Gene interactions and pathways from curated databases and text-mining

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Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Hirota et al., J Biol Chem 1999 : In the nucleus, however, TRX enhances NF-kappaB transcriptional activities by enhancing its ability to bind DNA ... This two-step TRX dependent regulation of the NF-kappaB complex may be a novel activation mechanism of redox-sensitive transcription factors
Zhang et al., Am J Physiol 1999 : Nitric oxide induced reduction of lung cell and whole lung thioredoxin expression is regulated by NF-kappaB
Chang et al., Am J Respir Cell Mol Biol 2000 : Taking these data together, a novel mechanism is proposed in which ATRA activates promoter activity of IL-8 gene through TRX dependent NF-kappaB activation
Hirota et al., Biochem Biophys Res Commun 2000 : Nucleoredoxin, glutaredoxin, and thioredoxin differentially regulate NF-kappaB , AP-1, and CREB activation in HEK293 cells
Das et al., J Biol Chem 2001 : c-Jun NH2-terminal kinase mediated redox dependent degradation of IkappaB : role of thioredoxin in NF-kappaB activation ... In addition, only the reduced form of thioredoxin activated NF-kappaB , whereas the oxidized form was without any effect ... Overexpression of human thioredoxin also caused activation of NF-kappaB and degradation of IkappaB ... On the contrary, dominant negative redox-inactive mutant thioredoxin expression did not activate NF-kappaB , further confirming the redox dependent activation of NF-kappaB ... We also investigated the mechanism of activation of NF-kappaB by thioredoxin
Gebel et al., Toxicological sciences : an official journal of the Society of Toxicology 2001 : The activity of NF-kappaB in Swiss 3T3 cells exposed to aqueous extracts of cigarette smoke is dependent on thioredoxin
Takeuchi et al., Antioxid Redox Signal 2000 : Thioredoxin inhibits tumor necrosis factor- or interleukin-1 induced NF-kappaB activation at a level upstream of NF-kappaB inducing kinase ... To elucidate the roles of TRX in the signal transduction of the cytokines, we investigated the effects of TRX on NF-kappaB activation induced by cytokine treatment or by overexpression of the signaling molecules ... In addition, we show that TRX inhibits NF-kappaB activation in a manner different from that for SAPK ( stress activated protein kinase ) inhibition
Gan et al., Zhonghua Yi Xue Za Zhi 2002 (Colitis, Ulcerative) : Glucocorticoids and SASP strongly inhibited NF-kappaB activation and expression
Gan et al., Zhonghua Nei Ke Za Zhi 2002 (Colitis, Ulcerative) : ( 2 ) Glucocorticoids and SASP strongly inhibited NF-kappaB activation and signficantly decreased the expression of IL-1beta mRNA and IL-8 mRNA
Kontou et al., Biol Chem 2003 (Chromosomal Instability...) : Cotransfection of the NF-kappaB dependent CAT plasmid with the Trx/nuc-plasmid into FA fibroblasts increased the CAT expression to almost that of control cells, indicating that in this model system with diminished thioredoxin content NF-kappaB requires thioredoxin for binding to its specific promotor
Matthews et al., Nucleic Acids Res 1992 : Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62
Chen et al., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2004 (Colitis, Ulcerative) : Glucocorticoids and SASP markedly inhibited NF-kappaB activation and significantly decreased mRNA and protein expression of ICAM-1 and VCAM-1 ( P < 0.05 )
Chandrasekaran et al., J Mol Graph Model 2008 : Oxidative stimuli in the cytosol are associated with nuclear translocation of NF-kappa B, whereas in the nucleus, reductive activation by thioredoxin is required for NF-kappa B to bind to DNA and activate target genes
Schenk et al., Proc Natl Acad Sci U S A 1994 : These results suggest that thioredoxin plays an important role in the regulation of transcriptional processes and oppositely affects NF-kappa B and AP-1 activation
Hayashi et al., J Biol Chem 1993 : We show that a cellular reducing catalyst thioredoxin (Trx) plays a major role in activation of the DNA binding of NF kappa B in vitro and stimulation of transcription from the NF kappa B-dependent gene expression ... We demonstrate evidence suggesting that redox regulation of NF kappa B by Trx might be exerted at a step after dissociation of the inhibitory molecule I kappa B, a cytosolic anchoring protein for NF kappa B