Gene interactions and pathways from curated databases and text-mining

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MAPK1 — TNFRSF1A

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Velarde et al., Am J Physiol 1999 : BK ( 10 ( -8 ) M ) promoted the association of p60 ( src ) with the adapter protein growth factor receptor binding protein-2 and also induced a significant increase in MAPK activity
Jupp et al., Biochem J 2001 (MAP Kinase Signaling System) : Conversely, only activation of the TNFR1 could stimulate mitogen activated protein kinase ( MAPK ) or p38 MAPK activities in a time dependent manner
Ryden et al., J Biol Chem 2002 : Use of receptor-specific TNF-alpha mutants showed that activation of MAPK is entirely mediated by the TNFR1 receptor
Mohamed et al., Biochem J 2002 (MAP Kinase Signaling System) : TNFR1 stimulated p42/44 MAPK and p38 MAPK activities were insensitive to pharmacological caspase inhibition or CrmA
Jupp et al., Biochem J 2003 (MAP Kinase Signaling System) : TNFR1 activates mitogen activated protein kinase ( MAPK ) and p38MAPK
Itatsu et al., Liver Int 2009 (Cholangiocarcinoma) : These data suggest that TNF-alpha/TNF-R1 interaction leads to the phosphorylation of Erk1/2 and p38MAPK and nuclear translocation of NF-kappaB, which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1
Winston et al., J Immunol 1995 : Activation of p42mapk/erk2 following engagement of tumor necrosis factor receptor CD120a ( p55 ) in mouse macrophages ... Collectively, the results from these experiments indicate that cross linking of CD120a ( p55 ), but not that of CD120b ( p75 ), was both necessary and sufficient for the activation of p42mapk/erk2 in mouse macrophages
Riches et al., Immunobiology 1996 : We have investigated the upstream kinases that mediate the activation of p42mapk/erk2 following cross linking of CD120a ( p55 ) in mouse macrophages