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CAV1 — KDR
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Labrecque et al., Mol Biol Cell 2003
:
Interestingly, we observed that in an overexpression system in which VEGFR-2 is constitutively active,
caveolin-1 overexpression
inhibits VEGFR-2 activity but allows VEGFR-2 to undergo VEGF dependent activation, suggesting that caveolin-1 can confer ligand dependency to a receptor system ... Removal of
caveolin and VEGFR-2 from caveolae by cholesterol depletion
resulted in an increase in both basal and VEGF induced phosphorylation of
VEGFR-2 , but led to the inhibition of VEGF induced ERK activation and endothelial cell migration, suggesting that localization of VEGFR-2 to these domains is crucial for VEGF mediated signaling
Fang et al., Cell cycle (Georgetown, Tex.) 2007
:
Recently, we have shown that overexpression of
caveolin-1 , a putative transformation suppressor gene,
inhibits VEGFR-2 and MEK-1 mediated mitogenic signal to the nucleus
Lin et al., Cancer Res 2007
(Carcinoma, Lewis Lung...) :
Thus, the loss of
Cav-1 increases tumor permeability and growth and that may relate to enhanced VEGF signaling
due to lack of Cav-1 inhibition of
VEGFR-2 or decreased VE-cadherin mediated VEGFR-2 phosphorylation