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Blix et al., Eur J Oral Sci 1999 (Aggressive Periodontitis) : In this study, the effect of lipopolysaccharides (LPS) extracted from A. actinomycetemcomitans on the expression of the leukocyte adhesion molecules CD11a/CD18, CD11b/CD18 , CD11c/CD18 and L-selectin ( CD 62L ) were measured in an ex vivo whole blood system by use of fluorescent antibodies followed by flow cytometry
Rizoli et al., J Surg Res 1999 (Shock, Hemorrhagic) : At this time, LPS caused an increase in both neutrophil lung sequestration and CD11b expression, regardless of the resuscitation regimen used ... In vitro studies showed that the duration of hypertonic pretreatment is an important determinant of cell responsiveness under the isotonic conditions : Four but not 2 h hypertonic exposure was able to prevent upregulation of CD11b induced by LPS added immediately after reestablishing isotonicity ... This study demonstrates that HTS resuscitation lessens lung neutrophil sequestration and CD11b surface expression induced by LPS
Rizoli et al., J Trauma 1999 : Hypertonicity had no effect on CD11b or CD14, caused a weak p38 phosphorylation, and completely prevented the LPS induced p38 phosphorylation and CD11b up-regulation ... p38 inhibition also abrogated CD11b up-regulation by LPS ... MAPKp38 is important in CD11b regulation by LPS
Diez-Fraile et al., Vet Immunol Immunopathol 2000 : Both IPN and DX caused a dose dependent inhibition of LPS induced CD11b expression
Monneret et al., Intensive Care Med 2003 (Inflammation...) : This study examined whether CGRP and N-PCT modulate the LPS induced expression of CD11b , which is one of the major integrins involved in monocyte and neutrophil chemotaxis during a response to microbial infections
Henneke et al., J Perinat Med 2003 (Escherichia coli Infections...) : LPS induced CD11b expression was dependent on binding of LPS to the surface protein CD14 as CD14 antibodies inhibited LPS dependent CD11b upregulation
Wang et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2004 (Acute Lung Injury...) : LPS could induce the release of large amount of IL-8, and it activates the expression of CD11b on the surface of PMN, which shows high degree of correlation with IL-8 and the degree of pathological changes in the lung
Collin et al., J Leukoc Biol 2004 (Disease Models, Animal...) : Zileuton also reduced the LPS induced expression of CD11b/CD18 on rat leukocytes
Diez-Fraile et al., Can J Vet Res 2004 (Mastitis, Bovine) : In addition, we evaluated the effect of lipopolysaccharide (LPS) and tumor necrosis factor (TNF)-alpha on CD11b surface expression in PMN at different stages of lactation in a whole blood model
Fiorucci et al., J Am Coll Cardiol 2004 : NCX-4016 also inhibited the rapid TF expression induced in monocytes by a proteinase activated receptor agonist ( thrombin receptor activator protein, 2 micromol/l ) as well as LPS induced expression of CD11b
Zhou et al., Am J Physiol Lung Cell Mol Physiol 2005 : LPS activation of Toll-like receptor 4 signals CD11b/CD18 expression in neutrophils
Jeyaseelan et al., Infect Immun 2005 (Respiratory Distress Syndrome, Adult) : The CD14 independent LPS response was dependent on CD11b
Dimayuga et al., J Neuroimmunol 2005 (Encephalitis) : Specifically, the effects of 17beta-estradiol on basal and LPS induced surface staining of Class I and II MHC, as well as CD40, CD80, CD86, CD152, CD28, CD8, CD11b , Fas, FasL, and also ERalpha and ERbeta, were examined in N9 microglial cells
Nandate et al., Anesth Analg 2005 : NAC ( > 10 mM ) significantly inhibited the lipopolysaccharide (LPS) induced upregulation of CD11b in a concentration dependent manner
Simms et al., J Surg Res 1992 : In the presence of fibronectin or laminin, LPS reduced CD11b/CD18 expression ( the fibronectin receptor ) as assessed using sheep erythrocytes coated with C3bi
Coimbra et al., J Trauma 2005 (Shock, Hemorrhagic) : Furthermore, a significant decrease in LPS induced neutrophil CD11b expression after PTX treatment ( 79 +/- 5 vs. 100 ; p < 0.05 ) and HSPTX40 ( 68 +/- 7 vs. 100 ; p < 0.05 ) was observed
Molloy et al., Biol Neonate 2006 : Both hypoxia and HS prevented the LPS induced increase in adult CD11b although it was unaltered in neonates
Roy et al., J Biol Chem 2006 (Neurodegenerative Diseases) : Bacterial lipopolysaccharide (LPS) induced the production of NO and increased the expression of CD11b in mouse BV-2 microglial cells and primary microglia ... Furthermore, co-microinjection of PTIO with LPS was also able to suppress LPS mediated expression of CD11b and loss of dopaminergic neuronal fibers and neurotransmitters in striatum in vivo ... Inhibition of LPS- and GSNO mediated up-regulation of CD11b either by NS2028 ( a specific inhibitor of GC ) or by KT5823 and Rp-8-bromo-cGMP ( specific inhibitors of PKG ), and increase in CD11b expression either by 8-bromo-cGMP or by MY-5445 ( a specific inhibitor of cGMP phosphodiesterase ) alone suggest that NO increases microglial expression of CD11b via GC-cGMP-PKG
Lynn et al., J Immunol 1991 : By using flow cytometry, we have characterized LPS induced expression of the beta 2 integrin CD11b/CD18
Zhou et al., Inflamm Res 2007 (Endotoxemia) : There was a significant decrease in LPS induced PMN respiratory burst activity and CD11b expression in three ketamine treatment groups when compared with LPS group ( p < 0.01 )
Ozaki et al., J Trauma 2007 : Ethanol inhibited this LPS induced upregulation of CD11b ( p < 0.001 )
Watkins et al., J Trauma 2008 (Disease Models, Animal...) : LDL attenuated LPS- induced lung injury, lung permeability, and rat PMN CD11b expression but not villous injury
Roy et al., Free Radic Biol Med 2008 (Neurodegenerative Diseases) : Bacterial lipopolysaccharide (LPS) stimulated the expression of CD11b in mouse BV-2 microglial cells and primary microglia, the effect that was blocked by antioxidants such as N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate ( PDTC ) ... Furthermore, comicroinjection of either NAC or PDTC with LPS was also able to suppress LPS stimulated expression of CD11b in striatum in vivo ... Complete inhibition of LPS stimulated expression of CD11b by catalase, induction of CD11b expression by H2O2 alone, and inhibition of superoxide stimulated CD11b expression by catalase suggest that H2O2, but not superoxide, is in fact involved in the expression of CD11b
Mayr et al., Shock 2008 (Endotoxemia...) : Finally, neither the LPS induced release of tumor necrosis factor, interleukin 6, leukocyte expression of CD11b , nor intercellular adhesion molecule 1 were affected by administration of bimosiamose
Wang et al., Cytokine 2010 : Furthermore, ApoA-I significantly inhibited LPS induced CD11b and VCAM-1 expression on THP-1 cells ( P < 0.01, P < 0.05, respectively )
McIlvain et al., Eur J Pharmacol 2010 : Microglia activation by LPS also caused an increase in CD11b expression and a reduction in process count ; however, in contrast to activation by ATP, morphological transformation was accompanied by a concentration dependent increase in TNFalpha secretion These data demonstrate that morphological transformation and TNFalpha release are separable events mediated by different, or non-convergent pathways and that although ATP can initiate morphological changes, additional factors are required to maintain activation over sustained periods
Izban et al., PloS one 2012 : In 1,25-D3 pretreated cells, LPS differentially regulated protein expression - CD14 ( 21-fold increase ) and CD11b ( a transient 2-fold decrease ) - principally at the posttranscriptional level
Lynam et al., Blood 1994 : Taken together, the data suggest that inhibition of neutrophil aggregation by LPS/LBP is related to the expression of L-selectin via CD14 rather than LPS inhibition of CD11b/CD18 function during cellular stimulation
Simms et al., Shock 1995 : We investigated the effects of lipopolysaccharide (LPS) on the subcellular location of the integrin receptor CD11b/CD18 ( Mac-1 ) ... Cytoplast and subcellular fractionation experiments were performed to distinguish between receptor shedding and intracellular receptor transport as mechanisms involved for the effects of LPS on CD11b/CD18 expression ... These results demonstrate that LPS regulates CD11b/CD18 expression by inducing intracytoplasmic translocation of this receptor to azurophilic granules
Simms et al., J Appl Physiol 1994 (Anoxia) : During hypoxemia ( 10-30 % O2 saturation ), LPS reduced CD11b/CD18 expression ... Incubation of whole blood PMNs with an anti-CD14 monoclonal antibody ( MEM18 ) largely prevented the LPS induced reduction of CD11b/CD18 expression
Connall et al., Arch Surg 1994 (Peritonitis) : CD11b expression on polymorphonuclear leukocytes increased threefold in the RDE/LPS ( mean +/- SEM, 91.3 +/- 8.1 ) and the saline/LPS ( mean +/- SEM, 89.8 +/- 11.4 ) groups compared with controls ( mean +/- SEM, 32.1 +/- 1.8 ) ( P < .05 )
Kaupke et al., Kidney Int 1996 : G-PDS, as well as the mixtures of spent and fresh G-PDS, significantly depressed the basal PMN expression of adhesion receptors CD11b and CD18 and monocyte expression of CD14, and substantially mitigated the LPS mediated up-regulation of CD11b and CD18
Blanco et al., Dev Comp Immunol 1997 : The expression of CD11b and CD11c antigens was augmented by LPS treatment of coelomocytes
Nakatomi et al., J Leukoc Biol 1998 : Immobilized LPS induced up-regulation of CD11b/CD18 and latent alkaline phosphatase and also enhanced the adhesive response of neutrophils
Rizoli et al., J Immunol 1998 (Inflammation...) : Specifically, hypertonicity induced shedding of L-selectin and prevented LPS stimulated expression and activation of CD11b , both of which might contribute to reduced sequestration in the lung