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TNF — WNT6
Text-mined interactions from Literome
Laurikkala et al., Dev Biol 2001
:
TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is
regulated by
Wnt and activin during tooth organogenesis
Gustafson et al., J Biol Chem 2006
(Diabetes Mellitus...) :
Remarkably, both IL-6 and
TNFalpha maintained and
augmented the canonical
Wnt signaling associated with low axin and high low density lipoprotein receptor related protein ( LRD ), Dishevelled, and beta-catenin levels
Al-Aly et al., Translational research : the journal of laboratory and clinical medicine 2008
(Calcinosis...) :
Arterial calcification : a
tumor necrosis factor-alpha mediated vascular
Wnt-opathy ... Furthermore, SM22-TNF-alphaTg ; TOPGAL mice exhibit greater beta-galactosidase reporter staining versus TOPGAL siblings in the aorta and coronaries, which indicates enhanced mural
Wnt signaling in
response to
TNF-alpha
Oguma et al., Future Oncol 2010
(Disease Models, Animal...) :
Accordingly, it is possible that the
TNF-alpha induced promotion of
Wnt signaling is a novel protumorigenic mechanism of inflammation in gastric carcinogenesis
Oshima et al., Gastroenterology 2011
(Cell Transformation, Neoplastic...) :
Macrophage derived
tumor necrosis factor-a promotes
Wnt signaling in epithelial cells, which contributes to gastric tumorigenesis
Almeida et al., J Biol Chem 2011
(Wnt Signaling Pathway) :
Glucocorticoids and
tumor necrosis factor a increase oxidative stress and
suppress Wnt protein signaling in osteoblasts
Hochstenbach et al., Cancer Epidemiol Biomarkers Prev 2012
(Micronuclei, Chromosome-Defective) :
In particular, male-specific
TNF-alpha-NF-kB signaling upon dioxin exposure and
activation of the
Wnt-pathway in boys upon acrylamide exposure might represent possible mechanistic explanations for gender specificity in the incidence of childhood leukemia
Zhang et al., J Clin Invest 2013
(Hyperalgesia...) :
WNT signaling activation
stimulated production of the proinflammatory cytokines IL-18 and
TNF-a and regulated the NR2B glutamate receptor and Ca2+ dependent signals through the ß-catenin pathway in the spinal cord