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RELA — VIP
Text-mined interactions from Literome
Delgado et al., J Immunol 2000
:
We showed previously that
VIP/PACAP inhibit
NF-kappaB nuclear translocation through the stabilization of IkappaB and reduce IFN regulatory factor-1 (IRF-1) binding to the regulatory elements found in the IL-12 p40 and inducible NO synthase promoters
Delgado et al., J Biol Chem 2001
(MAP Kinase Signaling System) :
First,
VIP/PACAP inhibit p65 nuclear translocation and
NF-kappa B DNA binding by stabilizing the inhibitor I kappa B alpha ... The
VIP/PACAP inhibition of
NF-kappa B at various levels and through different transduction pathways could offer a significant advantage over other anti-inflammatory agents
Delgado et al., J Immunol 2001
(Leukemia L1210...) :
VIP/PACAP inhibit the expression and/or DNA binding activity of several transcriptional factors involved in FasL expression, i.e., c-myc,
NF-kappaB , NF-ATp, and early growth factors (Egr) 2/3
Delgado et al., J Immunol 2001
(Acute Disease...) :
The
VIP/PACAP inhibition of both chemokine production and of
NF-kappaB binding and transactivating activity is mediated through the specific VIP receptor VPAC1, and involves both cAMP dependent and -independent intracellular pathways
Delgado et al., Glia 2002
(Encephalitis) :
The
VIP/PACAP inhibition of both chemokine production and of
NFkB binding is mediated through the specific receptor VPAC1 and involves a cAMP dependent intracellular pathway
Yin et al., Immunol Invest 2005
(Arthritis, Experimental...) :
Effects of
VIP and [ D-P-Cl-Phe ( 6 ), Leu ( 17 ) ] -VIP on
NF-kappaB activity were analyzed using luciferase gene reporter assays ...
Effects of VIP and [ D-P-Cl-Phe ( 6 ), Leu ( 17 ) ]
-VIP on
p65NF-kappaB expression of the synovial cells were examined by Western blot
Foster et al., J Dent Res 2005
:
In parallel, we showed that
VIP inhibits nuclear translocation of
NFkappaB and c-Jun in a time dependent manner, but does not decrease the expression of CD14 receptors
Fernández-MartÃnez et al., Mol Cell Endocrinol 2007
(Disease Progression...) :
In fact,
VIP increased the translocation of the
NFkappaB p50 subunit to the nucleus and the binding of the active form to its target gene promoter, as measured by Western blotting and ELISA, respectively