◀ Back to IL6

IL6 — TP53

Text-mined interactions from Literome

Rowley et al., Blood 2000 (Multiple Myeloma) : Stable expression of wild-type ( wt ) p53 in U266 cells results in a significant suppression of interleukin (IL)-6 gene expression and in the concomitant suppression of cell growth that could be restored by the addition of exogenous IL-6
Angelo et al., Cancer Res 2002 (Carcinoma, Renal Cell...) : We sought to determine whether p53 regulates constitutive IL-6 production ... Transfection of wt p53 into RCC cell lines bearing mut p53 ( UOK 121LN ) or wt p53 ( A498 and ACHN ) resulted in repression of IL-6 promoter chloramphenicol acetyltransferase activity ( P < 0.05 ) ... These data suggest that : ( a ) mutation of p53 contributes to the overexpression of IL-6 in RCC ; and ( b ) wt p53 represses IL-6 expression, at least in part, by interfering with specific transcription factor binding to the IL-6 promoter
Yamanishi et al., Proc Natl Acad Sci U S A 2002 (Arthritis, Rheumatoid) : Because IL-6 gene expression is regulated by wild-type p53 , IL-6 mRNA expression in microdissected tissues was quantified by using real-time PCR
Matthews et al., Wound Repair Regen 2004 (Choline Deficiency) : We investigated the role of human IL-6 on p53 null immortalized murine oval cell lines ( PIL ), finding that they express transcripts for the IL-6 receptor and gp 130, STAT-3 is phosphorylated upon IL-6 stimulation, IL-6 induces IL-6 production, and proliferation is induced by IL-6
Santhanam et al., Proc Natl Acad Sci U S A 1991 : Murine and human wt p53 derived from pCMVNc9 and pC53-SN3, respectively, strongly repressed the IL-6 ( promoter position -225 to +13 ), c-fos ( -711 to +42 ), beta-actin ( -3400 to +912 ), and MHC ( -528 to -38 ) promoters in serum induced HeLa cells ; additionally, IL-6 promoter/CAT transcription unit constructs induced by IL-1, phorbol ester, or pseudorabies virus were also repressed by wt human and murine p53 ... The human p53 mutant derived from pC53-SCX3 was also less active than the wt protein in repressing the IL-6, c-fos, beta-actin, and MHC promoters, except that serum induced IL-6/CAT expression was equally repressed by both human wt and mutant p53 ... These observations identify transcriptional repression as a property of p53 and suggest that p53 and RB may be involved as transcriptional repressors in modulating IL-6 gene expression during cellular differentiation and oncogenesis
Noman et al., Cell Immunol 2010 (Inflammation) : LPS induced tumor necrosis factor-alpha and interleukin-6 production was prevented by RIZ1 siRNA or a p53 pharmacological inhibitor
Sehgal et al., Oncogene 1993 : In HeLa cells, although wt p53 activated p50-2 but repressed the MCK and IL-6 promoters, p53 Val135 activated all three reporters
Margulies et al., J Biol Chem 1993 : In HeLa cells, wild-type ( wt ) human or murine p53 preferentially repressed the IL-6 promoter ... The p53 mutants Val-135 and Phe-132 up-regulated IL-6 promoter activity in these cells at both 32.5 and 37 degrees C