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EGF — EPS15

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: EPS15 → EGF (increases) de Melker et al., J Cell Sci 2004*
  Evidence: EGF-induced phosphorylation of Eps15, as well as recruitment of Eps15 to the plasma membrane and its co-localization with the EGF receptor in endosomes required the ubiquitin ligase activity of c-Cbl.
• NCI Pathway Database Internalization of ErbB1: EGFR/EGFR/EGF/EGF complex (EGFR-EGF) → EPS15 (EPS15) (modification, activates) Torrisi et al., Mol Biol Cell 1999*
  Evidence: assay, physical interaction
• Reactome Reaction: EGF → EPS15 (indirect_complex) Rosenthal et al., J Biol Chem 1999, Klapisz et al., J Biol Chem 2002, Haglund et al., Proc Natl Acad Sci U S A 2002, Sigismund et al., Proc Natl Acad Sci U S A 2005, Haglund et al., EMBO Rep 2005
• Reactome Reaction: EGF → EPS15 (reaction) Rosenthal et al., J Biol Chem 1999, Klapisz et al., J Biol Chem 2002, Haglund et al., Proc Natl Acad Sci U S A 2002, Sigismund et al., Proc Natl Acad Sci U S A 2005

Text-mined interactions from Literome

de Melker et al., J Cell Sci 2004 : EGF induced phosphorylation of Eps15 , as well as recruitment of Eps15 to the plasma membrane and its co-localization with the EGF receptor in endosomes required the ubiquitin ligase activity of c-Cbl
van Delft et al., J Cell Biol 1997 : In this report, we show that activation of the EGF receptor by either EGF or TGF-alpha results in phosphorylation of Eps15
van Delft et al., J Biol Chem 1997 : Our results establish ubiquitination as a second form of EGF stimulated covalent modification of Eps15