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CFL2 — EGF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CFL2 → EGF (decreases) Olsen et al., Cell 2006*
  Evidence: We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database

Text-mined interactions from Literome

Chan et al., J Cell Biol 2000 : EGF stimulation triggers a transient increase in cofilin in the leading edge near the membrane, which is precisely cotemporal with the appearance of free barbed ends there
Marcoux et al., Cell Signal 2005 : EGF receptor activity is essential for adhesion induced stress fiber formation and cofilin phosphorylation
Song et al., J Cell Sci 2006 (Neoplasms) : Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells ... Stimulation with epidermal growth factor (EGF) induces an increase in cofilin activity after 60 seconds together with an increase in phosphorylated cofilin ( p-cofilin ), indicating that cofilin dephosphorylation is not coupled to cofilin activation in these cells ... Suppression of LIMK function by inhibiting Rho associated protein kinase (ROCK) or LIMK siRNA inhibited the EGF induced cofilin phosphorylation but had no effect on cofilin activity or cofilin dependent lamellipod protrusion induced by EGF ... Phospholipase C, which has been implicated in cofilin activation following stimulation with EGF , does not regulate p-cofilin levels following stimulation with EGF
Wu et al., Invest New Drugs 2010 (Breast Neoplasms) : Furthermore, EGF induced cofilin phosphorylation, a critical step of cofilin recycle and actin polymerization, was also dampened, which was relevant to the decreased cell migration
Desmarais et al., Cell Motil Cytoskeleton 2009 (Breast Neoplasms) : They form in response to epidermal growth factor (EGF) , and contain the usual invadopodium core proteins N-WASP, Arp2/3, cortactin, cofilin , and F-actin
Nakashima et al., Molecular cancer 2011 (Carcinoma...) : EGF induced RhoA activity, as well as the phosphorylation of cofilin and myosin light chain ( MLC ), both targets of ROCK signaling, and Y27632 suppressed both of these processes, indicating that the phosphorylation of cofilin and MLC by EGF occurs through ROCK in Panc1 cells
Chung et al., BMC cancer 2013 (Neoplasm Invasiveness...) : Epidermal growth factor (EGF) increased the phosphorylation of cofilin and elevated the migration in T24 cells
Li et al., Carcinogenesis 2013 (Carcinoma, Non-Small-Cell Lung...) : To the best of our knowledge, this study is the first to report that PTTG1 promotes epidermal growth factor (EGF) induced the phosphorylation of LIN-11, Isl1 and MEC-3 protein domain kinase and cofilin , a critical step in cofilin recycling and actin polymerization