Gene interactions and pathways from curated databases and text-mining

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APOB — EGR1

Text-mined interactions from Literome

Heo et al., Biochem Biophys Res Commun 2008 : Inhibition of PKCbeta ( II ) or PKCtheta, as well as of Erk1/2 and GPCR, decreases LDL induced upregulation of Egr-1 , which is critical for cell proliferation
Heo et al., Mol Cells 2008 : Moreover, pretreatment with DIDS ( Cl- channel blockers ) but not LY294002 ( PI3K inhibitors ) completely abolished the LDL induced upregulation of Egr-1 to the same extent as PD98059 ( MEK inhibitors to inhibit Erk ), as judged by Western blot and luciferase reporter assays
Ko et al., Eur J Cell Biol 1995 : Native LDL induces a dose dependent increase of early growth response gene-1 (egr-1) mRNA expression