◀ Back to IKBKG
IKBKG — UBE2N
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Habelhah et al., EMBO J 2004
:
Inhibition of
Ubc13 expression by RNAi
resulted in inhibition of TNFalpha induced TRAF2 translocation and impaired activation of JNK but not of
IKK or p38
Shembade et al., J Virol 2007
:
Collectively, our results reveal that
Ubc13 is
essential for Tax ubiquitination, its interaction with
NEMO , and Tax mediated NF-kappaB activation
Xu et al., Mol Cell 2009
:
We demonstrate that K63 of ubiquitin and the catalytic activity of
Ubc13 , an E2 that catalyzes K63 polyubiquitination, are
required for
IKK activation by IL-1beta, but surprisingly, not by TNFalpha
Culver et al., Mol Cell Biol 2010
:
IKK complex activation following hypoxia
requires Ubc13 but not the recently identified LUBAC ( linear ubiquitin chain assembly complex ) ubiquitin conjugation system
Melvin et al., Cell cycle (Georgetown, Tex.) 2011
:
TAK1 and
IKK activation is dependent upon the calcium calmodulin kinase, CaMK2 and
requires Ubc13 as the E2 ubiquitin conjugation enzyme