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CXCL1 — PAK1

Text-mined interactions from Literome

Wang et al., Biochemistry 2002 : It is shown here that CXCL1 induces cdc42 and PAK1 activation in CXCR2 expressing HEK293 cells ... Moreover, CXCL1 activation of PAK1 is independent of ERK1/2 activation, a conclusion based on the observations that the inhibition of MEK-ERK activation by expression of dominant negative ERK or by the MEK inhibitor, PD98059, has no effect on CXCL1 induced PAK1 activation or CXCL1 induced chemotaxis ... Moreover, CXCL1 activation of PAK1 is independent of ERK1/2 activation, a conclusion based on the observations that the inhibition of MEK-ERK activation by expression of dominant negative ERK or by the MEK inhibitor, PD98059, has no effect on CXCL1 induced PAK1 activation or CXCL1 induced chemotaxis
Wang et al., Biochemistry 2003 : The cell surface HSPGs on cells are required for CXCL1 induced PAK1 activation ... Moreover, CXCL10 can inhibit CXCL1 induced PAK1 and ERK activation as well as the CXCL1 induced chemotaxis through decreasing CXCL1 binding to cell surface heparan sulfate ... Moreover, CXCL10 can inhibit CXCL1 induced PAK1 and ERK activation as well as the CXCL1 induced chemotaxis through decreasing CXCL1 binding to cell surface heparan sulfate ... These data indicate that HSPGs are involved in modulating CXCL1 induced PAK1 activation and chemotaxis through regulating CXCL1 binding activity to CXCR2 receptor ... CXCL10 inhibits CXCL1 induced PAK1 activation and chemotaxis by interfering with appropriate binding of CXCL1 to CXCR2 receptor