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SMG1 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yamashita et al., Genes Dev 2001
:
We also show that inhibitors of
hSMG-1 induce the accumulation of truncated
p53 proteins in human cancer cell lines with p53 PTC mutation
Brumbaugh et al., Mol Cell 2004
(Genomic Instability) :
Expression of
hSMG-1 is
required for optimal
p53 activation after cellular exposure to genotoxic stress, and depletion of hSMG-1 leads to spontaneous DNA damage and increased sensitivity to ionizing radiation ( IR )
Erker et al., Hum Mol Genet 2005
(Ataxia Telangiectasia...) :
Inhibition of phosphoinositide 3-kinase (PI3K) family members suggested that
SMG-1 was
responsible for the tempol mediated enhancement of
p53 serine 18 phosphorylation
Gehen et al., Oncogene 2008
(Hyperoxia) :
Here, we show
hSMG-1 is
responsible for the rapid and early phosphorylation of
p53 ( Ser15 ) and that ATM helps maintain phosphorylation after 24 h