Gene interactions and pathways from curated databases and text-mining

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AKT1 — UTP15

Text-mined interactions from Literome

Huwiler et al., Br J Pharmacol 2002 : Furthermore, the ATP- and UTP induced PKB phosphorylation is abolished by two inhibitors of the PI 3-kinase ... In addition, suramin, a putative P2Y(2) receptor antagonist, and pertussis toxin, an inhibitor of G ( i ) /G ( o ) activation, markedly block ATP- and UTP induced PKB phosphorylation
Choi et al., Pancreas 2013 (Carcinoma, Pancreatic Ductal...) : Activation of P2Y2 receptor by UTP transduced to phospholipase C, inositol 1,4,5-triphosphate ( IP3 ), and protein kinase C. Uridine triphosphate induced proliferation was mediated by protein kinase D, Src-family tyrosine kinase, Ca/calmodulin dependent protein kinase II, phosphatidylinositol 3-kinase (PI3K), Akt , and phospholipase D. Uridine triphosphate increased phosphorylation of Akt through protein kinase C, Src-family tyrosine kinase, Ca/calmodulin dependent protein kinase II, and PI3K