Gene interactions and pathways from curated databases and text-mining

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JUN — UTP3

Text-mined interactions from Literome

Ekokoski et al., J Cell Physiol 2001 : ATP, UTP , UDP and ATPgammaS increased ( 3 ) H-thymidine incorporation into DNA and expression of the protooncogenes c-Fos and c-Jun , while 2-MeSATP was ineffective, and alpha, beta-meATP gave a response only at 100-microM dose
Huwiler et al., Br J Pharmacol 1997 : Here we show that ATP and UTP potently stimulate the stress activated protein kinase pathway and phosphorylation of the transcription factor c-Jun ... 4. Down-regulation of protein kinase C-alpha, -delta and -epsilon isoenzymes by 24 h treatment of the cells with 12-O-tetradecanoylphorbol 13-acetate did not inhibit ATP- and UTP induced activation of c-Jun phosphorylation ... 5. Pretreatment of the cells with pertussis toxin or the tyrosine kinase inhibitor, genistein, strongly attenuated ATP- and UTP induced c-Jun phosphorylation