrosis factor ... The role of tumor necrosis factor (TNF) in interleukin (IL)-8 release in septicemia in the baboon ( 2-h infusion of live Escherichia coli, 5 x 10 ( 8 ) cfu/kg ) was investigated
Werth et al., J Invest Dermatol 2003 : Although interleukin-12 is considered to act primarily on lymphocytes, provoking a shift from T helper 2 to T helper 1 cells and an increase in lymphocyte derived tumor necrosis factor alpha, we hypothesized that interleukin-12 might also affect tumor necrosis factor alpha secretion from skin cells ... Remarkably, the exogenous interleukin-12 totally blocked ultraviolet-B induced tumor necrosis factor alpha production ... Thus, interleukin-12 strongly inhibits tumor necrosis factor alpha production by noninflammatory skin cells, mostly or entirely through inhibition of gene transcription via an element within the first 1.2 kb of the tumor necrosis factor alpha promoter
Ogawara et al., Arthritis Res Ther 2006 : RGD targeted adenovirus delivered the dnIkappaB via alphavbeta3 to become functionally expressed, leading to complete abolishment of TNF-alpha induced up-regulation of E-selectin, ICAM-1, VCAM-1, IL-6, IL-8 , VEGF-A and Tie-2
Boylan et al., J Clin Invest 1992 (Pleurisy) : As expected, tumor necrosis factor-alpha also led to the appearance of IL-8 in the rabbit pleural space and stimulated cultured pleural mesothelial cells to synthesize and release IL-8
Dauletbaev et al., Respiration 2010 (Cystic Fibrosis) : Both TNF-alpha and IL-1beta activated NF-kappaB and stimulated IL-8 production ... The present data do not support the hypothesis that ibuprofen down-regulates IL-8 production in response to TNF-alpha and IL-1beta in CF respiratory epithelium
Ogura et al., J Oral Pathol Med 2005 (Disease Progression...) : Production of interleukin (IL)-8 , growth related oncogene ( GRO ) -alpha, monocyte chemoattractant protein (MCP)-1, and regulated upon activation normal T-cell expressed and secreted ( RANTES ) protein by synovial fibroblasts was increased by TNF-alpha
Sadowska et al., Pharmacol Res 2006 : Neutrophils from healthy volunteers ( NAC naïve ) were pre incubated with NAC for 30 min and the effects on the release of elastase and IL-8 , the respiratory burst in response to fMLP and PMA, on TNFalpha induced NFkappaB activation and on the migration across an endothelial-epithelial bilayer were investigated
Marcet et al., J Cell Physiol 2007 : Furthermore, UTP had no effect on interleukin-(IL)-8 release and reduced the release of both CCL20 and IL-8 induced by TNF-alpha and LPS
Carolan et al., Am J Respir Cell Mol Biol 1996 : Although all three epithelia produced low amounts of IL-8 constitutively, the capacity of IL-1 and TNF alpha to induce transepithelial migration was directly associated with the ability of the epithelia to produce large amounts of IL-8 in response to IL-1 and TNF alpha
Chaudhary et al., J Biol Chem 1996 : Interleukin-8 (IL-8) , a potent neutrophil chemotactic peptide that elicits pleiotropic biological effects is secreted in large amounts by normal human osteoblastic and bone marrow osteoprogenitor stromal ( HBMS ) cells in response to IL-1beta and tumor necrosis factor-alpha
Borgatti et al., J Biomed Biotechnol 2010 (Cystic Fibrosis) : Induction by TNF-a of IL-6 and IL-8 in cystic fibrosis bronchial IB3-1 epithelial cells encapsulated in alginate microbeads
Bian et al., Exp Eye Res 2001 (MAP Kinase Signaling System) : In this study, the roles of p38 kinase and extracellular signal regulated kinase ( ERK ) signaling pathways were investigated for IL-1beta- or TNF-alpha induced IL-8 and MCP-1 secretion by hRPE cells
Zheng et al., Infect Immun 2008 : However, the increase in IL-8 secretion was independent of Campylobacter stimulated TNF-alpha secretion
Monick et al., Am J Physiol 1994 : Dexamethasone blocks the induction of IL-6 and IL-8 by IL-1 or TNF ... Both IL-1 and TNF increased release of IL-6 and IL-8 from the cells in a dose dependent manner and dexamethasone inhibited this effect
Bai et al., World J Gastroenterol 2004 : Probiotics inhibit TNF-alpha induced interleukin-8 secretion of HT29 cells
Spratte et al., Mol Hum Reprod 2013 : Unfractionated heparin significantly suppressed the TNF-a induced and NF-?B mediated secretion and expression of IL-8 and -6 as well as other molecules in decidualized and undifferentiated human ESCs
Pantschenko et al., Oncol Rep 2003 (Breast Neoplasms) : To begin to test this hypothesis, we evaluated the ability of : a ) human breast cancer cell lines ( BCC ) and normal human breast epithelial cell lines ( BEC ) to produce IL-8 in vitro ; and b ) IL-1 and TNF to regulate the expression of IL-8 ... TNF-alpha and TNF-beta induced a 3- to 24-fold increase in IL-8 protein expression of BEC, and a 2- to 8-fold increased IL-8 expression in estrogen independent BCC cell lines and no significant IL-8 expression in estrogen dependent cell lines
Lee et al., Curr Eye Res 2013 : Purpose : To investigate the effects of rapamycin on the TNF-a induced secretion of interleukin-6 (IL-6) and IL-8 in orbital fibroblasts and its possible mechanism ... Results : Rapamycin significantly enhanced TNF-a induced IL-6 and IL-8 secretion from orbital fibroblasts ... Down-regulation of PDCD4 by PDCD4 siRNA transfection reduced TNF-a induced IL-6 and IL-8 secretion from orbital fibroblasts ... Conclusion : Rapamycin enhances the TNF-a induced secretion of IL-6 and IL-8 by suppressing PDCD4 degradation in orbital fibroblasts
Kaplanski et al., J Immunol 1997 (Inflammation) : Although IL-1 and TNF-alpha also induce IL-8 and E-selectin, the thrombin effects in these experiments were not mediated by those cytokines, since neither IL-1 receptor antagonist nor anti-TNF-alpha Ab inhibited the effects of thrombin
Mukaida et al., J Biol Chem 1990 (Inflammation) : Among cytokines, only IL-1 and tumor necrosis factor (TNF) can induce IL-8 gene expression at the transcriptional level ... Transfection of a human fibrosarcoma cell line with chloramphenicol acetyltransferase expression plasmids linked to a 5'-flanking deletion mutants of the IL-8 gene demonstrated that the nucleotides between -94 and -71 base pairs from the start of the first exon are essential and sufficient for the IL-8 induction by either IL-1, TNF , or phorbol 12-myristate 13-acetate
Malhotra et al., Am J Respir Cell Mol Biol 2001 : Geldanamycin inhibited tumor necrosis factor (TNF)-alpha mediated IL-8 gene expression in A549 human respiratory epithelial cells as measured by enzyme linked immunosorbent assay and Northern blot analyses ... These results demonstrate that geldanamycin inhibits TNF-alpha mediated IL-8 gene expression in A549 cells by inhibiting activation of the IL-8 promoter
Hildebrand et al., Unfallchirurg 2005 (Inflammation...) : TNF-alpha and IL-1beta are early regulators of the immune response and both induce the release of secondary cytokines, such as IL-6 and IL-8
Al Haj Zen et al., Circ Res 2010 (Disease Models, Animal...) : In cultured human monocytes, Dll4 induces the transcription of Notch target gene Hes-1 and inhibits the basal and tumor necrosis factor-alpha stimulated production of interleukin-8 , the human functional homolog of murine CXCL1
Lee et al., International journal of molecular sciences 2012 : AP also effectively reduced TNF-a induced mRNA expressions of monocyte chemoattractant protein (MCP)-1 and interleukin (IL)-8 in a dose dependent manner
Cornell et al., Am J Physiol Lung Cell Mol Physiol 2009 (MAP Kinase Signaling System) : Ceramide dependent PP2A regulation of TNFalpha induced IL-8 production in respiratory epithelial cells ... TNFalpha stimulates IL-8 production in respiratory epithelial cells by activating both the NF-kappaB and MAP kinase pathways ... Inhibition of PP2A using okadaic acid or gene knockdown using siRNA resulted in an augmentation of TNFalpha induced IL-8 production
Gowen et al., Endocrinology 1990 : Human osteoblast cultures derived as out-growths from trabecular bone released tumor necrosis factor ( TNF alpha ) upon stimulation of the cells with human recombinant interleukin 1 ( IL1 ; 10 ( -13 ) -10 ( -11 ) M ), human recombinant granulocyte-macrophage colony stimulating factor ( 100-1000 U/ml ), and bacterial lipopolysaccharide ( 5-500 ng/ml )
Fulcher et al., Am J Physiol Lung Cell Mol Physiol 2009 (Cystic Fibrosis) : CF and non-CF cell lines produced similar levels of IL-8 at baseline and equally increased IL-8 secretion in response to IL-1beta, TNF-alpha , and the Toll-like receptor 2 agonist Pam3Cys
Cabello et al., Free Radic Biol Med 2009 (Melanoma...) : CA, but not Michael-inactive derivatives, inhibited NF-kappaB transcriptional activity and TNFalpha induced IL-8 production in A375 cells
Ding et al., Biochem Biophys Res Commun 1997 : Protein tyrosine kinase ( PTK ) inhibitor genistein at concentrations of 150, 300, and 450 microM dose-dependently reduced LPS- and TNF-alpha induced IL-8 expression by 29.43, 43.8, and 47.3 % and 20.5, 49.9, and 61.8 % respectively, whereas HP toxin induced IL-8 secretion could only be reduced at 450 microM by 35.7 %
Villacres et al., J Infect Dis 2012 (HIV Infections...) : Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure interleukin 1ß (IL-1ß), interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 12 (IL-12), and tumor necrosis factor a (TNF-a) responses to Toll-like receptor (TLR) 3 and TLR4 stimulation
Hessle et al., Inflammation 2003 (Inflammation) : We have seen that Gram-positives preferentially induce IL-12 and TNF-alpha , whereas Gram-negatives induce more IL-10, IL-6, and IL-8
Sendt et al., Surg Infect (Larchmt) 2002 (Peritonitis) : Stimulation with TNF-alpha led to a time dependent increase of IL-8 secretion to the apical compartment resulting in a gradient between both chambers, as well as to a time dependent increase of PMN transmigration and expression of adhesion molecules
Fujisawa et al., J Immunol 1998 : Staphylococcal enterotoxin A-induced injury of human lung endothelial cells and IL-8 accumulation are mediated by TNF-alpha
Sur et al., Arch Dermatol Res 2008 (Dermatitis, Contact...) : Furthermore, cells treated with avenanthramides showed a significant inhibition of tumor necrosis factor-alpha (TNF-alpha) induced NF-kappaB luciferase activity and subsequent reduction of interleukin-8 (IL-8) release
Kolios et al., Br J Pharmacol 1996 : In contrast, IL-10 had no effect on either IL-1 alpha or TNF-alpha induced IL-8 production
Hattar et al., Crit Care Med 2006 (Sepsis...) : Lipoteichoic acid (LTA) from Staphylococcus aureus stimulates human neutrophil cytokine release by a CD14 dependent, Toll-like-receptor independent mechanism : Autocrine role of tumor necrosis factor- [ alpha ] in mediating LTA induced interleukin-8 generation
Carlo et al., J Pediatr 2011 (Cerebral Palsy...) : The analyses were focused on 5 cytokines ( interleukin [ IL] 1ß ; IL-8 ; tumor necrosis factor-a ; regulated upon activation, normal T-cell expressed, and secreted ( RANTES ) ; and IL-2 ) reported to be most predictive of CP in term and late preterm infants
Jobin et al., J Immunol 1999 (Cell Transformation, Viral) : We characterized the effect of a dominant negative TRAF-2 delivered by an adenoviral vector ( Ad5dnTRAF-2 ) on the cytokine signaling cascade in several IEC and also investigated whether inhibiting the TRAF-2 transmitting signal blocked TNF-alpha induced NF-kappa B and IL-8 gene expression ... Induction of IL-8 gene expression by TNF-alpha was partially inhibited in Ad5dnTRAF-2 transfected HT-29, but not in control Ad5LacZ infected, cells
Männel et al., Rev Infect Dis 1987 : No TNF induced production of interleukin 1 ( which can induce similar effects ) was detected in macrophage/monocyte cultures
Tsuchiya et al., J Pharmacol Exp Ther 2010 (Arthritis, Rheumatoid) : TNFalpha stimulation induced production of inflammatory cytokines such as IL-6 and IL-8 in RSF, and the extent of IL-6 and IL-8 induction was dramatically reduced by CHPD under noncytotoxic concentrations
Cho et al., Int J Mol Med 2007 : However, it was unknown whether curcumin, showing inhibitory effects on NF-kappaB and MAPKs, attenuates the expression of TNF-alpha induced IL-1beta, IL-6, IL-8 , and TNF-alpha as well as cyclin E expression in HaCaT cells ... We found that curcumin inhibited the expression of TNF-alpha induced IL-1beta, IL-6, and TNF-alpha, but not IL-8 , in TNF-alpha treated HaCaT cells as well as the TNF-alpha induced cyclin E expression
Kaplan et al., J Dermatol Sci 1995 : NHEK cells spontaneously secrete IL-8 ( 243.4 +/- 55.5 pg/ml ), and this baseline level was augmented by TNF-alpha alone, or synergistically by TNF-alpha and IFN-gamma, which are thought to be secreted by T cells
Mo et al., Exp Eye Res 1999 (Uveitis) : In the present study, we investigated the role of IL-8 and MCP-1 and regulation of these chemokines by TNFalpha and IL-1 in LPS induced uveitis in rabbits
Gosset et al., Eur Respir J 1999 : Depletion of intracellular GSH by treatment with buthionine sulphoximine ( BSO ) reached 45.2 % after 3 h and was nearly complete at 24 h. Whereas a 24-h preincubation of AMs with BSO significantly increased LPS induced secretion of TNF-alpha and IL-8, a 3-h preincubation only enhanced LPS stimulated production of IL-8 ( p < 0.05 )
Bryan et al., Lipids 2006 : DHA and CLA significantly decreased the production of IL-8 in response to stimulation by TNF-alpha [ 2907 +/- 970 ( DHA ) and 6471 +/- 1203 ( CLA ) vs. 12,287 +/- 2309 ( control ) pg/mL ; P < or = 0.05, mean +/- SEM ], whereas both EPA and DHA reduced histamine stimulated RANTES ( regulation on activation, T cell expressed and -secreted ) production [ 2314 +/- 861 ( EPA ) and 877 +/- 326 ( DHA ) vs. 8526 +/- 1118 ( control ) pg/mL ; P < or = 0.03 ]
Fioretti et al., ACS Nano 2010 : Lipopolysaccharide (LPS) stimulated fibroblasts incubated with PGA-alpha-MSH showed an early time dependent inhibition of TNF-alpha , a late induction of IL-10, and no effect on IL-8 secretion
Taniguchi et al., Mol Cell Endocrinol 2009 (Endometriosis) : By transfection of TAK1 siRNA, TNFalpha induced phosphorylation of IkappaBalpha, JNK1/2, and p38MAPK, as well as IL-6 or IL-8 expression, were repressed
Chang et al., J Dent Res 2005 : Consistently, both TNF and LPS rapidly induced the expression of the NF-kappaB dependent gene interleukin-8 (IL-8)
Van Damme et al., J Invest Dermatol 1990 : This study focuses on interferon-beta (IFN-beta), interleukin-6 (IL-6), and interleukin-8 (IL-8) production by fibroblasts and epithelial cells in response to interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha)
Gerritsen et al., Am J Pathol 1995 (Inflammation) : Apigenin also inhibited IL-1 alpha induced prostaglandin synthesis and TNF-alpha induced IL-6 and IL-8 production, suggesting that the hydroxyflavones may act as general inhibitors of cytokine induced gene expression
Smith et al., J Immunol 1996 : TGF-beta 1 treatment did not significantly alter the TNF induced IL-8 mRNA stability, suggesting that the mechanism of action of TGF-beta 1 is on gene transcription
Ohira et al., Digestion 1997 : We investigated the production of interleukin-8 (IL-8) and chemotactic activity released from Chang liver cells subjected to long-term treatment with ethanol ( Et ) and subsequent stimulation with tumor necrosis factor-alpha (TNF-alpha)
Netea et al., Eur J Immunol 2000 (Chlamydia Infections) : Neutralization of TNF by TNF binding protein and blockade of IL-1 receptors by IL-1 receptor antagonist revealed that TNF, IL-1 and IL-6 production was independent from each other, whereas IL-8 synthesis was strongly dependent on endogenous TNF and IL-1
Jones et al., Am J Respir Cell Mol Biol 2002 : In addition, IL-17 was found to synergistically enhance TNF-alpha induced production of IL-8 , Groalpha, and G-CSF