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EFNB3 — EPHB2

Pathways - manually collected, often from reviews:

• KEGG Axon guidance: EPHB1/EPHB2/EPHB3/EPHB4/EPHB6 → EFNB1/EFNB2/EFNB3 (protein-protein, activation)
• NCI Pathway Database EPHB forward signaling: EPHB2 (EPHB2) → Ephrin B (EFNB3/EFNB2/EFNB1) (modification, collaborate)
  Zisch et al., Oncogene 2000, Himanen et al., Nature 2001, Gale et al., Neuron 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database EPHB forward signaling: EPHB2 (EPHB2) → Ephrin B/EPHB2 complex (EFNB3_EFNB2_EFNB1-EPHB2) (modification, collaborate)
  Zisch et al., Oncogene 2000, Himanen et al., Nature 2001, Gale et al., Neuron 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database EPHB forward signaling: Ephrin B (EFNB3/EFNB2/EFNB1) → Ephrin B/EPHB2 complex (EFNB3_EFNB2_EFNB1-EPHB2) (modification, collaborate)
  Zisch et al., Oncogene 2000, Himanen et al., Nature 2001, Gale et al., Neuron 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database EPHB forward signaling: RasGAP (RASA1) → Ephrin B/EPHB2 complex (EFNB3_EFNB2_EFNB1-EPHB2) (modification, collaborate)
  Elowe et al., Mol Cell Biol 2001, Holland et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database EPHB forward signaling: RasGAP (RASA1) → Ephrin B/EPHB2/RasGAP complex (EFNB3_EFNB2_EFNB1-EPHB2-RASA1) (modification, collaborate)
  Elowe et al., Mol Cell Biol 2001, Holland et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB2 complex (EFNB3_EFNB2_EFNB1-EPHB2) → Ephrin B/EPHB2/RasGAP complex (EFNB3_EFNB2_EFNB1-EPHB2-RASA1) (modification, collaborate)
  Elowe et al., Mol Cell Biol 2001, Holland et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database EPHB forward signaling: None → Ephrin B/EPHB2/Intersectin/N-WASP complex (EFNB3_EFNB2_EFNB1-EPHB2-ITSN1-WASL) (modification, collaborate)
  Irie et al., Nat Neurosci 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database EPHB forward signaling: CDC42/GDP complex (CDC42) → Ephrin B/EPHB2/Intersectin/N-WASP complex (EFNB3_EFNB2_EFNB1-EPHB2-ITSN1-WASL) (modification, collaborate)
  Irie et al., Nat Neurosci 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database EPHB forward signaling: Endophilin/SYNJ1 complex (SYNJ1) → Ephrin B/EPHB2 complex (EFNB3_EFNB2_EFNB1-EPHB2) (modification, collaborate)
  Irie et al., Nat Cell Biol 2005*
  Evidence: mutant phenotype, assay
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB2/KALRN complex (EFNB3_EFNB2_EFNB1-EPHB2-KALRN) → KALRN (KALRN) (modification, collaborate) Penzes et al., Neuron 2003
  Evidence: physical interaction, other species
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB2/KALRN complex (EFNB3_EFNB2_EFNB1-EPHB2-KALRN) → Ephrin B/EPHB2 complex (EFNB3_EFNB2_EFNB1-EPHB2) (modification, collaborate)
  Penzes et al., Neuron 2003
  Evidence: physical interaction, other species
• NCI Pathway Database EPHB forward signaling: KALRN (KALRN) → Ephrin B/EPHB2 complex (EFNB3_EFNB2_EFNB1-EPHB2) (modification, collaborate)
  Penzes et al., Neuron 2003
  Evidence: physical interaction, other species
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB2/RasGAP complex (EFNB3_EFNB2_EFNB1-EPHB2-RASA1) → RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Elowe et al., Mol Cell Biol 2001
  Evidence: genetic interaction
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB2/RasGAP complex (EFNB3_EFNB2_EFNB1-EPHB2-RASA1) → None (modification, activates) Elowe et al., Mol Cell Biol 2001
  Evidence: genetic interaction
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB2/RasGAP complex (EFNB3_EFNB2_EFNB1-EPHB2-RASA1) → RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS) (modification, activates)
  Elowe et al., Mol Cell Biol 2001
  Evidence: genetic interaction
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB2/RasGAP complex (EFNB3_EFNB2_EFNB1-EPHB2-RASA1) → None (modification, activates) Elowe et al., Mol Cell Biol 2001
  Evidence: genetic interaction
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB2/KALRN complex (EFNB3_EFNB2_EFNB1-EPHB2-KALRN) → PAK1 (PAK1) (modification, activates) Penzes et al., Neuron 2003
  Evidence: mutant phenotype, other species
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB2/Intersectin/N-WASP complex (EFNB3_EFNB2_EFNB1-EPHB2-ITSN1-WASL) → Ephrin B/EPHB2 complex (EFNB3_EFNB2_EFNB1-EPHB2) (modification, collaborate)
  Irie et al., Nat Neurosci 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB2/Intersectin/N-WASP complex (EFNB3_EFNB2_EFNB1-EPHB2-ITSN1-WASL) → Intersectin/N-WASP complex (ITSN1-WASL) (modification, collaborate)
  Irie et al., Nat Neurosci 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB2 complex (EFNB3_EFNB2_EFNB1-EPHB2) → Intersectin/N-WASP complex (ITSN1-WASL) (modification, collaborate)
  Irie et al., Nat Neurosci 2002
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: EFNB3 → EPHB2 (direct_complex) Himanen et al., Nature 2001, Himanen et al., Trends Neurosci 2003, Himanen et al., Curr Opin Cell Biol 2007
• Reactome Reaction: EFNB3 → EPHB2 (indirect_complex) Penzes et al., Neuron 2003
• Reactome Reaction: EFNB3 → EPHB2 (reaction) van Horck et al., J Biol Chem 2001, Marignani et al., J Cell Biol 2001, Himanen et al., Nature 2001, Himanen et al., Trends Neurosci 2003, Bokoch et al., Annu Rev Biochem 2003, Zhang et al., J Cell Biol 2003, Marston et al., Nat Cell Biol 2003, Zhang et al., J Neurosci 2005, Cowan et al., Neuron 2005, Tolias et al., Proc Natl Acad Sci U S A 2007, Himanen et al., Curr Opin Cell Biol 2007, Zhang et al., Nature 1990, Yao et al., Oncogene 1995

Text-mined interactions from Literome

Mann et al., J Neurobiol 2003 : Forward and reverse signaling mediated by EphB tyrosine kinase receptors and their transmembrane ephrin-B ligands play important roles in axon pathfinding, yet little is known about the intracellular pathways involved
Prestoz et al., Neuron Glia Biol 2004 : In addition, we demonstrate that coated EphB2-Fc receptors, which are specific for ephrinB2/B3 ligands, induce dramatic changes in the contact and migratory properties of OPCs, indicating that axonal EphB receptors activate ephrinB signaling in OPCs.Based on these findings, we propose that OPCs are characterized by an ephrin code, and that Eph-ephrin interactions between axons and OPCs control the distribution of OPCs in the optic axonal tracts, and the progress and arrest of their migration
Bush et al., Genes Dev 2009 : In addition to the ability of ephrin-B1 to forward signal through its cognate EphB tyrosine kinase receptors, ephrin-B1 can also act as a receptor and transduce a reverse signal by either PDZ dependent or phosphorylation dependent mechanisms
Li et al., J Neurosci 2011 : These data provide evidence for ephrin-B induced EphB2 forward signaling in presynaptic structural plasticity during classical conditioning
Barthet et al., Neurobiol Aging 2013 : Activation of EphB receptors by ephrinB ( efnB ) ligands on neuronal cell surface regulates important functions, including neurite outgrowth, axonal guidance, and synaptic plasticity
Srivastava et al., Mol Cell Neurosci 2013 : Taken together, our findings suggest that ephrinB activated EphB2 receptors recruit a novel Nck/Pak signaling complex to mediate repulsive cortical growth cone guidance, which may be relevant for EphB forward signaling dependent axon guidance in vivo