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CALM3 — PTH
Text-mined interactions from Literome
Lu et al., J Endocrinol 2011
(Adenoma...) :
Blocking of
calmodulin and CaMKII activity by the specific antagonists calmidazolium and KN-62 respectively
caused a rise in
PTH secretion from parathyroid adenoma cells in spite of increased [ Ca ( 2+ ) ] ( i ) ... The inhibitory
effect of Ca ( 2+ )
calmodulin on
PTH secretion may be due to the absence of synaptotagmin 1 protein in parathyroid adenomas, as demonstrated by western blot analysis ... Taken together, these results show that
calmodulin negatively
contributes to the regulation of
PTH secretion in parathyroid adenoma, at least partially via a CaMKII pathway