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IL6 — VAV1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: VAV1 → IL6 (increases) Lee et al., FEBS Lett 1997*
  Evidence: Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6.
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → VAV1 (VAV1) (modification, activates) Schuringa et al., Biochem J 2000

Text-mined interactions from Literome

Song et al., J Immunol 1999 : Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase dependent pathway ... Vav expression, but not expression of domain mutated Vav, increased IL-6 secretion from nonimmortalized bone marrow derived mast cells upon FcepsilonRI engagement ... We conclude that Vav phosphorylation contributes to IL-6 induction in mast cells
Hanazono et al., Acta Haematol 1996 : Here we report that granulocyte/macrophage-colony- stimulating factor ( GM-CSF ), interleukin-3 , and erythropoietin (Epo) induce rapid and transient tyrosine phosphorylation of Vav and that Vav is constitutively associated with the SH3 domain of Grb2/Ash in a human leukemia cell line UT-7
Lee et al., FEBS Lett 1997 : We show that interleukin-6 (IL-6) induces transient tyrosine phosphorylation of Vav in a human myeloma cell line, U266 ... A membrane-distal part of the cytoplasmic region of gp130 is critical for association between Vav and gp130, and the IL-6 induced tyrosine phosphorylation of Vav
Fischer et al., Curr Biol 1998 : Vav is a crucial regulator of TCR mediated Ca2+ flux, cytoskeletal reorganization and TCR clustering, and these are required for T-cell maturation, interleukin-2 production and cell cycle progression