◀ Back to NOS1
CAV1 — NOS1
Text-mined interactions from Literome
Segal et al., Am J Physiol 1999
:
In isolated cell systems,
nitric oxide synthase (NOS) activity is
regulated by
caveolin (CAV) , a resident caveolae coat protein
Shah et al., Gastroenterology 1999
(Liver Cirrhosis, Experimental) :
These studies provide evidence that enhanced expression and interaction of
caveolin with eNOS
contribute to impaired NO production, reduced
NOS activity, and vasoconstriction in the intact cirrhotic liver
Shah et al., Am J Physiol Gastrointest Liver Physiol 2001
(Hypertension, Portal) :
The purpose of this study is to characterize the expression and cellular localization of the NOS inhibitory protein caveolin-1 in normal rat liver and to then examine the
role of
caveolin in conjunction with calmodulin in regulation of
NOS activity in cholestatic portal hypertension ... We conclude that, in cholestatic portal hypertension,
caveolin may negatively
regulate NOS activity in a manner that is reversible by excess calmodulin
Sato et al., J Biol Chem 2004
:
CaV1p1 inhibited NO formation activity and NADPH oxidation of wild-type
nNOS in a dose dependent manner with an IC ( 50 ) value of 1.8 microM
Sbaa et al., Trends Cardiovasc Med 2005
:
The double
regulation of endothelial
nitric oxide synthase by caveolae and
caveolin : a paradox solved through the study of angiogenesis
Rasmusen et al., Ann Biol Clin (Paris) 2005
(Atherosclerosis...) :
The co-operation between cholesterol synthesis and the upregulation of
caveolin-1 on the one hand, and the
activation of endothelial
nitric oxide synthase on the other hand, is very tight
Shen et al., J Neurochem 2006
(Brain Ischemia...) :
Exposure to 1 h ischemia
induced the increases in
neuronal nitric oxide synthase (nNOS) and NO concentration with concurrent down-regulation of
caveolin-1 expression in the ischemic core of rat brains
Suh et al., J Korean Med Sci 2010
(Hypertension) :
HMG-CoA reductase inhibitor improves endothelial dysfunction in spontaneous hypertensive rats via down-regulation of
caveolin-1 and
activation of endothelial
nitric oxide synthase
Schreihofer et al., Vascul Pharmacol 2010
:
These data suggest that HS diets have no effect on vascular NO production, and that E2 may modulate basal NO production by reducing the expression of
caveolin-1 , an allosteric
inhibitor of
NOS activity
Dessy et al., Pflugers Arch 2010
:
The
regulation of endothelial
nitric oxide synthase by
caveolin : a paradigm validated in vivo and shared by the ` endothelium derived hyperpolarizing factor '
Tian et al., Free Radic Biol Med 2010
:
A novel
role for
caveolin-1 in regulating endothelial
nitric oxide synthase activation in response to H2O2 and shear stress
Kwok et al., Am J Physiol Gastrointest Liver Physiol 2009
:
Caveolin-1 mediates endotoxin inhibition of endothelin-1 induced endothelial
nitric oxide synthase activity in liver sinusoidal endothelial cells
Sud et al., Mol Endocrinol 2010
:
Caveolin 1 is
required for the activation of endothelial
nitric oxide synthase in response to 17beta-estradiol
Adebola et al., Afr Health Sci 2011
:
Nitric oxide synthase (NOS) is negatively
regulated by protein-protein interactions with
caveolin-1 before extracellular activating signals release it for nitric oxide ( NO ) production ... We conclude that unlike
caveolin-1 , a known pre-activation
inhibitor of nascent
NOS , PKG may be a post-activation inhibitor of NOS, possibly important for the recycling of the spent enzyme
Michel et al., J Biol Chem 1997
:
Reciprocal
regulation of endothelial
nitric-oxide synthase by Ca2+-calmodulin and
caveolin
Feron et al., Biochemistry 1998
:
Dynamic regulation of endothelial
nitric oxide synthase : complementary
roles of dual acylation and
caveolin interactions