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HAP1 — HSP90AA1

Text-mined interactions from Literome

Lee et al., J Biol Chem 2002 : The molecular chaperone Hsp90 mediates heme activation of the yeast transcriptional activator Hap1 ... By lowering the expression levels of wild-type Hsp90, using a highly specific Hsp90 inhibitor, and by examining the effects of various Hsp90 mutants on Hap1, we show that Hsp90 is critical for Hap1 activation by heme
Lee et al., Mol Cell Biol 2003 : Structural environment dictates the biological significance of heme-responsive motifs and the role of Hsp90 in the activation of the heme activator protein Hap1 ... Likewise, the role of Hsp90 in Hap1 activation is dictated by the conformational or structural state of Hap1, not by the mere strength of Hap1-Hsp90 interaction