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MAPK12 — ZAP70

Pathways - manually collected, often from reviews:

• KEGG T cell receptor signaling pathway: ZAP70 → MAPK11/MAPK12/MAPK13/MAPK14 (protein-protein, activation)
  

Text-mined interactions from Literome

Ahmed et al., J Mol Biol 2005 : We first demonstrate that ZAP70 plays a pivotal role in interferon stimulated MAPK activation, and that the tyrosine residue at position 319 of ZAP70 is important for interferon stimulated ERK activation
Kim et al., Biochem Biophys Res Commun 2009 : Hph-1-ZAP-70-Y319F inhibited the phosphorylation of ZAP-70-Tyr319, LAT-Tyr191, and p44/42 MAPK induced by TcR stimulation, NFAT- and AP-1 mediated gene transcription, and the induction of CD69 expression and IL-2 secretion
Pedraza-Alva et al., IUBMB Life 2011 : Consequently, the prolonged tyrosine phosphorylation and delayed degradation of ZAP-70 and of the ? chain lead to enhanced mitogen activated protein kinase activation and robust TC response