Gene interactions and pathways from curated databases and text-mining

◀ Back to IKBKG

IKBKG — UBE2N

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Habelhah et al., EMBO J 2004 : Inhibition of Ubc13 expression by RNAi resulted in inhibition of TNFalpha induced TRAF2 translocation and impaired activation of JNK but not of IKK or p38
Shembade et al., J Virol 2007 : Collectively, our results reveal that Ubc13 is essential for Tax ubiquitination, its interaction with NEMO , and Tax mediated NF-kappaB activation
Xu et al., Mol Cell 2009 : We demonstrate that K63 of ubiquitin and the catalytic activity of Ubc13 , an E2 that catalyzes K63 polyubiquitination, are required for IKK activation by IL-1beta, but surprisingly, not by TNFalpha
Culver et al., Mol Cell Biol 2010 : IKK complex activation following hypoxia requires Ubc13 but not the recently identified LUBAC ( linear ubiquitin chain assembly complex ) ubiquitin conjugation system
Melvin et al., Cell cycle (Georgetown, Tex.) 2011 : TAK1 and IKK activation is dependent upon the calcium calmodulin kinase, CaMK2 and requires Ubc13 as the E2 ubiquitin conjugation enzyme