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EPHB2 — RAPGEF3

Text-mined interactions from Literome

Laroche-Joubert et al., J Biol Chem 2002 : Protein kinase A-independent activation of ERK and H, K-ATPase by cAMP in native kidney cells : role of Epac I
Keiper et al., J Biol Chem 2004 (MAP Kinase Signaling System) : On the other hand, a cAMP-binding-deficient Epac1 mutant, the Rap GTPase activating proteinII, and a dominant negative Rap2B mutant suppressed receptor- and Epac mediated activation of H-Ras and ERK1/2
Wang et al., Mol Cell Biol 2006 : We confirm that the PKA independent activation of Rap1 by Epac1 activates a perinuclear pool of Rap1 and that this does not result in ERK activation
Fang et al., J Pharmacol Exp Ther 2007 : Inhibition of Epac1 expression with small interfering RNA substantially reduced A ( 2B ) AR-mediated and forskolin induced ERK1/2 phosphorylation and abolished that by 8CPT-2Me-cAMP
Woolson et al., Cell Signal 2009 : However, siRNA depletion and immunoblotting experiments revealed that neither Epac1 nor Epac2 contributed to the PKA independent activation of ERK1,2 observed following cAMP elevation ... Together, these observations suggest that while SOCS-3 induction and subsequent inhibition of cytokine mediated phosphorylation of ERK1,2 and STAT3 in response to cAMP require Epac1 and a transient PKA independent activation of the ERK pathway, these two events are controlled by distinct mechanisms