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DPM1 — DPM3

Pathways - manually collected, often from reviews:

• Reactome Reaction: DPM1 → DPM3 (direct_complex)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: DPM3 — DPM1 (physical association, affinity chromatography technology) Ashida et al., J Biol Chem 2006
• IRef Biogrid Interaction: DPM3 — DPM1 (association, biochemical) Maeda et al., EMBO J 2000*
• MIPS CORUM Dolichol-phosphate mannose (DPM) synthase: Dolichol-phosphate mannose (DPM) synthase complex (DPM1-DPM2-DPM3) Maeda et al., EMBO J 2000*
• IRef Corum Interaction: Complex of DPM1-DPM2-DPM3 (association, affinity chromatography technology) Maeda et al., EMBO J 2000*
• IRef Hprd Interaction: DPM3 — DPM1 (in vivo) Maeda et al., EMBO J 2000*
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Maeda et al., EMBO J 2000*

Text-mined interactions from Literome

Maeda et al., EMBO J 2000 : However, overexpression of DPM3 in Lec15 cells, a null mutant of DPM2, restored the biosynthesis of DPM with an increase in DPM1, indicating that DPM3 directly stabilized DPM1 ... However, overexpression of DPM3 in Lec15 cells, a null mutant of DPM2, restored the biosynthesis of DPM with an increase in DPM1, indicating that DPM3 directly stabilized DPM1 ... Schizosaccharomyces pombe has proteins that resemble three human subunits ; S.pombe DPM3 restored biosynthesis of DPM in Lec15 cells, indicating its orthologous relationship to human DPM3
Maeda et al., EMBO J 1998 : The class E mutant is defective in the DPM1 gene which encodes a mammalian homologue of Saccharomyces cerevisiae Dpm1p that is a DPM synthase, whereas Lec15 is a different mutant, indicating that mammalian DPM1 is not sufficient for DPM synthesis