Gene interactions and pathways from curated databases and text-mining

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NFKB1 — TRAF3IP2

Text-mined interactions from Literome

Qian et al., Proc Natl Acad Sci U S A 2002 : Overexpression of the NF kappa B activator 1 (Act1) leads to the activation of both NF kappa B and Jun kinase in epithelial cell lines
Kanamori et al., FEBS Lett 2002 : Act1 mediated NF-kappaB activation was inhibited by a dominant negative mutant of TRAF6 in a dose dependent manner, and IL-1 induced NF-kappaB activation was inhibited by a high level of Act1 expression
Lindén et al., Science's STKE : signal transduction knowledge environment 2007 : Act1 mediates activation of NF-kappaB and the subsequent production of IL-6 and chemokines that are chemotactic for neutrophils and macrophages
Huang et al., J Immunol 2007 : Requirement for both JAK mediated PI3K signaling and ACT1/TRAF6/TAK1 dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells
Sønder et al., J Biol Chem 2011 : IL-17 induced NF-kappaB activation via CIKS/Act1 : physiologic significance and signaling mechanisms