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EGF — EGR1

Text-mined interactions from Literome

Tsai et al., Am J Physiol Cell Physiol 2000 : The Egr-1 gene is induced by epidermal growth factor in ECV304 cells and primary endothelial cells ... The aim of the present study was to determine whether epidermal growth factor (EGF) induces Egr-1 expression in endothelial cells
Mechtcheriakova et al., FASEB J 2001 (MAP Kinase Signaling System) : The additional finding that EGF induces ERK and EGR-1 in a PKC independent manner and that this signal is not sufficient to up-regulate TF emphasizes the importance of a VEGF-specific signaling pattern for the induction of TF
Groot et al., Eur J Cell Biol 2000 (Insulinoma...) : EGF also stimulated Egr-1 promoter activity in both PC12 and INS-1 cells
Kaufmann et al., J Neurol Sci 2001 (Astrocytoma...) : The synthesis of Egr-1 in human glioma cells as a result of EGF or PDGF stimulation indicates that Egr-1 may be an important `` late '' part of the EGF and PDGF initiated signaling cascades suggesting that Egr-1 functions as a `` third messenger '' in glioma cells connecting growth factor stimulation with changes in gene transcription
Tsai et al., Am J Physiol Gastrointest Liver Physiol 2001 : The goal of the present study was to explore the role of epidermal growth factor (EGF) in mediating Egr-1 expression in hepatocytes under both in vitro and in vivo conditions
Kaufmann et al., J Cell Biochem 2002 (MAP Kinase Signaling System) : The synthesis of Egr-1 in HaCaT cells as a result of EGF or thrombin stimulation suggests that Egr-1 may be an important `` late '' part of the EGF and thrombin initiated signaling cascades
Al-Sarraj et al., J Mol Med (Berl) 2004 (Cell Transformation, Neoplastic) : These results indicate that activation of the EGF receptor as well as stimulation of the mitogen activated/extracellular signal regulated protein kinase is essential for arsenite induced upregulation of Egr-1
Lim et al., J Cell Biochem 2008 (Neoplasms) : RNA interference mediated depletion of endogenous Egr-1 or SRF impaired EGF- or serum mediated induction of UCP expression, which was required for cancer cell proliferation
Cabodi et al., J Cell Physiol 2009 : Integrin dependent adhesion plays a dual role in Egr-1 regulation, either being sufficient `` per se '' to induce Egr-1, or required for EGF dependent expression of Egr-1 , which occurs only in adherent cells and not in cells in suspension
Arora et al., Genome Biol 2008 (Prostatic Neoplasms) : Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip
Mayer et al., J Cell Sci 2009 (MAP Kinase Signaling System) : Stimulation of astrocytes with epidermal growth factor (EGF) induced proliferation and triggered the biosynthesis of the transcription factor Egr-1 , involving the activation of the extracellular signal regulated protein kinase ( ERK ) signaling pathway
Choi et al., Gene 2010 : Transcriptional activation of the human Klotho gene by epidermal growth factor in HEK293 cells ; role of Egr-1
Manente et al., PloS one 2011 : Coordinated sumoylation and ubiquitination modulate EGF induced EGR1 expression and stability ... The aim of this work was to assess the influence of sumoylation on EGF induced Egr1 expression and/or stability
Tarcic et al., FASEB J 2012 : In addition to strong activation of ERK by EGF, and AKT by serum, early transcription remarkably differed : while EGF induced early growth response-1 (EGR1) , and this was required for migration, serum induced c-Fos and FosB to enhance proliferation
Kerpedjieva et al., Stem Cells Dev 2012 (MAP Kinase Signaling System) : Since EGF strongly upregulates EGR1 , we hypothesized that EGF receptor (EGFR)-EGR1 signaling plays a pivotal role in MSC paracrine activity
Cheng et al., Oncogene 2013 (Ovarian Neoplasms) : EGF induced Egr-1 expression required the activation of the ERK1/2 and PI3K/Akt signaling pathways and was unrelated to EGF induced H ( 2 ) O ( 2 ) production and activation of the p38 MAPK pathway
Gregg et al., Genes & cancer 2011 : Transcriptional Regulation of EGR1 by EGF and the ERK Signaling Pathway in Prostate Cancer Cells ... As EGR1 expression and epidermal growth factor (EGF) signaling are frequently upregulated in prostate tumors, we tested the hypothesis that EGF induces EGR1 expression in prostate cancer cells ... Using RT-PCR to quantify EGR1 transcripts, we found that EGF induced EGR1 expression in a dose- and time dependent manner and the ERK pathway inhibitor, PD98059, abrogated the EGF mediated EGR1 response in LNCaP and PC3 cells
Jamieson et al., J Cell Physiol 1989 : Conversely, EGF , which stimulates Na/H exchange poorly, strongly activated EGR1 expression
Kujubu et al., J Neurosci Res 1993 : Both EGF and NGF result in the induction of the primary response gene egr-1/TIS8 and increased methylation of a variety of membrane associated proteins as early as 5 min after EGF or NGF treatment using a methylation assay that detects methyl esters as well as methylated arginine residues
Fang et al., Calcif Tissue Int 1995 : Inhibition of protein kinase C activity by pretreatment with 1 microM chelerythrine chloride or by prolonged stimulation with 50 ng/ml tetradecanoyl phorbol acetate ( TPA ) partially diminished the induction of Egr-1 by EGF
Iwami et al., Am J Physiol 1996 : Serum and epidermal growth factor (EGF) also induced Egr-1 , but norepinephrine ( NE ) and endothelin ( ET ) had no effect ... These results demonstrate that 1 ) ANG II both induces protooncogene expression and enhances fibronectin mRNA levels in cultured cardiac fibroblasts, whereas EGF only induces Egr-1 , and NE and ET have no effects on either function ; 2 ) ANG II effects are primarily mediated by the AT1 receptor ; and 3 ) growth factors can regulate AT1-receptor mRNA levels