◀ Back to IQGAP1

IQGAP1 — VEGFA

Pathways - manually collected, often from reviews:

• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VEGFR2 (dimer)/VEGFA (dimer)/Src complex (KDR-VEGFA-SRC) → IQGAP1 (IQGAP1) (modification, activates) Meyer et al., PloS one 2008*
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VEGFR2 (dimer)/VEGFA (dimer)/IQGAP1 complex (KDR-VEGFA-IQGAP1) → IQGAP1 (IQGAP1) (modification, collaborate) Yamaoka-Tojo et al., Circ Res 2004*
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VEGFR2 (dimer)/VEGFA (dimer)/IQGAP1 complex (KDR-VEGFA-IQGAP1) → VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) (modification, collaborate)
  Yamaoka-Tojo et al., Circ Res 2004*
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: IQGAP1 (IQGAP1) → VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) (modification, collaborate)
  Yamaoka-Tojo et al., Circ Res 2004*
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VE-cadherin/beta catenin/alpha catenin complex (CTNNB1-CTNNA1) → VEGFR2 (dimer)/VEGFA (dimer)/IQGAP1/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-IQGAP1-CDH5-CTNNB1-CTNNA1) (modification, collaborate)
  Carmeliet et al., Cell 1999, Yamaoka-Tojo et al., Arterioscler Thromb Vasc Biol 2006
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: IQGAP1 (IQGAP1) → VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) (modification, collaborate)
  Carmeliet et al., Cell 1999, Yamaoka-Tojo et al., Arterioscler Thromb Vasc Biol 2006
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: IQGAP1 (IQGAP1) → VEGFR2 (dimer)/VEGFA (dimer)/IQGAP1/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-IQGAP1-CDH5-CTNNB1-CTNNA1) (modification, collaborate)
  Carmeliet et al., Cell 1999, Yamaoka-Tojo et al., Arterioscler Thromb Vasc Biol 2006
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA) → VEGFR2 (dimer)/VEGFA (dimer)/IQGAP1/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-IQGAP1-CDH5-CTNNB1-CTNNA1) (modification, collaborate)
  Carmeliet et al., Cell 1999, Yamaoka-Tojo et al., Arterioscler Thromb Vasc Biol 2006
  Evidence: physical interaction

Text-mined interactions from Literome

Balenci et al., J Neurosci 2007 : We propose that VEGF synthesized by astrocytes could be involved in the guidance of neural progenitors to neurogenic niches and that IQGAP1 is an effector of the VEGF dependent migratory signal
Kaplan et al., Free radical research 2011 : VEGF increases IQGAP1-Cys-OH formation, which is prevented by N-acetyl cysteine or dimedone, which inhibits VEGF induced EC migration and capillary network formation