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NFKB1 — TRAF3

Pathways - manually collected, often from reviews:

• KEGG Pathways in cancer: NFKB1/NFKB2/RELA → TRAF1/TRAF2/TRAF3/TRAF4/TRAF5/TRAF6 (gene expression, expression)
  
• KEGG Small cell lung cancer: NFKB1/RELA → TRAF1/TRAF2/TRAF3/TRAF4/TRAF5/TRAF6 (gene expression, expression)
  

Text-mined interactions from Literome

Leo et al., J Biol Chem 1999 : A carboxyl-truncation mutant of CD40 lacking the last 32 amino acids required for TRAF2 and TRAF3 binding, CD40 ( Delta32 ), mediated NF-kappaB induction through a mechanism that was suppressible by co-expression of TRAF6 ( DeltaN ), a dominant negative version of TRAF6, but not by TRAF2 ( DeltaN ), implying that while TRAF6 does not directly bind CD40, it can participate in CD40 signaling
Puls et al., J Cell Sci 1999 (Inflammation) : Using LMP1 mutants, we show that activation of Cdc42 and JNK/NF(kappa)B occur through distinct pathways and that Cdc42 activation is independent of LMP1 's interaction with TRADD and TRAF proteins
Pomerantz et al., EMBO J 1999 : However, TANK also displays the ability to stimulate TRAF mediated NF-kappaB activation ... The TBK1-TANK-TRAF2 signaling complex functions upstream of NIK and the IKK complex and represents an alternative to the receptor signaling complex for TRAF mediated activation of NF-kappaB
Nomura et al., Genes Cells 2000 : NF-kappaB activation by IKK-i is significantly blocked by coexpression of the N-terminal domain of I-TRAF , dominant negative TRAF2, and dominant negative NIK and IKK-beta
Zapata et al., J Biol Chem 2000 : In contrast, TRAF2 mediated NFkappaB induction was partially inhibited by DTRAF1
Takaori-Kondo et al., Biochem Biophys Res Commun 2000 : TRAF3 blocked OX40-, TRAF2 induced NF-kappaB activation, but not NIK- and IKKalpha induced NF-kappaB activation, indicating that TRAF3 blocks the pathway between TRAF2 and NIK ... TRAF3 blocked OX40-, TRAF2 induced NF-kappaB activation, but not NIK- and IKKalpha induced NF-kappaB activation , indicating that TRAF3 blocks the pathway between TRAF2 and NIK ... C-terminal deletion mutants as well as the N-terminal deletion mutant of TRAF3 inhibited NF-kappaB activation induced by OX40 or TRAF2 ... Thus, it is suggested that TRAF3 actively inhibits NF-kappaB activation induced by OX40
Chandel et al., J Biol Chem 2001 : Consistent with its anti-apoptotic function, Bcl-x ( L ) interfered with TRAF mediated ROS generation but not NF-kappaB activation
Naito et al., Proc Natl Acad Sci U S A 2002 (Ectodermal Dysplasia) : Furthermore, TRAF6 is essential for the XEDAR mediated NFkappaB activation
Wu et al., Gene Expr 2002 : In addition, ZAS3 associates with a TNF receptor associated factor to inhibit NF-kappaB- and JNK/ SAPK mediated signaling of TNF-alpha
Lee et al., J Biochem Mol Biol 2002 : The inhibitory effect of the TAK1 mutant on RANK- and TRAF induced NF-kappaB activation was also observed, but less efficiently
Xu et al., J Immunol 2002 : Moreover, overexpression of TRAF3 inhibits BAFF-R mediated NF-kappaB activation and IL-10 production
Henkler et al., J Biol Chem 2003 : The role of tumor necrosis factor (TNF) receptor associated factor ( TRAF)-1 in NF-kappaB activation by various members of the TNF receptor family is not well understood, and conflicting data have been published
Bin et al., J Biol Chem 2003 : Moreover, TIRP mediated NF-kappaB activation is inhibited by dominant negative mutants of IRAK, IRAK-2, TRAF6 , and IKKbeta
Sakon et al., EMBO J 2003 : Importantly, TNF does not induce ROS accumulation or prolonged MAPK activation in wild-type MEFs, indicating that TRAF mediated NF-kappaB activation normally suppresses the TNF induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death
Fotin-Mleczek et al., J Biol Chem 2004 : Accordingly, TRAF1 inhibited CD40 dependent but not TNF-R1 dependent NF-kappaB activation
Dadgostar et al., FEBS Lett 2003 : More importantly, T3JAM and TRAF3 synergistically activate JNK but not nuclear factor (NF)-kappaB
Takada et al., J Biol Chem 2004 : NF-kappaB reporter activity induced by TNF receptor 1, TNF receptor associated death domain, TNF receptor associated factor-2 , NF-kappaB inducing kinase, and IkappaBalpha kinase, were all blocked by flavopiridol but not that activated by p65
Hauer et al., Proc Natl Acad Sci U S A 2005 : We observed that TRAF3 specifically blocked the NF-kappaB activation via TRAF2/5
Min et al., J Immunol 2005 : TNF related activation induced cytokine enhances leukocyte adhesiveness : induction of ICAM-1 and VCAM-1 via TNF receptor associated factor and protein kinase C-dependent NF-kappaB activation in endothelial cells
Shishodia et al., Cancer Res 2005 (Carcinoma, Small Cell...) : NF-kappaB dependent reporter gene expression was also suppressed by 4-HPR, as was NF-kappaB reporter activity induced by TNFR1, TRADD, TRAF2 , NIK, and IKK but not that induced by p65 transfection
Morlon et al., Hum Mol Genet 2005 (Ectodermal Dysplasia) : TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd ... Moreover, we show that dominant negative forms of TAB2, TRAF6 and TAK1 blocked the NF-kappaB activation induced by Edaradd
Conti et al., J Neurosurg 2005 (Brain Neoplasms...) : The authors investigated the expression of NF-kappaB , caspase 3, TRAF1, TRAF2, and TRAF associated NF-kappaB activator/TRAF interacting protein ( TANK/I-TRAF ), a regulator of TRAF activity, in human gliomas
Guasparri et al., EMBO Rep 2006 : TRAF2 and TRAF3 are required for induction of NF-kappaB and associated cell survival, as well as Jun amino-terminal kinase phosphorylation by vFLIP, whereas TRAF1, TRAF5 and TRAF6 are dispensable
Sethi et al., J Biol Chem 2006 : NF-kappaB reporter activity induced by TNFR1, TNF receptor associated death domain, TRAF2 , TAK1, NF-kappaB inducing kinase, and IKKbeta was inhibited by indirubin but not that induced by p65 transfection
Ryu et al., World J Gastroenterol 2006 (Hepatitis B) : During the initial state of HBV infection, hepatocytes facilitate the activation of NF-kappaB through up regulation of LT-alpha, TRAF2 , and NIK
He et al., J Exp Med 2006 : 25 : 280-288 ). We demonstrate that loss of tumor necrosis factor (TNF) receptor associated factor 3 ( TRAF3 ) results in constitutive noncanonical NF-kappaB activity
Noels et al., J Biol Chem 2007 (Lymphoma, B-Cell, Marginal Zone...) : In contrast, TRAF6 was essential for NF-kappaB activation by all fusion variants, and we identified a novel TRAF6 binding site in the second immunoglobulin domain of MALT1, which enhanced NF-kappaB activation when present in the fusion protein
Sung et al., Mol Pharmacol 2007 : NF-kappaB dependent reporter gene expression was also suppressed by fisetin, as was NF-kappaB reporter activity induced by TNFR1, TRADD, TRAF2 , NIK, and IKK but not that induced by p65 transfection
Sethi et al., Oncogene 2007 (Adenocarcinoma...) : Using dominant negative plasmids, we also demonstrated the role of TRADD, TRAF2 , NIK and Ras in EGF induced NF-kappaB activation
Matta et al., J Biol Chem 2007 : Furthermore, endogenously expressed TRAF2 and TRAF3 do not interact with K13 and play no role in K13 induced NF-kappaB activation or its interaction with the IKK complex
Sethi et al., J Immunol 2007 : NF-kappaB reporter assay revealed that NF-kappaB activation induced by TNF, TNFR1, TRADD, TRAF2 , NIK, and I kappaB alpha kinase was modulated in gene deleted cells
Zarnegar et al., Proc Natl Acad Sci U S A 2008 : Studies examining tumor-necrosis factor receptor associated factors ( TRAFs ) have identified positive roles for TRAF2, TRAF5 , and TRAF6, but not TRAF3, in canonical ( p50 dependent ) NF-kappaB activation ... Studies examining tumor-necrosis factor receptor associated factors ( TRAFs ) have identified positive roles for TRAF2, TRAF5, and TRAF6, but not TRAF3 , in canonical ( p50 dependent ) NF-kappaB activation ... In this article, we provide evidence that TRAF3 potently suppresses canonical NF-kappaB activation and gene expression in vitro and in vivo
Sethi et al., Biochem Pharmacol 2008 (Neoplasm Invasiveness) : This led to suppression of the phosphorylation and translocation of p65 and also of NF-kappaB reporter activity induced by TNFR1, TRADD, TRAF2 , NIK, and IKKbeta but not that induced by p65 transfection
Alff et al., J Virol 2008 : In contrast, the Gn tail of the nonpathogenic hantavirus Prospect Hill virus ( PHV ) failed to coprecipitate TRAF3 or inhibit NF-kappaB or IFN-beta transcriptional responses
Blackwell et al., Mol Cell Biol 2009 (Lymphoma) : Notably, TRAF2 phosphorylation increased both basal and inducible c-Jun and NF-kappaB activities and rendered cells resistant to stress induced apoptosis
Graham et al., J Immunol 2009 : Examination of TRAF binding, degradation, cytokine production, IgM secretion, and the activation of c-Jun kinase and NF-kappaB revealed that some events are dictated by TRAF binding site sequences, others are partially regulated, and still others are independent of the TRAF binding site sequence
Yao et al., J Clin Invest 2009 (Bone Resorption) : These findings suggest that upregulation of TRAF3 or NF-kappaB p100 expression or inhibition of NF-kappaB p100 degradation in OCPs could limit bone destruction and inflammation induced bone loss in common bone diseases
Yamazaki et al., Science signaling 2009 : After TAK1 mediated activation of NF-kappaB, TRAF6 subsequently activated NF-kappaB through MEKK3 independently of TAK1, thereby establishing continuous activation of NF-kappaB, which was required for the production of sufficient cytokines
Manna et al., J Biol Chem 2010 : It inhibits TRAF2 mediated NF-kappaB activation but not TRAF6 mediated NF-kappaB DNA binding by preventing its association with TANK ( TRAF for NF-kappaB )
Ikeda et al., FEBS Lett 2010 : Regarding the mechanisms involved, we found that BS69 directly interacted with TRAF3 , a negative regulator of NF-kappaB activation ... Furthermore, small interfering RNA mediated knockdown experiments revealed that TRAF3 was involved in the BS69 mediated suppression of LMP1/CTAR1 induced NF-kappaB activation
Bista et al., J Biol Chem 2010 : TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor
Song et al., Virus Genes 2010 : Roles of TRAF2 and TRAF3 in Epstein-Barr virus latent membrane protein 1-induced alternative NF-kappaB activation
Rothe et al., Science 1995 : Overexpression of TRAF2, but not TRAF1 or TRAF3 , was sufficient to induce NF-kappa B activation
Tewari et al., Curr Opin Genet Dev 1996 : Significantly, TRAF2 mediates the activation of NF-kappa B by both receptors
Cao et al., Nature 1996 : When overexpressed in human 293 cells, TRAF6 activates NF-kappaB
Duckett et al., Mol Cell Biol 1997 : NF-kappaB induction through domain 2 was inhibited by coexpression of either full-length TRAF3 or dominant negative forms of TRAF1 or TRAF2 ... TRAF dependent induction of NF-kappaB appears to be regulated by the relative levels of individual TRAF proteins in the cell
Wong et al., J Biol Chem 1998 : Dominant negative forms of TRAF2, TRAF5 , and TRAF6 and an endogenous inhibitor of TRAF2, TRAF interacting protein (TRIP), substantially inhibited TRANCE-R mediated NF-kappaB activation, suggesting a role of TRAFs in regulating DC and osteoclast function
Yamamoto et al., J Immunol 1998 : This NF-kappaB activation signal is inhibited by dominant negative TRAF2 or intact TRAF3 , indicating that TRAF2 and TRAF3 works as a mediator and an inhibitor, respectively