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ALK — EPHB2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Marzec et al., Oncogene 2007
(MAP Kinase Signaling System) :
The
NPM/ALK induced
MEK/ERK activation is independent of c-Raf as evidenced by the lack of MEK1/2 and ERK1/2 phosphorylation upon c-Raf inactivation by two different inhibitors, RI and ZM336372, and by its siRNA mediated depletion
David et al., J Cell Physiol 2007
:
Further, HMVEC-d wounding induced activation of both JNK and
ERK , and these were
inhibited by
ALK1ca expression
Takezawa et al., Clin Cancer Res 2011
(Cell Transformation, Neoplastic...) :
Role of
ERK-BIM and STAT3-survivin signaling pathways in
ALK inhibitor induced apoptosis in EML4-ALK positive lung cancer ... Forced expression of
EML4-ALK induced marked activation of extracellular signal regulated kinase (
ERK ) and STAT3, but not that of AKT