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MAPK11 — TGFB2
Text-mined interactions from Literome
Han et al., J Biol Chem 2000
:
TGF-beta1/TGF-beta2 increased phosphorylation of both
mitogen activated protein ( MAP ) kinase and PPAR-gamma, whereas MAP kinase inhibitors reversed suppression of CD36 and inhibited PPAR-gamma phosphorylation induced by TGF-beta1/TGF-beta2
Johansson et al., J Cell Sci 2000
(Carcinoma, Squamous Cell) :
In addition,
transforming growth factor- ( beta ) ( TGF- ( beta )
activated p38
MAPK in both cell lines, and ERK2 in A-5 cells
Westermarck et al., Mol Cell Biol 2001
(MAP Kinase Signaling System) :
In contrast, activation of stress activated c-Jun N-terminal kinase and p38 pathways by expression of constitutively active mutants of Rac,
transforming growth factor beta activated kinase 1 ( TAK1 ),
MAPK kinase 3 ( MKK3 ) , or MKK6 or by treatment with arsenite or anisomycin did not alone markedly enhance MMP-1 promoter activity
Bhowmick et al., J Biol Chem 2001
:
Integrin beta 1 signaling is necessary for
transforming growth factor-beta activation of
p38MAPK and epithelial plasticity
Sato et al., J Invest Dermatol 2002
(Scleroderma, Systemic) :
Role of p38
MAPK in
transforming growth factor beta stimulation of collagen production by scleroderma and healthy dermal fibroblasts ... In conclusion, this study demonstrates a costimulatory
role for p38
MAPK in
transforming growth factor beta induction of the collagen type I gene
Kimoto et al., Invest Ophthalmol Vis Sci 2004
(MAP Kinase Signaling System) :
TGF-beta 2 activates p38
MAPK and p38 MAPK plays a role in relaying the TGF-beta 2 signal to type I collagen production in the retinal pigment epithelium
Suzuki et al., Clin Exp Nephrol 2004
:
Role of
mitogen activated protein kinase in the regulation of
transforming growth factor-beta induced fibronectin accumulation in cultured renal interstitial fibroblasts
Jamora et al., PLoS Biol 2005
(MAP Kinase Signaling System) :
We found that
transforming growth factor beta2 signaling is necessary to transiently induce the transcription factor Snail and
activate the Ras-mitogen activated protein kinase (
MAPK ) pathway in the bud
Roux et al., J Biol Chem 2005
(Edema) :
The inhibitory effect of IL-1beta on alpha ENaC expression was mediated by the activation of p38
MAPK in both rat and human ATII cells and was
independent of the activation of alpha v beta6 integrin and
transforming growth factor-beta
Leung et al., Nephrol Dial Transplant 2005
:
The GDP induced VEGF and
transforming growth factor ( TGF ) -beta synthesis in HPMC was partially
reduced by either the p42/p44
MAPK inhibitor ( PD98059 ) or the PKC inhibitor ( staurosporine )
Saika et al., Lab Invest 2005
(Disease Models, Animal...) :
Exogenous
TGF-beta2 activates
p38MAPK in ARPE-19 cells
Gaide Chevronnay et al., Endocrinology 2008
:
In presence of ovarian steroids,
MAPK inhibitors ( p38 and ERK pathways ) stimulated TGF-beta3 but
inhibited TGF-beta2 expression ... The opposite
regulation of
TGF-beta2 and -beta3 by cAMP and
MAPK could account for their distinct expression in vivo
Cheng et al., Molecular vision 2008
(Fibrosis) :
TGFbeta2 induced sequential phosphorylation of Smad2 and Smad3 and p38
MAPK ... TGZ inhibited TGFbeta2 induced early Smad2 and Smad3 and late Smad3 phosphorylation but had no influence on
TGFbeta2 induced p38
MAPK activation ... On the other hand, TGZ does not alter the levels of
TGFbeta2 induced p38
MAPK phosphorylation, the effect of TGZ is unlikely to be mediated by p38 MAPK signaling
Krug et al., Hypertension 2010
:
MR blockade and extracellular signal regulated kinase 1/2
mitogen activated protein kinase inhibition
prevent age associated increases of
transforming growth factor-beta , intercellular adhesion molecule 1, and procollagen 1
Leenders et al., J Biol Chem 2010
(Hypertrophy, Left Ventricular) :
We show that
transforming growth factor-beta mediated
activation of p38
MAPK is necessary and sufficient to decrease KLF15 expression