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BAX — CAPN7

Text-mined interactions from Literome

Gao et al., J Cell Biochem 2000 : Both the calpain mediated Bax cleavage activity and the Bax/p18 fragment were found in the mitochondrial membrane enriched fraction
Choi et al., J Neurochem 2001 (Necrosis) : Cleavage of Bax is mediated by caspase dependent or -independent calpain activation in dopaminergic neuronal cells : protective role of Bcl-2 ... This proteolytic cleavage of Bax appeared to be mediated by calpain as determined by incubation with [ ( 35 ) S ] methionine labelled Bax
Oh et al., Biochem Pharmacol 2004 : Taken together, our results suggest that Cd-induced apoptosis was thought to be mediated at least two pathways ; caspase dependent Bid cleavage, and the other is calpain mediated mitochondrial Bax cleavage
Quiniou et al., J Pharmacol Exp Ther 2006 (Retinal Degeneration) : U-46619 induced calpain activation resulted in translocation of Bax to the mitochondria, loss of polarization of the latter ( using potentiometric probe 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolyl-carbocyanine iodide ; JC-1 ) and in turn release of cytochrome c into the cytosol and depletion of cellular ATP ; these effects were all blocked by calpain inhibitors
Cheng et al., Arch Biochem Biophys 2008 : We found that inhibition of calpain increased oridonin induced Bax activation, cytochrome c release and PARP cleavage, indicating that calpain plays an anti-apoptotic role in oridonin induced L929 cell apoptosis
Das et al., Cancer 2010 (Brain Neoplasms...) : Other events in apoptosis included overexpression of Bax , loss of DeltaPsi ( m ), mitochondrial release of cytochrome c and Smac into the cytosol, down-regulation of baculoviral inhibitor-of-apoptosis repeat containing proteins, and activation of calpain , caspase-9, and caspase-3
El-Khoury et al., Mol Cancer Ther 2010 (Leukemia, Lymphocytic, Chronic, B-Cell) : Moreover, MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9, caspase dependent amplification of mitochondrial depolarization, activation of calpain , and Bax cleavage
Yoo et al., J Biol Chem 2012 (Neoplasms) : Together, these results demonstrate that PDT with a chlorin based photosensitizer targets TG2 by activating calpain induced Bax translocation, which induces apoptotic cell death through both caspase dependent and AIF mediated pathways