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CA2 — CLIC2

Text-mined interactions from Literome

Board et al., Int J Biochem Cell Biol 2004 : Functional studies showed that CLIC-2 inhibited cardiac ryanodine receptor Ca2+ release channels in lipid bilayers when added to the cytoplasmic side of the channels and inhibited Ca2+ release from cardiac sarcoplasmic reticulum vesicles
Meng et al., J Mol Biol 2009 (Ion Channel Gating) : We found that : ( 1 ) CLIC2 facilitated [ 3H ] ryanodine binding to skeletal SR and purified RyR1, by increasing the binding affinity of ryanodine for its receptor without significantly changing the apparent maximal binding capacity ; ( 2 ) CLIC2 reduced the maximal Ca2+ efflux rate from skeletal SR vesicles ; ( 3 ) CLIC2 decreased the open probability of RyR1 channel, through increasing the mean closed time of the channel ; ( 4 ) CLIC2 bound to a region between domains 5 and 6 in the clamp shaped region of RyR1 ; ( 5 ) and in the same clamp region, domains 9 and 10 became separated after CLIC2 binding, indicating CLIC2 induced a conformational change of RyR1