Gene interactions and pathways from curated databases and text-mining

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EPHB2 — TSC22D3

Text-mined interactions from Literome

Soundararajan et al., J Biol Chem 2005 : In Xenopus oocytes with activated ERK, heterologous GILZ expression consistently inhibited phospho-ERK expression and markedly stimulated ENaC mediated Na+ current, in a manner similar to that of U0126 ( a pharmacologic inhibitor of ERK signaling )
Soundararajan et al., J Biol Chem 2007 : GILZ1 and GILZ3, and to a lesser extent GILZ2, inhibited ERK phosphorylation ... Furthermore, GILZ inhibition of ERK appears to play an essential role in stimulation of cell surface ENaC but not in inhibition of proliferation
Yang et al., J Immunol 2009 : GC-induced GILZ expression and GC inhibition of NF-kappaB activation were restored by expression of ANXA1 in ANXA1 ( -/- ) cells, and GILZ overexpression in ANXA1 ( -/- ) macrophages reduced ERK MAPK phosphorylation and restored sensitivity of cytokine expression and NF-kappaB activation to GC
He et al., PloS one 2012 (Inflammation...) : Further studies show that these antagonistic actions occur via mechanisms involving GILZ inhibition of TNF-a induced ERK MAP kinase activation and protein degradation
Cheng et al., J Immunol 2013 (MAP Kinase Signaling System) : GILZ overexpression also inhibited TNF induced activation of p38, ERK , and JNK MAPKs, as well as increased expression of the MAPK inhibitory phosphatase, MKP-1