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CDK1 — RB1

Pathways - manually collected, often from reviews:

• KEGG Cell cycle: Complex of CCNA1-CCNA2-CDK1 → RB1 (protein-protein, phosphorylation)
• WikiPathways Cell Cycle: CDK1 → RB1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CDK1 — RB1 (direct interaction, enzymatic study) Knudsen et al., Mol Cell Biol 1997*
• IRef Biogrid Interaction: CDK1 — RB1 (direct interaction, enzymatic study) Chen et al., Dev Cell 2002*
• IRef Biogrid Interaction: CDK1 — RB1 (direct interaction, enzymatic study) De Luca et al., J Cell Physiol 1997*
• IRef Biogrid Interaction: CDK1 — RB1 (direct interaction, enzymatic study) Horton et al., Oncogene 1997*
• IRef Biogrid Interaction: CDK1 — RB1 (direct interaction, enzymatic study) Lees et al., EMBO J 1991*
• IRef Biogrid Interaction: CDK1 — RB1 (direct interaction, enzymatic study) Jiang et al., Mol Cell 1998
• IRef Biogrid Interaction: CDK1 — RB1 (direct interaction, enzymatic study) Knudsen et al., J Biol Chem 1996
• IRef Hprd Interaction: CDK1 — RB1 (in vivo) Lees et al., EMBO J 1991*

Text-mined interactions from Literome

Kourea et al., Am J Pathol 1999 (Cell Transformation, Neoplastic...) : In this study, we investigated patterns of expression of p53 and pRB , cyclin dependent kinase inhibitors ( CKIs ) p21 and p27, as well as cyclins D1 and E, in a cohort of 35 well characterized MPNSTs and 16 NFs
Kuo et al., Cancer Lett 2006 (Glioma...) : After treatment with CAPE ( 50 microM ) for 6h, it demonstrated that the protein level of hyperphosphorylated pRb decreased, and cyclin dependent kinase inhibitors p21, p27, and p16 were marked up-regulated
Magenta et al., Mol Cell Biol 2008 : While the role of cyclin/cyclin dependent kinase complexes in the modulation of pRb phosphorylation has been extensively studied, relatively little is known about the molecular mechanisms regulating phosphate removal by phosphatases
Wakida et al., PloS one 2010 (Osteosarcoma) : In this study we ablate the centrosome by intracellular laser irradiation to understand the role of the centrosome in two vastly different cell types, human osteosarcoma ( U2OS ) and rat kangaroo kidney epithelial cells ( PtK )
Kratzke et al., Cancer Res 1996 (Adenocarcinoma...) : These findings establish the prognostic significance ( of the absence of p16INK4, in resected NSCLC and confirm the critical importance of disrupting the pathway of cyclin dependent kinase mediated phosphorylation of pRB in the molecular oncogenesis and progression of NSCLC