Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Jacobsen et al., Stem Cells 1994 : TNF-alpha , the great imitator : role of p55 and p75 TNF receptors in hematopoiesis
Li et al., Science 1999 : Mouse embryonic fibroblast cells that were isolated from IKK2-/- embryos showed a marked reduction in tumor necrosis factor-alpha (TNF-alpha)- and interleukin-1alpha induced NF-kappaB activity and an enhanced apoptosis in response to TNF-alpha
Dionne et al., Biochem Biophys Res Commun 1998 : These findings suggest a role for TNF-alpha in the regulation of intestinal epithelial cell growth and that the mitogenic effect of TNF-alpha requires protein tyrosine phosphorylation and MAPK activation
Ju et al., Chin Med J (Engl) 2007 (Pulmonary Disease, Chronic Obstructive) : Since TNF-alpha converting enzyme (TACE) is involved in the activation of both TNF-alpha and ErbB3, we established rat models of COPD to investigate the expressions of TACE, TNF-alpha and ErbB3 and to explore the correlations among TACE, TNF-alpha and ErbB3 respectively
Qin et al., Glia 2007 (Disease Models, Animal...) : Systemic TNFalpha and LPS administration activated microglia and increased expression of brain pro-inflammatory factors ( i.e., TNFalpha , MCP-1, IL-1beta, and NF-kappaB p65 ) in wild-type mice, but not in TNF R1/R2 ( -/- ) mice
Azuma et al., J Biol Chem 2000 (Bone Resorption) : The osteoclast progenitors expressed TNF receptors, p55 and p75 ; and the induction of TRAP positive MNCs by TNF-alpha was inhibited completely by an anti-p55 antibody and partially by an anti-p75 antibody
Belloni et al., Parasitol Res 2000 : Thus, in contrast to the results obtained in murine models but in accordance with those observed in other human models, the present study shows for the first time in human monocytic cells that T. gondii does not induce any TNF-alpha secretion and inhibits TNF-alpha production induced by IFN-gamma/LPS
Hideshima et al., Oncogene 2001 (MAP Kinase Signaling System...) : Importantly, the proteasome inhibitor PS-341 abrogated TNFalpha induced NF-kappaB activation, induction of ICAM-1 or VCAM-1, and increased adhesion of MM cells to BMSCs. Agents which act to inhibit TNFalpha may therefore abrogate the paracrine growth and survival advantage conferred by MM cell adhesion in the BM microenvironment
Nakamura et al., Eur Respir J 1996 : Phorbol ester upregulated and TNF-alpha down-regulated the TNF-R gene expression in A549 cells
Wang et al., Pflugers Arch 2006 (Inflammation) : In contrast, TNF-alpha induced rapid and substantial increases in expression of the genes encoding IL-6, MCP-1, NGF and TNF-alpha itself ; IL-6 and TNF-alpha mRNA levels peaked at 2 h with 75-fold and 600-fold increases, respectively
Viswanathan et al., Proc Natl Acad Sci U S A 2005 : An additional stress induced increase in infiltration was observed for neutrophils, in response to TNF-alpha , macrophages, in response to TNF-alpha and LTN, and natural killer cells and T cells in response to LTN
Ciallella et al., Eur J Pharmacol 2005 : CEP-11004 also inhibited TNF-alpha production in lipopolysaccharide stimulated microglial cells, but did not inhibit the initial increase in TNF-alpha mRNA expression as measured by real-time polymerase chain reaction ( PCR )
Warshamana et al., Exp Mol Pathol 2001 : TNF-alpha , PDGF, and TGF-beta(1) expression by primary mouse bronchiolar-alveolar epithelial and mesenchymal cells : tnf-alpha induces TGF-beta(1)
Yang et al., Proc Natl Acad Sci U S A 2005 : We report that the common action of these drugs is to block the TNF-alpha dependent binding of TNF receptor 1 to TNF receptor associated death domain
Chen et al., Phytother Res 2009 : In vitro studies showed that LBP and LBPF1-5 activated transcription factors NF-kappaB and AP-1 by RAW264.7 macrophage cells, induced TNF-alpha , IL-1beta, IL-12p40 mRNA expression, and enhanced TNF-alpha production in a dose dependent manner
Majumdar et al., Folia Microbiol (Praha) 2000 (Mycobacterium Infections) : TNF-alpha is probably required for the production of NO in J774A.1 cells by IFN-gamma and LPS but TNF-alpha and NO are independently involved in the killing of intracellular M. microti with IFN-gamma and LPS
Zhang et al., J Clin Endocrinol Metab 2001 : TNF alpha increased the messenger ribonucleic acid levels of ICE, TNF alpha , IL-1 beta, bcl-2, and NF kappa B in preadipocytes and adipocytes ( P < 0.01 )
Venza et al., J Periodontol 2010 (Chronic Periodontitis...) : These findings showed that : 1 ) in subjects without diabetes and patients with well controlled diabetes, TNF-alpha , CCR5, and CXCR3 may constitute distinctive biomarkers of P-IM; 2 ) poor glycemic control abolished the differences between CP and P-IM regarding the expression of these mediators ; and 3 ) type 2 diabetes affected the expression of TNF-alpha , IL-6 and -8, CCR5, and CXCR3
McLeish et al., J Leukoc Biol 1998 : TNF-alpha stimulated a dose dependent increase in ERK and p38 MAPK activities that was maximal at 10 min. JNKs were not stimulated by TNF-alpha or GM-CSF
Fernando et al., Shock 2000 : Although LPS induced TNFalpha production in LPS-tolerant cells was suppressed relative to the naive cells, okadaic acid induced comparable levels of TNFalpha in tolerant and naive cells
Powell et al., J Am Soc Nephrol 1991 (Fever...) : We conclude that : ( 1 ) plasma IL-1 beta and TNF-alpha are not chronically elevated in chronic renal failure, continuous ambulatory peritoneal dialysis, or HD patients ; ( 2 ) HD with new Cuprophan or cellulose triacetate membranes and high concentrations of dialysate endotoxin and bacteria does not cause elevation of circulating IL-1 beta or TNF-alpha ; and ( 3 ) pyrogenic reactions might be mediated by TNF-alpha
Luo et al., Infect Immun 1993 : The binding of labeled TNF-alpha to these bacterial receptors can be inhibited by cold TNF-alpha but not by cold TNF-beta
Saperstein et al., J Interferon Cytokine Res 2009 (Inflammation) : In this study, the impact of IL-1beta on TNF-alpha mediated chemokine production as well as TNF receptor surface expression and shedding were investigated from mouse pulmonary epithelial cells ( MLE-15 )
Raabe et al., J Biol Chem 1998 : A ribosomal sedimentation assay and an RNA transfection assay revealed that the translation rate of endogenous as well as transiently transfected TNF-alpha mRNAs increases only approximately 2-3-fold after stimulation with lipopolysaccharide for 2 h. Taken together, these results suggest that the large increase in the level of secreted TNF-alpha protein in RAW 264.7 cells is due primarily to activation of TNF-alpha gene transcription
Cho et al., J Cell Physiol 2010 (Calcinosis) : In this study, we determined the effect of TNF-alpha on osteogenic differentiation of stromal cells derived from human adipose tissue ( hADSC ) and the role of NF-kappaB activation on TNF-alpha activity
Fukuda et al., Leuk Res 1993 (Leukemia, Myelomonocytic, Acute...) : nIL-1, IFN gamma and TNF alpha could not differentiate between any of the cell lines but IFN gamma and TNF alpha induced monocytic surface antigens
Herbein et al., J Virol 1996 : These results demonstrate that TNFalpha is able to enhance host cellular resistance to HIV-1 infection and that selective inhibition of HIV-1 entry into primary TCDM by TNFalpha involves the 75-kDa TNF receptor but not the 55-kDa TNF receptor
Granger et al., Biochim Biophys Acta 2000 : Whilst the expression of JunD was not affected by any of the mediators, the mRNA levels of c-fos and JunB were induced by LPS, IL-6, IFN-gamma, PDGF and TNF-alpha , and that of c-jun by LPS, IFN-gamma, PDGF and TNF-alpha
Aggarwal et al., Nature 1985 (Uterine Cervical Neoplasms) : The binding of labelled TNF-alpha to these cells can be inhibited by both TNF-alpha and TNF-beta but not by gamma-interferon ( IFN-gamma )
Baker et al., Eur J Immunol 1994 (Encephalomyelitis, Autoimmune, Experimental) : Although biologically-active TNF was not detected in the circulation, TNF-alpha was detected in lesions within the central nervous system ( CNS )
De Bandt et al., Metabolism 1994 : These results indicate that ( 1 ) in the conditions of the study, IL-1 beta has no direct effect on hepatic amino acid exchanges and utilization ; ( 2 ) TNF alpha which exerted an inhibitory effect on these parameters, could be involved in the reduced amino acid exchanges during the end stage of sepsis ; ( 3 ) the TNF alpha induced increase in glucose uptake could be related to an inhibition of gluconeogenesis and/or to the activation of glucose utilization by Kupffer cells ; ( 4 ) IL-1 beta and TNF alpha both potentiate the action of glucagon on hepatic amino acid uptake and utilization ; and ( 5 ) complex interactions between Kupffer cells and hepatocytes on the one hand and between cytokines and hormones on the other hand could account for the differences in hepatic metabolism according to the stage of the response to injury
Lodato et al., J Immunother Emphasis Tumor Immunol 1995 (Hypotension) : TNF-alpha induced a marked drop in SAP in all three dogs ( mean decrease = 59.3 +/- 5.2 mm Hg ; to 61.5 % of baseline ; p = 0.008 ) ; whereas TNF-SAM2 caused a smaller and transient drop in SAP in four dogs ( mean decrease = 25.5 +/- 10.1 mm Hg ; to 81.2 % of baseline ; p = 0.086 )
Milosevic et al., Eur J Pharmacol 2000 : In hepatocyte cultures, the combined Pb/lipopolysaccharide treatment induced no significant increase in the release of the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) whereas in Kupffer cell cultures and in cocultures, at low lipopolysaccharide levels ( 0.1 and 1 ng/ml ), TNF-alpha release was synergistically increased ( up to 30-fold ) when compared to lipopolysaccharide exposure alone
Watts et al., J Leukoc Biol 1999 : In this study we have investigated some aspects of the regulation of expression and biological activity of transmembrane TNF-alpha by both soluble TNF-alpha receptors ( sTNF-alphaR ) and inhibitors of TNF-alpha processing
Jirillo et al., J Endotoxin Res 2002 (Toxemia) : An exaggerated production of TNF-alpha has been reported in murine viral infections, in which mice become sensitized to low amounts of LPS and both interferon (IFN)-gamma and IFN-alpha/beta are involved in the macrophage induced release of TNF-alpha
Meldrum et al., Am J Physiol Heart Circ Physiol 2002 (Kidney Diseases...) : TNF-alpha protein expression, TNF-alpha mRNA induction , and neutrophil infiltration increased significantly in both kidneys after unilateral renal I/R injury
Kotanidou et al., J Appl Physiol 1996 (Endotoxemia) : Urethan neither directly bound LPS by Limulus assay nor inhibited LPS stimulated TNF-alpha mRNA expression in cultured mouse peritoneal macrophages, but TNF-alpha mRNA expression was suppressed by serum from a urethan treated rat
Golovko et al., Life Sci 2005 (Adenocarcinoma...) : Transcriptional activation of TNF-alpha gene by calcitriol or CB1093 does not lead to TNF-alpha protein secretion, however calcitriol and CB1093 enhance TPA stimulated TNF-alpha production in LNCaP cells
Binder et al., Anticancer Res 1999 (Adenocarcinoma...) : Activation of the intracellular `` death domain '' ( DD ) of the 55kD-TNF alpha-receptor by TNF alpha initiates signal and effector cascades with pro- and anti-apoptotic function
Sheng et al., Acta Cardiol 2009 (Dilatation, Pathologic...) : The expression of TLR4, TNF-alpha and IL-6 in the myocardium significantly increased in the MI group and simvastatin markedly inhibits the expression of TLR4, TNF-alpha , and IL-6 in the myocardium after MI. Serum TNF-alpha and IL-6 levels between the MI group and the simvastatin group remained unchanged
Fotheringham et al., Eur J Pharmacol 2004 : Activation of adenosine receptors inhibits tumor necrosis factor-alpha release by decreasing TNF-alpha mRNA stability and p38 activity
Liu et al., Planta Med 2005 : Phthalide Lactones from Ligusticum chuanxiong inhibit lipopolysaccharide induced TNF-alpha production and TNF-alpha mediated NF-kappaB Activation
Rossol et al., J Immunol 2007 : Several lines of evidence indicated that signaling through TNFR1/2 and through mTNF ( reverse signaling ) is involved in TNF-alpha production by monocytes after T cell contact : 1 ) blocking mTNF on activated T cells leads to a significant reduction in TNF-alpha production ; 2 ) down-regulation of TNFR1/2 on monocytes by transfection with small interfering RNA results in diminished TNF-alpha production ; 3 ) blocking or down regulating TNFR2 on activated T cells inhibits TNF-alpha production, indicating that mTNF on the monocyte surface mediates signaling ; 4 ) ligation of mTNF on monocytes by surface TNFR2 transfected into resting T cells induces TNF-alpha production due to reverse signaling by mTNF ; and 5 ) ligation of mTNF on monocytes by a soluble TNFR2 : Ig receptor construct induces TNF-alpha production due to reverse signaling
Lisby et al., Exp Dermatol 2002 : The signalling mechanisms involved in both IL-1beta- and TNF-alpha mediated regulation of TNF-alpha are critically dependent upon protein kinase C ( PKC ), as demonstrated by blocking studies using protein kinase inhibitors
Oberyszyn et al., Mol Carcinog 1998 (Inflammation...) : Reverse transcription-polymerase chain reaction and immunohistochemical techniques were used to demonstrate that 24 h to 1 wk after UVB-light irradiation, PTX inhibited UVB induced TNF-alpha gene expression, inhibited the increase in epidermal TNF-alpha protein synthesis, blocked the increase in epidermal proliferation observed after exposure to UVB light, and decreased production of myeloperoxidase by neutrophils infiltrating into the dermis
Chen et al., Kidney Int 1998 : Together the results suggest that TNF alpha is a negative regulator of the hREN expression in the adrenal cells, and that the TNF alpha responsiveness may be controlled by elements located between the positions -3916 and -2822 of the hREN promoter
Zhou et al., Cell Mol Neurobiol 2010 (MAP Kinase Signaling System) : In this study, we found knockdown Src suppressed protein kinase C substrate ( SSeCKS ) expression suppressed TNF-alpha production induced by TNF-alpha , overexpression of SSeCKS could promoted TNF-alpha autocrine in SCs
Pei et al., Osteoarthritis Cartilage 2006 (Chondrosarcoma) : IL-1beta and TNFalpha strongly induced the expression of MMP-1 and -13 in SW1353 cells and HACs, whereas only TNFalpha was found to induce the expression of these two MMPs in JJ012 cells
Engers et al., Br J Cancer 1996 (Sarcoma) : The antiproliferative effect of TNF-alpha was mediated by TNF receptor 1(TNF-R1) and correlated positively with both the number of TNF-R1 per cell and receptor affinity
Pushparaj et al., J Immunol 2009 (Inflammation...) : In wild-type macrophages, TNF-alpha colocalizes with VAMP8 positive vesicles, and in VAMP8-deficient macrophages, the TNF-alpha release is inhibited
Pettigrew et al., Journal of neuroinflammation 2008 (Brain Infarction...) : In TNFalpha-Tg rat brain, the aggregate mouse and rat TNFalpha mRNA level was fourfold higher than in non-Tg littermates and the corresponding TNFalpha protein level was increased fivefold ( p < or= 0.01 )
Jiang et al., Chin Med Sci J 1997 (Shock, Hemorrhagic) : The results were : 1. expression of TNF alpha , IL-1 beta, IL-6 mRNA in vital organs successively increased after hemorrhagic shock and resuscitation, and TNF alpha expression was the first to appear followed by IL-1 beta
Podolin et al., J Immunol 2002 (Acute Disease...) : In addition, in the more robust LPS- and OVA induced arthritis models, which were characterized by increased levels of proinflammatory mediators in the synovial fluid, TNF-alpha , IL-8, PGE ( 2 ), leukotriene B ( 4 ), and leukotriene C ( 4 ) levels were significantly reduced, as was erythrocyte sedimentation rate, possibly as a result of the observed decreases in serum TNF-alpha and IL-8 levels
Hide et al., J Immunol 1997 : In Ag-stimulated cells, azelastine also inhibited TNF-alpha mRNA expression, TNF-alpha protein synthesis and release, and, possibly related to these effects, Ca2+ influx
Kwon et al., Biochem Biophys Res Commun 2003 : Using transient transfection, it was found that myeloid differentiation protein ( MyD88 ) and tumor necrosis factor receptor associated factor 6 are commonly required for activation of the TNF-alpha promoter by various CpG-ODNs with different potencies
Baumann et al., J Orthop Res 2005 (Osteolysis) : In comparison, LPS induced a much greater activation of NF-kappaB and TNFalpha promoters, and TNFalpha secretion into the supernatant was strongly induced
Boehm et al., Exp Dermatol 1996 (Dermatitis, Toxicodendron...) : The data provide evidence for an in vivo role for epidermal IL-1 alpha, IL-1 beta and TNF-alpha transcription in the regulation of IL-1 beta and TNF-alpha polypeptide levels in the epidermis in response to this common contact allergen
Hsu et al., Biochem Biophys Res Commun 2000 (Breast Neoplasms) : Activation of NF-kappa B by TNF-alpha mediates many functions of TNF-alpha
Togashi et al., J Hypertens 2000 (Body Weight...) : The aim of this study was to determine the role of tumor necrosis factor-alpha (TNF-alpha) in skeletal muscle tissue in insulin resistance and hypertension and the effect of anti-hypertensive medicine on skeletal muscle TNF-alpha in fructose induced insulin-resistant and hypertensive rats ( fructose fed rats : FFR )
Ikeda et al., Hepatology research : the official journal of the Japan Society of Hepatology 2008 : In cultured BEC, TNF-alpha , interleukin (IL)-1beta, IL-6, and interferon-gamma induced the expression of CDX2 mRNA, though only TNF-alpha additionally induced the expression of MUC2 mRNA
Hammond et al., Spinal Cord 2007 (Granuloma...) : Thalidomide is an immunomodulatory agent that acts to inhibit production of tumor-necrosis factor-alpha (TNF-alpha) , an important mediator in CNS inflammation, by enhancing TNF-alpha mRNA degradation
Frost et al., Endocrinology 2003 : The purpose of the present study was to determine whether LPS alters the expression of TNF alpha and IGF-I in mouse skeletal muscle and whether TNF alpha directly inhibits IGF-I mRNA expression in C2C12 myoblasts
Khan et al., J Oral Pathol Med 2003 (Lichen Planus, Oral) : TNF-alpha stimulation down-regulated IFN-gamma secretion and up-regulated TNF-alpha secretion
Yoo et al., Am J Physiol Lung Cell Mol Physiol 2001 (Pneumonia) : A high dose of ASA blocked IL-1 beta- and TNF-alpha induced TNF-alpha and IL-8 expression, respectively
Im et al., Cancer Lett 2009 : Upon exposure to LTA purified from Staphylococcus aureus, TNF-alpha expression was substantially induced , whereas pretreatment with PhIP significantly inhibited LTA induced TNF-alpha expression
Haslberger et al., Mol Biol Cell 1992 : Increased extracellular K+ concentrations or K ( + ) -channel blockers, such as quinine, tetraethylammonium, or barium chloride, inhibited the LPS stimulated release of TNF alpha, as well as the accumulation of cell associated TNF alpha as found by enzyme linked immunosorbent assay analysis, but did not inhibit TNF alpha mRNA accumulation
Brennan et al., Br J Rheumatol 1992 (Arthritis, Rheumatoid) : During the ongoing inflammation in RA, TNF alpha ( and other mediators ? ) induce the production of soluble TNF-R which can act as natural inhibitors
Kumawat et al., J Biol Chem 2010 (Acquired Immunodeficiency Syndrome...) : Nef inhibits ASK1/p38 MAPK dependent Mtb induced TNF-alpha production probably by inhibiting binding of ATF2 to the TNF-alpha promoter
Theiss et al., Mol Biol Cell 2009 (Adenocarcinoma...) : We examined the effect of tumor necrosis factor alpha (TNF-alpha) , a cytokine that plays a central role in the pathogenesis of IBD, on PHB expression and the effect of sustained PHB expression on TNF-alpha activation of nuclear factor-kappa B (NF-kappaB) and epithelial barrier dysfunction, two hallmarks of intestinal inflammation
Dai et al., Chest 2005 (Alveolitis, Extrinsic Allergic...) : The effects of TNF-alpha are mediated by membrane TNF receptor ( mTNFR ) -1 and mTNFR-2, and can be blocked by soluble TNF receptor ( sTNFR ) -1 and sTNFR-2
John et al., Cytokine 2007 : Stimulation with TNF-alpha or TNF-alpha and IL-10 significantly inhibited collagen type II and increased IL-10 and TNF-alpha mRNA expression
Panja et al., Clin Exp Immunol 1995 : LPS, IFN-gamma or TNF-alpha had no effect on spontaneous IL-6 production, and neither resulted in the secretion of IL-1 beta or TNF-alpha
Rabinovici et al., Shock 2002 (Respiratory Distress Syndrome, Adult) : In vitro, mob-1 and TNF-alpha increased each other 's production in RAW 264.7 cells and mob-1 or TNF-alpha inhibition prevented endotoxin induced upregulation of TNF-alpha or mob-1, respectively, from these cells
Sun et al., World J Gastroenterol 2006 : VacA alone induced expression of TNF-alpha , IL-8 and IL-1beta, while NaCl alone induced expression of TNF-alpha and IL-1beta
Han et al., Int Immunopharmacol 2007 (Dermatitis, Irritant) : Moreover, TNF-alpha induced expression of cytokines, such as TNF-alpha and IL-1beta, and a chemokine, IL-8, were suppressed by silymarin treatment in human keratinocyte cell line, HaCaT
Neumark et al., Int J Cancer 2003 (Acute Disease...) : Furthermore, additional results demonstrated that monocytic cell derived TNFalpha upregulated MCP-1 secretion from the tumor cells and that MCP-1 in turn promoted the secretion of TNFalpha from monocytic cells
Rodríguez-Berriguete et al., BMC cancer 2010 (Disease Progression...) : Inhibitions of IAPs, IL-1alpha and TNFalpha might be a possible target for PC treatment since IAPs are the proteins that inhibited apoptosis ( favour proliferation ) and IL-1alpha and TNFalpha would affect all the transduction pathway involucrate in the activation of transcription factors related to survival or proliferation ( NF-kB, Elk-1 or ATF-2 )
Muranaka et al., Infect Immun 1997 (Mycoses...) : Expecting to inhibit TNF-alpha, we administered anti-TNF-alpha intraperitoneally at the dose completely inhibiting TNF-alpha in plasma ( 2 x 10 ( 4 ) U ), but the TNF-alpha level in BALF and the lethality increased
Meldrum et al., J Surg Res 2001 (Kidney Diseases...) : The effect of simulated ischemia on renal tubular cells was then determined by measuring the time course of TNF-alpha protein expression ( ELISA ), TNF-alpha mRNA induction ( RT-PCR ), and renal tubular cell apoptosis ( TUNEL )
Wu et al., Biochim Biophys Acta 1996 : These results demonstrate that the cPLA2 gene expression is up-regulated by TNF-alpha and this effect may contribute to the TNF-alpha stimulated AA release in airway epithelial cells
Misseri et al., American journal of physiology. Renal physiology 2005 (Inflammation...) : Renal obstruction induced increased tissue TNF-alpha and Fas ligand mRNA levels, TNF-alpha protein production, apoptotic renal tubular cell death, and elevated caspase 8 and 3 activity, whereas treatment with PEG-sTNFR1 significantly reduced obstruction induced TNF-alpha production, renal tubular cell apoptosis, and caspase activity
Jacobsen et al., Proc Natl Acad Sci U S A 1994 : Using agonists ( antibodies ) specific for the 55- and 75-kDa TNF receptors, we demonstrate differential roles of the two TNF receptors in hematopoiesis in that only the 55-kDa TNF receptor mediates antiproliferative effects of TNF-alpha on mature Lin- hematopoietic progenitor cells responding to granulocyte colony stimulating factor or interleukin 3 alone
Yamamoto et al., Nihon Kyobu Shikkan Gakkai Zasshi 1997 (Lung Diseases, Obstructive...) : These data suggest that TNF-alpha is involved with malnutrition in patients with COPD, and that TNF-alpha may cause a decrease in fat mass in patients with COPD
Tummala et al., J Mol Cell Cardiol 2000 : DPI also inhibited TNF and LPS induced VCAM-1 and ICAM-1 cell surface expression and TNF- alpha , LPS, or IL-1 beta induced VCAM-1 and ICAM-1 mRNA accumulation
Kawakami et al., Clin Exp Immunol 1996 (Cryptococcosis) : In contrast, administration of recombinant murine IL-12 markedly induced TNF-alpha production and the neutralizing anti-TNF-alpha MoAb strongly blocked IL-12 induced protection of mice against cryptococcal infection
Candela et al., Mol Cell Biochem 1993 : Fibroblast growth factor increases TNF alpha mediated prostaglandin E2 production and TNF alpha receptor expression in human fibroblasts
Branch et al., Int J Biochem Cell Biol 1996 : However, little is known of the production of TNF alpha isoforms from normal macrophages or of the effects of cytokines on TNF alpha production by macrophages in the absence of co-stimulation by lipopolysaccharide
Badiola et al., Neurobiol Dis 2009 : By using knock-out mice for TNF-alpha receptor 1, we show that the activation of both caspase-3 and -8 by TNF-alpha is mediated by TNF-alpha receptor 1
Dufour et al., Blood 2003 (Fanconi Anemia) : TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro
Angel et al., J Interferon Cytokine Res 1995 (Acquired Immunodeficiency Syndrome) : When PMA induced TNF-alpha activity and HIV-1 replication were blocked by the presence of soluble TNF receptors, IL-10 independently enhanced HIV-1 replication
Chida et al., Biochem Biophys Res Commun 2007 (Fever) : Peripheral TNFalpha , but not peripheral IL-1, requires endogenous IL-1 or TNFalpha induction in the brain for the febrile response
Mangalam et al., Int Immunopharmacol 2001 : GSTM stimulated spontaneous TNF-alpha production and inhibited LPS stimulated TNF-alpha production in 16 of 24 ( 75 % ) individuals of LPS-responsive group and one of six individuals ( 17 % ) of LPS-non-responsive group
Arenas et al., Am J Physiol Cell Physiol 2004 : These results indicate that ANG II, via AT(1)R, modulates the secretion of TNF-alpha and MMP-2 from endothelial cells and that TNF-alpha mediates the effects of ANG II on MMP-2 release
Coller et al., J Leukoc Biol 2001 : The PKC inhibitor H7 reduced LTA dependent secretion of TNF-alpha by 94 % but inhibited poly I:C dependent TNF-alpha production only by 50 %
Xiao et al., J Zhejiang Univ Sci B 2005 (Brain Edema...) : Compared with Group B, NF-kappaB activation ( P < 0.01 ), the levels of TNF-alpha protein ( P < 0.01 ) and the water content of brain ( P < 0.05 ) began to decrease obviously after injury in Groups C and D. Beta-Aescin could dramatically inhibit NF-kappaB activation and the expression of TNF-alpha protein in the rat brain, alleviate rat brain edema, and that could partially be the molecular mechanism by which beta-Aescin attenuates traumatic brain edema
Zhang et al., J Am Dent Assoc 2003 (Chronic Disease...) : The results showed that lipopolysaccharide and tumor necrosis factor alpha, or TNF-alpha , induced COX-2 in macrophages, while IL-1beta and TNF-alpha induced COX-2 in oral epithelial cells
Suo et al., J Neurosci 2004 (Alzheimer Disease...) : We found that there were two phases of dose dependent Abeta effects on microglial cells : at the threshold of 5 microm and above, Abeta directly induced tumor necrosis factor-alpha (TNF-alpha) release, and at subthreshold doses, Abeta indirectly potentiated TNF-alpha release induced by certain G-protein coupled receptor ( GPCR ) activators
Gazin et al., Toxicol Appl Pharmacol 2004 : The regulation of TNFalpha secretion involves TNFalpha mRNA accumulation at least through the stabilization of TNFalpha mRNA, but p38 MAPK did not appear to be involved in this stabilization
Mizutani et al., J Urol 1994 (Carcinoma, Renal Cell...) : The expression of TNF-alpha mRNA in R11 cells, but not the production of TNF-alpha protein, was induced by TNF-alpha
Parker et al., Infect Immun 1995 : Anti-CD14 monoclonal antibodies MY4 and 3C10 inhibited LPS binding protein and CD14 dependent activation of TNF-alpha production by LPS at LPS concentrations up to approximately 1.0 ng/ml. R-HDL ( 2 mg of protein per ml ) blocked TNF-alpha production by LPS from both smooth- and rough-type gram negative bacteria at concentrations up to 100 ng of LPS per ml but had little effect on heat killed gram positive Staphylococcus aureus and no effect on other LPS independent stimuli tested
Danis et al., Clin Exp Immunol 1991 : GM-CSF did not enhance TNF-alpha secretion induced by IL-2 or TNF-alpha
Bethea et al., J Neuroimmunol 1992 (Astrocytoma) : Kinetic analysis demonstrated optimum TNF-alpha mRNA expression after a 4 h exposure to IL-1 beta, and peak TNF-alpha protein production at 18 h. Cycloheximide ( CHX ), an inhibitor of protein synthesis, markedly increased expression of TNF-alpha mRNA in IL-1 beta stimulated CH235-MG cells, indicating that de novo protein synthesis is not required for astroglioma TNF-alpha gene expression
Zeuthen et al., Clinical and vaccine immunology : CVI 2006 : Interestingly, we found that when weakly IL-12- and TNF-alpha inducing LAB and strong IL-12- and TNF-alpha inducing LAB were mixed, the weakly IL-12- and TNF-alpha inducing LAB efficiently inhibited otherwise strong IL-12- and TNF-alpha inducing LAB, yet when weakly IL-12- and TNF-alpha inducing LAB were mixed with G- bacteria, they synergistically induced IL-12 and TNF-alpha
Kim et al., Am J Respir Cell Mol Biol 1991 : SIC did not induce significant levels of TNF-alpha secretion by PAM ; however, SIC with cytochalasin B-pretreated PAM induced equivalent levels of TNF-alpha secretion as IIC activated PAM
Myśliwska et al., Mech Ageing Dev 1999 : The ` almost-healthy ' elderly are characterised by a higher release of TNF alpha from the cultures of non- and stimulated PBMC and an activation of the TNF alpha gene in the non stimulated PBMC
Falvo et al., Proc Natl Acad Sci U S A 2000 : Strikingly, in mice lacking one copy of the CBP gene, TNF-alpha gene induction by TCR activation is inhibited, whereas virus induction of the TNF-alpha gene is not affected
Zheng et al., Am J Pathol 2004 (Glomerulosclerosis, Focal Segmental...) : The effect of TNF-alpha on RANTES expression was mediated by TNF receptor 1
Lacoste et al., J Virol 1990 : TNF-alpha was able to increase expression of the HIV LTR in T cells, but in monocytic cells, TNF-alpha did not induce the HIV LTR above a constitutive level of activity
Rieckmann et al., Res Exp Med (Berl) 1995 : TNF-alpha , LT, IFN-gamma and IL-6 mRNAs were detected in patients with active multiple sclerosis, whereas TNF-alpha , IL-6, and endothelin-1 mRNA expression was found frequently in patients with HIV encephalitis
Husain et al., J Ocul Pharmacol Ther 2008 : Secreted TNF-alpha may then activate TNF-receptors in the uvea and trabecular meshwork, increasing both uveoscleral and conventional outflow
Wang et al., J Huazhong Univ Sci Technolog Med Sci 2009 (Neurodegenerative Diseases...) : TNF-alpha-siRNA down-regulated the expression of TNF-alpha gene in vitro and in vivo, which provided a potential tool for studying and treating neurodegenerative diseases and TNF-alpha related diseases
Matsui et al., Life Sci 1994 (Disease Models, Animal...) : Plasma TNF-alpha reached a maximum level 1 hour after LPS challenge, and vesnarinone reduced the plasma level of TNF-alpha , when administered at the same time as LPS injection
Zwiech et al., Pol Arch Med Wewn 2005 (Glomerulonephritis, IGA) : Interleukin-1 receptor antagonist ( IL-1ra ) and tumor necrosis factor soluble receptors ( sTNFR ) type I and II reducing the activity of IL-1 and TNFalpha may inhibit inflammatory reactions
Kuwano et al., Free Radic Biol Med 2008 : Interleukin-1beta, flagellin, interferon-gamma, and tumor necrosis factor alpha (TNF-alpha) similarly induced Nox1 in a colon cancer cell line ( T84 ), whereas only TNF-alpha fully induced NOXO1 and upregulated superoxide producing activity by ninefold
Sopasakis et al., Int J Obes Relat Metab Disord 2005 : TNFalpha increased the mRNA levels of TNFalpha itself as well as IL-6, IL-8, IL-1beta and PAI-1, but not leptin
Ocvirk et al., Melanoma Res 2000 (Melanoma...) : The soluble TNF receptor TNF-R55 ( sTNF-R55 ) inhibits TNFalpha functioning
Ebisawa et al., J Immunol 1992 : IL-1 beta and TNF-alpha treatment of HuVEC ( 4 h, 5 ng/ml ) induced significant transendothelial migration of eosinophils ( a 4.1 +/- 0.4-fold ( IL-1 beta ) and 2.0 +/- 0.9-fold ( TNF-alpha ) increase from the spontaneous value of 3.2 +/- 0.3 % )
Jackman et al., Exp Cell Res 2009 : Both TNF-alpha and taxol induce the degradation of endogenous IkappaBalpha and either taxol or TNF-alpha induction of NF-kappaB activity was blocked by inhibitors of NF-kappaB acting at different sites in the signaling pathway
Steinshamn et al., APMIS 2000 : In 10 experiments a marked TNF alpha production in the range 10-70 ng/ml was detected in the supernatants, whereas unstimulated cells did not produce TNF alpha
Miller et al., J Gerontol 1991 (Fever) : These findings confirm that ( a ) TNF alpha has a role in the pathogenesis of fever ; ( b ) aging alters significantly the febrile response ; and ( c ) a mechanism of this age related blunted febrile response may involve TNF alpha
Prabhakar et al., Int J Immunopharmacol 1995 : We have demonstrated that CGS-21680, a highly selective A2 agonist inhibited production of TNF alpha at the protein level by 75 % whereas the A1 selective agonist N6 reduced TNF alpha production by only 25 %
Byun et al., J Bone Miner Res 2005 (Bone Resorption) : Our data show that TNF-alpha increases intracellular ROS in hBMSC and that TNF-alpha and H2O2 induce apoptosis in hBMSC through the activation of JNK and NF-kappaB
Nishida et al., Am J Physiol Gastrointest Liver Physiol 2008 : Furthermore, LY294002 suppressed both IL-1beta- and TNF-alpha induced NF-kappaB activation and IL-1beta-, TNF-alpha- , and IFN-gamma induced activated protein-1 (AP-1) activation
Opara et al., Surgery 1995 (Anorexia) : Increase in plasma TNF-alpha with no increase in CSF-TNF-alpha during TPN, when food intake decreased, suggests an association between TPN and TNF-alpha but not necessarily cause and effect
Yamada et al., FEMS Immunol Med Microbiol 2000 (Listeriosis...) : KB-R7785 inhibited soluble TNF-alpha production in spleen cell cultures stimulated by heat killed L. monocytogenes and the drug treatment reduced serum TNF-alpha levels in infected mice, whereas the compound was ineffective on the modulation of interferon-gamma and interleukin-10 production
Wankowicz et al., J Leukoc Biol 1988 (Inflammation) : In comparison, TNF alpha even at 100,000 U, induced only mild PMNL accumulations, although IL-1 alpha and TNF alpha were similarly active in inducing PMNL adherence to human umbilical vein endothelium
Bluth et al., International journal of medical sciences 2009 (Hepatitis, Autoimmune) : In contrast, before treatment, IL-12 and TNFalpha were not detected in serum ; however after treatment the levels of IL-12 and TNFalpha dramatically increased
Cho et al., Int J Mol Med 2007 : However, it was unknown whether curcumin, showing inhibitory effects on NF-kappaB and MAPKs, attenuates the expression of TNF-alpha induced IL-1beta, IL-6, IL-8, and TNF-alpha as well as cyclin E expression in HaCaT cells ... We found that curcumin inhibited the expression of TNF-alpha induced IL-1beta, IL-6, and TNF-alpha , but not IL-8, in TNF-alpha treated HaCaT cells as well as the TNF-alpha induced cyclin E expression
Zuany-Amorim et al., Int Arch Allergy Immunol 2004 (Bronchial Hyperreactivity...) : Induction of TNF-alpha autoantibody production by AutoVac TNF106 : a novel therapeutic approach for the treatment of allergic diseases
Hase et al., Proc Natl Acad Sci U S A 2006 : In parallel studies, we find that TSH directly inhibits TNFalpha production, reduces the number of TNFalpha producing osteoclast precursors, and attenuates the induction of TNFalpha expression by IL-1, TNFalpha , and receptor activator of NF-kappaB ligand
Kang et al., Biochem Pharmacol 2005 : These results suggest that the inhibitory effect of equol on TNF-alpha expression is mediated, at least in part, by blocking NF-kappaB activation and the inhibition of TNF-alpha expression by equol might be involved in its osteoprotective effect
Kaiser et al., Gastroenterology 1997 : The regulation of intestinal cell mitogenesis by TNF-alpha seems to be mediated differentially by the two TNF-alpha receptors, with the TNF-alpha R1 receptor inhibiting proliferation and the TNF-alpha R2 receptor promoting proliferation
Wei et al., Biochimie 2006 : Promutoxin is also able to stimulate the release of IL-12, TNFalpha , IL-6 and IL-1beta from human monocytes, and induce IL-2, TNFalpha and IL-6 release from T cells, indicating that this snake venom group IIA PLA(2) is actively involved in the inflammatory process in man caused by snake venom poisoning
Li et al., J Infect Dis 2006 (Disease Models, Animal...) : Tumor necrosis factor (TNF)-alpha and interleukin-10 mRNA expression was elevated in H. pylori infected mice, but only TNF-alpha mRNA expression was further increased by COX deficiency
Keller et al., Biochem Biophys Res Commun 2004 (Insulin Resistance) : TNF-alpha is linked with insulin resistance, as greater amounts of TNF are detected in muscle and adipose tissue in glycemically challenged people and TNF-alpha inhibits insulin receptor signalling
Hashizume et al., Rheumatology (Oxford) 2008 (Arthritis, Rheumatoid) : On the other hand, TNF-alpha and IL-17 did not induce RANKL expression, although TNF-alpha , IL-17 or IL-1beta stimulated cell growth and IL-6 production
Chuluyan et al., Life Sci 1998 (Neuroblastoma) : VCAM-1 expression on SK-N-SH was induced by IL-1alpha and TNF alpha and IFN gamma synergized with TNF alpha in this respect on both NB cell lines
Srinivasan et al., Apoptosis 2010 (Prostatic Neoplasms) : Our results suggest that psoralidin inhibits constitutive and TNF induced expression of TNF-alpha and its downstream prosurvival signaling molecules such as NF-kappaB and Bcl-2 in AIPC cells
Alaaeddine et al., J Rheumatol 1997 (Osteoarthritis) : The TNF-R55 was found to be the major receptor species responsible for ligand binding activity, such as COX-2 induction and PGE2 synthesis, since a specific antireceptor TNF-R55 blocking antibody inhibited about 76 % of TNF-alpha binding and TNF-alpha stimulated COX-2 induction and PGE2 production
Yang et al., J Huazhong Univ Sci Technolog Med Sci 2007 (Carcinoma, Hepatocellular...) : TM-TNF-alpha predominantly induced apoptosis while s-TNF could induce both apoptosis and necrosis